tumor necrosis factor inhibitors
Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
Ngày tải lên :
21/02/2014, 15:20
... TNFreceptor-associated factor family Scaffold molecules for cytokine receptors, kinases and their regulators Cell Signal 13, 389–400 Bradley, J.R & Pober, J.S (2001) Tumor necrosis factor receptorassociated factors ... Chenard, M.P., Wendling, C., Mattei, M.G., Tomasetto, C & Rio, M.C (1998) Tumor necrosis factor receptor associated factor (TRAF4) expression pattern during mouse development Mech Dev 71, 187–191 ... G., Peters, N., Scheurich, P., Schmid, R.M & Wajant, H (1999) The human tumor necrosis factor (TNF) receptor-associated factor gene (TRAF1) is up-regulated by cytokines of the TNF ligand family...
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Báo cáo khoa học: Catalytic digestion of human tumor necrosis factor-a by antibody heavy chain pot
Ngày tải lên :
06/03/2014, 22:21
... human serum albumin (HSA), BSA, human IgA, human IgM, human IgE, human hemoglobin, KLH and tumor necrosis factor- b (TNF-b) (Fig 1) ETNF-6 mAb possessed very high specificity against hTNF-a The apparent ... possibility that we can prepare catalytic antibodies capable of cleaving molecules of interest Tumor necrosis factor- a (TNF-a) is a crucial molecule as an inflammatory cytokine, and causes severe diseases ... SRIAVSYQTK VNLLSAIKSP 101 CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLLFAESGQV 151 YFGIIAL [28], factor VIII [4], gp120 [32], and H pylori urease [24], have been shown to possess a multicleavage...
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Báo cáo khoa học: Tumor necrosis factor-a converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation pptx
Ngày tải lên :
08/03/2014, 02:20
... by tumor necrosis factor- a converting enzyme Biochem J 357, 787–794 33 Schlondorff, J., Becherer, J.D & Blobel, C.P (2000) Intracellular ¨ maturation and localization of the tumour necrosis factor ... Peschon, J.J., Johnson, R.S., Castner, B.J., Cerretti, D.P & Black, R.A (1998) Evidence that tumor necrosis factor a converting enzymeisinvolvedinregulateda-secretasecleavageoftheAlzheimer amyloid ... 31 Merlos-Suarez, A., Fernandez-Larrea, J., Reddy, P., Baselga, J & Arribas, A (1998) Pro -tumor necrosis factor- a processing activity is tightly controlled by a component that does not affect Notch...
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Báo cáo khoa học: Tumor necrosis factor-a-induced caspase-1 gene expression pptx
Ngày tải lên :
16/03/2014, 05:20
... (1995) Fas- and tumor necrosis factor- induced apoptosis is inhibited by the poxvirus gene product J Biol Chem 270, 3255–3260 Miura M, Friedlander RM & Yuan J (1995) Tumor necrosis factor- induced ... between interferon-c and tumor necrosis factor- a in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription and nuclear factor jB J Biol Chem ... to the activation of transcription factor nuclear factor- jB (NF-jB), which directly mediates the induction of several genes, including interferon regulatory factor- 1 (IRF-1) [4,5] Caspase-1 is...
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Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx
Ngày tải lên :
16/03/2014, 06:20
... 26 27 28 29 30 31 32 Luger TA et al (1993) The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor- alpha and by ultraviolet B radiation J Clin Invest ... were interested to know whether factors involved in maintaining epidermal homeostasis affect DNp63a expression We were particularly interested in tumor necrosis factor- a (TNF-a), as this pleiotropic ... Lind MH, Rozell B, Wallin RP, van Hogerlinden M, Ljunggren HG, Toftgard R & Sur I (2004) Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by...
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Báo cáo khoa học: Tumor necrosis factor receptor cross-talk docx
Ngày tải lên :
28/03/2014, 23:20
... nuclear factor kappa B; RIP, receptor interacting protein; TRADD, TNF receptorassociated death domain; TRAF, TNF receptor associate factor; TNF, tumor necrosis factor; TNFR1, tumor necrosis factor ... homolog deleted on chromosome ten; NFjB, nuclear factor kappa B; TRAF, TNF receptor associated factor; TNF, tumor necrosis factor; TNFR2, tumor necrosis factor receptor-2 TRAF2 plays a pivotal role ... Bradley JR & Pober JS (2001) Tumor necrosis factor receptor-associated factors (TRAFs) Oncogene 20, 6482 78 Kalb A, Bluethmann H, Moore MW & Lesslauer W (1996) Tumor necrosis factor receptors (Tnfr)...
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Báo cáo khoa học: Nuclear factor kappa B and tumor necrosis factor-alpha modulation of transcription of the mouse testis- and pre-implantation development-specific Rnf33⁄Trim60 gene pot
Ngày tải lên :
29/03/2014, 00:20
... Expression of tumor necrosis factoralpha in mouse spermatogenic cells Endocrinology 133, 389–396 33 Mauduit C, Gasnier F, Rey C, Chauvin MA, Stocco DM, Louisot P & Benahmed M (1998) Tumor necrosis factor- alpha ... transcriptional activity of differentially phosphorylated nuclear factor- kappa B J Biol Chem 280, 244–252 31 Lysiak JJ (2004) The role of tumor necrosis factoralpha and interleukin-1 in the mammalian testis ... targeted by the p65 ⁄ RelA and p50 ⁄ NFjB1 nuclear factor- jB (NF-jB) subunits, and the jB-dependent transcription was also modulated by tumor necrosis factor alpha (TNF-a) p65 ⁄ p50 transcriptional...
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Báo cáo khoa học: Induction of PAI-1 expression by tumor necrosis factor a in endothelial cells is mediated by its responsive element located in the 4G/5G site ppt
Ngày tải lên :
30/03/2014, 11:20
... produce tumor necrosis factor- alpha in response to proinflammatory cytokine stimulation Crit Care Med 27, 2184–2187 19 Imaizumi T, Itaya H, Fujita K et al (2000) Expression of tumor necrosis factor- alpha ... Dixon JD, Schoenhard JA & Vaughan DE (2004) Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site J Biol Chem 279, 18127–18136 ... Janssen-Heininger YM, Macara I & Mossman BT (1999) Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor NF-jB: requirement of Ras ⁄ mitogen-activated protein kinases in...
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Báo cáo Y học: Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification pdf
Ngày tải lên :
31/03/2014, 08:20
... cytotoxicity in tumor necrosis serum Cancer Res 41, 4885–4890 Niitsu, Y., Watanabe, N., Sone, H., Neda, H., Yamauchi, N & Urushizaki, I (1985) Mechanism of the cytotoxic effect of tumor necrosis factor ... M.Z., Sedger, L.M., Maliszewski, C.R & Fanger, N.A (1999) Monocyte-mediated tumoricidal activity via the tumor necrosis factor- related cytokine, TRAIL J Exp Med 189, 1343–1354 Kayagaki, N., Yamaguchi, ... human tumor necrosis factor and interferon-c in damage of liposome membranes J Biol Chem 262, 4597–4601 24 Baldwin, R.L., Stolowitz, M.L., Hood, L & Wisnieski, B.J (1996) Structural changes of tumor...
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tumor necrosis factor, methods and protocols
Ngày tải lên :
11/04/2014, 10:38
... Pharmacological Target 1 Tumor Necrosis Factor as a Pharmacological Target Pietro Ghezzi and Anthony Cerami Summary Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties ... Vol 98: Tumor Necrosis Factor Edited by: A Corti and P Ghezzi © Humana Press Inc., Totowa, NJ Ghezzi and Cerami rhagic necrosis of tumors in vivo and of killing tumor cells in vitro This factor ... human inhibitor of tumor necrosis factor alpha J Exp Med 167, 1511–1516 Seckinger, P., Zhang, J H., Hauptmann, B., and Dayer, J M (1990) Characterization of a tumor necrosis factor alpha (TNF-alpha)...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
Ngày tải lên :
19/06/2014, 22:20
... abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice Int Immunol 1996, 8:23-36 Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP: Tumor necrosis factor ... differential expression of tumor necrosis factor- alpha mRNA in the CNS Mol Brain Res 1996, 36:287-291 Knoblach SM, Fan L, Faden AI: Early neuronal expression of tumor necrosis factor- alpha after experimental ... RK: Elevation of tumor necrosis factor in head injury J Neuroimmunol 1990, 30:213-217 Ross SA, Halliday MI, Campbell GC, Byrnes DP, Rowlands BJ: The presence of tumour necrosis factor in CSF and...
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báo cáo hóa học: " Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells" pptx
Ngày tải lên :
19/06/2014, 22:20
... survival on target derived neurotrophic factors such as nerve growth factor (NGF), brainderived neurotrophic factor (BDNF) or glia-derived neurotrophic factor (GDNF) The same neurodegenerative ... fatal head injury J Neurotrauma 2002, 19:279-84 Macdonald NJ, Taglialatela G: Tumor necrosis factor alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma cells Neuroreport ... Neet KE, Taglialatela G: Tumour necrosis factor- alpha- vs growth factor deprivation-promoted cell death: different receptor requirements for mediating nerve growth factor- promoted rescue Aging Cell...
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báo cáo hóa học: " Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte " ppt
Ngày tải lên :
19/06/2014, 22:20
... interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes Neurobiol Dis 2000, 7:682-689 Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS: Tumor necrosis factor- alpha, ... APPswe: Amyloid precursor protein Swedish mutation PS1: Presenilin Aβ : Beta-amyloid TNF-α : Tumor necrosis factor- alpha Tg: Transgenic PBS: Phosphate-buffered saline Competing interests The author(s) ... innate immune cells, activates macrophages cytokine, inhibits cell growth cytokine, T cell growth factor cytokine, B and T cell growth and differentiation cytokine, secreted by macrophage(predominately...
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báo cáo hóa học: " Modulation of spinal cord synaptic activity by tumor necrosis factor alpha in a model of peripheral neuropathy" potx
Ngày tải lên :
19/06/2014, 22:20
... Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons J Neurosci 1997, 17:975-982 Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM: Tumor necrosis factor ... induced by tumor necrosis factor- alpha J Neurosci 2010, 30:12844-12855 Zhang H, Dougherty PM: Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor J Physiol ... of tumor necrosis factor receptors and in injured and adjacent uninjured dorsal root ganglia in the rat Neurosci Lett 2003, 347:179-182 Xu JT, Xin WJ, Zang Y, Wu CY, Liu XG: The role of tumor necrosis...
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Bước đầu nghiên cứu nồng độ yếu tố hoại tử u alpha TNFa (tumor necrosis factor alpha) trong huyết thanh bệnh nhân viêm tụy cấp
Ngày tải lên :
24/07/2014, 01:57
... cytokin ny VTC Vỡ vy chỳng tụi tin hnh ti Bc u nghiờn cu nng yu t hoi t u alpha TNF (Tumor Necrosis Factor- alpha) huyt bnh nhõn viờm ty cp, nhm hai mc tiờu sau: Tỡm hiu nng TNF huyt bnh nhõn...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... Roux-Lombard P, Meyer O, Dayer JM, Vischer T, Yazici H, Guerne PA: Circulating levels of tumor necrosis factor soluble receptors in systemic lupus erythematosus are significantly higher than in ... Yoshimura T, Brocker EB, Rapp UR, Ludwig S: The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor- alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells ... ISG15 and IRF7 showed almost no response to TNF in vitro These data suggest that other soluble factors might be involved in the regulation on the gene expression Indeed, high levels of interferon...
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Báo cáo y học: "Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... Goldfeld AE: Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells Proc Natl Acad Sci USA 1994, 91:7007-7011 Rieckmann P, Tuscano JM, Kehrl JH: Tumor necrosis factoralpha ... Ewijk W, McDevitt HO: Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development Int Immunol 1998, 10:727-741 Jacob CO: Tumor necrosis factor alpha in autoimmunity: ... roles for tumor necrosis factor- alpha and lymphotoxin alpha/beta in immunity and autoimmunity Arthritis Res 2002, 4(suppl 3): S141-S152 Kehrl JH, Miller A, Fauci AS: Effect of tumor necrosis factor...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
Ngày tải lên :
09/08/2014, 01:23
... Zhang HG, Wang Y, Xie JF, Liang X, Liu D, Yang P, Hsu HC, Ray RB, Mountz JD: Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein ... death domain of TNFRI, TNF-α activates mainly signalling pathways and transcription factors such as nuclear factor- κB, which mediate the survival of cells Thus, it is understood that, in rheumatoid ... sFas in their cell culture supernatants than did control tenocytes Stimulation with tumour necrosis factor (TNF)-α over 24 hours resulted in a dose dependent upregulation of sFas in all tenocytes,...
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Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
Ngày tải lên :
09/08/2014, 01:23
... soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti -tumor necrosis factor alpha treatment Arthritis Rheum ... by tumor necrosis factor or interleukin-1 J Biol Chem 1992, 267:1846-1852 28 Haynes DR, Crotti TN, Loric M, Bain GI, Atkins GJ, Findlay DM: Osteoprotegerin and receptor activator of nuclear factor ... < 0.01, * P < 0.05 versus medium alone See Fig for an example of an actual picture TNF, tumor necrosis factor R194 The combination of the three cytokines was even more potent, leading to a synergistic...
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Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
Ngày tải lên :
09/08/2014, 06:22
... collagen mRNA by TNF-α, by EGF or R132 tumor necrosis factor alpha (TNF-α) Epidermal growth factor (EGF) does not alter NF-κB activation by tumor necrosis factor alpha (TNF-α) (a) Chondrocytes ... (TNF-α) maintained in the presence of tumor necrosis factor Cell viability is and/or epidermal growth factor (EGF) alpha (TNF-α) and/or epidermal growth factor (EGF) Subconfluent monolayers of ... individual factors and partially protected against the effect of TNF-α and EGF in combination (TNF-α) or epidermal growth factor (EGF) aggrecan of type II kinase C does by tumor necrosis factor alpha...
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