transcription factors and their target properties
Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt
Ngày tải lên :
09/08/2014, 22:24
... of transcription factors and their associated targets in the yeast regulatory network, relationships between gene properties such as expression and binding status and breast cancer type, and ... drug properties and target properties To investigate more complex non-obvious connections, we applied CRIT to identify relationships between small molecule properties and properties of their ... where the target/ target-property matrix was partitioned on the basis of sensitivity and those target properties that were able to discriminate between the TF propertysensitive targets and TF property-insensitive...
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
Ngày tải lên :
18/02/2014, 06:20
... plant and regulate their translation and ⁄ or turnover A large number of APUM target candidates: is this plausible? RNA-binding proteins have been associated with diverse aspects of post-transcriptional ... human and mouse possess two; and Drosophila and Dyctiostelium have only one member [5] Recently, new studies have revealed the presence of ten, two and one homologs in Trypanosome, Plasmodium and ... NRE(A+B)); and in both Box A and B, NRE(A–B–) (C) Qualitative analysis of LacZ reporter activation in the interaction of APUM-2 and APUM-7 with NRE WT and NRE mutants The iron responsive element RNA and...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
Ngày tải lên :
07/03/2014, 05:20
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were...
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Báo cáo khoa học: "Learning to Translate with Source and Target Syntax" pot
Ngày tải lên :
07/03/2014, 22:20
... similar to the expanded set recently used for Hiero (Chiang et al., 2009), but with bigram features (source and target word) instead of trigram features (source and target word and neighboring ... bitexts, and one on two billion words of English These were smoothed using modified Kneser-Ney (Chen and Goodman, 1998) and stored using randomized data structures similar to those of Talbot and Brants ... source and target side, which reduces the number of eligible phrases Table shows an analysis of phrases extracted from human word-aligned and parsed data and automatically word-aligned and parsed...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
Ngày tải lên :
08/03/2014, 06:20
... iron and steel and motor vehicles (2.8 per cent and 5.3 per cent respectively) and approximately the same size as the international trade in textiles (7.5 per cent), oil and gas (8.6 per cent) and ... Europe: Belgium, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country ... specific dates and magnitudes), cases of SARM increased by a factor of in Germany and Spain, and a factor of approximately in Austria, Belgium, Italy and Switzerland In France and the United...
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Báo cáo khoa học: "Bridging Morpho-Syntactic Gap between Source and Target Sentences for English-Korean Statistical Machine Translation" pot
Ngày tải lên :
17/03/2014, 02:20
... any English words, and can simply and easily be removed by referring to their POS information The unaligned words are case particles, final endings, and auxiliary particles, and they call these ... particle and an objective particle , and insert them after the corresponding dependents Eugene and guitar respectively on content-words, which can deteriorate the performance of candidate ... 2005; Xia and McCord, 2004; Zwarts and Dras, 2007) Some reordering approaches have given significant improvements in performance for translation from French to English (Xia and McCord, 2004) and from...
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Báo cáo khoa học: "Resolving Translation Ambiguity and Target Polysemy in Cross-Language Information Retrieval" potx
Ngày tải lên :
17/03/2014, 07:20
... Resolution Models In the recent works, Ballesteros and Croft (1998), and Bian and Chen (1998) employ dictionaries and co-occurrence statistics trained from target language documents to deal with translation ... the use o f a power or right; and so on The multiplication effects of translation ambiguity and target polysemy make query translation harder Translation Ambiguity and Polysemy Resolution Models ... these words be CW~, CW2, , and C W m Assume the corresponding English translations of C, CW~, CW2, , and CWm are E, EW,, E W , , and EWm, respectively EWe, EW2, , and EWm form an augmented translation...
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the effect of the hydrothermal treatment with aqueous naoh solution on the photocatalytic and photoelectrochemical propertiesof visible light-responsive TiO2thin films
Ngày tải lên :
20/03/2014, 13:11
... patterns of Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti and (b) the expanded XRD patterns of (a) (2u = 5–158) Fig XPS spectra of the Ti 2p (right) and Na 1s (left) peaks of the Vis-TiO2/Ti and NaOH(X)-Vis-TiO2/Ti ... hydrothermal treatment of Vis-TiO2 thin films on their characteristics, photoelectrochemical properties, and photocatalytic activities for the separate evolution of H2 and O2 from water under solar light ... (Laforet Engineering, XD50D) and the evolved H2 and O2 were analyzed by a gas chromatograph (GC, G2800-T, Yanaco) with a thermal conductivity detector (TCD) Results and discussion Photoelectrochemical...
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financial statement analysis Abbott Laboratories and Target
Ngày tải lên :
25/03/2014, 12:18
... retail and credit card Target is known for their operations in general merchandise and food items Their general merchandise segment includes household essentials, electronics, apparel and accessories, ... 2010 Executive Summary Target s main lines of business are retail and credit card Target is well known for their operations in general merchandise and food items They owe their success to positive ... Analysts believe that Target s recent decision to expand their food format will likely go over well with their customers and will increase store sales Target recently announced that their credit card...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
Ngày tải lên :
28/03/2014, 10:20
... hydroxylamines and oximes and secondary amines to N-hydroxy and nitrone products Aromatic amines and amides are not substrates Thioethers can be oxidized to sulfoxides; and thiols, thioamides, and thiocarbamates ... be used as a teaching and/ or reference tool to delineate and understand the “why” and “how” with regard to the many creative uses of mass spectrometry in drug metabolism and disposition studies ... Lee, and Guodong Chen Characterization of Impurities and Degradants Using Mass Spectrometry Mike S Lee and Mingshe Zhu Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
Ngày tải lên :
29/03/2014, 08:20
... withdrawn and their ATP content was determined ATP content is expressed as a percentage of the ATP content of the control K562 cells and their Pgp over-expressing cells (4.6 ± 0.6 and 5.3 ± 0.7 ... unstirred and dense with proteins Moreover, TMRM and anticancer drugs, such as anthracyclines, are positively charged and therefore bind to acidic groups in proteins and membranes Thus, their movement ... sodium azide resulted in little change in their ATP content These cells relied mainly on glycolysis for their ATP supply and only poisoning the mitochondria and glucose deprivation lead to a reduction...
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For Medicare Advantage Plans, Medicare Advantage Prescription Drug Plans, Prescription Drug Plans, and 1876 Cost Plans ppt
Ngày tải lên :
29/03/2014, 23:20
... name(s) or brand(s) of the co-branding entity or entities on its marketing materials to signify a business arrangement Co-branding arrangements allow a plan sponsor and its co-branding partner(s) ... Drug Program’s (NCPDP’s) “Pharmacy and/ or Combination ID Card” standard This standard is based on the American National Standards Institute ANSI INCITS 284-1997 standard titled Identification Card ... by their subcontractors to market their plan(s) All marketing materials used by plan sponsors or their subcontractors must be submitted by the plan sponsor (or its designee) to CMS for review and...
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Báo cáo khoa học: "Combining Source and Target Language Information for Name Tagging of Machine Translation Output" ppt
Ngày tải lên :
31/03/2014, 00:20
... output (target language part) and 1968 named entities in the ET output (source language part); 1171 of them are the same This means that 38.14% of the names tagged in the target language and 40.5% ... the source and target NER may have different strengths on name tagging We checked the names which are tagged differently, and there are 347 correct names from ET missed by English NER and 418 from ... previous token F4 and F5 are used to help resolve the type conflicts, and F6 and F7 to resolve boundary conflicts When there is a conflict, we need the confidence information from both ET and English...
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fragment based drug discovery and x-ray crystallography
Ngày tải lên :
29/05/2014, 23:54
... Davies and Ian J Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening 61 Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, and Roderick E Hubbard Combining NMR and ... metal-coated chip and ligands are allowed to flow past Ligands that bind to the protein cause changes in the reflectivity properties of the metal that are related to the mass of the ligand and the mass ... Marsh, Sandra Greive, and Marko Hyvonen Fragment Screening and HIV Therapeutics 181 Joseph D Bauman, Disha Patel, and Eddy Arnold Fragment-Based Approaches and Computer-Aided...
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báo cáo hóa học: " Simultaneous buried object detection and imaging technique utilizing fuzzy weighted background calculation and target energy moments on ground penetrating radar data" potx
Ngày tải lên :
21/06/2014, 00:20
... Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, USA (13-17 April 2009) DJ Daniels, P Curtis, O Lockwood, Classification of landmines ... Development of dual sensor hand-held detector, in SPIE Defense and Security Symposium, Detection and Remediation Technologies for Mines and Mine like Targets, Orlando, ABD, (5-9 April 2010) M ... (8) and (9) It uses first- and secondorder moments of target energy function and is calculated through a sliding window If we consider detection threshold selection ranges for both e(m) and ADF(m),...
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Báo cáo hóa học: " Target estimation algorithm design using quantity data and target feature" pptx
Ngày tải lên :
21/06/2014, 03:20
... 30 0 Target2 50 -30 -50 30 0 Figure Simulation results of tracking two target Table RMS error of tracking two targets Position error(m) Velocity error(m/s) 135.7 32.7 Target2 136.3 33.3 Target1 ... the attribute of targets, the preprocessing step is used with image processing method to determine the features of targets In this way, more reliable and more accurate of multiple -target tracking ... tracking two targets x(m) ˙ x(m/s) y(m) ˙ y(m/s) Target1 100 230 100 130 Target2 100 130 300 200 20~40 step 60~80 step a(x) (m/s2) a(y) (m/s2) a(x) (m/s2) a(y) (m/s2) a(x) (m/s2) a(y) (m/s2) Target1 ...
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DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx
Ngày tải lên :
27/06/2014, 17:20
... access to a target site, desirable pharmacokinetic profile, and a practical dosing regimen Many drug candidates due to their physicochemical properties suffer from a poor solubility and/ or poor ... can be utilized to expand the current understanding of obesity, metabolic syndrome, and diabetes 2.3 Discovery through pre-clinical studies for understanding mechanism and targets for Ayurvedic ... vertebrates and plants as organism complexity evolved As discussed in sections and 4, an understanding of the evolutionary rates and relationships between homologues in model and target organisms...
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Báo cáo khoa học: "SemiFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma" potx
Ngày tải lên :
09/08/2014, 08:22
... (66.7%) cases and disease-free and overall survival (DFS and OS) rates were 66.7% and 77.8% respectively Acute and late toxicity higher than grade (RTOG/EORTC) was observed in 7/27 (25.9%) and 1/27 ... study and drafted the manuscript MEM, LT, CB and LD were involved in data collection and review EM, BC and MC worked on analysis of data EI and MB participated in the design of the study and contributed ... was given by cisplatin and 5-fluorouracil in 15 cases and mytomicin and 5-fluorouracil in cases Statistical analysis PET-GTV and PET-CTV were respectively compared to CT-GTV and CT-CTV by Wilcoxon...
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Báo cáo y học: " Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohort" ppt
Ngày tải lên :
10/08/2014, 05:20
... one NRTI and at least one PI and at least one NNRTI, 3) an abacavir- or tenofovir-containing regimen with at least NRTIs, 4) a regimen containing ritonavir and saquinavir and one NRTI, and no NNRTIs ... contributions to conception and design, acquisition of data, and analysis and interpretation of data; 2) have been involved in drafting the manuscript; and 3) have read and given approval of the ... switch or discontinue their initial HAART regimen Our approach capitalized on commonality of data collection instruments and use of common variable definitions, selection criteria, and algorithms for...
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