topical drug delivery to the back of the eye

... with respect to histological analysis The histological features of the knee joints of the test and control mice at day after the i-a injection confirmed that the presence of a magnet neither induces ... with the PBS control (without a magnet), which (together with the absence of deleterious effects) proves the efficacy of our system The histological scoring of the cartilage damage after the treatment ... order to assess the magnet location A model of the acquired image is presented in Figure These images allowed the calculations of the distance between the magnet and the knee and of the magnetic...

Ngày tải lên: 09/08/2014, 14:20

... commercially available electrodes for delivery to the skin The purpose of the experiments described here is to further investigate localized cutaneous plasmid delivery with the 4PE Localized transgene ... Alternatively, exposure of the liposomes to EP may release the DNA prior to contact with the membranes and reduce the transport of plasmid through the cell membrane which would also lead to reduced transgene ... participated in the animal work, participated in the design of the study and reviewed the manuscript DC performed the histological evaluation of samples and assisted in data analysis RH conceived of the...

Ngày tải lên: 14/08/2014, 19:22

... cases, the modification of the drug molecules may change the therapeutic properties of the drug, resulting in the dysfunction of drug Therefore, a better drug delivery strategy is required to transport ... controlling the uptake of drugs into the brain parenchyma and the target for drug 11 INTRODUCTION delivery to the brain (Pardridge, 1995) 2.1 Structure of the BBB 2.1.1 Endothelial cells The BBB ... entering from the blood to brain, including CNS drugs The limited penetration of drugs through the BBB into the brain parenchyma is the rule, not the exception In the treatment of brain infection...

Ngày tải lên: 11/09/2015, 09:10

... However, the low efficiency of non-viral gene delivery remains a critical drawback of the system On the other hand, viral gene delivery systems are favoured because of the high efficiency of infective ... member of the retrovirus family The main advantage of lentivirus-based vectors is their ability to integrate into the host genome of both dividing and nondividing cells, thereby providing the potential ... adenovirus, there is virtually no immune response in the brain following direct injection of “gutless” vectors in rats However, the high antigenicity of the Ad virion and toxicity of the virion penton...

Ngày tải lên: 14/09/2015, 11:28

... transfers the gene into the nuclei of target cell is another key Chapter Introduction issue of gene therapy The tropism of the vector can essentially determine the cell type-specificity of the transgene ... expression in the CNS, and to test or modify viral vectors suitable to harbor these promoters The ultimate objective of the study is to use these promoters and vectors for gene therapy of neurological ... of the cell types in the CNS greatly increase the difficulty of gene delivery In sight of these considerations, special attention has to be paid to the gene delivery system, especially to the...

Ngày tải lên: 16/09/2015, 08:30

... that the performance of this washing include intention to purify one’s bad acts and the washing of the mouth, nose, face, ears, back of the neck, hands, arms up to the elbows, and feet to the ... translate into a number of cultural clashes related to medical care The Islamic world view tends to emphasize the will of God as the mover of all actions and the originator of all fate and events The ... acceptance of the will of God All events kharyun ow sharr, happen according to the will of God Part of being Muslim is submission to the will of God and acceptance of fate Sickness is also the will of...

Ngày tải lên: 05/03/2014, 21:20

... argument in favor of the regulatory role of the fVIIIa–fX complex in the activation of fX This role of the fVIIIa–fX complex outlines the directions for a further refinement of the model of the intrinsic ... function of fVIIIa (Fig 5C) with the slope of 1.00 ± 0.12 nm of KM per nm of fVIIIa and with the intrinsic KM value (the intersection of the line with the ordinate axis) of 8.0 ± 1.5 nm Because of ... indicator of an important role of fVIIIa in the delivery of the substrate fX to the phospholipid surface Role of the fVIIIa–fX complex in activation of fX by intrinsic tenase We next addressed the...

Ngày tải lên: 23/03/2014, 11:20

... revolve around topical drug delivery as this is the main focus of the present study I-B1 Advantages and limitations of topical drug delivery The principal advantage of topical drug delivery lies ... Factors affecting topical drug delivery The success of topical drug delivery is dependent on the interplay among various factors; physiological factors, physicochemical properties of the drug, formulation ... and topical drug delivery Transdermal drug delivery involves transport of drug through the skin into the systemic circulation for treatment of disorders remote from the site of application As the...

Ngày tải lên: 15/09/2015, 17:10

... new technology of visitor management, one in which the museum was to speak to the ears as well as the eyes For the greater part of the later nineteenth century, however, the visitor was treated ... the authorship of the 1885 report than in the general currency of the proposition that museums should 'speak to the eyes' and the arguments on which it drew Indeed, from this point of view, the ... the anonymity of the report is a part of its historical value in view of the way in which it simply takes for granted a view of the museum as an automated learning Speaking to the eyes 27 environment...

Ngày tải lên: 24/01/2014, 04:20

... vasculature of the dermis allows rapid distribution of the drug into the systemic circulation.13,14 Factors Affecting Drug Permeation: Properties of the Permeant The capacity of a molecule to enter the ... direct evidence of the histological localization of topically applied compounds.75 The structure of the stratum corneum lipids contributes to the barrier properties of the skin Within the intercellular ... Partition Topically applied drugs must partition into the lipophilic domain of the SC (lipid bilayers), then into the more hydrophilic milieu of the VE before reaching the systemic circulation Therefore,...

Ngày tải lên: 05/03/2014, 22:21

... elevated throughout the active disease phase, indicating a continuous activation of T cells, probably because of the presence of an Mt depot at the base of the tail However, in the PLN the percentage ... internalize the cell-bound liposomes This lack of internalization determined the strategy of drug delivery We here employed the mechanism of lipid-coupled drug transfer between membranes to achieve ... liposomes For delivery of modulating compounds to the potentially arthritogenic CD134+ T cells, we selected a mAb-targeted liposomal system To investigate whether the CD134+ CD4+ T cells in the draining...

Ngày tải lên: 09/08/2014, 06:22

... compared to most other drugs used for the rapid intravenous induction of anesthesia This is one of the most important advantages of propofol compared to other intravenous anesthetic drugs Inhalation ... opioid to blunt the response to noxious stimulation Because of the synergistic interaction between the drugs, the anesthesiologist faces difficulty in adjusting the amount of infused drugs to get the ... onset of unconsciousness In addition to the anesthetic drug, a bolus dose of opioid must be given to most of the patients Hypnotic drugs and opioids work synergistically to induce anesthesia These...

Ngày tải lên: 14/09/2015, 08:25

... directed toward the development of delivery systems which will allow the fate of drugs within the patient to be controlled by modifying these processes Although drug carriers usually act on the second ... LDL receptor becomes an attractive target for the selective delivery of anti-neoplastic drugs to tumors There are nine members of the LDL receptor family which includes the LDL receptor (LDL-R), ... enhanced prolongation of the plasma retention of the emulsion, probably due to the suppression of the lipolysis The source of vegetable oils can also influence the disposition of lipid submicro-emulsion...

Ngày tải lên: 16/09/2015, 08:30

... operating at various steps in the cytotoxic activity of the drug, from a decrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance Often several different ... release of these drugs (ADR and VCR) [5] PrPC-mediated multidrug resistance (MDR) was thought to be related to upregulation of P-glycoprotein (P-gp) [6] and inhibition of apoptosis [6–9]; these ... 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cells exhibiting IR The overall score was the...

Ngày tải lên: 07/03/2014, 03:20

... defective nucleation or growth of microtubules at centrosomes leading to an arrest in the formation of the mitotic spindle [7,8] We therefore sought to examine whether deletion of YBL046w ⁄ PSY4 in S ... obligatory core subunit of Pph3p required for the binding of Psy2p, we examined the sensitivity of the YBL046w ⁄ Psy4p deletion strain to cisplatin The comparable increased sensitivities to cisplatin ... we examine the properties of the putative S cerevisiae R2 orthologue, YBL046w, and show that deletion of YBL046w, similarly to deletion of PPH3, confers sensitivity to the anticancer drug cisplatin...

Ngày tải lên: 07/03/2014, 12:20

... Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system ... Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered to ... enhancers: SELECTION OF ROUTE OF DRUG ADMINISTRATION  Affects the onset and duration of drug action Ex: Administration of nitroglycerin  Depends on the desired drug concentration profiles to be achieve,...

Ngày tải lên: 18/04/2014, 15:37

... Republic, to submit for the consideration of the Government of the United States the following statement of facts and of the attitude of my Government decision of the Allied and people concerning the ... nobility to govern, to exploit and to oppress the ; Ukrainians of the eastern portion of the province in exchange for the support of the Poles in the Austrian parliament According to the International ... even the arguments of the balance of power and of the necessity of subordinating democratic considerations to the programme of a great and strong Poland not in the least justify the placing of...

Ngày tải lên: 04/06/2014, 17:32

... sequence) through the area of abnormality on SPECT, is recommended to confirm the diagnosis and stage the lesion If SPECT is negative, pars stress is unlikely to be the cause of the low back pain and ... suggestive of some type of derangement of the posterior elements of the spine [16] Imaging studies used to evaluate patients with low back pain include: radiographs, bone scintigraphy, computed tomography ... predict the probability of ultimate bone healing [22,23] However, CT of the spine results in higher ionizing radiation exposure compared to bone scintigraphy [24] Furthermore, there are reports in the...

Ngày tải lên: 20/06/2014, 04:20

... techniques, and there are great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery ... sites The unique capability of CNTs to penetrate cell membranes paves the road for using them as carriers to deliver therapeutic agents into the cytoplasm and, in many cases, into the nucleus The ... This delivery system provided the first instance for nanocarriers to deliver drugs into neurons in the central nervous system, opening the door for the drug delivery system for the treatment of the...

Ngày tải lên: 20/06/2014, 22:20

... 24 h, there is a spread of the number of differentiated cells, being about 85% of the total cells In the second day, the number increased up to 90% and, in the third day, about 96% of the cells ... 3) where C2 is the protein in the bulk, C10 is the concentration inside the gel, S and V1 are, respectively, the surface and the volume of film, V2 is the volume of the bulk, h is the massive exchange ... driven by the capillary force of water droplets In order to prevent the CNT sticking in a liquid environment, and to improve mechanical features of CNTs, a thin layer of SiO2 is deposited onto the...

Ngày tải lên: 22/06/2014, 00:20