Sensory evaluation techniques
... attributes, e.g., the visual, olfactory, gustatory, and tactile/kinesthetic senses The briefness of the chapter is dictated by the scope of the book and is not an indication of the importance of the subject ... stimulus, the chemical state of the saliva, and the presence of other tastants in the solution being tasted The incidence of ageusia, or the absence of the sense of taste, is rare However, variability ... of the unsolved mysteries of science (see below) The anatomy of the nose is such that only a small fraction of inspired air reaches the olfactory epithelium via the nasal turbinates, or via the...
Ngày tải lên: 23/05/2014, 13:39
... entrapped in 0.1 ml of the final packed erythrocytes Efficiency of entrapment The percentage of the loaded amount of pravastatin to the total amount of that added during the entire loading process ... administration of statins with certain juices [6] or inhibition of Pgp [3] Unfortunately these strategies are frequently associated with increase the risk of side effects of the statins [3,7].Therefore the ... recovery The percentage ratio of the hematocrite value of the final loaded cells to that of the initial packed cells, both measured using equal suspension volumes In vitro characterization of pravastatin...
Ngày tải lên: 25/10/2012, 11:10
... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was ... in the absence and presence of EDTA, on the oxidation of Hb A0 The mean ± SD of three independent experiments is shown Other conditions as in Fig Our studies of the effect of the structure of the ... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth...
Ngày tải lên: 08/03/2014, 10:20
Financial Relationships and Interests in Research Involving Human Subjects: Guidance for Human Subject Protection pdf
... for the disclosure of certain financial interests held by clinical investigators The purpose of these regulations is to provide additional information to allow FDA to assess the reliability of the ... by the outcome of the trial, (2) any proprietary interest in the product studied held by the investigator; (3) significant payments of other sorts over $25,000 beyond costs of the study; or (4) ... conflicts of interest or affect the rights and welfare of human subjects HHS recognizes the complexity of the relationships between government, academia, industry and others, and recognizes that these...
Ngày tải lên: 15/03/2014, 20:20
BELMONT REPORT: ETHICAL PRINCIPLES AND GUIDELINES FOR THE PROTECTION OF HUMAN SUBJECTS OF RESEARCH ppt
... to be among the beneficiaries of subsequent applications of the research C Applications Applications of the general principles to the conduct of research leads to consideration of the following ... conflicting judgments Thus, there should first be a determination of the validity of the presuppositions of the research; then the nature, probability and magnitude of risk should be distinguished, ... that the procedure is neither necessary for their care nor perhaps fully understood, can decide whether they wish to participate in the furthering of knowledge Even when some direct benefit to them...
Ngày tải lên: 22/03/2014, 15:21
Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... and endothelial cells [73] In theory, hiPSC technology could allow the production of specific cell types for the treatment of various patients or diseases [74], but the suitability of these cells ... in the endothelial cells of patients suffering Fig Schematic representation of hematopoietic development in the embryo The surface markers proving hematopoietic commitment at each stage of the ... than 60% of the transplanted mice died after the transplantation due to aggregation of human ESCderived hematopoietic cells in the presence of rodent serum, resulting in the formation of pulmonary...
Ngày tải lên: 22/03/2014, 17:20
ETHICAL AND LEGAL ASPECTS OF HUMAN SUBJECTS RESEARCH ON THE INTERNET docx
... into the group The faceless nature of online interactions may not always allow for this course of action Finally, there is the nature of the consent form and the validity of the process In the ... between the public and private domains based not on the accessibility of the data, but on the psychological perception of the subjects with regard to the information The technological point of view ... since a determined reader of a study who knows the name of the studied group could trace the message and discover the login name of the person who sent the message Supporters of this position cite...
Ngày tải lên: 29/03/2014, 20:20
Báo cáo hóa học: " Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects" potx
... existence of various subsets of cells with EPC potential residing outside of the CD34+ KDR+ fraction Further studies are required to elucidate functional importance of the variable kinetics of mobilization, ... number based amount of cells plated was performed twice The coefficient for normalization was calculated from the level of ATP for the same amount of plated cells after days of plating in medium ... conclusion, the current study suggests feasibility of significant mobilization of cells expressing hematopoietic stem cell and EPC markers and properties The area of nutritional modulation of the stem...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Are quantum dots ready for in vivo imaging in human subjects?" docx
... depended on the molecular size of the PEG and on the density of substitution Most importantly, the injected dose of all types of QDs tested in these studies was excreted in the feces within 1–2 days ... control the number of molecules attached to the surface of a single QD In an attempt to reduce the overall size of the QD conjugate, researchers have used direct crosslinking to attach ligands to the ... unclear whether the ‘‘stop and go’’ pattern is typical for the majority of injected QD conjugates or if it is only limited to a small subset of QDs It is likely that the majority of the QD conjugates...
Ngày tải lên: 22/06/2014, 18:20
báo cáo khoa học: " Human subjects protection issues in QUERI implementation research: QUERI Series" pptx
... are often a cornerstone of implementation research The nature of PDSA cycles means that implementation researchers may not be able to specify all aspects of the project ahead of time for the ... standards that may impede the conduct of evidence-based QI implementation research because they are not consistent with the spirit of the Belmont Report, a summary of the three basic ethical principles ... approach, we submitted the first study component along with an overview of the entire project We then submitted additional project activities for individual review in the context of the project overview...
Ngày tải lên: 11/08/2014, 05:22
Báo cáo y học: "valuation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine." pps
... runs The standard error of the loss estimate was simply the standard deviation of the observed differences divided by the square root of the number of runs in which a difference was calculated The ... analysis The potency losses associated with lyophilization were calculated as the average of the differences observed between the liquid samples and the -70°C (lyophilized) samples tested in the same ... contains the following: a minimum of 1350 plaque forming units (PFU) of Oka/Merck varicella virus, approximately 18 mg of sucrose, 8.9 mg of hydrolyzed gelatin, 3.6 mg of urea, 2.3 mg of sodium...
Ngày tải lên: 11/08/2014, 10:23
Báo cáo khoa học: "Bench-to-bedside review: Human subjects research – are more standards needed" ppsx
... would prefer one treatment over the other; and the patient and surrogates are informed of the institution’s policy regarding the criteria for waiver of informed consent These criteria are reasonable ... court ruled in favor of Washington University in another case of patient ownership of their tissues In this case, a Washington University clinician researcher moved to another institution When ... ownership of their tissues The judge ruled that the court recognized the research participants’ right to discontinue participation in a study, but that this did not extend to ‘a right to control the...
Ngày tải lên: 13/08/2014, 03:20
Tài liệu Báo cáo khoa học: Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins pdf
... steroid biosynthesis The process of binding and uptake of maternal lipoproteins is carried out by placental trophoblast [17], which lines the chorionic villi and represents the epithelial layer ... tumors of epithelial origin but have been shown to display characteristics of invasive trophoblasts [19] Choricarcinoma cells are morphologically similar to their cell of origin, the trophoblast of ... [39] calculated on the basis of the specific activity of the correspondingly labeled HDL preparation used that would be necessary to deliver the observed amount of tracer These calculations are performed...
Ngày tải lên: 20/02/2014, 23:20
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... representative of the totality of the single-stranded overhang, and which may be important for these ligands being able to differentiate telomeric quadruplexes from others in the genome It has ... [19] because it ensures that the 3¢-end is inaccessible to hybridize with the telomerase RNA template, the essential first step in the catalytic cycle The induction of quadruplex stabilization ... when the telomeric protein TRF2 is knocked out This response is a consequence of the displacement of bound proteins from the singlestranded overhang, chiefly hPOT1, as well as possible uncapping of...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... used in chemotherapy of tongue cancer, but the effectiveness of monotherapy with PYM for preoperative chemotherapy is only about 67% [5,6] Moreover, the therapeutic benefits of chemotherapy can ... extensively used in chemotherapy for the treatment of neoplasms in the head and neck region [10] However, the therapeutic benefits of PYM can be attenuated in the clinic, because of intrinsic and ⁄ ... developed in China in the 1980s It is a member of the bleomycin family, and is also known as bleomycin A5 It has been found to reduce the DNA synthesis of cancer cells and cut off the DNA chain [8]...
Ngày tải lên: 06/03/2014, 22:21
Research " HUMAN CAPITAL INVESTMENT BY PRIVATE EMPLOYERS IN BLAIR COUNTY, PENNSYLVANIA, AS MEASURED " pptx
Ngày tải lên: 07/03/2014, 02:20
Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identification ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt
... affinities to the protein of interest In the case of the rpL32 fragment or the (GCC)9 sequence, there are several repeated ZF5-binding sites within a single oligonucleotide Therefore, the affinity of those ... Influenza, Ministry of Health of the Russian Federation The first pair of primers (5¢-GGCCTTCAAGGCATTAAG-3¢, 5¢-AAACAAATGG CCTGTCCG-3¢) spanned a 958 bp 5¢-part of the ZF5 coding region; the second pair ... (1994) Identification of a GC element in the promotor of the murine L32 ribosomal protein L32 gene and the 3¢-terminal region of the human apolipoprotein A-I gene, capable of binding with murine...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene pptx
... transfection efficiency The values of the activities are set relative to the activity of the clone carrying wt Site-2 and Site-3 elements The results represent the mean value ± S.E of five independent ... Identification of the Site-2 and Site-3 binding protein as a member of the NF1 family of transcription factors (A) Binding of purified, recombinant NF1 to the Site-2 and Site-3 elements was monitored by the ... 0.25 mL of sample The column was eluted at 0.1 mLÆmin)1 Fractions of 0.5 mL were collected after the void volume of the column SDS/PAGE and protein identification by MALDI-TOF MS Samples from the...
Ngày tải lên: 07/03/2014, 15:20
Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
... Since the September 11 bombings in the United States, the locality of this virus has become less isolated as the threat of bioterrorism looms large The Ebola virus is now on the “A” list ... as the Democratic Republic of Congo In these two instances the mortality rate was between 50 –90% Following those epidemics, Ebola hit Africa in many other instances the worst yet being in the ... This concept of can be used to explain the world’s shockingly small response to the Ebola Virus Because there was little travel to that region by people of more developed countries, there was...
Ngày tải lên: 15/03/2014, 13:09
Báo cáo khoa học: Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation pptx
... stabilization The functional folding of membrane proteins overproduced by the new cell-free (CF) approach is of primary interest, and we therefore further analyzed the quality of ETB samples ... T7-tag at the N-terminus and a poly(His)10-tag at the C-terminus (Fig 1) To obtain the highest yields of the individual constructs, optimization of the Mg2+ and K+ concentrations in the ranges ... or as a precipitate in the absence of detergents We analyzed the yield and sample quality of ETB synthesized in the presence of FEBS Journal 274 (2007) 3257–3269 ª 2007 The Authors Journal compilation...
Ngày tải lên: 16/03/2014, 10:20