theories and techniques in the characterization of drug substances and excipients

... produced, and how the artefact is produced using those materials For example: what are the origins of the yellow, red and black pigments of parietal paintings of the Magdalenian era in the caves of the ... founded in 1997 with the main objective of promoting research and education in the field of cultural heritage, based on the directions and recommendations given in the Professional Guidelines of the ... of the paint layer, the characteristic touche of the author, the eventual existence of an underlying painting, the pentimenti, the alterations, the restorations, the modifications of frame, the...

Ngày tải lên: 22/03/2014, 09:20

... on the functioning of e-commerce and Internet marketing and selling techniques in the retail of goods • Many consumers research information on products and prices offline and then buy them online: ... online prices were lower than offline prices in 13 of the 15 Civic Consulting Consumer market study on the functioning of e-commerce and Internet marketing and selling techniques in the retail of ... the functioning of e-commerce and Internet marketing and selling techniques in the retail of goods Table 12: Consumer survey – Perceived savings while buying online or offline28 Online shopping...

Ngày tải lên: 23/03/2014, 08:21

... uptake of the plastic antibody was compared against that of the NIP and the imprinting efficiency was found to be 1.3 The imprinting efficiency is defined as the ratio of the binding ratio of the MIP ... success of the imprinting process as seen from the difference in binding between the MIP and the NIP while selectivity was defined as the efficiency in binding structural analogues of the template ... of vision and pinpointing of the pupils [9] Nerve agent poisoning may be treated with timely administration of antidotes such as atropine and diazepam The blister agents cause blistering of the...

Ngày tải lên: 14/09/2015, 14:08

... concentrations of organic substances in the aqueous environment has been a matter of increasing interest to the water industry, scientists and the general public alike, from the point of view of possible ... aspiration of the ASP, following the first sampling cycle, ensures that both the OF and the ASP are periodically renewed, and thus the OF would be in contact with fresh aqueous sample having the initial ... amphetamines and phencyclidine in urine were investigated using LPME combined with GC analysis [57] The optimized method was capable of detecting drugs in urine at concentrations below the Substance...

Ngày tải lên: 17/09/2015, 17:20

... War Memorial The photograph of the original painting was taken by the author in the course of her investigations, and is not an official reproduction of the painting (ART40317) in the Australian ... reflection, and the shape of the capillary determines the overall flux gain and the uniformity of the focussed spot Gains in flux of 100 and more have been reported However, there is a degradation in the ... plain photograph and two hyperspectral images of a painting in the collection of the Australian War Memorial Left: Photograph of the original painting Centre and Right: Hyperspectral images of the...

Ngày tải lên: 06/12/2015, 10:58

... integrated in a language processing chain (LPC), so that the output of a given NLP tool is used as an input for the next tool in the chain The baseline LPC for each of the supported languages includes ... system and the benefits of using it The chapter “Evaluation” briefly discusses the user evaluation of the new system The last chapter “Conclusion and Future Work” summarises the main achievements of ... or binary documents) in the “preprocessing” phase Secondly, the text is annotated by several NLP tools, chained in a sequence in the “processing” phase The language processing tools are integrated...

Ngày tải lên: 22/02/2014, 03:20

... publishers The remaining two areas – conflict of interest leading to biased selection of evidence, and bias in the interpretation of evidence – fall within the domain of the compendia publishers and ... Conflict of interest in the process of making study data available; 3) Conflict of interest leading to biased selection of indications to review, and of evidence sources; and, 4) Bias in the interpretation ... conflict of interest in mind 21 Relevant information for assessing potential conflict of interest includes the identification of the sponsor, determination of whether an independent team reviewed the...

Ngày tải lên: 09/03/2014, 00:20

... MUPT The SMUP is determined by using the firing times of the main spike of each individual MUP firing within a MUPT and relating these to the potential observed at a surface electrode overlying the ... column, which indicate the number of samples assigned to each target class; in the case of Table these are MUPTs, in the remaining tables these are muscles The value at the foot of the “Per-class ...  in which d is the dimensionality (the number of input features) in the problem As can be seen in (2), this factor drops out in the construction of the discriminant through the application of...

Ngày tải lên: 19/06/2014, 08:20

... define the parity values The data processing operations are combined with the parity generating function to provide one set of parity values The k is the basic block size of the input data, and ... by examining the magnitude of the respective syndromes and comparing against thresholds five times the standard deviation of syndrome values when only low levels of round-off error appear The simulation ... 1-out -of- 2 code indicating that no error has occurred in the data processing unit and its checking facilities The precision required for the two parity values, the value characterizations in Figure...

Ngày tải lên: 20/06/2014, 22:20

... elimination of the excess during the carbon washing process The effect of the increase in proportion of the impregnation over the carbon porous structure is greater than the one obtained with the ... number of works increased in the years from 2000 to 2010 The obtained carbons were mainly employed in the removal of water pollutants In the present chapter the principal methods used in the preparation ... according with the following equation, (1) where W0 is the weight of the original carbon and W1 refers to the mass of the activated carbon The use of CO2 during the activation process of a carbon...

Ngày tải lên: 28/06/2014, 17:20

... Facing the Reality of Drug- Resistant Tuberculosis: Challenges and Potential Solutions in India: Summary of a Joint Workshop by the Institute of Medicine, the Indian Nation FACING THE REALITY OF ... 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute ... become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and...

Ngày tải lên: 05/03/2014, 11:20

... protein content in their latex; and (2) the presence of other cysteine proteinases or isoforms in the latex To investigate these two hypotheses, the protein concentration per milligram of dried ... coding for cysteine proteinases in the latex of V stipulata and V · heilbornii Based on these sequences, the evolution of the cysteine proteinases within the Caricaceae was investigated Furthermore, ... aid in the protection against degradation, or in targeting or maturation of the enzyme, as was shown before in cathepsin C, which also belongs to the papain family of cysteine proteinases [27] The...

Ngày tải lên: 07/03/2014, 11:20

... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS-1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction ... N-terminal domain of the polypeptide of each of these organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in ... was located in the band This may be due to diffusion of some complexed protein as the band migrates in the native gel Band contains the excess of TbPEX14-N,H In a second experiment, the same two...

Ngày tải lên: 23/03/2014, 17:21

... Comparison of the amino-acid sequence of the chrysophsins with other antimicrobial peptides Alignment of the mature amino-acid sequences of chrysophsin-1, chrysophsin-2 and chrysophsin-3, misgurin [15], ... phenylthiohydantoin amino-acid standards Tricine/SDS/PAGE The molecular mass of the sample was estimated by Tricine/ SDS/PAGE using a 16.5% separating gel, 10% spacer gel and 4% stacking gel in the presence of ... concentration of purified and synthetic chrysophsin-1 and chrysophsin-2 was obtained from the A280 [24], and that of chrysophsin-3 with the DC-protein assay kit Solid-phase peptide synthesis Circular...

Ngày tải lên: 23/03/2014, 20:22

... excitation of H-1 H-resonance of the GlcNAc residue in the TOCSY step and of H-3/H-4 1H-resonance of the GlcNAc residue in the NOESY step (A) The assignments of the 1H-resonances of the Gal II ... 4-substituted and confirming the 3-linkages for the galactose residues of the Sial-lNnT unit (Fig 7) This confirms that a terminal Sial-lNnT unit is linked to the Hep I residue of the LPS inner core in the ... supplemented with Neu5Ac The structure of the inner core glycoforms is shown and ions arising from the inner core and from the addition of the sialylated tetrasaccharide are indicated Ó FEBS 2002...

Ngày tải lên: 23/03/2014, 21:21

... utilization of galactose when the concentration of galactose is decreasing in the medium To explain the mechanism of MRG19 in facilitating GAL gene induction, under low induction signal, we consider the ... the binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of ... b-galactosidase activity in wild-type and MRG19 disrupted strains bearing the indicated fusion constructs Transformants were grown to D600 of 0.5 and 1.5, in minimal synthetic medium containing glycerol...

Ngày tải lên: 31/03/2014, 08:20

... growing need to understand the impact of HAART use on the quality of lives of HIVinfected individuals [4-8] There is a sizeable body of research on the impact of HAART on health-related quality of ... widely used in studies of quality of life in HIV-positive patients in both developed and developing countries, and has performed well in all of these settings [11,12,14,25-28] The instrument has ... study therefore supports the findings of Stangl et al [18] and Jelsma et al [19] who both reported an increase in HRQoL within the first three months of therapy in similar patient populations The...

Ngày tải lên: 20/06/2014, 08:20

... PiT1-binding immunoadhesin generated by fusing the aminoterminal residues of the GALV (SEATO strain) Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... distribution in basal conditions With HRBD, the GLUT1 ligand, we observed a staining of GLUT1 in the corpus callosum and the basal ganglia apparently weaker than in the cerebellum and in the cortex These ... distinct binding of the GLUT1 ligand was detected, with the structure rather presenting a diffuse staining (data not shown) PiT1, on the other hand, showed a reticular pattern with several stained...

Ngày tải lên: 10/08/2014, 05:21

... within the ruptures of a temporary cavity in the gelatin block revealed a deposition of particles along the entire bullet path for both types of projectiles examined In the case of the soft point ... and reproducible method of systematic examination in the field of terminal ballistics The model permits the infiltration depth of exogenous particles leading to contamination in relation to the ... were found 6.0-10.0 cm behind the point Page of of impact of the projectile on the gelatin block In this area, the gelatin blocks at which shots were fired with soft point bullets showed significantly...

Ngày tải lên: 11/08/2014, 20:21

... [39,40] In conclusion, our findings clearly suggest that the newly recruited ED7+ AM are involved in the regulation of the ongoing inflammatory process Whether the antiinflammatory effects of IL10 ... < 0.01 the proinflammatory cytokine TNF-α However, significantly increased mRNA levels were found in the ED7+ population for IL-12 p40 and iNOS Interestingly, the expression of the antiinflammatory ... exert antiinflammatory properties [36] and, therefore, ED7+ AM seem to play a role in the control of the inflammatory reaction On the other hand these ED7+ AM also produce higher amounts of IL-12,...

Ngày tải lên: 12/08/2014, 16:20