the sequence of integers

... divisors of n, Ω(n) is the number of prime power divisors of n, π(x) is the number of primes ≤ x, τ(n) is the number of divisors of n. P(s, t) is the set of positive integers composed of prime ... is the set of square-free members of P (s, t). We list a few estimates from prime number theory and sieve theory. The first is the Brun-Titchmarsh inequality and the second is a consequence of the Prime ... author enjoyed the hospitality of the Institute of Mathematics and Informatics, Bulgarian Academy of Sciences. Finally, the author acknowledges the referee for a thorough reading of the paper and...

Ngày tải lên: 06/03/2014, 08:21

... of a4v over the entire sequence defines the aggregation profile of the polypeptide. The hot-spot threshold (HST) was defined as the average of the a3v of the 20 natural amino acids weighted by their ... [36]. Thus, there are three scales which allow the predic- tion of amyloidogenic regions in a protein sequence (or rather, the ability of a peptide to be amyloido- genic): the scale of the packing ... propensity enter the scoring function as a physical property term S physprop consisting of the sum of the products of the amino acid frequency with the normalized property value of the respective...

Ngày tải lên: 06/03/2014, 00:20

... at the last base, G to A, abolished the interaction of HIPPI, so the last motif would not interact with HIPPI. The other two motifs might be the target of HIPPI. In the upstream sequence of the Table ... confirmed the in vitro result that mutation of the motif abolished the binding of HIPPI to the specific sequence of the caspase-1 gene upstream sequence, and the increased expression of caspase-1 ... decrease in the fluorescence intensity of 6X(HN)-pDED due to the addition of the 60 bp region of the caspase-1 gene upstream sequence was observed. Addition of the caspase-1 gene upstream 60 bp sequence...

Ngày tải lên: 07/03/2014, 10:20

... localization in the ER [19]. We found that the TMD of UGT1A pro- teins appended to the C-terminus of the ectodomain of CD4 plasma membrane glycoprotein was able to retain the chimeric protein in the ER ... together, these data indicated that the TMD domain of UGT1A was sufficient to retain the ectodomain of CD4 protein in the ER. Because the carbohydrate moieties of proteins that are trans- ported to the ... in combination with that of the TMD did not prevent membrane targeting and insertion of the enzyme. These findings resulted in the identification of an internal signal sequence localized between...

Ngày tải lên: 07/03/2014, 16:20

... FEBS fungal sequences is clearly distant from the other bran- ches, which was indeed predicted. The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences ... analyses The localization of the DIDO1 gene in the context of chromatin stability was addressed experimentally. Although the experiments conducted were preliminary, they indicated the involvement of ... from the CGBP family (Figs 1, 3 and S1); otherwise, the fungal sequences could well constitute CGBP homologues. The presence of a TFS2M domain is also indicative of a possible function for the...

Ngày tải lên: 07/03/2014, 21:20

... however, the lower S/N ratio of the spectra in Fig. 4E than in 4B that has an effect on the accuracy of the deconvoluted spectrum. Lability of the Asn residues in the autoregulatory sequence The 28-residue ... neighbour amino acids and the loop structure are the same in the two proteins. The perturbation of the overall conformation of the loop structure as a result of deamidation of Asn32 to Asp/isoAsp have ... that at least two of the labile Asn residues are located in the catalytic domain of the protomer [13]. Furthermore, on the basis of a nearest neighbour amino acid analysis of all the Asn residues...

Ngày tải lên: 08/03/2014, 08:20

... PpTGase Although the overall identity with the mammalian TGase primary sequence is low in the deduced sequence of the Physarum TGase, the middle region of the sequence is significantly conserved. The sequences ... shown. Data represent the mean of triplicate assays. Fig. 4. Phylogenetic tree of the full-length amino acid sequences of several TGases. The full-length amino acid sequences of several eukaryote ... that the enzymatic activity of TGase 4 was inhibited by the presence of GTP or ATP, as in the case of PpTGase [51]. These results suggest that the mechanism by which nucleotides inhibit the enzymatic...

Ngày tải lên: 17/03/2014, 23:20

... seen in the topological studies. The misfit dislocation of the pores interrupts the periodic arrangement of the pores. As another important result, the domains size is changed as a function of time (Fig. ... the ini- tial stages of anodization. However, it is assumed that the pits formed in the electropolishing contributing in the nucleation of pores on the aluminium in the order of 10 10 to 10 12 [18]. ... pores, the hexagonally ordering of pores is just achieved in the first stages of anodizing at the bottom of porous oxide layer and cannot grow up to the thick anodized layers. After removing the...

Ngày tải lên: 20/03/2014, 13:05

... high on the list of organisms whose genomes will be fully sequenced in the near future, the composition of the 43 kDa band would not have been revealed otherwise. Cloning of the two isoforms may ... a reason for the different migration behaviour. Molecular cloning of the new hyaluronidase isoform, Ves v 2b Aiming at the molecular cloning of the cDNA of the newly discovered hyaluronidase isoform ... spectrum of a glycopeptide from the 43 kDa band. The masses of (glyco-)peptides are written vertically, those of free glycans horizontally, and that of the mother ion tilted. From the loss of two...

Ngày tải lên: 23/03/2014, 15:20

... min; then 10 lLofincreasing concentrations of PCI or ProNtPCI were added and the measures were continued for 2 min. The slope of the first part of the assay corresponded to m o and the slope of the ... [18,19]. The extremely inefficient folding of PCI in vitro [18], together with the presence of the above-mentioned long pro-sequences, suggest a possible involvement of them in the in vivo folding of ... investi- gated the role of both pro-sequences in the in vitro refolding of PCI, together with studies of the influence of the N-terminal pro-region on its in vivo expression. Both studies conclude that the...

Ngày tải lên: 23/03/2014, 21:20

... genome of CCHFV Kosova Hoti strainFigure 2 The protein analysis of the complete genome of CCHFV Kosova Hoti strain. A. Scheme of the M polyprotein of Kos- ova Hoti. B. Scheme of the L protein of ... nucleotide sequences of CCHFV from Kosovo have been published [9-12]. Three of them are partial sequences of S segment, the remaining 2 represent complete sequences of S and M segment of different CCHFV ... during the epidemic in Kosovo in 2001 [6]. The blood was taken on the 5 th day after onset of symptoms. Results of the laboratory analysis showed the presence of IgM antibodies (titer 1:400) and the...

Ngày tải lên: 20/06/2014, 01:20

... technique that has helped facilitate the demonstration of these rela- tionships has been the use of dominant-negative mutant versions of one or more of the protein components of the MVB complexes [31]. Dominant-negative ... motif, although there were no further sequence similarities. P93 is located in a sequence similar to the YP(x) n L motif, and the P329 and P332 residues were targeted because of sequence similarity to the ... deletion of the YPLGVG motif resulted in either less pronounced or an absence of the filamentous structures accompanied by nuclear localization of the mutant M protein. These data suggest that the...

Ngày tải lên: 20/06/2014, 01:20

... cytomegaloviruses was most prominent in the central ~60% of the genome, with divergence of sequence and lack of conserved homologs at the respective genomic termini. Of interest, the GPCMV genome was found ... comparisons of GPCMV ORFs with homologous ORFs from the other sequenced CMVs are provided in additional file 3. In summary, the complete DNA sequence of GPCMV was determined, using a combination of sequencing ... cells are reminiscent of the mutations and deletions that occurred during fibroblast-passage of HCMV [34] and rhesus CMV [35]. The congruence of these events suggests that the selective pressures...

Ngày tải lên: 20/06/2014, 01:20

... and microfibrils in the outer layers of the fibre wall structure (Figure 1a). The surface structure of chemical pulp Figure 1 Structure of wood pulp fibres.(a) Note the network of microfibrils ... mole- cule, the elementary fibril, the microfibril, the macrofi- bril and the lamellar membrane. In the work of Maier [13], the term “ele mentary fibril” was reported to have a diameter of 3.5 nm ... respect to (1) the fraction of fibrillated fibres, (2) the fraction of nano- fibrils and (3) the morphology of the nanofibrils in an MFC material. Provided that a given MFC is composed of an appropriate...

Ngày tải lên: 21/06/2014, 03:20

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