the search for candidate genes involved in pathogenesis

... approach in searching for candidate genes involved in specific biological processes of interest General trends in the expression of common groups of genes in response to a specific stimulus in diverse ... biological processes driven by these genes Starting from the notion that genes coding for proteins involved in the same biological processes are regulated in coordinated manner, and that expression ... finding that indirectly validates our approach (Table 2) Given the pre-eminent importance of the vascular component in ALI pathogenesis, our primary trait in selecting candidate genes was their...

Ngày tải lên: 09/08/2014, 20:20

... when interpreting the outcome results For example, salt stress treatment results in a rapid decline in photosynthesis within minutes [37] Therefore, genes that are regulated by photosynthetic ... stresses in sunflower Among them, many genes potentially encoding components involved in photosynthesis, such as photosystem proteins, chlorophyllbinding proteins, Rubisco and light harvesting proteins ... but they are not regulated by salt stress per se In another study the expression of 150 genes in response to wounding and insect feeding was carried out [58], finding that some of the responding...

Ngày tải lên: 12/08/2014, 05:20

... which lack this domain, is scant This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetase domain of the PKSs for polyketide biosynthesis [35] Therefore, AtaPKS1 could ... fragment only contains the initial 67 bp and the final 68 bp of the pur4 coding sequence It was inserted in plasmid pGM9 The resulting construct was introduced, via S lividans, into S alboniger ... implicated in the biosynthesis of the aminonucleoside moiety of A201A Here we report the sequencing of a total of 6946 bp, which include the ata genes most likely implicated in the biosynthesis of...

Ngày tải lên: 21/02/2014, 01:21

... regulated in wild-type cells For example, the genes involved in amino acid metabolism were not regulated by amino acid starvation in GCN2) ⁄ ) cells, whereas enrichment for the genes involved in cholesterol ... that the GCN2 pathway is directly involved in the regulation of amino acid and protein metabolism, as many of the genes involved in these processes are not regulated in GCN2) ⁄ ) cells These ... nature of the stimulus, RNA binding factors and the sequence of the target mRNA [35] Another amino acid sensing mechanism involves mTORC1 Therefore, it is tempting to speculate that the mTORC1...

Ngày tải lên: 07/03/2014, 03:20

... enthusiasm for Mr Bush’s style by complaining that there wasn’t enough use of instinctive judgment in forming foreign policy The regress from the seventeenth-century “Age of Reason” to the instinctive ... the growth engine of the U.S economy, indicated his uncertainty by referring to the tentativeness of our projections.” He then asked, “What if, for example, the forces driving the surge in the ... if the benevolence of the gods driving the surge in the flood waters begins to dissipate or reverse in ways we not now foresee?” There is nothing new in the way that irreducible uncertainty induces...

Ngày tải lên: 11/06/2014, 10:32

... network of the JA biosynthesis pathway The genes in the yellow boxes in the network correspond to the yellow-colored components of the JA biosynthesis pathway indicated in Figure The genes in white ... genes for ETR1 and MPK6 (represented by the pink and green dot almost in the middle of the network), are in between the super cluster with the genes encoding proteins involved in SA signaling (red ... network of the ET biosynthesis and signaling pathways In panel A, the genes in the blue boxes in the network correspond to the blue-colored components of the ET biosynthesis pathway indicated in Figure...

Ngày tải lên: 11/08/2014, 11:20

... containing genes of interest involved in conifer defence First, many conifer defence genes exist as closely related members of large families For example, genes encoding the oleoresin producing ... presumably inserted into the BAC during proliferation The left and right arms of the BAC vector (pIndigoBAC-5) were used to orient the remaining contigs, resulting in the final builds of PGB02 ... binding sites (37 for 3CAR; 19 for CYP720B4), implicated in light responsiveness in several other plant species Interestingly, the promoter sequence including the transcribed 5'-UTR of the 3CAR gene...

Ngày tải lên: 12/08/2014, 03:21

... underscored the benefit of incorporating distinct disciplines, in this case engineering, in defining and understanding new phenotypes He also pointed out the importance of understanding the relationships ... patterns, the mouse is no longer susceptible to tumorigenesis or metastasis Despite the initial success of integrating the mouse genome assembly into the process of QTL mapping, it is certainly not the ... and, in the case of the Abca1 gene, expression data She provided some of the best evidence that a critical mass of converging information and understanding has now tipped the scale and will, in the...

Ngày tải lên: 14/08/2014, 14:21

... green indicating the region involved in the stem-loop-stem structure, and pink indicating the domain that binds Sm proteins The corresponding interaction region in U6atac snRNA is also marked in ... for all other core protein genes, indicating that all 24 genes are active There are 63 Arabidopsis proteins corresponding to the 35 snRNP-specific proteins used as queries in our genome mapping ... SMN protein complex In human, the SMN protein (survival of motor neurons) can interact with a series of proteins including Gemin2, Gemin3 (a helicase), Gemin4, Gemin5 and Gemin6 to form an SMN...

Ngày tải lên: 14/08/2014, 14:21

... interest in Arabidopsis Changes in the scientific culture of the 1980s which paralleled these technological advances also increased interest in the plant (Fink, 1998) and set the stage for a boom in ... of the Trichome Spacing Pattern The mechanism responsible for generating the spacing pattern on the surface of first true leaves has been intensely investigated during the past decade (Larkin ... preferentially with the bHLH dimer, preventing expression of genes involved in trichome development TTG would act in the cytoplasm most probably aiding in the association of the bHLH dimer 13 enters the nucleus...

Ngày tải lên: 14/11/2014, 11:55

... interest in Arabidopsis Changes in the scientific culture of the 1980s which paralleled these technological advances also increased interest in the plant (Fink, 1998) and set the stage for a boom in ... of the Trichome Spacing Pattern The mechanism responsible for generating the spacing pattern on the surface of first true leaves has been intensely investigated during the past decade (Larkin ... preferentially with the bHLH dimer, preventing expression of genes involved in trichome development TTG would act in the cytoplasm most probably aiding in the association of the bHLH dimer 13 enters the nucleus...

Ngày tải lên: 14/11/2014, 12:16

... with epithelial cells’ lining, studies have document the presence of the of the stem cell in the luminal discharges due to the proximity of the stem cell niche to their luminal cavities For example, ... little adjustment, for instance, a slight increase in food intake or a slight increase in weight loss, is needed to compensate for the increase Chapter Introduction in metabolic needs for secretion ... Proteins Human milk proteins are a source of peptides, amino acids and nitrogen for the infant, but also in the protein fraction reside other properties of HBM that further benefit the developing...

Ngày tải lên: 11/09/2015, 09:57

... to form a neural tube (Smith and Schoenwolf, 1989) The bending of the neural plate involves the formation of hinge regions The cells at the midline of the neural plate are called the medial hinge ... improvement in the management of diabetic pregnancies in the past decades, congenital malformations including NTDs in infants of diabetic mothers remain two to three times higher than in the non-diabetic ... are formed during gastrulation: the endoderm, the mesoderm, and the ectoderm The ectoderm gives rise to: (1) the Chapter 1: Introduction internally positioned neural tube, which forms the brain...

Ngày tải lên: 30/09/2015, 06:36

... involved in the early development of chronic pain, while astrocytes function in sustaining the pain (Vallejo et al., 2010) An interesting finding was that nerve injury induces an increase in interleukin-18 ... Peroxidase xiv IL-1 Interleukin-1 IL-1β Interleukin-1β IL-6 Interleukin-6 IL-8 Interleukin-8 IL-10 Interleukin-10 IL-18 Interleukin-18 i.t Intrathecal L-PGDS Lipocalin-type Prostaglandin D Synthase ... more TNF-α in other brain regions including the hippocampus, thus leading to aggravated neuropathic pain TNF-α may act by inducing the production of other cytokines and activating the prostanoid...

Ngày tải lên: 02/10/2015, 17:15

... segment of chain in α-1,6 position 2.3.3 Genes encoding enzymes involving in glycogen biosynthesis Table 2.4 lists the genes encoding the enzymes involved in glycogen synthesis Genes glgC, glgA ... 2 Cloning of PHA biosynthesis genes While the genes involved in PHA, glycogene and polyP synthesis are all important in EBPR process, this study focused on the genes involved in PHA synthesis ... identical in all known PHA synthases, suggesting an important role of these residues for enzyme function 2.2.3 Genes encoding enzymes involving in PHA synthesis Genes encoding for enzymes in PHA synthesis...

Ngày tải lên: 03/10/2015, 21:58

... recorded for any of the scenarios included in the survey According to 69% of respondents, the closing of the Strait of Hormuz would negatively affect them However, the closing of the Strait by Iran in ... 56 67 The Search for Growth Opportunities and risks for institutional investors in 2012 Which of the following industries you think offer the best opportunities for revenue growth over the next ... 2012 The Search for Growth Opportunities and risks for institutional investors in 2012 Whilst every effort has been taken to verify the accuracy of this information, neither The Economist Intelligence...

Ngày tải lên: 04/12/2015, 00:24

... interaction between the interviewer and the interviewed during the interviews that could influence the statements of the interviewed e.g., the use of leading questions In the phase of analysis ... primarily followed their own definitions of different scoring values, such as excluding certain scores (see examples in table 1) They find the definitions incorrect If the veterinarian strictly ... had told DBL during the morning's herd visits that 'a cow scored could smell more in one herd than in another' He is asked to elaborate on the statement during the interview VETERINARIAN: "When...

Ngày tải lên: 25/10/2012, 10:45

... chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut ... provides a potential therapeutic approach when considering the reported high expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma Gankyrin binds to the cell-cycle ... with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma derived cell lines The resistance against anticancer drugs...

Ngày tải lên: 31/10/2012, 15:28

... with the intention of producing a work of art The experiment reported in this article is clearly in line with the latter trend Second, despite the fact that much of the effort put into the research ... as the 48 specific distracters (one for each target) in a random order and including the masking screens The participants were asked to state whether they had seen each of the stimuli in the ... apparent effect However, an intriguing issue is raised by the results in the interesting dimension for which the relationship is different in both groups When rating the interest of artistic stimuli,...

Ngày tải lên: 19/02/2014, 17:20

... nonspecific metal binding Specificity of Zn(II) binding by the purified Zn(II)-binding proteins The specificity of Zn(II) binding was also examined for the purified Zn(II)-binding proteins The binding of radioactive ... plasmids for zinc-binding proteins The genes coding for zinc-binding proteins were amplified by PCR using the whole genome DNA of E coli W3110 (A) as template The forward primers used included the ... open reading frames) If the relative amount of Zn(II)-binding proteins in terms of total protein species is the same for other E coli proteins, the total number of zinc-binding proteins in E coli...

Ngày tải lên: 22/02/2014, 04:20