... University Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Indirect Contributions ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education...
Ngày tải lên: 21/02/2014, 01:20
... designed on the basis of side-chain packing criteria from a modelled structure of the enzyme resulted in restor- ation of the energy of activation to the levels of the native enzyme and in an increased ... flexibility limits the exploitation of the full potential of protein engineering in the redesign of psychro- philic enzyme properties [15]. In particular, the effects of local flexibility in psychrophilic ... respectively. By introducing an Ala residue in the place of Gly it is expected that the conformational flexibility of the main chain can be constrained with a minimum perturba- tion of the local structure,...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... antigen in itself [7,20]. At least for these antibodies, the role of the V L domain might be to increase the affinity by supporting the V H domain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clear whether or not H39 is dominantly tuning the V H ⁄ V L interaction of other Fvs, including HyHEL-10. In addition, the effect of the H39 ... clarify the effect of the interface mutations on the antigen- binding affinity. To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the V H ⁄ V L interaction...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... example, in the case of question Q209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol- cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop- erties of lava, the following question semantic The Role of ... “Where did the ukulele originate ?”, the expected answer type is LOCATION. In the paragraph the ukulele intro- duced from Portugal into the Hawaiian islands” contains two named entities of the category...
Ngày tải lên: 08/03/2014, 05:20
Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content of the message which only emphasizes the benefits of ... gift giving is instrumental in maintaining social ties and serves as a mean of symbolic communication in social relationship. Most of the researches before and after the appearance of Sherry’s ... described in details the stages of the whole gift- exchange processes, researchers have examined the influence of many variables within these stages. This model divides gifting activities into...
Ngày tải lên: 14/03/2014, 14:20
The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college. Further, when net worth is included in the model, Black youth are ... youth. Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of this money ... ―very concerned‖ about the cost of college, compared to 19% of high-income parents. Further, they find that 71% of low-income youth say they are very concerned about the cost of college (ACSFA,...
Ngày tải lên: 15/03/2014, 10:20
Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydro- lysis in the absence of detectable changes in glucose phosphorylation. S4048 causes inactivation of ... glu- cokinase and hexokinase I in distinct pools [3,24], or by the involvement of mechanisms, additional to Glc6P, in mediating the effects of glucokinase over- expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres- sion. The validity of S4048 for testing the role of Glc6P was supported by its lack of effect on glucokinase binding and...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... documents and find that the fea- ture vectors corresponding to some of these docu- ments (particularly the short ones) have all zeroes in them. In other words, none of the bigrams from the training set ... cap- turing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie. The over- generalization resulting from these “stemmed” ... rating of ≤ 2 (out of 5) or ≤ 1.5 (out of 4). 614 Finally, previous work has also investigated fea- tures that do not fall into any of the above cate- gories. For instance, instead of representing...
Ngày tải lên: 17/03/2014, 04:20
Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... tight binding affinity was demonstrated towards lauric acid, resulting in the synthesis of mainly x-1 hydroxylated lauric acid, suggesting a role in the lipid oxidative metabolism. Interestingly, the ... occurring in the soil. Furthermore, branched chain fatty acids make up 80% of the fatty acid content of the Bacillus sp. mem- branes and when the hydroxylation of these substrates was studied in ... enzymes. The FUM6 protein (CYP505B1) inter- venes in one of the first steps in fumonisin synthesis by hydroxylation of the polyketide-amino acid at C-14 and C-15 (Fig. 3). Fum6 deletion mutants of F....
Ngày tải lên: 22/03/2014, 16:21
The Role of Interest Rate Swaps in Corporate Finance doc
... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility. The timing of the appearance of interest rate swaps, coming as it did during a pe- riod of ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk. The Role for Hedging in the Theory of Corporate ... system of margin requirements, along with the guarantee of the exchange clearinghouse (which, in turn, is jointly backed by the paid -in capital of the clearinghouse member firms). This system of safeguards...
Ngày tải lên: 22/03/2014, 17:20
A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... rapidly, causing the unfolding of one of the I27 modules in the chain. Unfolding then extends the over- all length of the protein, relaxing the pulling force to a low value. As the slack in the length ... stretching a polyprotein re- sults in a well-defined series of step increases in length, mark- ing the unfolding and extension of the individual modules in the chain. [37] The size of the observed steps ... b-strands of the I27 protein during the main unfold- ing barrier. [39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, we repeated these...
Ngày tải lên: 22/03/2014, 18:20
The Role of Digital Identity Management in the Internet Economy doc
... maintained in multiple accounts within the organisation. The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information. ... take into account in the assessment of the security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security. In the case of sensitive ... managing and protecting digital identities, with a view to strengthening confidence in the online activities crucial to the growth of the Internet Economy. The primer is a product of the Working...
Ngày tải lên: 23/03/2014, 23:21
Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
... dur- ing lipid raft isolation. Moreover, these studies have provided some insights into the significance of the localization of the P2X 7 receptors in lipid rafts regard- ing the regulation of intracellular ... (glycero-)sphingolipids. In addition the fatty acid chains of the phospholipids composing these rigid domains are generally more saturated than those in the lipids of the surrounding membrane. In fact, this ... muscarinic receptors, endo- thelin receptors, rhodopsin) are located in lipid rafts [65–70] where they are in close proximity to their transducing GTP-binding protein (Gs, Gi, Go, Gq and transducin...
Ngày tải lên: 30/03/2014, 02:20
Báo cáo khoa học: Tertiary structure in 7.9 M guanidinium chloride ) the role of Glu53 and Asp287 in Pyrococcus furiosus endo-b-1,3-glucanase pot
... suggested by the lack of coincidence of the changes in relative fluorescence intensity and in k and by the hysteresis of the reversibility process (Fig. 4). At the end of the transition, the intrinsic ... that of the wild-type; however, the integrity of the calcium bind- ing site formed by Asp287 and Glu53 is essential for interaction with the cation in 7.9 m GdmCl. An interesting finding of the ... pfLamA in the native state, indepen- dently of their interaction with calcium. The role of electrostatic interactions in protein stability has been widely investigated and the stabilizing effect of...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf
Ngày tải lên: 30/03/2014, 13:20
Beautiful Places: The Role of Perceived Aesthetic Beauty in Community Satisfaction docx
Ngày tải lên: 30/03/2014, 16:20
The role of PDO/PGI labelling in Italian consumers’ food choices
Ngày tải lên: 08/04/2014, 18:33
báo cáo sinh học:" The role of nurses and midwives in polio eradication and measles control activities: a survey in Sudan and Zambia" pdf
Ngày tải lên: 18/06/2014, 17:20
Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Ngày tải lên: 19/06/2014, 08:20
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