the phase 1 study of dmxba in schizophrenia

... non-platinum containing salvage agents, including docetaxel in 12 (30.8%), gemcitabine in 11 (28.2%) and topotecan in (23 .1% ) All prior Page of 11 platinum-containing regimens were counted as regimen ... population in a phase randomized study [7,20] In our phase study, the response rate of 25.6% and DSR of 76.9% supports that the combination regimen is more active in the treatment of platinum resistant ... Screening Program Mol Pharmacol 19 96, 50 (1) :14 9-59 Page 10 of 11 14 Meng F, Brown GL, Keck JG, et al: TLK286-induced activation of JNKdependent apoptotic signaling pathway Proceedings of the AACR-NCIEORTC...

Ngày tải lên: 10/08/2014, 22:20

... (p.p.m.) H3ax 1. 61 H3eq 2.62 H4 4.02 H5 3.53 H6 3.95 H7 3.89 H8 3.89 H9 1. 20 NAcCH3 2.08 1. 86 1. 89 2.48 2. 51 3.33 3.37 ND ND 4 .19 4 .13 3.68 3.75 4 .19 4 .13 1. 17 1. 16 2 .17 ND C1 17 4.47 C2 10 1.86 C3 39.40 ... dH 2. 51 Z) in COSY, and for H7 (dH 3.68 E, dH 3.75 Z) and CˆO of the 7-acetamido group (dC 17 5. 91 E, dC 17 5.74 Z) in the 1H ,13 C HMBC experiment In addition, signals for H9 (dH 1. 17 E, dH 1. 16 Z) ... derivative of L-fucose in the LPS of Bordetella pertussis strain 14 14 [48,49], in which the N-methyl group gave a single singlet in the 1H NMR spectra Similarly, the minor pair of signals at dH 2.97...

Ngày tải lên: 08/03/2014, 10:20

... United Kingdom and internationally (The Telegraph, 2 012 ; Wikipedia, 2 012 ) The Telegraph Online is the online version of the newspaper It includes the articles from the print editions of The Daily ... archive of three million stories In the 19 90s, in the midst of the price war amongst the other broadsheets, The Guardian remained at full price, “investing resources in journalism and distancing ... and the Public Agenda of the University of Maryland in terms of transparency The Guardian was awarded the National Newspaper of the Year in 19 99, 2006 and 2 011 by the British Press Awards in addition...

Ngày tải lên: 10/09/2015, 09:22

... Utilising the USAS semantic domains within WMatrix as the starting point of the analysis, an analysis of the semantic tagset was carried out, with the initial focus being the frequency counts of the ... examination of the lexical item ‘oil’ (Fig 3.8) clearly shows that virtually all the top-30 instances in the concordance refer to either the size and scale of the oil spill (Lines 1, 7, 10 , 11 , 15 , ... overcoming the pressure of the oil spewing out of the well/ the experimental procedure will help stem the flow of crude oil spewing into the Gulf of Mexico/ the picture of an uncontrolled gusher of...

Ngày tải lên: 10/09/2015, 09:22

... strengthen the moral legitimacy of the Obama administration while galvanizing the electorate against the “other”, concealing the multiple failings of the US government In contrast, the predominantly ... eight concordance lines references the 9 /11 attacks in terms of the scale and unprecedented nature of the oil spill, rather than on the incompetence of the parties involved or in the search for justice ... displays all eight instances of the 9 /11 references in the NYT-corpus A dominant unifying thread in these concordances is the constant allusion to the details associated with the “9 /11 victim’s compensation...

Ngày tải lên: 10/09/2015, 09:22

... important role in the development of Mechanical Engineering The thesis studies the English – Vietnamese translation of terms in the materials for Mechanical Engineering First, the thesis collects ... The thesis aims to draw out common translation strategies which can be applied in the English-Vietnamese translation of terms in materials for mechanical engineering Hopefully, the result of the ... Engineering terms and Vietnamese ones Next, the thesis works out and compares the English terms with the Vietnamese ones to finds out appropriate Vietnamese equivalents for the English terms The...

Ngày tải lên: 07/09/2013, 13:04

... % Incorrect % Athletics 28 18 .79 16 10 .74 Boxing 19 12 .75 23 15 .44 Swimming 17 11 . 41 13 8.72 Basketball Football 23 15 .44 10 6. 71 Handball Volleyball Total 87 (58.39%) 62 ( 41. 61% ) 14 9 (10 0%) The ... Athletics 24 14 .12 19 11 .18 Boxing 28 16 .47 22 12 .94 Swimming 19 11 .18 17 10 .00 Basketball Football 26 15 .29 15 8.82 Handball Volleyball Total 97(57.06%) 73(42.94%) 17 0 (10 0%) From the results of table ... line instead of side tended to add a "to" before the second verb or to change the form of line, *cross goal line instead of goal line, * two in zero instead of two the second verb into the V-ing...

Ngày tải lên: 26/11/2013, 13:19

... enhance the author to this thesis Then, the purpose of the study introduces the aims to the thesis And the scope of the study gives the details about the objects that the thesis studies and the main ... further research in the future In conclusion, the thesis will present all the results of the process of studying the theoretical background, then working out the real difficulties in learning the ... the current situations of teaching and learning the English listening skill in the Asemlink of International Language Center 3.2 .1. 1 The difficulties in teaching and learning English in the international...

Ngày tải lên: 14/12/2013, 00:41

... mechanical engineering terminology, it is time to give standards on the terminology In the process of carrying out the study, the author finds different English-Vietnamese mechanical engineering term ... twofold meaning: (1) it is the discipline concerned with the principles and methods governing the study of concepts and their designations (terms, names, symbols) in any subject field, and the ... the precise contextual meaning of the original within the constraints of the TL grammatical structures” and “it attempts to be completely faithful to the intentions and the text-realization of...

Ngày tải lên: 29/01/2014, 10:43

... neutrality of the Internet may be at risk.” 12 0 Therefore, there is “growing international interest as to whether, and to what extent, traffic management should 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 Note ... core of the examination of any interference in the exercise of freedom of opinion is therefore a balancing of interests in which the Court takes account of the significance of freedom of opinion ... schools.” The OSCE PC Decision 633 further asks the participating States to study the effectiveness of laws and other measures regulating Internet content” 13 10 11 12 13 Final Act of the Conference...

Ngày tải lên: 18/02/2014, 00:20

... towards the end of the 19 30s, and the number of workers in the estates fell However they became more active again in the 19 50s The fall of the French in the fighting against the Communist Party of Indochina, ... (Robequain 19 44; Slocomb 2007 :10 ), the era of Indo-chinese rubber began in the 19 00s Agricultural estates were set up in the Cochinchina area to the south of Indochina (see map), close to the populated ... development The beginnings of the land concessions in Lao PDR are directly related to the change in economic development policy at the end of the 19 80s to the beginning of the 19 90s, with the first...

Ngày tải lên: 21/02/2014, 04:20

... like in the caseins and synucleins They also show positive intensity in the range » 16 70 16 75 cm )1 characteristic of disordered/PPII structure Some of the negative ROA intensity in the range » 12 40 12 66 ... side-chain±backbone hydrogen bonding interactions, thus helping to maintain, along with the abundance of proline residues, the open conformation of the protein The ®nding that a combination of low ... that the former is likely to be in the Cterminal half and the latter in the N-terminal half of the protein [29,48± 51] Sequence-based structure prediction methods suggest that the caseins are of the...

Ngày tải lên: 21/02/2014, 15:20

... specify 55% 36% 29% 21% 12 % 12 % 12 % 11 % 10 % 6% 13 CASE Social Media Survey • Summary Topline Findings • April 13 , 2 011 29 To what degree is your unit considering each of the following? Not at all ... for successful use of social media 3% 10 % 62% 22% 3% CASE Social Media Survey • Summary Topline Findings • April 13 , 2 011 13 Which of the following you use the most in meeting your unit's goals? ... Lack of relevant human resources in my unit 16 % 20% 28% 21% 15 % 3.0 Expertise in how to implement it 14 % 29% 33% 18 % 7% 2.8 Slow pace of change 14 % 27% 35% 17 % 8% 2.8 Funding 18 % 31% 27% 16 % 8%...

Ngày tải lên: 08/03/2014, 19:20

... all findings of Clouded Apollo, 15 (13 %) have been located on the banks of lakes, 10 (9%) on the coastal area of the Baltic Sea and all the rest ( 91; 78%) on the riparian areas of the rivers The ... - including the influence of the landscape context - was analyzed on 11 8 sites The presence of the burnet depended mainly on the presence of nectar plants and of nutrient-poor dry grasslands in ... recorded, 16 in 2003 and 16 in 2004 The monthly trend of the butterfly community in the sampling area showed that, apart from fire disturbance, the phenology of the species remained constant in all the...

Ngày tải lên: 23/03/2014, 01:20

... core +1 chimeric protein containing the first 8 11 amino acids of core fused to amino acids encoded by the core +1 ORF [15 17 ] By contrast, internal translation initiation of core +1 can occur at the ... levels in the presence of core was the result of an overloading of the cellular protein-synthesis machinery and of a shortage of its components Finally, we examined the possible effect of core +1 ⁄ ... pHPI -15 07 pHPI -15 07 kDa 24 17 pHPI -14 94 kDa Control MG132 Lactacystin DMSO MG132 pHPI -15 07 pHPI -14 94 Control pHPI -14 95 MG132 pHPI -14 95 (a) B 20 14 pHPI -15 79 +MG132 pHPI -15 79 pHPI -14 96 +MG132...

Ngày tải lên: 30/03/2014, 03:20

... certain point mutations [16 ,38,39] This is one of the main reasons why the aim of this study was to determine the solution structure of the intact monomeric form of this protein One of the main ... the (1 96)Vpr structure (in blue) with the (1 51) Vpr (in pink) and (52–96)Vpr (in green) domain structures The (17 –46) domain backbone of the N-terminal (1 51) Vpr (pink) is superimposed with the ... Thus, during the early stages of HIV -1 replication, binding of NCp7 to the C-terminal domain (80–96)Vpr [8] may expose the N-terminal (1 39) portion of the protein and allow its tight binding to...

Ngày tải lên: 31/03/2014, 23:20

... of Quality: an Australian 11 Gronroos, C (19 84) A Service Quality Model and its Marketing Implications European Journal of Marketing 12 Gruber T, Fub S, Voss R, Glaser-Zikuda M (2 010 ) Examining ... University of Central England, Birmingham 14 Hom, W (2002) Applying Customer Satisfaction Theory to Community College Planning of of Student Services 15 Kotler, P (19 85) Strategic Marketing for ... tangibility RESEARCH PURPOSE v The overall objective of the research is to recognize the underlying factors of service quality of Danang university of economics (DUE) q To examine the relationship between...

Ngày tải lên: 18/04/2014, 16:25

... plan these type studies since the Page 10 of 11 combination treatments may result in worsening of the response rate as it was seen in the aforementioned study of ipilimumab and gp100 [17 ] In conclusion, ... epitopes were used for the in vitro sensitization procedure Cytokines promoting the expansion of activated T-cells were added to the wells on days 1, 6, and 10 or 11 of the 14 day in vitro sensitization ... between the results of an immune monitoring assay in peripheral blood and tumor responses [15 ] The results of the current study should be interpreted in the context of other recently reported vaccine...

Ngày tải lên: 18/06/2014, 16:20

... 000 population 11 3 14 8 18 2 212 Working at hospitals (%) 43 56 62 63 Female (%) 10 13 17 Working in rural areas (%) 14 14 13 11 Total 47.6 (14 .0) 46.9 (14 .9) 46.7 (15 .4) 47.8 (15 .2) Hospital-based ... statistics of the classes of 19 70, 19 80 and 19 90 Class of 19 70 Class of 19 80 Class of 19 90 2706 6326 6994 11 18 26.3 (2.2) 26.7 (2.7) 26.7 (2.7) Clinics Hospitals 91 93 94 Others 4 1. 5 (2.0) 0.8 (1. 3) ... 19 84; F2, the number between 19 85 and 19 94; F3, the number between 19 95 and 2004 n1, the number of physicians working in clinics in 19 74; n2, the number in 19 84; n3, the number in 19 94; n4, the number...

Ngày tải lên: 18/06/2014, 17:20

... 14 5 11 9 16 -14 .37 -5. 71 -12 .63 19 .49 16 .99 15 .66 -0.75 -0.28 -0.64 -0.74 -0.32 -0. 81

Ngày tải lên: 18/06/2014, 19:20