the objectives of the regulation
The objectives of satire in gulliver's travels of jonathan swift = những đối tượng châm biếm trong gulliver du kí của jonathan swift
Ngày tải lên :
18/12/2013, 21:45
... 1.2 the aims and objectives of the thesis 1.3 the scope of the thesis 1.4 the methods of the thesis 1.5 Design of the Thesis Part ii : investigation Chapter I: satire and the development of satire ... All of above things are the reasons why I choose The objectives of satire in Gullivers Travels of Jonathan Swift for my graduation thesis 1.2 The Aims and Objectives of the Thesis - To help the ... condemns the cruelty of the ruling class to the people The fourth part describes the voyage of hero to the country which was controlled by the horses Although these horses had the shape of men, they...
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Tài liệu Reading Our Lips: The History of Lipstick Regulation in Western Seats ... doc
Ngày tải lên :
16/01/2014, 22:20
... but rather a vital part of the war effort; they turned lipstick into a symbol of resilient femininity in the face of danger, a symbol that would boost the morale of both the women wearing the lipstick ... from, the additive and of any substance formed in or on food, drugs or devices, or cosmetics because of the use of the additive, (ii) the cumulative effect of such additive in the diet of man ... provided the Secretary of Agriculture with the name and address of the person who had caused dissemination of the offending advertisement Id at 75 Second, opposition arose regarding the Secretary of...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
Ngày tải lên :
16/02/2014, 09:20
... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... However, as in most other CDE ⁄ CHR promoters, mutation of the CHR results in a smaller remaining cell cycle -regulation than alteration of the CDE [37] Interestingly, the core of the human Tome-1 ... Moreover, orientation of the CDE ⁄ CHR in the general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have been performed for AP-2a Up to now, there have been ... further analyze their interactions with AP-2 and the functional role of these in chondrocytes Furthermore, it is speculated that in melanoma, where AP-2a acts as a tumor suppressor, the loss of...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
Ngày tải lên :
18/02/2014, 08:20
... into the potential biologically relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 ... differentiation Taken together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation miR-27 prevents the induction of PPARc and C ⁄ EBPa ... involved in the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
Ngày tải lên :
18/02/2014, 16:20
... trafficking of the CD95 from inside the hepatocyte to the plasma membrane [39], which depends on a ROS-mediated tyrosine phosphorylation of the epidermal growth factor (EGF)-receptor, the association of ... apoptosis include activation of the protein kinase B survival pathway [31], p53 activation [32], induction of the serum- and glucocorticoidinducible kinase Sgk [33], expression of the heat shock protein ... association of CD95 with the EGF-receptor, and phosphorylation of CD95 on Tyr232 and Tyr291 by the EGF-receptor tyrosine kinase activity [15] Although the appearance of CD95 at the plasma membrane...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
Ngày tải lên :
06/03/2014, 01:20
... by application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain ... auto-phosphorylation by modulating the kinase activity of the enzyme To determine the roles of the SH3 and ⁄ or SH2 domains in Src regulation of NMDAR phosphoryla- tion, the protein fragment corresponding ... blocking the enzyme activity of Src [3,18] The peak amplitudes of NMDAR currents during PP2 application were 96 ± 4% (n = 7) of those of controls before PP2 application (Fig 1D) Taken together, these...
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Guidance for Business on the Provision of Services Regulations pptx
Ngày tải lên :
06/03/2014, 21:20
... changed because of these Regulations or the Directive Annex C – Authorities that fall within the remit of the Regulations 39 � 42 � 51 � Guidance for Business on the Provision of Services Regulations ... in the UK, both providers of UK origin and those from other EEA states The Regulations apply whether the provider has a UK establishment from which the service is provided (as in Part of the Regulations) ... services in the UK regardless of where they are established (i.e they can be based anywhere in the world) You not have to be doing business outside the UK to fall within the remit of the Regulations,...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... polymerases, and the solution of the crystal structure of Pol II shows that these two subunits are located close to each other at the surface of the polymerase [29,124] and participate in the transcription ... domain and then to the nascent RNP, where actin in complex with the hnRNP U can facilitate recruitment of PCAF or P2D10 to the active gene Formation of actin filaments in the proximity of the Pol ... components of the yeast Nu4A HAT complex [38,42] In the yeast Nu4A HAT complex, actin and Act3 ⁄ ARP4 are essential for the structural integity and activity of the complex [38] The presence of actin...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
Ngày tải lên :
07/03/2014, 21:20
... analysis, we found a set of DIDO1 homologues in the context of DNA binding and chromatin regulation These homologues include members of the CpG binding protein (CGBP) family of proteins that bind ... modifications of chromatin [9] Little is known, however, of the functional role of the remaining subclass members In this study, the yeast protein SPP1 (alias cps40), a member of the COMPASS complex ... constitute CGBP homologues The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... regulators the activation status of GSK3 is likely to be a key determinant of GS activity Whilst there is considerable evidence implicating GSK3 in the regulation of glycogen metabolism there are ... 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by 85%, whereas that of the a isoform is virtually undetectable in differentiated adipocytes...
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Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
Ngày tải lên :
15/03/2014, 11:20
... to the development of multiple diseases Fibrosis is characterized by the excess deposition of extracellular matrix (ECM) components, which is the end result of an imbalance of metabolism of the ... and the development of diabetic nephropathy through the down -regulation of PTEN and the subsequent activation of Akt (Fig 1) [43] Increased expression of miR-377 is also thought to regulate the ... failure of a number 2016 of organs Although current treatments typically target the inflammatory response, the mechanism of fibrosis is poorly understood and there are few effective therapies For these...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
Ngày tải lên :
16/03/2014, 18:20
... major role in determining both the level of expression and the location of the start of transcription of PS1 In the Ets family of transcription Ó FEBS 2004 Regulation of the presenilin gene (Eur J ... requires at least one of the two sites It appears that the )70 Sp1 motif is required whether initiation is directed by either of the )10 or +90 Ets site Ó FEBS 2004 Regulation of the presenilin gene ... using the concentration of protein in the extract as an internal standard The activity of ()119/+178) PS1CAT in the presence of the empty vector was taken as 100% The values represented in the...
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Báo cáo khoa học: Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells doc
Ngày tải lên :
16/03/2014, 22:20
... Reversibility of the effects of calcium-induced contraction of cardiomyocytes on the kinetics of regulation of mitochondrial respiration by exogenous ADP The kinetics of respiratory regulation was ... alteration of the regular arrangement of mitochondria in the cells, in the changes in the kinetics of regulation of mitochondrial respiration by exogenous ADP and ATP, and in the direct channelling of ... under the conditions of our experiments Figure 3A shows that the addition of ADP activated the respiration of permeabilized bers in the presence of lm free calcium, and that the addition of exogenous...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
Ngày tải lên :
17/03/2014, 17:20
... (right) images of the liver of a control mouse acquired using the FLASH sequence (TR ¼ 10 ms, TE ¼ ms) The rectangles indicate the location of the volume of interest, % 400 lL (8.5 · · mm3) The 13Clabeled ... net synthesis of glycogen or the combination of both The rates of total glycogen synthesis and 13C label incorporation into glycogen (Fig 5) suggest that the overall rate of glycogen synthesis ... activity of the indirect pathway of glycogen synthesis In addition, this study reports for the first time the simultaneous detection of increased signal intensity for the glycogen C2–C5 resonances These...
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
Ngày tải lên :
17/03/2014, 23:20
... Although the predicted aminoacid sequence had similarity with the sequences of mammalian TGase, the length of the cDNA was smaller than the length deduced from the molecular size of the purified ... Although the overall identity with the mammalian TGase primary sequence is low in the deduced sequence of the Physarum TGase, the middle region of the sequence is significantly conserved The sequences ... shown that the enzymatic activity of TGase was inhibited by the presence of GTP or ATP, as in the case of PpTGase [51] These results suggest that the mechanism by which nucleotides inhibit the enzymatic...
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Báo cáo khoa học: The regulation of the endosomal compartment by p53 the tumor suppressor gene docx
Ngày tải lên :
23/03/2014, 04:21
... or they are in the same pathway, but each raises the rate of production of exosomes (two distinct rate-limiting steps) p53 regulates the internalization of EGFR from the plasma membrane into the ... whether a p53 response could accelerate removal of the EGFR from the plasma membrane In H460 cells, the localization of the EGFR was determined by fluorescent immunostaining In the absence of ... activity The results confirmed the conclusions presented in Fig 5D, activation of p53 increased the removal of both EGFR and caveolin-1 proteins from the surface and they colocalized within the cell These...
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The Constitution of Private Governance Product Standards in the Regulation of Integrating Markets pptx
Ngày tải lên :
23/03/2014, 05:23
... WIDESPREAD SCHOLARLY neglect of the phenomenon of the use of standards in modern market regulation seems all the more striking in the light of the preoccupation of modern theorising in sociology, ... 3.5 The State of the Art Defence: the European Community 3.6 The State of the Art Defence: the United States 3.6.1 Between Custom and the Frontiers of Science 3.6.2 Standards Bodies and the Constitution ... the EUI, I spent the remainder of the implausible number of years it has taken to write the thesis at the Zentrum für Europäische Rechtspolitik in Bremen, the Centre de Théorie Politique at the...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... HD These processes may not be independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we specifically focus on the role of ... only on the amount of the interacting proteins but also on the affinities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 ... might also be involved in the regulation of apoptosis Even though the exact function of HIPPI remains unknown, knockout mice for Hippi (HIPPI) ⁄ )) exhibit downregulation of the Sonic hedgehog (Shh)...
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The Economic Impact of Environmental Regulation pptx
Ngày tải lên :
23/03/2014, 20:20
... dumping some of their costs on the environment (and thereby compel the public to subsidize their operation) never were really competitive in the true sense of the term But the loss of such companies ... to the same river as either a public subsidy or imposing a public cost As one CEO explained “ Look, the public benefits from our products They use them and they get jobs Part of the price of ... proponents of environmental deregulation On the one hand three of the four estimated coefficients are negative And the odds slightly favor a true underlying negative effect The size of the negative...
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