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Báo cáo khoa học: Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin potx
... detailedmap of the epitopes for the mAbs, where 45M1 recog-nizes an epitope located in the N-terminal region of the C-terminal cysteine-rich part of MUC5AC, pre-sumably in the last CysD domain of the ... epitopes locatedin the MUC5AC C-terminal cysteine-rich part.Further localization of the epitopes of 45M1,2-12 M1 and 166M1In order to further locate the epitopes of the hithertounmapped 45M1, ... mucin. The epitope of 2-12M1 is located in the sequence corre-sponding to the expression product of the L31 clone,whereas the epitope for 166M1 is located C-terminallyto the GDPH-cleavage site of...
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Economic Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU – doc
... positions which depend on the production trends for each MS and the distribution of demand amongst them.17 These trends of the baseline are in line with the market outlook for the dairy sector (European ... Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU" (AGRI-2007-0444). The project aimed at a thorough policy impact analysis of the EU ... through either the transfer of an entire farm, the leasing or purchase of quota, or the allocation of quota from a national reserve. The transfer of milk quota may take place via a variety of administrative...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
... PufXD2)7neither affects the photo-synthetic capability of the bacteria nor the efficiency of exchange of the ubiq uinol molecules between th e RC and the bc1, a s judged from the reduction kinetics of ... an inhibitory effecton the formation of the LH1 complex. This result suggeststhat the central core of the PufX protein is responsible of the break in the continuity of the LH1 ring in vivo [14], ... the role of the C-terminal amino-acid residues of the LH1 apolypeptide in the organization of the LH1–RC complex[12]. In the present work, we have investigated the possible involvement of the...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... which the N-terminus of the OTR is replaced with the corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning mutagenesis of the N-terminus ... mutation of Arg46 had the dualeffect of (a) decreasing agonist affinity and (b) promoting the agonist-induced active conformation due to the loss of astabilizing constraint on the ground state of the ... off-state. The unique ability of arginyl to fulfil this constraining function in the N-terminus of the V1aR is similar to the unique constraining role of alanyl previously reported for Ala293 in the...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... BS-RNase. The former substitution destabilizes the mono-meric form, and the latter specifically favours the swappeddimer.AcknowledgementsWe thank the CIMCF of the University ÔFederico IIÕ of Naples ... P19A/L28Q-mBS has the same thermalstability of the parent protein, in spite of greater similarity toRNase A.To directly characterize the process of exchange of the N-termini, we prepared dimers of all ... pro-cess for a recombinant sample shows that it folds mainly in the MẳM form, then undergoes interconversion into the MxM form, reaching the same 7 : 3 equilibrium ratio. Toinvestigate the role of the...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... per-formed using Lipofectamine 2000 (Invitrogen) as recom-mended by the manufacturer. For stress treatment, HeLacells were cultured in the presence of 0.5 mm arsenite for 1 h. The procedure for ... copies of the N protein, respectively. (C) The RNA binding efficiency of N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The ... suppression.Moreover, phosphorylation of the RS motif modulates the ability of the N protein to form SGs.RS motif deletion induces the N protein to formlarge RNP complexes The SARS-CoV N protein might...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... between the projection of the tilt of the z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes. The orientation of the ... to the iron and positioned toprovide the H-bond to the bound cyanide, and byimplication, to the bound O2in the reduced form in each of the three globins. The extensive sequence homology for ... Thus the movement of the B-helix towards the heme in the WTmetHbrelativetothatintherWTmetHbH2OcrystalFig. 3. Schematic representation of the sequential NOESY cross peakpattern for the six...
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Báo cáo khoa học: Structure of the exceptionally large nonrepetitive carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-82164 doc
... and showed, in particular, the configuration of ManNAc to beD.From the combined the data on the structures of the isolated oligosaccharides, the overall structure of the P. frisingensis LPS carbohydrate ... with 7a (Table 1) because of the b-effect of the acetylation. Acetylation of 7b was confirmed byESI MS data, which gave the expected mass of 3221.4 Da. The spectra of oligosaccharide 6 were ... 1bare the fragments of the larger structure 2, thus the NMRdata for 1a,b are very close to those for the respectiveresidues in 2 and are not presented. The position and anomeric configuration of...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
... observed for the NR1 FMNdomain, suggesting that the midpoint reduction potentials for the FAD ox/sq and sq/hq couples are much closertogether than those for the FMN. Typically for this class of diflavin ... enzymes, the potentials for the FAD/NADPHdomains are rather more negative than those for the FMNdomain, reflecting the direction of electron transfer fromNADPH through FAD, then FMN and on to the ... FAD/NADPH domain(% 16-fold) (29). However, the domain mixture still recon-stituted only % 2% of the activity of the full length CPR. InthecaseofNR1,thekcat for the full length enzyme is low(1.3 s)1)...
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Báo cáo khoa học: Structure of the O-polysaccharide fromProteus myxofaciens Classification of the bacterium into a newProteusO-serogroup pptx
... LPS)[5,6]. The serological specificity of the bacteria is definedby the structure of the O-specific polysaccharide chain(O-antigen) of the lipopolysaccharide. On the basis of the O-antigens, the strains ... the Dconfiguration (the b effect on C3 of L-GlcAwouldbeclosetozero[27]).On the basis of the data obtained, it was concluded that the repeating unit of the O-polysaccharide of P. myxofac-iens has the following ... 2.01–2.10.These data together suggest that the tetrasacchariderepeating unit of the polysaccharide consists of two residues of GlcNAc and one residue each of GalNAc, GlcA andAlaLys. The 1Hand13C...
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AUDIT OF THE CONTROL SYSTEM GOVERNING THE PRODUCTION, PROCESSING, DISTRIBUTION AND IMPORTS OF ORGANIC PRODUCTS potx
... on the type and format of information they have to submit. The reports have since then been written in a more uniform format. The Commission has now embarked on a process of improving the format ... is the responsibility of the competent authority of the Member State to verify the competence of the control body to issue a certificate of inspection, and in particu-lar the evidence that the ... send these supervision reports. There were no reports from Austria, for example. At the end of the audit (November 2004), of the 48 reports due over the period 2000–03 in respect of the 12...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... amounts of the ECDs of the non-a sub-units of human muscle AChR for use as starting material for the determin-ation of the 3D structure of the receptor ECDs and for the characterization of the ... datafrom electron images of the AChR found in largeamounts in the electric organ of the marine ray,Torpedo californica [3]. The acquisition of the crystallo-graphic structure of the mollusc acetylcholine-bindingprotein ... con-tains the major part of the binding site for the cho-linergic ligands. The two sites are nonequivalent, onebeing formed at the interface between one a subunitand the c ⁄ e subunits and the other...
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LORD NEUBERGER OF ABBOTSBURY, MASTER OF THE ROLLS JUSTICE IN A TIME OF ECONOMIC CRISIS AND IN THE AGE OF THE INTERNET ppt
... buildings owe their design to the necessities of parties, witnesses and their lawyers attending court for hearings, and, behind the scenes, the needs of the judges and of the back offices, which ... Parliament, the executive, and, of course, the justice system. 10. Reform of the justice system, to our courts and the legal profession, like reform of the law, must clearly be consistent with the ... of the internet, regulatory reform, recent and possibly further constitutional reform, the present economic situation and, if Bobbitt is right, the transformation of the nation-state into the...
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Review of the Literature Regarding Critical Information Needs of the American Public
... account of the increasing failure of the news ecosystem to adequately report on education nationally and locally, with some suggestions for the formation of a non-profit reporting sector. The third, ... terms of the content and access platforms available to them; and in terms of the extent to which they want to engage with media as both consumers and producers of information. While on the surface ... down into the complexities surrounding the questions of if and how local community information needs are being served and whether any barriers exist to the fulfillment of these information...
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