the irp ire regulatory network

... data, have been proposed in recent years Nevertheless, the theory and practice of computational network inference is not completely established There is still a need for suitable models of gene ... gene regulation The continuous part considers the concentration of proteins, some of which are transcription factors regulating the activity of a gene and others of which are the products of ... whether the concentration of the corresponding protein is increasing or decreasing Proteins either bind to or dissociate from a promoter according to certain thresholds, thus influencing the...

Ngày tải lên: 14/08/2014, 16:21

... that depends more specifically on the overall function of the network Therefore, understanding the relationship between network structure and the evolution of network components will depend on ... on the yeast transcription network and previous work on the yeast metabolic and PPI networks [4-6] show that the structure of cellular networks influences the evolution of proteins within these ... Metabolic and gene regulatory networks have a different level of complexity than PPI networks because they are directed and explicitly model the flow of information passing through the nodes Moreover,...

Ngày tải lên: 14/08/2014, 21:20

... parameters such as the binding constants and the extent of autoregulation The regulatory proteins may reside either in the nucleus or in the cytoplasm or in both, thus controlling the network The existence ... constrain the operation of the network However, the response for a specific system is constrained by the connection between these elements The response is also influenced by the relative dominance of these ... best describe the input–output experimental data The individual components of the selected model provide insights into the importance of their roles in the overall performance of the network A similar...

Ngày tải lên: 07/03/2014, 16:20

... analyze the results according to four different aspects: the impact of the estimator, the impact of the discretization, the impact of the inference algorithm, and the influence of sample and network ... [10] The paper presented an experimental study of the influence of the information measure and the estimator on the quality of the inferred interaction network The study concerned both synthetic ... In the second step, the chosen algorithm is applied to the mutual information matrix in order to compute a score that is used to weigh the links between network nodes 3.1 The MRNET Method The...

Ngày tải lên: 22/06/2014, 00:20

... bootstrap dataset, and then (a) assessing the agreement between these bootstrap networks and the original network (stability) and (b) using the regression models from the bootstrap networks to predict ... Arabidopsis The last column gives the number of modules (and in parenthesis the number of genes) regulated by the factor in our systems biology-based network and in the co-expression network, respectively ... factors are the two modules with the strongest competitive regulatory mechanisms in the network (Figure 6) Both these regulators have a significant individual influence on the expression of the modules,...

Ngày tải lên: 11/08/2014, 11:21

... IFN-βR β SOCS1 T-bet STAT1 GATA3 Figure The Th network The Th network The regulatory network that controls the differentiation process of T helper cells Positive regulatory interactions are in green ... version of the Th network, the molecular basis of which is included in the Methods Also, we implement for the first time a continuous model of the Th network By applying Equation to the network ... constitutes the discrete version of the dynamical system representing the Th network Similarly, the continuous version of the Th network was obtained by applying Equation to the network in Figure...

Ngày tải lên: 13/08/2014, 23:20

... uncover the design principles of transcriptional networks [3,14], although it should always be remembered that these networks are the products of evolution, rather than design So far, it is mainly the ... does the frequency of certain motifs differ between endogenous and exogenous regulatory networks, but also the length of regulatory cascades varies between these two contexts It has been shown theoretically ... 206.3 comment network itself Thus, it is essential to integrate the outputs of signaling networks with the inputs of gene regulatory networks to build a more complete representation of the cell’s...

Ngày tải lên: 14/08/2014, 14:21

... research The regulatory network inference procedure was then performed on these 300 biclusters and 159 individual genes, resulting in a network containing 1,431 regulatory influences (network ... the definitive regulatory network but rather as a network that suggests (possibly indirect) regulatory interactions [27] The predicted network model is consistent with the data in such a way that ... dominant functional theme from Figure The red line indicates the measured expression profile, and the blue line shows the profile as predicted by the network model Conditions in the left-most region...

Ngày tải lên: 14/08/2014, 16:21

... 19 arrays (e, f) The chromosomal position of the genes, as well as the genomic scale, is represented along the xaxis The fold enrichment of the probes is shown on the y-axis These enrichment ... govern the transcriptional regulatory circuitry Recent genomic studies in ES cells have provided the foundation for understanding the genetic network that is the collective output of these pluripotency ... derived from the inner cell mass of the embryo and possess the property of pluripotency, which is the ability to develop into any cell lineage of the organism [1-3] The derivation of these cells...

Ngày tải lên: 14/08/2014, 20:22

... significant conservation in cis -regulatory networks Alternatively, although the general properties of gene regulatory networks are conserved, the underlying cis -regulatory networks may have undergone ... manner Finally, the authors find that the transcriptional profile of human chromosome 21 genes in Tc1 mice resembles their transcription in the native human environment, rather than the transcriptional ... in the underlying cis -regulatory networks [9,16] One important remaining question from the hepatocyte studies [11,12] concerns the functional activity of speciesspecific TF binding Although the...

Ngày tải lên: 14/08/2014, 21:20

... interactors) with their CREs, and the causal links of the trans-acting factors with their target genes, can be mapped into a comprehensive conceptual framework – the gene regulatory network (GRN) The transcriptional ... [69] They contain only the paired-domain and the octapeptide motif, and share a high protein sequence similarity of 79%, diverging mainly at their C-terminal ends Within the paired-domain they ... the link between the Pax1/Pax9 TFs and the other TFs in the chondroosteogenic pathway Furthermore, literature search and existing gene expression data for other TFs (eg Sox5, Sox6, Sox9) in the...

Ngày tải lên: 08/09/2015, 21:57

... of LFY (Yu et al, 2002), there is no evidence for the direct relationships between these genes Some other intermediators may function in the gaps To investigate the regulatory components downstream ... signals They activate the expression of a group of flowering time integrators to promote the transformation of the vegetative shoot apical meristem (SAM) into the inflorescence SAM, which has the ... Arabidopsis, perform the flowering only once in their lifecycle, and the reproductive success depends entirely on this one opportunity (Komeda, 2004) During floral transition, the change in the developmental...

Ngày tải lên: 08/11/2015, 17:07

... influence the optimum choice: b The primary current of the transformer b The insulating medium of the transformer b The position of the substation with respect to the load centre b The kVA rating of the ... insulation to the metal, can raise the voltage of the envelope to a dangerous level (depending on the ratio of the resistance of the leakage path through the insulation, to the resistance from the metal ... the start of the loop to the substation immediately downstream of the fault and open the switch on the substation immediately upstream of the fault on the loop These measures isolate the cable segment...

Ngày tải lên: 19/10/2013, 22:15

... network and the services members on the other d Use two connected hubs to separate the workgroups from each other Connect the accounting members to one hub and the services members to the other 1-2 ... Viewing the Animations To view the animations, complete the following: Load the course CD in the CD drive on your computer In your Web browser, load the INDEX.HTM file located in the \ANIMATIONS directory ... Describe the role and function of the OSI Network Layer in the OSI Model, including connectivity devices that operate at the Network Layer (Section 4) Describe the role and function of the OSI...

Ngày tải lên: 22/10/2013, 16:15

... connected to the distribution network b The location along the distribution network of the proposed new load, i.e close to the substation, or near the remote end of the distribution network, etc ... Three-wire: Earthed mid point (k) Single-phase; Two-wire: Earthed end of phase (l) Single-phase; Two-wire Unearthed (i) Three-phase open delta: Earthed junction of phases Vk (m) Single-wire: Earthed ... star; Four-wire: Earthed neutral (f) Three-phase delta: Three-wire (b) Three-phase star: Three-wire (c) Three-phase star; Three-wire: Earthed neutral (g) Three-phase delta; Four-wire: Earthed mid...

Ngày tải lên: 23/10/2013, 20:15

... customer/professional communities/knowledge networks) The fundamental premise of this talk… Because marketing is relational, social network theory (SNT) helps to advance marketing theory and practice Discussion ... does the marketing perspective compare to the sociological perspective? What are the three key perspectives of SNT that have influence marketing theory and practice? How have researchers used these ... advance marketing theory and practice? A Look at the Future • • How current trends reflect the importance of SNT to marketing thought and practice? How could social network theory enhance my...

Ngày tải lên: 24/10/2013, 20:15

... the Network Implementing the Network IG 9-3 Objectives IG 9-3 Exercise 9-1: Pre-Test IG 9-5 Plan the Network and Install the Network Cabling IG 9-7 Plan the Network ... 7-9 The Novell Guide to Network + (Volume 2) 0 In the previous figure, an IP network has been assigned the network address of 132.132 Its network address uniquely identifies it from all other networks ... on the internetwork Each host or node on this network must have an IP address of the form 132.132.x.x, where the last two bytes of the address must be unique on the network A node assigned the...

Ngày tải lên: 26/10/2013, 23:15

... computer users have to learn the safe practices for their computers, their business networks, and the Internet The security basics of “what to do” and “what not to do” become the front-line defense ... sales, and efficiency These intangibles have been the driving force to make the technology revolution the most important revolution during the existence of man Along with the social and economic ... about the CompTIA Security+ • The focus of the certification • Key benefits for becoming CompTIA Security+ certified: Over the course of several centuries, the Industrial Revolution saw the development...

Ngày tải lên: 21/12/2013, 06:18

... the Network Implementing the Network IG 9-3 Objectives IG 9-3 Exercise 9-1: Pre-Test IG 9-5 Plan the Network and Install the Network Cabling IG 9-7 Plan the Network ... 7-9 The Novell Guide to Network + (Volume 2) 0 In the previous figure, an IP network has been assigned the network address of 132.132 Its network address uniquely identifies it from all other networks ... on the internetwork Each host or node on this network must have an IP address of the form 132.132.x.x, where the last two bytes of the address must be unique on the network A node assigned the...

Ngày tải lên: 21/12/2013, 06:19