the interplay between signaling pathways and transcription regulation

... controlled by signaling pathways, some of the pathways are inside-out signals that might occur through regulation of the interaction of the cell with the extracellular matrix and through the response ... throughout the body of the cell, and the substrate at the basal surface of the ECs Interestingly, forces acting at one surface may be propagated internally or even to other surfaces of the cell, or they ... blood flow and effects from other neighboring cells and matrix The biophysical aspects of the endothelium through which the leukocytes transmigrate, in addition to the biophysical aspects of the leukocytes...

Ngày tải lên: 22/03/2014, 21:20

... placed between the IκBα promoter and the luciferase gene to optimize the luciferase expression in transgenic mice The transgene cassette was separated from the vector backbone sequences and used ... SB203580 atheroscleorosis, asthma and tumor development [21,22] The luciferase activity in the IκBα-luc mice could be used as a sensor for monitoring the NF-κB activation and to further understand ... the mouse body in accord with the pseudo-color scale shown on the right of the images Red represents the highest photons/sec while blue represents the lowest photons/sec B Quantification of the...

Ngày tải lên: 11/08/2014, 08:21

... binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afnity of the enzyme for the other substrate (GST-IjBa) [59] ... cells in terms of the peak periods and frequency This clearly demonstrated that these cells have the ability to synchronize their oscillations with each other The study of signaling pathway dynamics ... monolaurate)] was dispensed into the wells and the plates left to incubate for 15 The plates were inverted to remove the detergent after the 15 incubation period and the wells were washed twice with...

Ngày tải lên: 16/03/2014, 11:20

... tool They proposed and compare two such schemes, based on arithmetic coding and turbo coding, respectively We present this special issue believing that the interplay between compression and encryption ... compression and encryption In their paper “Multimedia encryption with joint randomized entropy coding and rotation in partitioned bitstream,” Xie and Kuo propose a framework that couples randomized ... randomized entropy coding and bitstream rotation in order to improve the security They show that their scheme makes known and chosen plaintext attacks extremely difficult The last paper by Magli...

Ngày tải lên: 21/06/2014, 22:20

... regulates Pn(σ) The length of the common border between σ and ρ is lρ, σ, which is the count of all 8-connected lattice sites between and ρ, and σ, g(x) = , f (x) = x and n(σ) returns the set of cells ... point (the centroid of the cell's lattice sites) of each primary cell Let D be the set of distances between the center of each Voronoi cell and its vertices, then the VRI is the ratio of the mean ... acquire new signaling properties and in so doing influence the final form the pattern will take The process is both iterative and dynamic In this work, we explore how the interplay between three...

Ngày tải lên: 13/08/2014, 16:21

... arousal, or is there a fundamental change in the pathophysiology of the acute brain dysfunction with this transition? These questions remain unanswered at present The paper by Pandharipande and colleagues ... layer of complexity to understanding acute brain dysfunction in these patients As noted by Pandharipande and colleagues [1], there is some evidence that benzodiazepines and alpha-2 adrenoceptor agonists ... advance in our understanding of the complex Page of interconnections between acute brain dysfunction, sedation, and sepsis However, we need further progress in our understanding of the complex pathophysiology...

Ngày tải lên: 13/08/2014, 20:22

... some other receptor proteins have been involved in the signaling pathways mediated by semaphorins, like c-Met and Ron, 11 ErbB2, integrins, and L1 The characteristics and functions of these receptors ... domain and three PSI domains at the N-terminus of their extracellular domain At the C-terminus of PSI domains, there are three IPT (Ig-like, plexins and transcription factors) domains in their ... activates receptor signaling (Takahashi and Strittmatter, 2001) The Sema domain prevents plexin-A1 activation in the basal state Both the Sema portion and the remainder of the extracellular domain...

Ngày tải lên: 11/09/2015, 09:11

... slow the economy Therefore, we may conjecture that the relationship between default risk and interest rates is sensitive to some measure of where the economy is in the business cycle and/ or other ... over the change in the 10-year Treasury bond yield, the change in slope (defined as the difference between 10-year and 2-year Treasury bond yields), the convexity, the change in leverage, the ... BBB and maturities ranging from intermediate to long-term They find the relation between credit spreads and interest rates (level and slope) differ based on the maturity, credit ratings, and the...

Ngày tải lên: 26/10/2012, 11:21

... general statement about the relative strengths of SHãããO and NHãããS On the other hand, it would be fair to claim that the CHãããO H-bond is weaker than either of the other two Note, however, that ... from the NHãããS H-bond Rather than the CS antibond, the SS s* orbital is the recipient of charge in the next minimum m, this time extracted from both the N lone pair and the CO p* orbital An Nlp ... CHãããO The pattern changes when the H of the SH group is replaced by a second methyl group in CH3SCH3 The enhancement of the S atoms proton-accepting ability strengthens the NHãããS H-bond to the...

Ngày tải lên: 16/12/2012, 15:21

... three-digit random numbers and served under identical conditions to the trained descriptive testing Consumers ranked the three cheeses in their order of preference, and then evaluated them using ... compared with the other cheeses (7- and 12-month) The 12-month-ripened cheese had the lowest mean score of liking of 5.75, which is categorized as between “like slightly” and “neither like nor ... AGED 7, AND 12 MONTHS acid, diacetyl and methional In the aroma attribute terms used in the descriptive analysis, these can be described as “free fatty acid,” “buttery” and “sulfur” aromas The principal...

Ngày tải lên: 03/04/2013, 21:06

... performance and thus stock price decreases is not conducive to stockholder theory and implies that in agency theory there is a conflict of interest between the CEO and the shareholders they represent Other ... in the null and alternative forms Statistical analysis allows the researcher to either accept or reject the null hypotheses The null and alternative hypotheses for this study are: H01 (null) There ... stockholder theory and agency theory as the foundation for its approach and consequently is limited by the theory itself According to Veliyath and Bishop (1995), agency theory predicts that there is...

Ngày tải lên: 11/09/2013, 11:44

Ngày tải lên: 13/02/2014, 12:20

... changes in the level and the slope I measure the level of the Treasury term structure with the three-month Treasury bill yield, denoted YT,104, t , and measure the slope with the spread between the ... relation between yield spreads and the slope of the Treasury term structure is weaker, and the thirty-year yield no longer summarizes the relevant information in the term structure The hypothesis ... rating and maturity band The x ~4! test of equality of bs, i, m,1 and bs, i, m,2 across the three sectors is reported in the final column of Table II The x test does not reject the hypothesis...

Ngày tải lên: 06/03/2014, 04:20

... companies from the rest of the pack They are in a position to view their marketing mix in the form of 4+1P and 1R, and thereby customize their offerings to the rural market Further, to ensure ... wells, handpumps and ponds For the first in the history of advertising - these were branded Special stickers were put on the handpumps, the walls of the wells were lined with advertising tiles and ... is the application of the marketing concepts and not the concepts themselves that need to be looked at Often, in the rural marketplace it is the application of these concepts which differs the...

Ngày tải lên: 08/03/2014, 02:21

... reason, the research focuses on understanding the value of the corporate culture, in particular, understanding the relationship between the corporate culture and the innovation of management accounting ... company Therefore, this research aims to: i Systematize the basic issues of corporate culture and the management accounting innovation ii Understand what is the relationship between the corporate ... receive the enthusiastic supports from all managers, chief accountant and other accounting staff who are involved in the survey conducted in this thesis Although the relationship between me and those...

Ngày tải lên: 13/03/2014, 14:20

... altered Notably, PR1a and PR5 are the marker genes for SA signaling, and PR4 is the marker gene for MeJA signaling Thus, we propose that the GhMPK2-dependent activation of the PR genes plays a ... Expression of the defense-related genes and ET biosynthesis genes in transgenic and wild-type plants (A) The mRNA levels of defense-related genes and ET biosynthesis genes in transgenic and wild-type ... conferred by upregulation of the expression of multiple antioxidant enzymes, and suggest that GhMPK2 may be involved in the regulation of ROS network pathways Discussion The role and significance...

Ngày tải lên: 14/03/2014, 23:20

... of the organization and the licensing practice of the pool.55 Surprisingly enough, however, at this level the Commission tends to ignore the link between the exclusivity and standardization, and ... neither the supply of equipment nor the licensing of technology by the principal but the supply of goods by the sub-contractor according to the specications and instructions of the principal, and ... on the combination of the principles that, on the one hand, the market of reference for the territorial exercise of national intellectual property is the entire Internal Market, and, on the other,...

Ngày tải lên: 16/03/2014, 12:20

... spectra and in the rest of the mutants the probe was not significantly affected by the sTF–FVIIa complex formation As the purpose of our study was to map the interaction between FXa and sTF in the ... sTF and the effect of the modified sTF–FVIIa complex on FX activation In another study [17], these authors also examined the interaction between FXa and sTF–FVII in a similar way by observing the ... with sTF in the quaternary complex Residues E99 and L104 are located in the TF1 domain, and T197 is situated in the N-terminal portion of the TF2 domain, i.e close to the TF1 domain at the level...

Ngày tải lên: 17/03/2014, 03:20

... with the differences discussed in the text 27 The 17 in the sample of movers The key is that Plantinga and Bernell study nlsy79 respondents between 1996 and 2000, rather than between 1988 and ... particular First, the physical characteristics of the built environment, such as the separation between residences and the ease with which one can walk between them, and second, the neighborhood ... relationship between the residential landscape and weight because we measure the wrong aspect of landscape There are three reasons to believe that this is not a problem First, the existing literature and...

Ngày tải lên: 19/03/2014, 11:20

... controversy exists whether these are the patients who have early-stage disease and would benefit from detection or whether these are the patients who have indolent forms of prostate cancer Therefore, recommendations ... phenomenon, the other problem was the lack of calibration against a universal standard In an effort to standardize PSA methods, the World Health Organization (WHO) developed a standard, the WHO (90:10) ... SR comparison method Differences between test and comparison methods were estimated at 2.5, 4.0, and 10.0 ng/mL (2.5, 4.0, and 10.0 µg/L) for tPSA and 15%, 20%, and 25% for percentage of fPSA Relative...

Ngày tải lên: 21/03/2014, 12:19