the human body in health and disease notes

Ngày tải lên: 18/12/2013, 21:45

Ngày tải lên: 06/07/2014, 15:19

... directly involved in ligand binding, presumably abolishing the interaction with signaling partners. The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce ... lymphoproliferative dis- ease. Arginine 335 is found in the ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain. Thus, these patients ... prolines on peptide folding [21]. Thus, proline is a rigid amino acid creating a fixed kink in a protein chain. Similar to the situation in many other genes, CpG dinucleotides in the BTK gene are more...

Ngày tải lên: 14/02/2014, 18:20

... explain these interactions. The special status of the brain in having its own insulated circulation system the cerebrospinal fluid contained in the ventricles and ducts—is also under- lined. The ... metabolites and to remove waste products. The Neuronal Environment: Brain Homeostasis in Health and Disease examines the function of all the components involved, including their perturbation dur- ing ... fluids in the brain at the mercy of the brain cells themselves. The subse- quent necessity to shield the central nervous system from uncontrolled systemic influ- ences, and in order to minimize the...

Ngày tải lên: 15/03/2014, 19:20

... decorin in the regulation of IGF-IR and to clarify whether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin signaling is further expanded by ... with the EGF-binding domain [32]. The structural constraints of the EGFR binding region support a stochiometry of 1 : 1 for the decorin pro- tein core and EGFR, suggesting that decorin is bio- logically ... signaling, including vinculin and focal adhesion kinase [82]. Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe- sion formation, thereby...

Ngày tải lên: 15/03/2014, 23:20

... Zonula occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calc ium ⁄ calmodulin-associated serine kinase, since the C2 region contains a ... motif) that maintains them as inactive zymogens, and a catalytic domain with a z inc-binding site (Zn, HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc. Interaction between ... cannot bind proMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting its activity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2...

Ngày tải lên: 15/03/2014, 23:20

... against, that of covering up the infant in its cot with too much clothing throwing over its face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together. The ... rendered a painful and difficult one, by errors in the management of the regimen and health of the infant, previously to the coming of the teeth, and during the process itself. Thus, chiefly in consequence ... feeding must in part be here resorted to. THE INJURIOUS EFFECTS TO THE MOTHER AND INFANT OF UNDUE AND PROTRACTED SUCKLING. UPON THE MOTHER The period of suckling is generally one of the most healthy...

Ngày tải lên: 23/03/2014, 02:20

Ngày tải lên: 11/08/2014, 12:20

Ngày tải lên: 14/08/2014, 14:21

Ngày tải lên: 29/01/2014, 00:23

Ngày tải lên: 21/02/2014, 23:20

... selected; the amino acid with the lowest score is defined as the limiting amino acid. The chemical score of the limiting amino acid is the protein's score. Typically, the limiting amino acids in ... dietary proteins are lysine, the sulfur-containing amino acids, threonine, and/ or tryptophan. The BCAAs and phenylalanine/tyrosine are not usually limiting. The scoring method points out the obvious: ... at the sites of protein synthesis in the body in the same proportions that go into the protein ( 177). Assuming that any nonessential amino acid would not be limiting, they proposed that the...

Ngày tải lên: 06/03/2014, 05:21

... One involves proteolytic processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the protein- ase and involves the HPX domain. A DNA-binding domain ... various domains of the MMP participated in the activation. Both the HPX and the Cat-Hinge regions activated the promoter, whereas the prodomain and the hinge-region alone had no effect on the activation. ... interacting with the conserved cysteine in the prodomain. Another is the induction of conforma- tional changes through binding of chaotropic agents and detergents such as SDS. In all cases, the...

Ngày tải lên: 15/03/2014, 00:20

... to the TIM-barrel fold [73]. The predicted heparanase structure led to the hypothesis that the seemingly distinct protein domains observed in the 3D model, namely the TIM-barrel and C-domain ... evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by main- taining the structural integrity and self-assembly of the ECM ... variant Almost all protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced. Alternative splicing increases the coding capacity of the genome,...

Ngày tải lên: 15/03/2014, 23:20

Ngày tải lên: 22/03/2014, 16:20