the human body in health and disease 12th edition pdf
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... directly involved in ligand
binding, presumably abolishing the interaction with
signaling partners. The remaining mutations alter
amino acids located outside the ligand-binding pocket
and reduce ... lymphoproliferative dis-
ease. Arginine 335 is found in the ‘BG loop’ not
involved in phosphotyrosine binding and mutation to
tryptophan most probably causes instability of the
SH2 domain. Thus, these patients ... prolines
on peptide folding [21]. Thus, proline is a rigid amino
acid creating a fixed kink in a protein chain.
Similar to the situation in many other genes, CpG
dinucleotides in the BTK gene are more...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot
Ngày tải lên :
15/03/2014, 19:20
... explain these
interactions. The special status of the brain in having its own insulated circulation
system the cerebrospinal fluid contained in the ventricles and ducts—is also under-
lined. The ... metabolites and to remove waste products.
The Neuronal Environment: Brain Homeostasis in Health and Disease
examines the function of all the components involved, including their perturbation dur-
ing ... fluids in the brain at the mercy of the brain cells themselves. The subse-
quent necessity to shield the central nervous system from uncontrolled systemic influ-
ences, and in order to minimize the...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
Ngày tải lên :
15/03/2014, 23:20
... decorin in the regulation of IGF-IR and to clarify
whether decorin ⁄ IGF-IR signaling might be operative
in carcinoma cells as well.
The complexity of decorin signaling is further
expanded by ... with the EGF-binding domain [32]. The
structural constraints of the EGFR binding region
support a stochiometry of 1 : 1 for the decorin pro-
tein core and EGFR, suggesting that decorin is bio-
logically ... signaling,
including vinculin and focal adhesion kinase [82].
Lumican alters the relationship between actin filaments
and b1 integrin, which in turn would affect focal adhe-
sion formation, thereby...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
Ngày tải lên :
15/03/2014, 23:20
... Zonula
occludens-domain-containing proteins such as syntenin,
Ga-interacting protein (GAIP)-interacting C-terminus ⁄
synectin and calc ium ⁄ calmodulin-associated serine kinase,
since the C2 region contains a ... motif) that maintains them as inactive
zymogens, and a catalytic domain with a z inc-binding site
(Zn, HEXXHXXGXXH) and a conserved methionine
(Met-turn) supporting the catalytic zinc. Interaction
between ... cannot bind
proMMP2, but the N-terminal region of TIMP-2 binds
the catalytic domain of MT1-MMP inhibiting its
activity, whereas its C-terminal domain binds to the
hemopexin-like domain of Pro-MMP-2...
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The Maternal Management of Children, in Health and Disease ppt
Ngày tải lên :
23/03/2014, 02:20
... against, that of covering up the infant in its cot with too much clothing throwing over
its face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together. The ... rendered a painful and difficult one, by
errors in the management of the regimen and health of the infant, previously to the coming of the teeth, and
during the process itself.
Thus, chiefly in consequence ... feeding must in part be here resorted to.
THE INJURIOUS EFFECTS TO THE MOTHER AND INFANT OF UNDUE AND PROTRACTED
SUCKLING.
UPON THE MOTHER The period of suckling is generally one of the most healthy...
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Modern Nutrition in Health and Disease pot
Ngày tải lên :
06/03/2014, 05:21
... selected; the amino acid with the lowest score is defined as the limiting amino acid. The chemical score of the limiting amino acid is the
protein's score. Typically, the limiting amino acids in ... dietary proteins are lysine, the sulfur-containing amino acids, threonine, and/ or tryptophan. The BCAAs and
phenylalanine/tyrosine are not usually limiting. The scoring method points out the obvious: ... at the sites of protein synthesis in the body in the same proportions that go into the protein ( 177). Assuming that
any nonessential amino acid would not be limiting, they proposed that the...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
Ngày tải lên :
15/03/2014, 00:20
... One involves proteolytic processing
of one or several nuclear proteins, whereas the other is
independent of the processing capacity of the protein-
ase and involves the HPX domain. A DNA-binding
domain ... various domains of the
MMP participated in the activation. Both the HPX
and the Cat-Hinge regions activated the promoter,
whereas the prodomain and the hinge-region alone
had no effect on the activation. ... interacting with the conserved cysteine in
the prodomain. Another is the induction of conforma-
tional changes through binding of chaotropic agents
and detergents such as SDS. In all cases, the...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
Ngày tải lên :
15/03/2014, 23:20
... to the TIM-barrel fold [73]. The predicted
heparanase structure led to the hypothesis that the
seemingly distinct protein domains observed in the 3D
model, namely the TIM-barrel and C-domain ... evidences indicate that
HSPGs act to inhibit cellular invasion by promoting
tight cell–cell and cell–ECM interactions, and by main-
taining the structural integrity and self-assembly of the
ECM ... variant
Almost all protein-coding genes contain introns that
are removed in the nucleus by RNA splicing and are
often alternatively spliced. Alternative splicing
increases the coding capacity of the genome,...
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