the hormone responsible for lowering blood calcium levels is
Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
Ngày tải lên: 18/06/2014, 16:20
Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
... (<34 ng/POCIS) NC (<14 ng/POCIS) 37 ng/POCIS 40 ng/POCIS 20 ng/POCIS Ethopabate NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ... ng/POCIS) Endosulfan II NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) cis-Permethrin NC ... chemicals (Alvarez and others, in press; Rastall and others, 2004). Published procedures were used for preparing the POCIS samples for analysis in this study (Alvarez and others, 2004, 2007, in...
Ngày tải lên: 14/02/2014, 08:20
Tài liệu The Portable Ethicist for Mental Health Professionals A Complete Guide to Responsible Practice Second Edition pptx
... unmarried. If the client and therapist went to a bar, make it a health food juice bar. If the client or therapist is married, change the status to single, or cohabiting. If the therapist is under the ... keep? Guidance for all these problem areas is set forth in the published codes of ethics of the state board (and published in one form or another in the board rules of most sister states). The argument ... maxims or sayings for risk-free practice. They are set out in list form for easy reference. To the educator, they might serve: As subjects for discussion and debate. As a basis for essay questions...
Ngày tải lên: 15/02/2014, 02:20
Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... within NBDs. The best evidence for an interaction between the two domains is the ability of numerous substrates and modulators of ABCG2 (and the R482G isoform) to stimulate the rate of ATP hydrolysis [21,24,25], albeit ... pumps is assumed to correspond to the outward-facing confor- mation. The energy produced by the hydrolysis of ATP is harnessed for the resetting of the transporter to the initial high-affinity, inward-facing ... malignancies. One of the most prevalent primary cellular defence mechanisms against chemotherapeutic agents is the membrane- bound transporter [1]. The defining feature of these transporters is their ability...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate specificity docx
... is disrupted, and this gives rise to an increase in K m . Also, the polarity is changed, and the increase in the size of the side chain may create steric hindrance for the substrate, making the ... binding lost due to the mutation. At the same time, it is possible that the positioning of 5¢-OH is chan- ged, and this may be the reason for the low k cat value. Q81N The kinetic data for Q81N show ... with the information from HSV1-TK suggest that the increased distance between base and amino acid is the main reason for the increase in K m values. The point mutation probably does not alter the...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... analysis, and the determination of released ammonia. The coupled enzyme assay revealed the mechanism of the deamination reaction and the subsequent metabolism, including the deamination step. The ... cells; therefore, the s ynthesis of the e nzyme was indu cible. Table 1 shows a summary of a typical enzyme purification. The enzyme was purified 103-fold with an overall yield of 2%. The specific ... SDS/PAGE (Fig. 3B). Therefore, the enzyme is a homodimer with 1 5-kDa subunits. The N-terminal amino acid sequence o f the enzyme was determined to be PKILVHSDAAPTTGFTNXHTP. The purified enzyme...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... hydrolysis), corresponding to that expected for the F variant. This result is the first evidence for the heterozy- gous status (M/F) of the individual goat milk analysed. In addition to this, t ... phosphorylation of Ser64 in the M variant. The sequence determined is consistent with the molecular mass measured for the native protein. The phosphorylated residues a re therefore Ser46, 48, 65, 67, ... 2 3 in the 9th exon of the A alle le, which is deleted in the F allele, is mutatedtoTintheMallele, giving rise to a Ser fi Leu substitution. Analysis of the intronic flanking sequences The flanking...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
... this distal part is unique for GIRK1 among the Kir3.x isoforms. Further truncations of the C-terminus revealed a 49 amino acid stretch (amino acids 362–411) that was the most prominent target for ... contributed to the remaining PKA effect. The distal C-T of GIRK1, which is unique amongst GIRK isoforms, has given rise to various proposals about its peculiar func- tion in the past. In the present ... well as in the regulation of the heartbeat, is now well established and, increasingly, their importance in other organs is being acknowledged [3–7]. Generally, the G-protein b ⁄ c dimer is considered...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase l isoform pdf
... involved. The cytosolic mSMOa is the major isoform, while the mSMOl enzyme, displaying an extra protein domain corresponding to the addi- tional exon VIa, is localized in both the cytoplasm and the ... shows the lack of this extra domain. This observation suggests that the presence of the extra exon VIa is a mammalian feature that is strictly related to the high homology displayed by the 31 ... targeting. The presence of the translated region encoded by exon VIa in mSMOl is thus necessary, but not sufficient, for the correct localization of this isoform within the nucleus. In con- clusion, the...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo khoa học: The gene carD encodes the aldehyde dehydrogenase responsible for neurosporaxanthin biosynthesis in Fusarium fujikuroi potx
... termed CarD, responsible for the final step in neurosporaxanthin biosynthesis in F. fujikuroi, which is predicted to be the oxidation of the aldehyde group of b-apo-4¢-carotenal. On the basis of sequence ... which is then con- verted by the cyclase activity of the bifunctional enzyme AL-2 into the cyclic isomer neurosporaxanthin [25]. The goal of this work was to identify and charac- terize the YLO-1 ... respectively). Recently, we identified in this fungus the gene ylo-1 [24], which is responsible for the aldehyde oxidation step in neurosporaxanthin formation, and showed the ability of the encoded enzyme to convert...
Ngày tải lên: 14/03/2014, 22:20
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... [9]. In this model, Asp17 does not face the C-terminal frag- ment. A possible explanation for this is that, in the case of CPT1B, the docking of the N-terminal fragment might differ from that of the ... carnitine: 1 mm (for standard comparison with other published data), and a concentration equal to the K m for carnitine of each enzyme (for comparison between mutants). In this article, we show ... expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: resi- dues within the N-terminus of the muscle isoform influ- ence the kinetic properties of the enzyme. Biochem...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... side-chain approach the other Aib methyl group (Fig. 3B). The average distance between the vicinal Val18 and Aib15 methylsismeasuredas3.206A ˚ in the mean structure, while the other methyl of Aib15 is found ... helix bending dimi- nishes the exposure of the hydrophobic core of Phe12, Aib15 and Val18 to the solvent, while establishing the structural basis for the side-chain interaction of the charged residues ... perpendicularly to the [ D -Phe12, Aib15]CRH axis is presented at Fig. 4B and C. Non-native interaction between charged groups in this synthetic analogue is discussed below. DISCUSSION Analysis of the calculated...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx
... (Ecm17) is found within the biosynthetic operon proposed to be responsible for disulfide formation [35]. This oxidore- ductase, although lacking in the gene cluster enabling thiocoraline biosynthesis, ... Under these conditions, premature hydrolysis is reduced, increasing the stability of the acyl-O-TE oxoester inter- mediate that is capable of reacting with further mole- cules to give rise to the ... suggested that the size of the resulting ring and the preorganization of the substrate determine whether a ligation or a cyclization step is carried out [39]. Unfortunately, the prefold of the lin- ear...
Ngày tải lên: 23/03/2014, 06:20
The Portable Ethicist for Mental Health Professionals A Complete Guide to Responsible Practice pot
... brings a child to the therapist for treatment, who is the client, the parent or the child? If it is the child, can the therapist date the parent? Or can the therapist date the uncle of the child? Can ... unmarried. If the client and therapist went to a bar, make it a health food juice bar. If the client or therapist is married, change the status to single, or cohabiting. If the therapist is under the ... keep? Guidance for all these problem areas is set forth in the published codes of ethics of the state board (and published in one form or another in the board rules of most sister states). The argument...
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... specificity of the substrate) [26]. Consequently, substitution of Val371 to isoleucine might prevent the full development of the active conformation. This hypothesis is further con- firmed by the results ... active conformation, Val371 forms contacts with neighboring residues that are important for stabi- lizing the active state (e.g. Asp189, which is part of the S1 pocket responsible for the binding ... to the activated FXI, in the structure of the FXI zymogen, Val371 is located on a loop region, exposed to solvent, and does not form many contacts with other residues (Fig. 6). Therefore, the...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein pptx
... either re-enter the elongation cycle, or be hydrolyzed to ACO and the acyl moiety for the synthesis of phospholipids or sphingolipids, or become diverted for other modifica- tions [9]. All of the ... surrounding the active site tunnel is electropositive. This positively charged patch is posi- tioned at the entrance of the active site and is thought to be involved in the recognition of the highly ... as the reference surface. The reference surface was treated in the same way as the ligand surface, except that the PfFabG was not passed over this surface. This is important to normalize the...
Ngày tải lên: 23/03/2014, 10:20
Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
Ngày tải lên: 29/03/2014, 22:21
