... explanations of aging, such asOrgel’s error catastrophe theory and the somatic mutationtheory, were based on the idea that aging results from the accumulation of synthetic errors [26,27]. Adequate supportfor ... 774–779.48. Yoneda, M., Chomyn, A. , Martinuzzi, A. , Hurko, O. & Attardi,G. (1992) Marked replicative advantage of human mtDNA car-rying a point mutation that causes the MELAS encephalomyo-pathy. ... maintenance.Mitochondria are the main source of ROS formation, aswell as the main target for free radical attack. The accumulation of defective mitochondria within aging cellssuggests that some are not properly autophagocytosed.Aged...
... nificant factors (with eigenvaluesgreater than unity) that are capable of explaining 94.5% of the variance and thus most ofthe infor mation in the original data set. The new “latent” factors are ... Valladolid. Valladolid. Spain.SELECCIÓN DE LAS VARIABLESANTROPOMÉTRICAS MÁS ADECUADASPARA CARACTERIZAR UNA POBLACIÓNDE PERSONAS MAYORES SANASResumenEl objetivo es la selección de las variables antropométri-cas ... nullhypothe sis of spherical distribution ofthe original vari-ables can be rejected and the FA can be used to reduce the dimen sionality ofthe data set. Table VI shows the results ofthe FA, based...
... III andinteraction with the alpha subunit. Nucleic Acids Res35, 2825–2832.20 Abe Y, Jo T, Matsuda Y, Matsunaga C, Katayama T& Ueda T (2007) Structure and function of DnaAN-terminal domains: ... Zawilak-Pawlik A, KappU & Terradot L (2009) The structure ofa DnaA ⁄ HobAcomplex from Helicobacter pylori provides insight intoregulation of DNA replication in bacteria. Proc NatlAcad ... The actual DNA synthesis is performed by the catalytic a- subunit (PolIIIa), which belongs to the C-family of DNA polymerases [2]. Polymerases of the C-family fall into two major groups, DnaE and...
... he was a member ofthe Imperial War Cabinet during the First World War, played a significant role in the foundation ofthe League of Nations,and was made Chancellor ofthe University of Cambridge. ... constitutionexhibits the values ofa substantive conception ofthe rule of law and thatthese values make the exercise of legal authority legitimate.At one level, then, my ambition is to sketch the basis for a ... on an appeal from Pondoland.I asked the date, and he gave me the date within six months. I turned up the Reports and found that he was right in every particular, and a page and a half of that...
... conception ofthe rule of law. For they maintain that they areupholding the rule of law when at most there is rule by law, a statutorywarrant for the executive.Iwill then set out the view that in fact ... determine the content ofthe law inaccordance with the aspirations of (ideal) legal order; and the legislatureand the executive have exactly the same duty.It is not, I must hasten to add, that the ... interpreting the laws of apartheid illuminated debates in philosophy of law about the relationship between law and morality. My main focus was on the statutory regime put in place to maintain national...
... quantitative and qualitative orientations. These approaches were developed in several fields, and they were, to a large degree, an outgrowth ofthe popularization of triangulation methods (Tashakkori ... types of triangulation: 1. Data Triangulation- the use ofa variety of data sources in a study. 2. Investigator Triangulation – the use of several different researchers. 3. Theory Triangulation ... 45 DATA ANALYSIS 45 Introduction 45 Summary Statistics 45 Analysis at the Organizational-Level 50 Results of Factor Analysis 58 Results of Reliability Test 59 Analysis for Individual Units...
... is located at the newN-terminus ofthe protease domain, undergoes a largemovement towards the activation pocket of FXIa. As a result, in the structure of FXIa [25], the surface area of Val371 ... 88,2611–2618.30 Solera J, Magallon M, Martin-Villar J & Coloma A (1991) Identification ofa new haemophilia BM caseproduced by a mutation located at the carboxy terminalcleavage site of activation peptide. ... FXI-deficient plasma as sub-strate (Hemoliance, Salt Lake City, UT). FXI antigen wasmeasured by an ELISA based on a goat anti-human FXIaffinity purified IgG as capture antibody and a goat anti-human FXI...
... GGCAACGAGCAAGGTCCGAAGsapE–R 2590 R GACGTCGTGAGTGCCTCCGTGmopB–F 3103 F CGACGTGCAGTATTACTTTTCTAGGGmopB–R 3103 R AGTATCAAACCGTGCTGGTCTCCHeme protein identification in M. capsulatus O. A. Karlsen ... CCP-similarcore. A similarity search against the translated GenBanknucleotide database (tBLASTn) revealed significantsimilarity between MCA2590 and an unannotatedORF of Methylomicrobium album ... centrifugation(Amicon, 10 kDa cut-off) and the polypeptide migra-ting with an apparent molecular mass of 80 kDa in the SDS ⁄ PAGE analysis ofthe concentrate was excisedfrom the gel and subjected to MS analyses...
... from the Marian Chace Foundation to Madeleine Hackney and a grant from the American Parkinson Disease Association to Gammon Earhart.ReferencesArgue, J. (2000) Parkinson’s disease and the art of ... Responses The tango group stated on the exit questionnaire what they liked bestand least about the program. They greatly appreciated the camaraderieand socialization engendered by the program. Being ... together withothers like them because ofthe supportive and therapeutic aspects. Theyrequested that they have lunch together at the end ofthe sessions.During the dance classes, they were...
... area.This led to 14 possible combinations: (B ¼ b-Rha, A ¼ a- Rha, A ¼ a- Fuc3NAc (1fi2) a- Rha)B A, B– A B A A, B A A, B A A, B A A B AA A, B AA A, B AA A, B AA A, B AA A, B– A A A, B AA A, ... bold):B A B A, B A B– A, B AA A, B AA A, B AA A/ B, AA A, AA B, A A B, B A B, B A A, B A A, A A B (Table 1).In summary, eight ofthe 14 possible combinations couldbe assigned by NMR, as illustrated ... by the a- Fuc3NAc(1fi2) a- Rha disaccharide. The conclusion is that b-Rha could be assigned in the following combinations (the assigned b-Rha are in bold): A- B A A/ B, A- B A A/ B, A- B A AandA–B A A. (Table...
... the king ofthe asuras. This chapter represents a Buddhist adaptation of what is often referred to as the våmana-avatåra of the Vai˚¶avite tradition, the story of Vi˚¶u’s appearance as a våmana, ... he is a manifestation of Maheßvara, Nåråya a or the råk˚asa Råva a: the last of these three is, of course, the name ofthe great demon ofthe Råmåya a who captures andcarries off Sƒtå, Råma’s ... conversion story ofthe Sarvatathågata-tattvasaµgraha, Íiva is then identified as the tathågata Bhasmeßvara, or “Lord of Ashes.” This is an allusion to the predeliction of Íiva (and the Íaivite yogin)for...
... 5'-GTCCCTACAATGGCACAAGG-3'R: 5'-GGTTCATCAGCATCCGAGTAG-3'JUN F: 5'-GAGCGGACCTTATGGCTACA-3'R: 5'-TGAGGAGGTCCGAGTTCTTG-3'FOS F: 5'-CAAGCGGAGACAGACCAAC-3'R: ... 5'-CAAGCGGAGACAGACCAAC-3'R: 5'-GAGCTGCCAGGATGAACTC-3'HSPB8 F: 5'-AGCCAGAGGAGTTGATGGTG-3'R: 5'-TGCAGGAAGCTGGATTTTCT-3'GAPDH F: 5'-GAGTCAACGGATTTGGTCGT-3'R: 5'-TTGATTTTGGAGGGATCTCG-3'* ... the analysis of serum samples. The microarray experiment and the analysis of array data were carried out by AlmacDiagnostics, Craigavon, N. Ireland. PMW was responsible for the annotation of the...