telomerase deficient mice with short telomeres are hypersensitive to ionizing radiation
Báo cáo khoa học: Modified merozoite surface protein-1 peptides with short alpha helical regions are associated with inducing protection against malaria docx
... interproton distances, respectively Distance Geometry (DGII) software was used to generate a family of 50 structures These structures were refined by using simulated annealing protocol with DISCOVER ... described as follows: proton spectra were assigned by using DQF-COSY [17], TOCSY [18] and NOESY [19] The TOCSY and NOESY (400 ms mixing time) spectra were first used to identify individual spin ... determined by MS (Bruker Protein MALDI-TOF spectrophotometer) Peptide analogues (called polymers) were synthesized with Cys-Gly in the C- and N-terminus of each peptide to allow polymerization forming...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 6
... Cidea-null mice had enhanced lipolytic activities Cidea null mice have a hyperactive thermogenesis and increased lipolysis in response to cold and with increasing age compared to wild type mice Notably, ... objective of this work was to investigate the physiological role of Cidea, a molecule presumably related to apoptosis Cidea had been shown originally as an apoptotic effector when ectopically overexpressed ... UCP1 hyperactive Cidea null animals are metabolically inefficient, with energy being wasted as heat and fat storage depleted quickly in response to cold When mice are housed at room temperature under...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 5
... levels in BAT of these treated mice were maintained at roughly similar levels compared to mice of the same age The contrasting changes in Cidea levels with age compared to that of UCP1 suggest that ... null mice we generated provided an excellent tool to test this hypothesis 78 Chapter 4.3 Cidea null mice not exhibit a difference in differentiation and cell death compared to wild type mice ... adipocytes of Cidea-null mice compared to that of wild type mice, consistent with a lesser lipid accumulation in WAT (Figure 32 lower panel, right) The reduced adiposity was not due to a difference in...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 4
... be crossbred with 129 to obtain pure 129 inbred genetic background mice Alternatively the heterozygous of 129/C57BL mice can be crossbred with C57BL/6J mice for several generations to get pure ... mouse blastocysts to generate chimeric mice Because the ES cells are derived from male mice, 21 viable chimeras were generated and all were male The chimeric mice were subsequently crossbred with ... type C57BL/6J mice to obtain germline transmission of the targeted allele Cideb heterozygous mice were fertile and were crossbred to obtain mice homozygous for Cideb deletion The mice genotypes...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 3
... Cideb null mice The targeted ES cells clones with Cidea or Cideb gene disruption were recovered from the frozen master plates and injected into C57BL/6J blastocysts to generate chimeric mice for ... DH5α E coli strain was streaked onto an Luria-Bertani (LB) (pH 7.5) agar plate (containing 1% bacto-tryptone, 0.5% bacto-yeast extract, 1% NaCl, and 1.5% agar) without antibiotics and incubated ... (CIAP/ CIP) was used to remove the phosphate group from the 5’ end of linearized vector DNA to prevent singly digested vectors from self-ligation The reaction was carried out either with the recommended...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 2
... initiator caspase-8 Activation of caspase-9 by several apoptotic stimuli requires release of cytochrome c into the cytosol from the mitochondria Chapter Upon apoptotic stimulation, initiator caspases ... body’s fat stores, a brain receiver analogous to a thermostat, where fat-store reports are compared with a set-point, and a downstream effector system using behavior and metabolic processes to correct ... Although such mice appeared normal, thymocytes from these mice are more resistant to apoptosis than that from wild-type animals (Wu et al., 1999) The degradation of genomic DNA into nucleosomal...
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Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant
... Cidea deficient mice have lean phenotype and are resistant to obesity Nat Genet 35(1): 49-56 Chen, Z., Guo, K., Toh S.Y., Zhou, Z., Li, P (2000) Mitochondria localization and dimerization are required ... exposure Most strikingly, Cidea-/- mice are much leaner than wild type mice, with a 64% weight reduction in white adipose tissue (WAT) The Cidea-/- mice are resistant to diet-induced obesity and diabetes ... laboratory for his suggestions I am deeply grateful to Drs Bor Luen Tang and Victor Nurcombe for their critical comments on my thesis writing I appreciate very much the friendship with Dr Tong...
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Tài liệu Seropositivity for celiac disease in children and adolescents with short stature doc
... weight loss, failure to thrive and signs of malnutrition) to atypical and silent forms with no gastrointestinal symptoms(3,4) A great deal of research has been carried out into short stature in isolation ... more and is operator-dependent, which can lead to errors(14,17,19,20) Chart – Physical and laboratorial characteristics and signs and symptoms of anti-tTG-positive patients with short stature Sex ... different studies have compared AEA with anti-tTG in terms of sensitivity and specificity and have concluded that they are similar(21) In patients with little or no symptomology, both tests offer...
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Tài liệu Protest Fee Schedule for Thunder Cars: Protestor must verify with the INEX inspector that the proper tools are available to check protested items ppt
... disconnecting the alternator are permitted The engine must continue to run at an idle with the battery disconnected BALL JOINTS: The upper and lower ball joints must remain stock, within the stock dimensions, ... airflow onto the carburetors or air filters Hood louvers may not direct -52- air to the carburetors or air filters The 1934 Chevy and Ford hoods are 26” to 27” in length and may not be shortened ... magnetic, aluminum and titanium bolts are illegal BRAKES: Any of the brake parts that are attached to the rear end or the spindles must remain stock, within the stock dimensions, steel thickness,...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... their complexes with Cu(II), as well as the DAHKam complex with Ni(II) in the presence of 0.1 M KNO3 were performed at 25 C over the pH range 311.5 (Molspin automatic titrator) with 0.1 M NaOH ... In line with electrostatic considerations presented there, this rate enhancement is likely due to the facilitated anchoring of neutral NiHPO4 to nitrogen donors of the peptide, compared to a positively ... pH 7.4 are provided in Table UVVis spectroscopy Table Protonation constants (log b values) for peptides at I = 0.1 M (KNO3) and 25 C Standard deviations on the last digits are given in parentheses...
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Patients With Pulmonary Tuberculosis Are Frequently Positive for Anti–Cyclic Citrullinated Peptide Antibodies, but Their Sera Also React With Unmodified Arginine-Containing Peptide potx
... antibodies Certain drugs that are commonly used to treat TB, such as INH and RIF, are known to be associated with drug-induced lupus and the production of antinuclear and antihistone antibodies The majority ... findings are mistakenly attributed to an RA disease flare Biologic agents that inhibit tumor necrosis factor ␣ have rapidly become a part of standard therapy in RA, but they are associated with an ... in TB reacts with both CCP and CAP The poor capability of liquid-phase CCP or CAP to cross-inhibit the reactivity of sera from patients with TB compared with sera from patients with RA (Figure...
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Báo cáo hóa học: " Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors" docx
... compared with Control Untreated # p = NS as compared with Rapamycin 10 20 30 40 50 60 70 80 90 100 110 Days of Treatment * p < 0.05 as compared with Control Untreated # p = NS as compared with ... Tsc2 +/- mice in a C57BL/6 mixed strain to show that mTOR inhibitor treatment reduces kidney tumor severity, to investigate the timing of mTOR inhibitor Page 13 of 18 treatment, and to show that ... efficacy of alternatives to mTOR inhibitors as either single agents or in combination with an mTOR inhibitor Single agent drugs which are FDA approved for other indications that are effective in mouse...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
... accordance with the finding that T cell numbers are lower in the brain of wild type mice compared to MT-I/II-/- mice at DPI Comparison of chemokine and cytokine expression in wild type and MT-I/II mice ... DPI in MT-I/II -/- mice compared to wild type mice In vitro, the aaMF response has been shown to be much less neurotoxic than the caMF response which is purported to be due to the higher production ... antibodies to unstained cells Samples were assayed by flow cytometry (BD Canto II flow cytometer) and were analysed using BD FACS Diva software v6.1.1 A quadratic gate was applied to the scatter...
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Báo cáo sinh học: " Research Article Iterative Frequency-Domain Channel Estimation and Equalization for Ultra-Wideband Systems with Short Cyclic Prefix" pot
... length 50 Moreover, using 50 CP symbols with IBI cancellation, the estimator does not perform significantly closer to the full CP performance compared to shorter CP This shows that using long CP ... presented to combat with the deteriorating effects of using short CP for IR UB systems An IBI estimation and cancellation scheme that can be used both with an FD channel estimator and with an FD ... estimator implemented by the FD recursive least squares (RLSs) algorithm, EURASIP Journal on Advances in Signal Processing a minimum mean squared error (MMSE) FDE, and a repetition decoder to extract...
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Báo cáo khoa học: "Phenotype of peroxisome proliferator-activated receptor-α(PPARα)deficient mice on mixed background fed high fat diet" doc
... of male PPARα-/- mice had severe fatty change with various fat droplets compared to wild type in the cytoplasms (Fig 3E-H) There were many macrovesicles in the cytoplasm of hepatocytes, and some ... peroxisome proliferator-activated receptor-α (PPARα) deficient mice on mixed background fed high fat diet 241 Fig Histological analyses of livers from male or female PPARα+/+ and PPARα-/- mice at week ... PPARα-/- mice was influenced by other factors, including diet and genetics PPARα-/- mice with unclear genetic background had a late onset, sexually dimorphic, and obese phenotype [5] PPARα-/- mice with...
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Báo cáo khoa học: " Immunization of mice with recombinant P27/30 protein confers protection against hard tick Haemaphysalis longicornis (Acari: Ixodidae) infestation" pps
... that applied on rP27/30-immunized mice compared to those in the control Egg weights in ticks fed rP27/30immunized mice compared to the control exhibited an apparent slight difference Kemp et al ... were immunized with rP27/30, and nine were immunized with control gene 10 proteins One hundred micrograms of the rP27/30 and gene 10 proteins were injected into mice intraperitoneally after emulsifying ... Immunization of mice with recombinant P27/30 protein confers protection against hard tick 49 following feeding on rP27/30-immunized mice were 9.3 ± 0.2 and 10.8 ± 0.3 days compared to 9.1 ± 0.3...
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Báo cáo khoa học: "Decrease in intestinal endocrine cells in Balb/c mice with CT-26 carcinoma cells" ppsx
... density of the endocrine cells in the small intestine of Balb/c mice with and without implantation of CT-26 Antisera Serotonin Somatostatin hPP† Gastrin CCK-8‡ Glucagon Non-implanted sham CT-26 ... density of the endocrine cells in the large intestine of Balb/c mice with and without implantation of CT-26 Antisera Serotonin Somatostatin hPP† Gastrin CCK-8‡ Glucagon Non-implanted sham CT-26 ... similar to the sham group (about 8.3% was decreased) (Tables and 3) Discussion CT-26 cells are rectal carcinoma cells that are established by administrating N-methylmorpholine N-oxide to Balb/c mice...
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Báo cáo y học: "Collagen-induced arthritis is exacerbated in IL-10-deficient mice" pps
... [36] Only when mice are immunized with collagen in CFA is there an increase in disease severity in IFN-γ receptor -deficient mice Ablation of IFN-γ in these mice is associated with extramedullary ... disease severity in CIA is enhanced in IFN-γ receptor -deficient mice, and loss of the IFN-γ receptor turns mice normally resistant to CIA into an arthritis-susceptible strain [34,35] IFN-γ thus ... 12), and IL-10–/– (n = 11) mice; and (b) WT (n = 13) and IL-10–/– (n = 7) mice * P < 0.05 in comparison with WT mice Discussion These data are consistent with the inhibitory effects of IFN-γ on...
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Báo cáo y học: "Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice" pptx
... change and fully stained cartilage to = total loss of toluidine blue staining and erosions in cartilage) These three scores were added together to obtain a total histological score, as previously ... panel (b) data shown are means ± SEM in one experiment Joint swelling was significantly greater on days and in ob/ob as compared with +/? mice, and in db/db as compared to db/+ mice (*P < 0.01) R259 ... administration of leptin [28] OB receptor deficient fa/fa rats also exhibit enhanced LPS-induced hepatotoxicity [29] Similarly, ob/ob and db/db mice are more likely to succumb after administration...
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Báo cáo y học: "A proinflammatory role for Fas in joints of mice with collagen-induced arthritis" docx
... susceptibility of mice to CIA, the incidence of disease (number of diseased mice divided by total number of mice) , the mean score (total score of diseased mice divided by total number of mice) , and ... a18 of the lpr/lpr mice and 16 of the lpr/+ mice are from Ma and co-workers [45] bNumber of diseased mice divided by all mice cScore of diseased mice divided by all mice ± SEM dTotal of days of ... Fas-mediated apoptosis Several studies demonstrated that autoreactive lymphocytes infiltrating the rheumatoid synovium are resistant to apoptosis either because of expression of the anti-apoptotic proteins...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25