t40214 pei complex shows no toxicity

Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"

Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"

... transfer Microinjection of Retroviral Vector Gene targeting possible? No (rate is too low) No (not yet established ) No (not yet established ) Overall efficiency Up to ca 6% Up to ca 80% Cost ... ca 65% Not necessarily (lentiviral vectors) No Yes (likely to be similar to pronuclear microinjection) Chimeric No Transgene capacity Unlimited: could even be used to deliver MACs Not known Depends ... mice Becoming well established Yes: human ESCs required No Use in human germline GM conditional upon scientific breakthroughs? No No No No Scientific advances required before method could become...

Ngày tải lên: 03/11/2012, 10:01

16 507 1
Tài liệu The Influence of Human Activity on the Environment ppt

Tài liệu The Influence of Human Activity on the Environment ppt

... extinction What can we Do? Organic Farming? • This produces less food and is more expensive but it does not produce the pollution problems of intensive farming Use farmyard manure as a fertiliser and ... Control of Pests • This means using natural predators to eat pests instead of pesticides • It does not have harmful effects Develop alternative energy sources • Conserve our rapidly diminishing fossil ... to over a thousand powerpoints submitted by teachers This is a completely free site and requires no registration Please visit and I hope it will help in your teaching ...

Ngày tải lên: 26/01/2014, 10:20

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Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc

Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc

... et al v Suehs, No 1:12-CV-00322 (W.D.TX, Apr 11, 2012) 42 Texas v Sibelius, No 6:12-cv-62 (W.D.TX, Mar 16, 2012) 43 Planned Parenthood of Austin Family Planning, et al v Suehs, No No 12-50377 (5th ... Governor of Texas has said that the state is prepared to finance WHP with state funds if federal matching funds are not available, the level of state funding that will be available is unknown As noted ... Letter to Cindy Mann, CMS., Aug 20, 2012 Office of the Governor Rick Perry http://governor.state.tx.us/initiatives/womens_health/ non-PPFA) providers served very few (ten or less) patients.8...

Ngày tải lên: 13/02/2014, 06:20

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Tài liệu Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals pdf

Tài liệu Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals pdf

... MBP mono-n-butyl phthalate MBzP mono-benzyl phthalate MEHHP mono(2-ethyl-5-hydroxy-hexyl) phthalate MEHP mono(2-ethylhexyl) phthalate MEOHP mono(2-ethyl-5-oxo-hexyl) phthalate MMP mono-methyl ... First, diagnosis of cryptorchidism is not straightforward and the exact position of the testis is not always recorded and reported This means that the use of registry data (in some, but not all, ... seminoma cells derive via CIS, is unknown but seems likely However, even if this occurred, it is not obvious how this might relate to the formation of CIS cells or their development into TGCT No...

Ngày tải lên: 13/02/2014, 10:20

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Tài liệu Evaluation of physical activity programmes for elderly people - a descriptive study using the EFQM’ criteria ppt

Tài liệu Evaluation of physical activity programmes for elderly people - a descriptive study using the EFQM’ criteria ppt

... years /no limit 55 years/80 years 72 65 1 no Municipal Government or + or + or + no no Municipal Government Municipal Government D [5; 10] 55 years /no limit 70 E [5; 10] 55 years /no limit 71 2 no ... + no Municipal Government P ≥10 60 years /no limit 70 or + no Municipal Government Q [5; 10] 55 years /no limit 71 or + no Municipal Government R S [5; 10] [5; 10] 55 years /no limit 65 years /no ... no no Municipal Government Municipal Government T [1; 5] 55 years /no limit 65 or + no Senior University (Municipal) U ≥10 55 years /no limit 71 or + no Municipal Government V [1; 5] 65 years/no...

Ngày tải lên: 14/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

... have no Lewy bodies [55], most have typical Lewy body disease [8] The mechanism of this variability is not clear Similarly, it is not obvious that LRRK2 plays a role in the ceramide pathway as no ... clinical phenotype Patients with the ‘classic’ childhood-onset type C usually appear normal for or years with symptoms appearing between and years They gradually develop neurologic abnormalities ... suggested that a-synuclein turnover may occur via chaperone-mediated autophagy, a specialized form of lysosomal turnover [35–39] It has also been shown that a-synuclein turnover is slowed in mouse...

Ngày tải lên: 18/02/2014, 14:20

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Tài liệu An Empirical Analysis of Political Activity in Hollywood pptx

Tài liệu An Empirical Analysis of Political Activity in Hollywood pptx

... Connie Nielsen Christopher Nolan Nick Nolte Stephen Norrington Jeremy Northam Edward Norton Jack Noseworthy Chris Noth Phillip Noyce Jerry O' Connell Frances O' Connor Chris O' Donnell Catherine ... Redford Vanessa Redgrave Norman Reedus Keanu Reeves Tara Reid John C Reilly Rob Reiner Paul Reiser Ivan Reitman Brad Renfro Jean Reno Paul Reubens Burt Reynolds Ryan Reynolds Ving Rhames Jonathan ... assigned the most common value Thus, for instance, if I did not know whether the individual was college-educated, I assumed he was not Career film histories were derived from the All Movie Guides...

Ngày tải lên: 19/02/2014, 10:20

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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

... characterization of novel alkylperoxo mononuclear iron(III) complexes with a tripodal pyridylamine ligand: a model for peroxo intermediates in reactions catalyzed by non-heme iron enzymes Inorg Chem 38, ... N R2 C B N N R1 N H NH N N N E F Fig Nitrogenous ligands used to construct the corresponding iron complexes as mimics of bleomycin and mononuclear nonheme metalloenzymes Data taken from [192,248,252,254] ... peroxo ligand in metalloporphyrin complexes Reaction of sulfur dioxide with iron and titanium porphyrin peroxo complexes to give sulfato complexes or sulfate Inorg Chem 23, 35483552 Lenk, W &...

Ngày tải lên: 19/02/2014, 16:20

26 747 0
Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx

Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx

... radicals are normally not assumed to play a crucial role in the dynamics of the peroxidaseoxidase reaction [13], and therefore they not appear in most detailed models of the reaction The pronounced ... during the nonoscillatory and the oscillatory states and some examples are shown in Fig 1C,D, respectively In Fig 1C we show the spectra of the enzyme before the onset of the NADH inow and 750 ... transition from the nonoscillatory to the oscillatory state [12] Thus, oscillatory kinetics seem to protect the enzyme against degradation Moreover, during experiments in which no reaction took...

Ngày tải lên: 20/02/2014, 11:20

9 435 0
Tài liệu AMAZONIAN ACCESSIONS OF WILD HEVEA GERMPLASM - A POTENTIAL SOURCE OF DROUGHT TOLERANCE pptx

Tài liệu AMAZONIAN ACCESSIONS OF WILD HEVEA GERMPLASM - A POTENTIAL SOURCE OF DROUGHT TOLERANCE pptx

... growth (height and girth) and girth increment MT 1616 No. of leaves, no of whorls, RWC, good growth (height and girth) MT 1627 No. of leaves, no of whorls, RWC, good growth (height and girth) MT ... (height and girth, no of whorls and leaves) RO 2524 Good growth (height and girth, no of whorls) MT 945 Good growth (height and girth, no of leaves) MT 58 Good growth (height and girth, no of leaves) ... selected accessions Genotypes Plant height (cm) Basal diameter (mm) AC 1044 102.79 c 11.14 ab MT 55 147.06 a 13.23 ab AC 446 115.77 abc c 13.49 ab 11.61 ab No of flushes SLW No of leaves Inter flush...

Ngày tải lên: 21/02/2014, 04:20

23 573 0
The Health Benefits of Physical Activity for Girls and Women ppt

The Health Benefits of Physical Activity for Girls and Women ppt

... Khan A Chapter Overview B Introduction Terminology C Literature Review Studies of children and adolescents Premenopausal women Perimenopause Postmenopausal women Physical activity and prevention ... lifestyle practices may not be related to healthlocus-of-control [50] Hoy [47] makes the point that perceived self-efficacy and locus of control are not the same phenomenon measured at different ... Gaps in the Literature Unfortunately, what we not know about the benefits of physical activity for psychosocial health makes a much longer list We not know the nature of the relationship between...

Ngày tải lên: 05/03/2014, 13:20

214 560 1
Mortgage Loan Fraud: An Update of Trends based Upon an Analysis of Suspicious Activity Reports doc

Mortgage Loan Fraud: An Update of Trends based Upon an Analysis of Suspicious Activity Reports doc

... address, and date of birth), there was no apparent attempt to steal another person’s identity Identity theft involved an attempt to obtain credit using another person’s identity The distinction ... that the lender would likely not have offered if the true facts were known, but the perpetrators of the fraud abscond with the proceeds of the loan, with little or no intention to purchase or ... Illinois, Georgia, and Texas This represented a change in position from the initial report where the top five subject address states were California, Florida, Georgia, Texas and Illinois Illinois...

Ngày tải lên: 06/03/2014, 19:20

54 318 0
Báo cáo khoa học: Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution ppt

Báo cáo khoa học: Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution ppt

... Directed evolution of tyrosine phenol-lyase E Rha et al from phenolics, such as hydroxylated or halogenated derivatives of phenol, 4-chlorophenol, 4-nitrophenol and catechol [1,6] Although most ... into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoid intermediates J Biol Chem 283, 29206–29214 25 Zhao H & Arnold FH (1997) Optimization of DNA shuffling for ... Biotechnol 20, 37–45 Kim DY, Rha E, Choi SL, Hong SP, Sung MH & Lee SG (2007) Development of bioreactor system for l-tyrosine synthesis using thermostable tyrosine phenol-lyase J Microbiol Biotechnol...

Ngày tải lên: 07/03/2014, 00:20

8 429 0
Báo cáo khoa học: Kinetic properties of catecholoxidase activity of tarantula hemocyanin pot

Báo cáo khoa học: Kinetic properties of catecholoxidase activity of tarantula hemocyanin pot

... lower than the dopamine turnover in other phenoloxidases Nevertheless, turnover rates as low as 25 s)1 have been reported for the monophenol tyramine, and this turnover rate is only four-fold ... is unable to catalyze the monohydroxylation reaction is not known With regard to diphenolic substrates, the best substrate by far is dopamine, whereas other diphenols are converted at a much ... Jaenicke and H Decker Hemocyanins as oxygen carriers normally not exhibit phenoloxidase activity However, some are also latent phenoloxidases, as phenoloxidase activity can be induced by at least three...

Ngày tải lên: 07/03/2014, 05:20

11 442 0
Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx

Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx

... genomic Sau3A fragment containing full length RAS2 pFL38-RAS2 Low copy number, URA3 marker, RAS2 – ORF plus endogenous regulatory regions YEp 351-SUT2 High copy number, LEU2 marker, 1.9 kb genomic ... a Zeiss Axioscop equipped with a Spot RT Monochrome CCD camera (Diagnostic Instruments Inc., USA) and evaluated by using the SPOT 3.02 software (Diagnostic Instruments Inc., USA) Results SUT2 ... suppressors of the synthetic slow growth phenotype of Dgpa2 Dras2 we produced the double deletion genotype in a CEN.PK2 background To avoid emergence of spontaneous genomic suppressors, the parental strain...

Ngày tải lên: 07/03/2014, 15:20

8 485 0
The Carbon and Global Warming Potential Impacts of Organic Farming: Does It Have a Significant Role in an Energy Constrained World? pptx

The Carbon and Global Warming Potential Impacts of Organic Farming: Does It Have a Significant Role in an Energy Constrained World? pptx

... system in Canada, with the exception of some provinces, most notably Nova Scotia, the system is likely not minimizing its losses Another type of waste arises from ―unnecessary‖ consumption The ... [43] survey data Note: The no- till system surpassed the organic, however, with GWP of only 14 compared to the organic at 41, and conventional at 114 [15].When compared to a no- till treatment ... unit product, there is no consensus in the data available to suggest organic dairy systems management is significantly beneficial It must be noted, however, that Canadian and North American data...

Ngày tải lên: 08/03/2014, 23:20

41 524 1
Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc

Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc

... results in destabilization of the hydroquinone FAD:apoFNR complex relative to those complexes involving the quinone and semiquinone Such effect would not be produced in the case of the E301A mutant, ... J.T., Medina, M., ´ Gomez-Moreno, C & Tollin, G (2000) Highly nonproductive complexes with Anabaena ferredoxin at low ionic strength are induced by nonconservative amino acid substitutions at Glu139 ... exhibited by this mutant, is not due to an alteration of its reduction potential, but more likely to a nonoptimal mutual orientation of the cofactors within the intermediate complex [13] Replacement...

Ngày tải lên: 08/03/2014, 23:20

6 437 0
POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc

POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc

... that did not include non-published studies They might, hence, be more likely to institute editorial policies that did not include retrieval of information from ClinicalTrials.gov 25 Another route ... shall not publish excerpts without AHRQ review and approval For AHRQ-approved excerpts, use the following citation iii *Note: This paper contains material copyrighted by others For material noted ... the contents are not changed in any way (including covers and front matter) and that no fee is charged by the reproducer of the product or its contents for its use The product may not be sold for...

Ngày tải lên: 09/03/2014, 00:20

111 403 0
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