summary of functional characterization studies in sod2 and sod2 deficient mice
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... understanding on the association of risk factors in the pathogenesis of idiosyncratic DILI 30 Table Summary of functional characterization studies in Sod2- /- and Sod2+ /deficient mice Genotype Sod2- /- ... the minor groove of PPRE consensus sequence interacts with the DNA-binding domains of PPARγ and RXRα and shields the highly polar side chains of the interacting residues (Asn 160 from PPARγ, and ... evidence linking DILI with mitochondrial dysfunction 16 Table Summary of functional characterization studies in Sod2- /- and Sod2+ /- deficient mice 31 Table Advantages and disadvantages...
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phrasal verbs followed by the -ing form
... and some of the famine victims got nothing Don't make the pieces of wedding cake too big, otherwise there won't be enough to go around 150 Infinitive Go off present tense go off & goes off -ing ... are you taking it out on me? 160 Infinitive present tense think ahead think ahead S thinks ahead -ing form past tense past participle thinking ahead thought ahead thought ahead think ahead p.v ... went off without a hitch The invasion didn't go off the way the general planned it go off p.v When a road, trail, path, and so on, goes off, it leaves the main road, trail, or path, and goes in...
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Báo cáo y học: " Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report" pptx
... shoulders, and in his legs in difficulty climbing stairs and rising from a low chair During the following days weakness also appeared in his distal arm muscles, and gradually increased in his upper and ... prevalence of C jejuni in many geographical areas including Serbia as a triggering organism in the etiology of GBS and other post-infectious sequelae In addition, there is a lack of evidence ... weakness and his tendon reflexes were brisk Because of the clinical signs and the history of a preceding gastrointestinal infection, a stool sample was sent to the Republic Institute of Public...
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40185 prepositional verbs followed by the gerund
... cannot rely their (share) _ a common context to interpret the other's casual, compact or cryptic speech If you usually keep your windows/doors open, then count (change) the air filter...
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Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx
... arises as a result of the tilt of the peptide and interactions between the embedded region of the peptide and the acyl chains, it presents an interesting insight into the interactions between ... motion and tilting of this embedded segment Thinning of the bilayer in the presence of Ab40 Because Ab40 is known to disrupt the integrity of the lipid membrane [11,12], another parameter of interest ... mismatch of the C-terminal region of Ab within the lipid bilayer and the favorable interaction of the N-terminal segment of Ab with the polar environment of the lipid headgroups Understanding this...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... within 2.1 A of the metal ion) Azide binding residues include the three His metal ligands (H26, H81 and H171) and gateway residues H30 and H34 A further gateway residue, H31, is involved in FeSOD ... conserved in FeSOD and MnSOD sequences Simulation suggests that Q77 bonding to N74 also disrupts the active site residues, causing a shift in the position of Y34 and a twist in the ring of the metalbinding ... iron- and manganese-containing superoxide dismutases Protein Eng 1, 393–397 Meier, B., Sehn, A.P., Schinina, M.E & Barra, D (1994) In vivo incorporation of copper into the iron-exchangeable and...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... that the binding of target proteins occurs in the groove between monomers, and involves a b-sheet region located at the beginning of the a-crystallin domain corresponding to residues 70–88 in aA-crystallin ... Frequency of amino acid residues in the flexible region of the C-terminal extensions of human and murine sHsps Residues present in the flexible region of the C-terminal extension of each of the eight ... bind noncovalently to regions on proteins that contain exposed clusters of hydrophobic aminoacyl residues, resulting in an increase in fluorescence [39] ANS binding fluorescence of wild-type and...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... the presence of [33P]ATP[cP] and then to SDS ⁄ PAGE and western blotting (B, C) The band corresponding to Grx4p in (C) is indicated (*) In (A), the starting amounts of Bud32p present in the cell ... participates in the in vivo phosphorylation status of Grx4p Phosphorylation of Ser134 of Grx4p by Bud32p contributes to the functionality of the glutaredoxin in yeast cells As indicated by previous in ... micrograms of recombinant, purified Bud32–His (lane 1), bound to the NiNTA resin, were incubated with 500 lg of a cellular lysate of strain SCH9-HA The resin was washed with a buffer containing imidazole,...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... in the following in vitro and in vivo bioassay Production of the recombinant MeMIH-B Functional study of rMeMIH-B by explant assay and in vivo injection The cDNA encoding the mature peptide of ... after injection (Figs 4A and 5A) In conclusion, the use of recombinant protein or RNAi alone may not be sufficient to confirm the function of a neuropeptide The combined use of recombinant protein and ... analysis of the hemolymph and ovary total protein of dsRNA-injected females (A) Hemolymph sample of NaCl ⁄ Piinjected and dsRNA-injected females Lanes 1–3: NaCl ⁄ Pi-injected and 4–6 dsRNA-injected...
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Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx
... incubated in deuterated NaCl ⁄ Pi opposite changes of secondary structure are found at the end of strand D and the beginning of strand E, i.e a further loss in D and a stabilization in E of the ... [15,18] and requires the checking and redetermination of most of the resonance assignments of the molecule under investigation according to the standard methodology, i.e going through scalar and ... temperature setting of 283 K The f and s conformers are indicated (B) Details of two-dimensional NMR TOCSY spectra of dK58-b2m and cK58-b2m obtained at 500 MHz, and b2m devoid of the N-terminal tripeptide...
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Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... were inspected Labeling of aminoglycerophospholipids in vivo Labeling of aminoglycerophospholipids in vivo was determined by following the incorporation of [3H]serine into PtdSer, PtdEtn and PtdCho ... targeting sequence Processing of Psd1p was continued by cleavage of a kDa fragment representing the intermembrane space sorting signal, yielding the second intermediate of 50 kDa Assembly of Psd1p ... stained with iodine vapor, scraped off and suspended in mL scintillation cocktail (Packard BioScience, Groningen, the Netherlands) containing 5% water Radioactivity was determined by liquid scintillation...
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Báo cáo hóa học: "Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" pdf
... This mixture was injected under vigorous stirring and an argon flow into another flask (2) containing a hot (170 °C or 205 °C) solution of ml of degassed oleylamine and 0.2 g of tetradecylphosphonic ... bis(diethyldithiocarbamato) tin(II) in oleylamine at elevated temperature The shape and size tunability of SnS NCs can be achieved by controlling the reaction temperature and time, and the nature of stabilizing ligands ... obtained due to insolubility of SnS NCs in the short chain ketone and then separated by centrifugation The retrieved flocculate precipitate containing the desired SnS NCs was redissolved in chloroform...
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Báo cáo hóa học: " Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" ppt
... This mixture was injected under vigorous stirring and an argon flow into another flask (2) containing a hot (170 °C or 205 °C) solution of ml of degassed oleylamine and 0.2 g of tetradecylphosphonic ... bis(diethyldithiocarbamato) tin(II) in oleylamine at elevated temperature The shape and size tunability of SnS NCs can be achieved by controlling the reaction temperature and time, and the nature of stabilizing ligands ... obtained due to insolubility of SnS NCs in the short chain ketone and then separated by centrifugation The retrieved flocculate precipitate containing the desired SnS NCs was redissolved in chloroform...
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report" ppsx
... after ingestion and a half-life of approximately nine hours [4] The acute effects of ecstasy include: a feeling of improvement in interpersonal skills: loquacity; an enhanced perception of music; ... additionally, inhibits serotonin reuptake and increases its levels in the postsynaptic receptors The drug is also a potent dopamine and noradrenaline releasing agent [7] Typically, users ingest at ... acidosis (Table 1); and lactate was in the normal reference range The patient received immediate intravenous rehydration, regular insulin using a continuous infusion pump and potassium replacement...
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report." docx
... after ingestion and a half-life of approximately nine hours [4] The acute effects of ecstasy include: a feeling of improvement in interpersonal skills: loquacity; an enhanced perception of music; ... additionally, inhibits serotonin reuptake and increases its levels in the postsynaptic receptors The drug is also a potent dopamine and noradrenaline releasing agent [7] Typically, users ingest at ... acidosis (Table 1); and lactate was in the normal reference range The patient received immediate intravenous rehydration, regular insulin using a continuous infusion pump and potassium replacement...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps
... selection in Hygromycin-containing media and tested for NFκB-mediated induction of luciferase reporter activity using recombinant TNF-α and filtrates of a clinically isolated mucoid strain of PA ... experimentally induce inflammation in the field of CF research and is relevant to airway inflammation noted in patients [14,15] Inflammation in CF is caused by a complex mixture of bacterial products including ... as Indian Ginseng and Ashwagandha), which is widely used in traditional Indian medicine as an antiinflammatory agent [11] Recent reports indicate that this natural product is an inhibitor of...
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A study on the structure of the speech “ I have a dream” by Martin Luther King A systemic functional grammar analysis
... the experience of drilling with a number of grammar exercises in schooling as well as being the teacher for many grammar classes, I am deeply interested in improving the language proficiency along ... great attention to Functional Grammar (or FG for short) The further I am absorbed in this linguistic aspect, the stronger my notion of its applications in language teaching and learning becomes Hence, ... structure and meaning of the speech “I have a dream” by Martin Luther King - a systemic functional grammar analysis based on Halliday’s functional grammar as the theoretical framework 1.2 Aims of the...
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Tài liệu Protein Data Bank Contents Guide: Atomic Coordinate Entry Format Description Version 3.20 Document Published by the wwPDB ppt
... ID ID code code code code code code code code code code code code code code of of of of of of of of of of of of of of related related related related related related related related related related ... 3.1: Minor addenda to Version 3.0, introducing a small number of changes and extensions supporting the annotation practices adopted by the wwPDB beginning in August 2007 including chain ID standardization ... file is presented in a number of lines Each line in the PDB entry file consists of 80 columns The last character in each PDB entry should be an end -of- line indicator Each line in the PDB file...
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Tài liệu Báo cáo khoa học: Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening docx
... chaperon and plays a role in maintaining mitochondrial homeostasis, whereas MPTP opening is a key step in the process of cell death Therefore, we aimed to determine whether MPTP opening mediates ... apoptosis and maintaining mitochondrial homeostasis and function Silencing TRAP1 enhances cytochrome c release from the mitochondria and apoptosis induced by b-hydroxyisovalerylshikonin and VP16 ... MPTP inhibitor, prevents MPTP opening by inhibiting the activity of the peptidyl-prolyl cis-trans isomerase of CypD [27,28] The consequences of MPTP opening are cell necrosis and apoptosis and, ...
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx
... Stimulation of TLR leads to activation of a series of signalling proteins, and to the expression of pro- and in ammatory cytokines There is evidence that the heteromeric guanine nucleotidebinding regulatory ... mediating the effects of a broad spectrum of biological signals After ligand binding, the receptor undergoes a conformational change Ligands include hormones, biogenic amines, histamine, serotonin ... give the inactive heterotrimeric form [15] Regulators of G-protein signalling (RGS) interact directly with the G protein a subunit in order to inhibit G-protein signalling [16] RGS proteins belong...
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