structure function and the importance of microtubule dynamics

... know the benefit of having the connection of their latrines to biogas plants At the installation, the community agreed to share the 20% of the installation cost and the 100% of cleaning cost of ... because the people were involved from the beginning of the installation and they understood the benefit of the option from the combination of hygiene education and their experience from the test ... according to the baseline and follow-up surveys, 98% of the sampled households used only one of the pits of the alternate pit latrine The other pit was no more used and the people extended their house...

Ngày tải lên: 05/09/2013, 09:08

Ngày tải lên: 16/03/2014, 03:20

... BKI1 to the C-terminal portion of BRI1 In the presence of BR, BKI1 is released by the direct binding of BR to the 70-amino acid island region in the extracellular domain of BRI1 [7] Then, BRI1 ... line To determine the hormone sensitivity of bri1-120, we added 20 μM of IAA, GA, kinetin, and ACC and 50 μM of JA to 1/2 MS MS plates and processed them the same way All of the chemicals were ... domain of BRI1 revealed that the 70-amino acid island domain and the subsequent four LRRs before the transmembrane domain are frequent mutation sites, indicating their functional importance to the...

Ngày tải lên: 11/08/2014, 11:21

... (IGFBP)-4 and IGFBP-5 Proteolysis of IGFBPs regulates the bioavailability of IGFs, and because of the association between IGF levels and prostate cancer [33], strategies for the direct inhibition of ... against the consensus sequence of the known transcripts for the target gene Microarrays carry multiple probes against the same gene distributed throughout the length of the transcript, some of which ... performed the RTPCR detection of the TMPRSS:ERG fusion product MS is the surgeon who provided the patient samples, pathology results and other clinical data NJM participated in the study design and...

Ngày tải lên: 14/08/2014, 08:21

... Department of Biochemistry who, through the peculiarities and profundities of weekly seminar, have expanded the globe of my scientific exploration I thank every single member of the Clapp and Yang ... of Mek-Erk inhibition in disease management verges on the immediate horizon Of concern, though, many of the mechanistic and functional conclusions regarding Erk1 and Erk2 derive either from the ... (JMML), and tumors such as optic glioma and the namesake neurofibroma The disease’s hallmark signs include hyper-pigmented areas of the skin (café au lait macules) and hamartomas on the iris...

Ngày tải lên: 24/08/2014, 12:53

... Yang Lili and Wu Yayun, for their friendship and the happy days we have been together Finally, I would like to thank my parents, my sister and brother for their love, understanding, and patience ... STUDY ON STRUCTURE, FUNCTION AND DIACHRONIC EVOLUTION OF CHINESE EXTENDED MIDDLE CONSTRUCTION 蔡淑美 CAI SHU MEI (Ph D, NUS) 新加坡国立大学中文系 博士学位论文 A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... literature review on the current research of this construction, and briefly outline the organization of my dissertation The central claim of chapter two is that, although there exists disagreement...

Ngày tải lên: 09/09/2015, 17:57

... -Assess the yield in the U.S market on the modified BRE of the emerging Market credit, then add the sovereign yield spread Finally, compare the resulting required yield with the yield in the market ... Rate One can measure the cumulative mortality rate (CMR) over a specific time period (1,2,…, T years) by subtracting the product of the surviving populations of each of the previous years from ... cumulative defaults 10 Marginal and Cumulative Mortality Rate Equation MMR(t) = Total value of defaulting debt in year (t) total value of the population at the start of the year (t) MMR = Marginal...

Ngày tải lên: 04/10/2015, 10:26

... Concerns in Education What is the purpose of school? Concerns in Education What is the purpose of school? ? Interdisciplinary Students not see the connections between the different subject areas ... Instruction Authentic projects for authentic audiences Science Classes Project-Based Instruction Authentic projects for authentic audiences Communities Learning with the community, in the community, ... Instruction key ingredients: Authentic projects Authentic audiences Extend learning beyond the school & school day Collaborate with the community for resources, opportunities, and expertise Projects...

Ngày tải lên: 30/11/2015, 00:46

... tumors and liquid tumors Solid tumors are tumors of solid tissues, consisting of two types: carcinomas and sarcomas Carcinoma is the cancer of the epithelium lining inside and outside of the organ ... with other cancer therapies Targeted therapy is the newest form of treatment that is developed based on human knowledge about the molecular aspect of cancer biology Targeted therapy is the use of ... block the activity of critical protein molecules involved in the growth, spread and death avoiding machinery of cancer (12) The main advantage of targeted therapy is that they focus to the specific...

Ngày tải lên: 20/06/2016, 23:20

... ether strands mimic the distance between the nucleobase and the diphospho-bridge, but on the other hand likely are involved in polar interactions with the cADPR receptor protein Certainly, the ... northern and southern riboses are primarily necessary as linkers between the base adenine (or hypoxanthine) and the diphospho-bridge, as they can be replaced by much simpler ether strands These ... properties of derivatives modified in the northern ribose of cADPR in permeabilized T-cells, it was observed that replacement of the hydroxyl group at C2¢¢ [for clarity atoms of the ‘northern ribose’...

Ngày tải lên: 20/02/2014, 01:20

... 270) Ó FEBS 2003 Fig Structure of the 4-kDa peptide A, the best-fit superposition of the backbone (N, Ca and ¢C) atoms of the 15 NMR-derived structures of the 4-kDa peptide The structures are superimposed ... Maryland) Results and discussion Possible physiological function of the 4-kDa peptide To investigate the physiological functions of the 4-kDa peptide, we transiently expressed the peptide in the cultured ... the venom of cone snail and x-agatoxin-IVB from the venom of funnel web spider [23] (Fig 6C) The X-ray crystal structure of CPA–CPI complex has revealed that CPI recognizes the enzyme using the...

Ngày tải lên: 31/03/2014, 07:20

... zero even at the 95% level in Canada, Finland, the Netherlands, Norway, Sweden, Switzerland, the UK and the US Moreover, while in some countries, (including Finland, the UK and the US) residential ... also for these countries the existence of cointegration could not be rejected We therefore specify the VAR models in the level of the variables Nevertheless, we neither impose the number of cointegrating ... to offset the macro economic effects of the collapse of the bubble).2 Of course, it is by no means clear that central banks are better able to judge the appropriate level of asset prices and the...

Ngày tải lên: 24/10/2012, 09:40

... in the wrist due to gout [6,8,9] The prevalence of gout in the USA ranges between 0.5–2.8% in men and 0.1–0.6% in women [2] The prevalence rises to 4.4% of men and 1.8% of women over the age of ... at the carpal-metacarpal joint at the base of the thumb The report stated that the radiographs were otherwise normal The patient's symptoms worsened with increased pain and swelling over the ... incidence of gout has been reported in the USA and New Zealand over the past 30 years, while the prevalence of gout has been reported to have risen three-fold in the UK over 20 years of follow-up...

Ngày tải lên: 25/10/2012, 10:06

... for the operation of the Bank rests with a Board of Directors, which consists of fifteen members: • the governor (currently Mark Carney, who is the chief executive officer and chairman of the ... policy and for the regulation of Canada’s deposit-based financial institutions Copyright  2011 15 - Origins of The Bank of Canada II Copyright  2011 15 - Formal Structure of the Bank of Canada ... the Board of Directors) • the senior deputy governor, • the deputy minister of finance, and • twelve outside directors Copyright  2011 15 - Formal Structure of the Bank of Canada II • The Board...

Ngày tải lên: 05/01/2014, 16:57

... onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18] ... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription of the ITK gene and is key for the productive infection of HIV in these...

Ngày tải lên: 14/02/2014, 18:20

... has the right to earn income, i.e., the cash flow right And third, the owner has the right to transfer the share and the associated control and cash flow rights to another party The value of the ... 25% of Firm B the weakest link in the chain of voting rights At the same time, the entrepreneur owns about 8% of the cash flow rights of Firm B, the product of the two ownership stakes along the ... have noted the importance of the effects of earnings credibility Teoh and Wong (1993) report that the market perception of the quality of accounting earnings, as proxied by the size of the firm’s...

Ngày tải lên: 18/02/2014, 01:20

... despite (i) the very similar structural architecture of OYE1 and PETN reductase, and (ii) geometry for the binding of steroid compounds and 2-cyclohexen-1-one [2,19] The structure of the Y186F ... resolved and are bound between the progesterone and the protein (Fig 7A) In comparison to the oxidized structures, the FMN isoalloxazine ring is less planar, with both the N5 atom and the C8-C7 ... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and...

Ngày tải lên: 20/02/2014, 02:21

... measure the quality of the legal system and enforcement (i.e., efficiency of the judicial system, rule of law, and corruption index) SIZE is the book value of total assets at the end of the fiscal ... (1) the classification of the legal origin, and (2) the general quality of the legal system and enforcement (LEGAL) measured by the mean of three institutional variables (i.e., efficiency of the ... is the book value of total assets at the end of the fiscal year (in EUR thousands) Financial leverage (LEV) is measured as the ratio of total debt to the sum of total debt plus book value of...

Ngày tải lên: 06/03/2014, 21:20

... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... By these definitions, and due to the importance of the role of project management in the success of projects, the authors consider related department collaboration on product development by the ... in SMEs To understand the importance of coordinating these sections with the project manager and validated the model, the author interviewed 20 project managers The majority of project managers...

Ngày tải lên: 07/03/2014, 00:20

... significantly absorbed in the intestinal tract, and reach the colon mainly intact [27] They are therefore bioavailable to the epithelial cells in the intestinal wall, where procyanidins and other phenolics ... investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization and percentage of galloylation, with their antiproliferative potential and their ... from green tea, is a potent antioxidant and chemopreventive agent [21,22] These and other results suggest that the galloylation of catechins and the presence of gallocatechin moieties in natural...

Ngày tải lên: 07/03/2014, 05:20