sjogren s syndrome to other connective tissue and autoimmune disorders

... these autoantibodies occur in response to glandular tissue damage, apoptosis and/ or the expression of neoantigens such as cleaved La/SSB [85] and Ro/SSA-hYRNA complexes on the blebs of apoptotic ... have to be distinguished from pSS such as SLE, RA and secondary Sjögren s syndrome (SS) [68,69] In comparison with either healthy subjects or patients with pSS, patients with SLE have increased ... structures in a single biopsy reflects a snapshot of a slowly progressive inflammatory disease, pSS, or a subpopulation of patients with a more severe disease and/ or a distinct immune response...

Ngày tải lên: 09/08/2014, 10:20

... Immunohistochemistry (IHC) Tissue samples Formaldehyde-fixed, paraffin-embedded tissue samples were obtained from minor labial salivary gland biopsies of a smaller subset of 13 patients with histologically ... salivary glands leads to the local production of autoantibodies and cell-mediated mechanisms of tissue damage Although the presence of Th2 cytokines in salivary glands of patients with SS has ... of SS Increased serum levels and salivary gland expression of IL18 in patients with SS is in keeping with an active role for this cytokine in the tissue pathogenesis IL-18 serum concentrations...

Ngày tải lên: 09/08/2014, 01:23

... depression in PSS is consistent with that of previous studies Valtysdottir measured psychological status in a Swedish cohort (N = 67) of PSS patients and reported that possible depression was present ... details on this scale see Additional file 1, Table S1 ); and, depressed mood with the Center for Epidemiologic Studies Depression Scale(CESD) [16] The PROFAD-SSI was also used to assess sicca severity ... Sjogren' s syndrome and history of a positive minor salivary gland biopsy and/ or a positive anti-SSA/Ro or anti-SSB/La test result Questionnaires were also mailed to all active patient members...

Ngày tải lên: 18/06/2014, 18:20

... recombination biases predisposing to systemic autoimmunity in SLE and SS, there are some exceptions In some circumstances, specific autoantibodies express marked biases in IgV gene usage One example is the ... Bridts CH, Stevens WJ: Expression of CD5 and CD23 on B cells of patients with rheumatoid arthritis, systemic lupus erythematosus and Sjögren s syndrome Relationship with disease activity and treatment ... role in SLE Notably, different autoimmune diseases, such as pSS and SLE, seem to have characteristic abnormalities of particular censoring mechanisms IgV gene usage in patients with pSS is preferentially...

Ngày tải lên: 09/08/2014, 01:21

... against La-antigen; hLFS, lymphocytic focus score ≥ 1.0 in sublabial minor salivary glands biopsy DM, dermatomyositis; Pt, patient; SSc, systemic sclerosis; SLE, systemic lupus erythematosus aIgA, ... Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH: Classification criteria for Sjogren s syndrome: a revised ... the presence of these autoantibodies in SLE patients [11] Witte and collaborators showed much lower disease sensitivities, of 64% and 47% in primary and secondary Sjögren s syndrome, respectively,...

Ngày tải lên: 09/08/2014, 01:23

... with SS (nd, not determined; ns, not significant) observed for the Vλ repertoire, this suggests a positive selection of these mutations in the parotid gland Discussion The present study has identified ... autoantibodies, however, can precede disease manifestations in SS [22] This suggests the possibility that enhanced migration or homing of activated lymphocytes into the salivary glands from other ... WD, Slocum L, Ebbs WL, Fox PC: Serum anti-SS-B/La and IgA rheumatoid factor are markers of salivary gland disease activity in primary Sjögren s syndrome Arthritis Rheum 1992, 35:1368-1372 Kassan...

Ngày tải lên: 09/08/2014, 03:24

... patients without antiSSA/SSB autoantibodies, in whom disease is usually less systemic Moreover, we previously reported that BAFF level was not associated with systemic features in pSS [8] Likewise, ... Hjelmervik TO, Petersen K, Jonassen I, Jonsson R, Bolstad AI: Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren' s syndrome patients from healthy control subjects ... polymorphism is associated neither with predisposition to pSS nor with a specific pattern of antibody secretion, including anti-SSA/SSB autoantibodies, rheumatoid factor, and serum gammaglobulin and...

Ngày tải lên: 09/08/2014, 07:20

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 09/08/2014, 10:20

... potential presence of SS-unrelated histopathology or of other subclinical autoimmune diseases in mouse models for SS represents a common problem of all mouse models used in SS research [13,31] This divergence ... and entered simultaneously In serum no data were missing and in saliva missing values were excluded pairwise from all analyses except PCA and DA All analyses were computed using SPSS 13 (SPSS ... have assessed interactions between several immune molecules and their association with disease parameters Summarizing findings regarding immune mediators such as cytokines in SS, it was concluded...

Ngày tải lên: 09/08/2014, 10:23

... (HCs) by solid-phase capture associated with functional prothrombinase assay Results are expressed as nM PS Eq Solid bars show the mean poorly assessed in pSS, we assessed plasma levels of sCD40L ... properties, MPs have been associated with systemic inflammation or excessive risk of thrombosis in various diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), vasculitis and ... microparticles (MPs), secretory phospholipase A2 (sPLA2), sCD40L, sCD62P in patients with primary Sjögren syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and in healthy...

Ngày tải lên: 09/08/2014, 14:22

... control system); and HACCP and HACCP (the analysis and control system for essential foodstuff processing steps) 3.1.3 To set up applying e-commerce in business Vietnam enterprises should step up ... attention to arguments over unfair subsidies settled by WTO Critics charge that subsidies cover cost that truly competitive industries should be able to absorb on their own In this sense, subsidies simply ... both suppliers and buyers 1.2.2.3 Diversify sales Exporting permits companies to diversify their sales In other words, they can offset slow sales in one national market (perhaps due to recession)...

Ngày tải lên: 27/10/2012, 16:55

... Windows ports of GNU tools, such as GCC or MinGW, to build Windows programs with an Autotools build system I’ve seen truly portable build systems that use these environments and tool sets to build ... the Autotools, it s important to distinguish between a maintainer s system and an end user s system The design goals of the Autotools specify that an Autotools-generated build system should rely ... questions, and discussions with him uncovered some bugs in the Autotools sources and documentation, as well as some issues in his tutorial www.it-ebooks.info Autotools_02.book Page xvi Tuesday, June...

Ngày tải lên: 20/02/2014, 11:20

... nurses, physical educators, athletic directors, sports coaches, fitness club owners and managers, personal trainers, organizational consultants, sport psychology consultants, allied health and ... regiments, and less successful when applied to exercise” (p 224) Studies have shown, in fact, that perceived susceptibility was inversely associated with exercise adherence This suggests that physical ... Targeting specific processes of change to facilitate progression of exercise behavior across stages is based on the assumption that differences between adjacent stages found in cross-sectional studies...

Ngày tải lên: 05/03/2014, 21:20

... packages directly to waiting airplanes Today s UPS repairs laptops, shapes baseball bats, stocks parts for Bentleys, provides warehouse storage for shoes and cameras, and refurbishes cell phones Oh, ... Let s turn now to the foundation of any successful business plan: the mission statement Defining the Business Mission The focus of a business plan is to define the organization s mission for the ... Entrepreneur s Guide to Writing Business Plans and Proposals SOME MISSION STATEMENT EXAMPLES Here are some famous mission statements: Mary Kay Cosmetics: ‘ To give unlimited opportunity to women.’’...

Ngày tải lên: 17/03/2014, 11:20

... who want to program images, animation, and sound It is used by students, artists, designers, architects, researchers, and hobbyists for learning, prototyping, and production It is created to teach ... fundamentals of computer programming within a visual context and to serve as a software sketchbook and professional production tool Processing is developed by artists and designers as an alternative to ... proprietary software tools in the same domain.” — www.processing.org To sum up, Processing is awesome First of all, it is free It doesn’t cost a dime Secondly, because Processing is built on top of...

Ngày tải lên: 17/03/2014, 12:20

... Scale) This basically lets you scale an image without distorting its primary subjects You might have seen presentation videos on this too, but again, these videos represent “best case” scenarios Reality ... (I chose #0b57f0) and create some middle size snowflakes by using Custom Shape tool and Merge all layers (or you can use Flatten Image): Let s add some Noise (Filter->Noise->Add Noise): Close the ... assuming that you are familiar with basic tools and techniques (which were already described in previous guides) However, I will try to make things as simple as possible Also note that I’m using...

Ngày tải lên: 19/03/2014, 13:28

... Calcium-Sulfonate-based Greases Paraffins Olefins Phospholipids Alcohols Ethers Esters Polymers Starch Amides Special Issues Side Reactions Silicate-Based Muds Studies on Pipe Sticking Differential Sticking ... prevents hydration and dispersion of the shales Water-based Muds These muds have water as the continuous phase, which may contain several dissolved substances such as alkalies, salts and surfactants, ... Emulsions, and Foams Dispersions Dispersants Emulsions Oil-in-water Emulsions – Invert Emulsions Water-in-water Emulsions Oil-in-water-in-oil Emulsions Microemulsions Solids-stabilized emulsion...

Ngày tải lên: 02/04/2014, 16:06

... market now dwarfs the US stock or bond markets As the pulling down of trade and capital barriers has led to investors and corporations seeking to expand and diversify in other countries, so the global ... trade — Such a concept would imply zero import tariffs, r r r r zero export subsidies and perfect competition across all business sectors Needless to say, this is not the case Whatever progress we ... money/cash Since money/cash has to share its gains with equities, one should assume that the effect on money demand and therefore prices is reduced Prices should rise less than they would otherwise...

Ngày tải lên: 23/04/2014, 15:52

... market now dwarfs the US stock or bond markets As the pulling down of trade and capital barriers has led to investors and corporations seeking to expand and diversify in other countries, so the global ... trade — Such a concept would imply zero import tariffs, r r r r zero export subsidies and perfect competition across all business sectors Needless to say, this is not the case Whatever progress we ... money/cash Since money/cash has to share its gains with equities, one should assume that the effect on money demand and therefore prices is reduced Prices should rise less than they would otherwise...

Ngày tải lên: 23/04/2014, 15:53