signal transduction and transcriptional regulation

... structural and biochemical properties of signaling molecules and their regulation, the interaction of signaling proteins at VIII Preface the various levels of signal transduction and to work ... Receptor 135 Signal Amplification 139 Regulation of Inter- and Intracellular Signaling 141 Membrane Anchoring and Signal Transduction 142 Myristoylation 144 Palmitoylation 145 Farnesylation and Geranylation ... lectures on regulation and signal transduction that are offered to students of biochemistry, biology and chemistry at the University of Bayreuth The idea to write a book on signal transduction...

Ngày tải lên: 08/04/2014, 12:41

... Localization and transcriptional regulation of TRAF4 (Eur J Biochem 269) 4827 Fig TNF and PMA up-regulate TRAF4 mRNA in T-cells Jurkat (A) and D23II-7 T-cells (B) as well as primary human T-cells and ... of the respective mRNA signal To obtain relative TRAF4 and L32 expression values the ratio between the signal intensities of bands of treated cells and the corresponding band of the untreated group ... in the T-cell lines Jurkat (Fig 9A) and D23II-7 (Fig 9B) both TNF and PMA/Ionomycin, induced a significant and reproducible up -regulation of TRAF4 mRNA TNF- and PMA-induced TRAF4 expression was...

Ngày tải lên: 21/02/2014, 15:20

... Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies 307 Michael A Beaven and Thomas R Hundley 11 Rheumatology and Signal Transduction 357 Keith M Hull and Daniel L Kastner 12 Molecular ... for- Signal Transduction and Human Disease, Edited by Toren Finkel and J Silvio Gutkind ISBN 0-471-02011-7 Copyright © 2003 John Wiley & Sons, Inc ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND ... host defense or signal transduction (Fig 1.7) 13 14 ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND NITROGEN RADICALS Figure 1.7 The divergent role of high and low levels of RNS and ROS A potential...

Ngày tải lên: 11/04/2014, 10:31

... ORF3 (3), E (4), M (5) and N (6) The right panel shows the MHV and HCoV-NL63 genome organization and the HCoV-NL63 sg-mRNAs strand during viral replication because most (-) strand RNAs are sub-genomic, ... nucleotide and G and in particular C as underrepresented nucleotides HCoV-NL63 has the most extreme nucleotide bias among the coronaviridae, with 39% U and only 14% C As a general trend, U and C seem ... ORF3 and E genes (43%) and the lowest C-count in the 1a/1b genes and the 3' UTR (13%, 14% and 14%, respectively) The N gene is most moderate in its nucleotide bias, with 21% C and 32% U, confirming...

Ngày tải lên: 18/06/2014, 22:20

... ORF3 (3), E (4), M (5) and N (6) The right panel shows the MHV and HCoV-NL63 genome organization and the HCoV-NL63 sg-mRNAs strand during viral replication because most (-) strand RNAs are sub-genomic, ... nucleotide and G and in particular C as underrepresented nucleotides HCoV-NL63 has the most extreme nucleotide bias among the coronaviridae, with 39% U and only 14% C As a general trend, U and C seem ... ORF3 and E genes (43%) and the lowest C-count in the 1a/1b genes and the 3' UTR (13%, 14% and 14%, respectively) The N gene is most moderate in its nucleotide bias, with 21% C and 32% U, confirming...

Ngày tải lên: 20/06/2014, 04:20

... and down-regulated genes 116 Figure 84 Profile of FAIRE signal for E2 and Tamoxifen 117 Figure 85 Profile of FAIRE signal for E2 and Raloxifene 118 Figure 86 Profile of H3K4Me1 signal ... milk ducts and glands, thus forming a lump or tumour If untreated, the cancer will invade the nearby stroma which consists of blood and lymphatic vessels and metastases to lung, bones and liver ... probes and lastly randomly removed 4546 regions Selection of ER binding sites from literature references and in-house studies Validated ER binding sites and non binding sites were collected and...

Ngày tải lên: 14/09/2015, 14:05

... (DAPK) and signal transduction: blebbing in programmed cell death FEBS J 276, doi:10.1111/j.1742-4658.2009.07412.x Kang C & Avery L (2009) Death-associated protein kinase (DAPK) and signal transduction: ... distinct genes involved in the regulation of apoptosis, DNA repair, cell cycle regulation and metastasis are aberrantly methylated in cancer cells, resulting in their transcriptional repression [19] ... signalling pathway and that DAPK levels are critical for modulating cell fate decisions that lead to survival or death, highlighting the capacity of DAPK to integrate signals from apoptotic and...

Ngày tải lên: 29/03/2014, 08:20

... addressing how signal transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate ... mechanism of gene regulation by cohesin is vertebrate specific Epigenetic regulation of inflammatory gene expression Two talks addressed the role of epigenetic mechanisms in regulation of inflammatory ... they addressed the induction of primary response genes (direct transcriptional targets) and secondary response genes (indirect transcriptional targets that require de novo protein synthesis for...

Ngày tải lên: 14/08/2014, 20:22

... QGP-1 cells using random hexamers and Superscript III (Invitrogen Corp.) One and two of 20 lL of the resulting single strand cDNA reaction were used as templates for RT-PCR and quantitative real-time ... DNASE1 of QGP-1 cells and pancreas (A) RT-PCR analysis Total RNA prepared from QGP-1 cells or pancreas was reverse-transcribed with random primer, and the resulting single-strand cDNA was used as ... lines indicate intron of 75 bp in fragments B and C, 3¢ portion of 35 bp in intron in fragments C and D, and 3¢ portion of 25 bp in intron in fragments F and I The number at the right of each RT-PCR...

Ngày tải lên: 19/02/2014, 06:20

... Amplification and control of B cell antigen receptor signaling M Reth and Y Kulathu Institute for Biology III and Max-Planck-Institute for Immunobiology, Freiburg, Germany E-mail: reth@immunbio.mpg.de Signal ... main role is to control 1.5 Signaling and Cancer: Nuclear Receptor Connection S1.5-1 Androgen action and prostate carcinogenesis F Saatcioglu ¸ ˘ Division of Cellular and Molecular Biology, Department ... signalling pathways, for example by down -regulation of ROCK or Rho activation and up-regulating Rac activation S1.6-2 Signal transduction via receptors for PDGF and TGF-beta – possible targets for...

Ngày tải lên: 19/02/2014, 07:20

... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... was transcriptionally and/ or translationally regulated by as yet unidentified mechanisms To begin to identify the potential modes of the regulation of iPLA2c synthesis at the transcriptional and ... while the nucleotide binding and lipase consensus sites occur in exons and 8, respectively, and the peroxisomal localization signal occurs in exon 13 (Fig 5) Ó FEBS 2004 Regulation of iPLA2c biosynthesis...

Ngày tải lên: 19/02/2014, 16:20

... Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction J Biol Chem 273, 2617–2623 17 Blaukat A, ... differential signaling is less likely to explain differences in internalization than in two receptors signaling through different G proteins Internalization patterns of truncations I347* and N338*, and ... motifs in the region between the palmitoylated C324 and N338 Candidates would include G328-C329 and ⁄ or the negatively charged residues E332 and E337, as they are highly conserved in B2wt among...

Ngày tải lên: 07/03/2014, 16:20

... gene expression with a brief overview of transcriptional regulation in prokaryotes However, it is now clear that Gene Expression and Signal Transduction gene regulation in eukaryotes is far more ... is called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction ... include MYC and MYB Both phytochrome (see Chap- Gene Expression and Signal Transduction ter 17) and gibberellin (see Chapter 20) are believed to regulate gene expression via the up-regulation...

Ngày tải lên: 07/03/2014, 21:20

... controls the expression of IgM H- and L-chain genes, through upregulated transcriptional regulation of EBF1, Pax5, Aiolos and Ikaros, and downregulated transcriptional regulation of E2A Moreover, our ... cells, BCR signaling is transduced from BCR and membrane-proximal factors (Syk, BTK, BLNK and PLCc2, etc), via mainly PKCd, PKCe and PKCf, to NF-jBs (probably c-Rel and NFp50) This activated signal ... mediated by BCR signaling is probably transducted separately into two apoptotic pathways, i.e direct transduction of the signal into the CAD/ICAD system and transduction of the activated signal into...

Ngày tải lên: 16/03/2014, 04:20

... vector Effect of unliganded RARa and RXRa and retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the ... Differential effects of ligand-activated RARa and RXRa on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-cisRA, on the ... RARa and ⁄ or RXRa (without RA treatment), simultaneous ligand activation of RARa and RXRa (cotransfection of RARa and RXRa together with treatment of both ATRA and 9-cisRA) provided further up-regulation...

Ngày tải lên: 16/03/2014, 10:20

... linked to multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in ... cycle (steps and 2) and cycle (steps and 4) (Eqn 7) and the values of a, c and b only depend on the KS value (Eqn 8) The concentrations of interconvertible forms are: c¼a¼ þ KS and b¼ À KS ð8Þ ... requirements in signaling are constrained: a and c only vary between ⁄ and ⁄ 2, whereas b varies between and ⁄ is studied for different sets of parameters, resulting in (a) a single steady state and (b)...

Ngày tải lên: 16/03/2014, 13:20

... both duration and integral signal strength The control for all processes together equaled for peak amplitude and nal signal strength and it equaled )1 for duration and integral signal strength ... amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling pathways, ... concerning protein kinase signaling, such as the possibility of spatially resolved signaling [21] and have also shed light on the control of kinases and phosphatases on signal transduction [22] For...

Ngày tải lên: 16/03/2014, 18:20

... the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by SA and by a yet unknown signal produced during the HR, respectively, which mediate PR-1a ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... support for our model of distinct signal transduction pathways leading to the independent activation of the tobacco PR-1a gene by SA and by an unknown HR released signal, we have made use of transgenic...

Ngày tải lên: 23/03/2014, 15:21

Ngày tải lên: 29/03/2014, 08:20