screening of polymers for amorphous drug stabilization
Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... one of the primary reasons for the failure of drug candidates in later stages of drug development. Moreover, adverse drug reaction (ADR) during post-approval stage is among the leading causes of ... Singapore for the reward of research scholarship and Department of Pharmacy for the support of all resources and opportunities. In addition, I am very appreciative of my PhD committee members for ... APPLICATION OF COMPUTATIONAL METHODS AND TOOLS FOR ADVERSE DRUG REACTION AND TOXICITY PREDICTION HE YUYE (B.Sc. (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF
Ngày tải lên: 10/09/2015, 09:02
Nanomedicine multifunctional nanoparticles of biodegradable polymers for cancer treatment
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER TREATMENT LIU YUTAO NATIONAL UNIVERSITY OF SINGAPORE 2011 NANOMEDICINE: MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER ... . 130 Chapter : A Strategy for Precision Engineering of Nanoparticles of Biodegradable Copolymers for Quantitative Control of Targeted Drug Delivery ... multifunctional nanocarriers as novel formulations of cancer nanomedicine, especially for breast cancer. The desired properties of such developed nanoparticle formulations for drug delivery include small
Ngày tải lên: 10/09/2015, 15:49
Designing and synthesis of shape memory polymers for biomedical application
... DESIGNING AND SYNTHESIS OF SHAPE-MEMORY POLYMERS FOR BIOMEDICAL APPLICATION XUE LIANG NATIONAL UNIVERSITY OF SINGAPORE 2010 DESIGNING AND SYNTHESIS OF SHAPE-MEMORY POLYMERS FOR BIOMEDICAL APPLICATION ... THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHYLOSOPHY DEPARTMENT OF CHEMICAL & BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2010 To My Family ACKNOWLEDGEMENTS First of all, I would ... . 124 LIST OF PUBLICATIONS……………………………………………….141 vi LIST OF FIGURES Figure 1.1 A simplified scheme for shape-changes of SMP from deformation to recovery upon application of external stimulus.
Ngày tải lên: 11/09/2015, 09:58
Application of HCRSV protein cage for anticancer drug delivery
... APPLICATION OF HCRSV PROTEIN CAGE FOR ANTICANCER DRUG DELIVERY REN YUPENG (B. Sc., CHINA PHARMACEUTICAL UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHARMACY ... physicochemical properties of the drug, for example, by improving drug stability... the role of the folic acid receptor in mediating its uptake It also accounted for the failure of fPC-Dox to ... a sustained drug release profile at simulated physiological condition. About 40% of the drug load was released within the initial h, followed by a slower release of the remaining drug load from
Ngày tải lên: 11/09/2015, 14:22
Multifunctional nanoparticles of biodegradable polymers for diagnosis and treatment of cancer
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS AND TREATMENT OF CANCER PAN JIE NATIONAL UNIVERSITY OF SINGAPORE 2009 MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS ... folate-decorated nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging for cancer diagnosis at its early stage Two polymers of poly(lactide)-vitamin ... nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging In order to reduce the cytotoxicity of QDs, two... is feasible for targeted imaging
Ngày tải lên: 14/09/2015, 08:45
Trastuzumab decorated nanoparticles of biodegradable polymers for targeted small molecule chemotherapy
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR TARGETED SMALL MOLECULE CHEMOTHERAPY SUN BINGFENG (M Eng., Tianjin University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DIVISION OF BIOENGINEERING ... surface of cancer cells, thus achieving highly-specific targeting function This work developed two novel drug delivery systems of trastuzumabdecorated nanoparticles (NPs) of biodegradable polymers for ... docetaxel-loaded NPs of a blend of two novel copolymers One is poly(lactide)-D-α-tocopheryl polyethylene glycol succinate (PLA-TPGS), which is of ideal hydrophobic-lipophilic balance for high drug encapsulation
Ngày tải lên: 14/09/2015, 08:48
Construction of bacterial artificial chromosome library for kineosphaera limosa strain lpha5t and screening of genes involved in polyhydroxyalkanoate synthesis
... cycle program consisted of one cycle of 94 °C for 10 min, 51 °C for 2 min, 72 °C for 2 min, and 35 cycles of 94 °C for 20 s, 57 °C for 45 s (decreased by 1 s per cycle), 72 °C for 1 min, and then ... protein CNBN0690 hypothetical protein CNN00710 [Cryptococcus neoformans var. [Cryptococcus neoformans var. N-P P-P neoformans B-3501A] neoformans JEC21] Identities = 13/36 (36%), Identities = 13/36 ... metabolic pathway of these GAOs under alternating anaerobic/aerobic conditions is therefore important for the optimization and stability of the EBPR process. Therefore, metabolism of the biopolymers (PHA,
Ngày tải lên: 03/10/2015, 21:58
Nanoparticles of biodegradable polymers for gene therapy of hepatitis b
... ENGINEERING THE DNA: NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR GENE THERAPY OF HEPATITIS B JUNPING WANG NATIONAL UNIVERSITY OF SINGAPORE 2006 ENGINEERING THE DNA: NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR GENE ... main disadvantage of this drug is the drug- resistance and drug durability because lamivudine therapy can only transiently block the synthesis of the new virus and prolong treatment is necessary for patients. ... most of the current polymers for gene delivery. Finally, the author discussed the application of biodegradable nanoparticles for gene delivery which is viewed as the most promising field for current
Ngày tải lên: 05/10/2015, 21:33
Nanoparticles of biodegradable polymers for controlled and targeted delivery of protein drugs and small molecule drugs
... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS LEE SIE HUEY NATIONAL UNIVERSITY OF SINGAPORE 2007 NANOPARTICLES OF BIODEGRADABLE POLYMERS ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer drug ... Nanoparticles of biodegradable polymers for clinical administration of paclitaxel, Current Medicinal Chemistry, 11, pp.413-424 2004 Feng, S S Nanoparticles of biodegradable polymers for new-concept
Ngày tải lên: 26/11/2015, 22:41
Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... release of drug in the brain to prolong the pharmacological action of drug molecules; 6 Nanoparticle formulation is a platform technology,... mechanisms for transport of MRP substrates ... barrier and increase the bioavailability of the drug in the brain and CNS The aim of this thesis is to develop nanoparticles of biodegradable polymers for drug delivery across the blood brain barrier ... EE of the nanoparticles The EE of sample was about 3.3 times of that of sample This may due to the hydrophilicity of polymer Sample was made up of PLA-PEG (70:30) while sample is made up of PLA-PEG
Ngày tải lên: 26/11/2015, 22:48
EFFECTS OF HIV PROPHYLAXIS FOR INJECTING DRUG USERS (IDU) IN QUANG NAM
... NATIONAL SCIENTIFIC CONFERENCE ON HIV/AIDS EFFECTS OF HIV PROPHYLAXIS FOR INJECTING DRUG USERS (IDU) IN QUANG NAM Tran Van Kiem Quang Nam Provincial Center of HIV/AIDS Control Contents Introduction Research ... sampling in districts/city Mapping of gathering points: making a map of all gathering points of IDUs in districts Sample is distributed to districts Making a list of communes with IDUs in the districts ... the average number of ICUs per commune Randomly select communes until the number of IDUs for one district is reached; and continuing to so until reaching the required number of IDUs in districts/city
Ngày tải lên: 23/05/2017, 15:10
DSpace at VNU: An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice
... in formulations of sustained T release (SR) systems to achieve slow release of drug over an extended period of time [1-4] IP due to low cost, ease of manufacture and relative independence of ... commonly used to control release of drug due to their capability of swelling in the presence of water and forming a gellike substance To compare effect of types of rice on dissolution rates, the ... pertain ACCEPTED MANUSCRIPT An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice IP T Vuong
Ngày tải lên: 14/12/2017, 17:50
DSpace at VNU: A Rational Workflow for Sequential Virtual Screening of Chemical Libraries on Searching for New Tyrosinase Inhibitors
... (http://www.msdiscovery.com/spectrum.html) and Drugbank (www.drugbank.ca), which consists of 000 and 827 Le-Thi-Thu et al compounds, respectively, that were screened using a sequential strategy for virtual screening looking for potential ... and Drugbank were some drug- likeness filters or similarity searching methods are implemented as tools for search and retrieving Therefore some of these services were used in these studies DRUG- LIKENESS ... influence the drug- like properties of a molecule in some specific type of research Lipinski et al.[30] defined the so-called “rule of five” (sometimes abbreviated as RoF) in an effort to solve
Ngày tải lên: 17/12/2017, 18:55
Dissertation summary: Study on the synthesis and application of polymers containing suitable funtional groups for seperation some light rare earth elements
... condition for the copolymerization of acrylamide and sodium vinyl sulfonate: reaction temperature 90oC for 60 minutes, 30% of monomer, 8% of crosslinker (in monomer), 1% of initiator, 0,3% of Span ... ability of polymers on separating each of the rare earth metal ions on the ion exchange column Main contents of dissertation - Synthesis polymers containing suitable funtional group for the separation ... 90oC for 60 minutes, 30% of monomer, 10% of crosslinker (in monomer), 1% of initiator, 0,3% of Span 80 at 300 rpm and ¼ of the phase ratio monomer/oil + Characteristic of PHA-gel: Particle size
Ngày tải lên: 09/01/2020, 15:30
Methods to improve virtual screening of potential drug leads for specific pharmacodynamic and toxicological properties
... Performance of Ensemble for Hepatic Effects Classification Performance of Base Classifiers in Ensemble Performance of Best Base Classifier Performance of Ensemble for Similar ... necessary for virtual screening of chemical libraries for Lck inhibitors 4.3.4 Evaluation of Prediction Performance Some of the performance measures described in Section 2.6 were calculated for this ... Virtual Screening for Lck Inhibitors 37 39 39 5.1 5.2 5.3 5.4 PI3K Diversity Index Performance of AODE for PI3K Inhibitors Classification Performance of kNN for PI3K...
Ngày tải lên: 10/09/2015, 08:34
R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
... Classification of Diseases (ICD)13 helps with reporting the reasons for taking a drug For purposes of drug safety a correct diagnosis and assessment of causality of a suspected ADR are of particular ... common understanding and the uniform use of terms for the monitoring of drug safety The established definitions and basic requirements for the proper use of adverse-drugreaction terms will undoubtedly ... (comments that may be of help to validators of reports of ADRs) Proposed definition of the term (including a list of published definitions) Basic requirements for use of the term (for validating the...
Ngày tải lên: 07/03/2014, 10:20
In Vitro Screening of Plant Resources for Extra-Nutritional Attributes in Ruminants: Nuclear and Related Methodologies pptx
... Tim A McAllister 87 In Vitro Screening of Feed Resources for Efficiency of Microbial Protein Synthesis Harinder P.S Makkar 107 Screening of Plants for Inhibitory Activity Against ... storage of plants for nutritional analysis xi xii Introduction Chapters 3–10 are dedicated to various techniques used for screening a large number of plants and plant compounds for a wide range of ... Geographic Information System (GIS) derived parameters Undertake an expert review of listing of species Germplasm collection of prioritised species and collection of samples for testing of nutrient...
Ngày tải lên: 15/03/2014, 04:20
Báo cáo khoa học: Piezoelectric sensors based on molecular imprinted polymers for detection of low molecular mass analytes potx
... Detection of low molecular mass analytes Y Uludag et al ˘ For all the examples cited above, the binding capacity of the sensor surface is critical to maximize the sensitivity of the sensor for the ... analysis Therefore extra care needs to be taken to remove the template from the polymer and the 3D structure of the polymer should allow for easy regeneration of the template from the polymer for repeated ... amount of a particular drug or any other chemical in body fluids For instance, Tan et al determined the amount of nicotine and paracetamol in human serum and urine [55,58] The detection limit of nicotine...
Ngày tải lên: 23/03/2014, 07:20
Guidelines for the early detection and screening of breast cancer ppt
... detection of cancer 24 Cancer screening 24 Screening for breast cancer 26 Screening approach 26 Guidelines for the early detection and screening of breast ... detection and screening of breast cancer 51 Annex Consensus opinion of the regional task force for developing breast cancer prevention, screening and management guidelines 52 Foreword In ... assessment of regional guidelines for the early detection and screening of breast cancer, and has given special attention to supporting the development of national programmes for the early detection of...
Ngày tải lên: 28/03/2014, 23:20
LISTS OF ACCEPTABLE POLYMERS FOR USE IN FOOD PACKAGING APPLICATIONS ppsx
... and thus can be very crystalline For this reason they are often used to make block copolymers with soft rubbery polymers These block copolymers have properties of thermoplastic elastomers 32 33 ... chains of polybutadiene growing out of it Food Packaging Materials These rubbery chains hanging off of the backbone chain some good things for polystyrene Polybutadiene and polystyrene homopolymers ... filed for a patent outside Germany) Tons of new uses for this wonderful waterproof material followed, and PVC was a smash hit the second time around For Nylon 6,6 at a glance, click here! For Nylon...
Ngày tải lên: 01/08/2014, 07:20