... preferentially via the ễperoxide shuntế: the sluggish autodecomposition of HbO2 (k % 10)3 M)1ặs)1) in the presence of the anilines [166] to nally yield H2O2 together with the relatively low rate of peroxide ... [227] A key to the unique reactivity of the nonheme iron(II) site of BLM (Fig 5) toward O2 seems to reside in one of its equatorial ligands, the pyrimidine moiety [228] The mechanism of oxygen ... either NADPH-P450 reductase or the NADH-cytochrome b5 reductase/cytochrome b5 segment of the electron transfer chain in the presence of NAD(P)H [163,164] Under these conditions, addition to the...
Ngày tải lên: 19/02/2014, 16:20
... participation in the research study They must also know the reasons of their participation in the research study – what they will talk about in the study – so that they can give answers to all the questions ... have to let them grow up to a certain age They will have to be told when they have a sense of understanding and wisdom giving such information to a child can be fatal to him and at that moment, then, ... should be told at the beginning of the research Their reasons focused on reducing the children being taken aback upon learning their status during the course of the research and for enhancing the children's...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo y học: "Conservative management of a grade V injury to an ectopic pelvic kidney following blunt trauma to the lower abdomen: a case report" ppsx
... imaging revealed resolution of the retroperitoneal hematoma, return of the pelvic kidney to its anatomical position in the right pelvis, and perfusion defects in the lower pole, likely representing ... tomography of the abdomen and pelvis with intravenous contrast demonstrating resolution of the retroperitoneal hematoma, return of the pelvic kidney to its anatomical position in the right pelvis, ... devascularizing injuries to the renal pedicle, or avulsion of the main renal artery [3] In this case the patient presented with multiple deep lacerations to the parenchyma of the ectopic pelvic kidney...
Ngày tải lên: 11/08/2014, 06:23
Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... contributed to the embryo, the resultant offspring will be chimeric (up to ca 50% of animals) The ESC contribution to a mouse can high (up to ca 80% of the cells), and will often include the germline ... attributed to the fortuitous removal or inhibition of IF(s) [43] Seminal fluid reportedly contains an inhibitory factor (IF-1) that appears to actively block the binding of exogenous DNA to sperm and to ... of minimal potential use, due to the high levels of mosaicism associated with these vectors However, the new generation of lentiviral vectors would avoid such problems [21, 22, 23] These vectors...
Ngày tải lên: 03/11/2012, 10:01
Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... in the specific section Figure 1: Geographical location of the province of Parma (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of ... this case the patient had a panuveitis, which recovered only after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme ... P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of severe Toxocara uveitis J Infect 2006; 52:159-161 http://www.medsci.org ...
Ngày tải lên: 03/11/2012, 11:11
Contributions of Various Noncovalent Bonds to the Interaction between an Amide and S-Containing Molecules
... group of NMA represents a likely proton source The carbonyl O atom is a prime proton acceptor, as is the N atom One usually thinks of the lone pairs of O as the source of charge transfer, but the ... transfer from the S lone pairs to the CO p* antibonding orbital Altogether, these interactions add up to a total stabilization energy of more than kcal mol1, the largest of any of the complexes ... in CH3SCH3 The enhancement of the S atoms proton-accepting ability strengthens the NHãããS H-bond to the point where it is the sole contributor to the global minimum in the CH3SCH3/NMA heterodimer,...
Ngày tải lên: 16/12/2012, 15:21
Acute and Subchronic Toxicity of Tributyltin Chloride (TBTCl) to the Marine Harpacticoid Copepod Tigriopus japonicus Mori
... Most of these studies have focused on the evaluation of TBT concentration on acute and/or chronic toxicity to various marine organisms In general, acute toxicity studies have measured the LC50 (the ... under the “Law Concerning the Examination and Regulation of Manufacture, etc of Chemical Substances” in Japan The toxicity level of TBTCl may be as high as that of tributyltin oxide (TBTO) (e.g ... control Acetone solution of 0.05 mL/L, which was made by adding 0.1 mL of acetone to L of filtered seawater, was used as acetone-control The TBTCl solution was made by adding 2000 mg of tributyltin...
Ngày tải lên: 05/09/2013, 10:15
The role of leadership theory in raising the profile of women in management
... ability to persuade in leading their followers A powerful autocratic leader influenced followers because of the power of the leader’s position, or the power of the leader as a person made others ... of the organizations of which they are members’’ (House et al., 2004, p 56) Here the focus extends beyond influence to include motivation and enabling of others to help achieve the goals of the ... will further explore the recent theories of leadership, and evaluate if these make a further contribution to the recognition of the skills and attributes of women in management or leadership roles...
Ngày tải lên: 08/10/2013, 15:56
Customer satisfaction: review of literature and application to the product-service systems
... collected data, due to the general nature of these tools and availability of sources, which can provide help in these respects 2.4 Outline of the report An overview of the sections of the report is ... organisation of repair and maintenance of tools and their final disposal at the end of their life For the example of the tool library, the following attributes could be suggested in the above context ... restrict themselves to the role of income and prices in determining consumption choices Other presuppositions of economic theory of consumer demand are that desires are not diminishing as mo re of them...
Ngày tải lên: 04/11/2013, 10:15
Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... (SENSE factor of 2) Imaging time of DWI was 90 s for 20 slices Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue On the other hand, in sarcomas the ADC ... endometrium In the uterine myometrium, the ADC value may play a limited role due to the large overlap between sarcomas and benign leiomyomas The role of DWI for the differentiation of benign and ... pulse, the low ADC values of the cystic component of mature cystic teratomas have been attributed to artifacts caused by coexisting fat within the tumor [21, 22] Furthermore, mature cystic teratoma...
Ngày tải lên: 13/02/2014, 06:20
Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf
... farmer of the Post Office, furnished to the Secretary of State "a perfect list" of all officers in the Post Office According to this list there were eight Clerks of the Roads, viz.:—Two of the Northern ... cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the toast of "the Visitors," and said that they had amongst them two representatives of the ... the street; on the east side being another building answerable thereto." These premises served as the Post Office for the long period of 118 years The first half of the present Bristol Post Office...
Ngày tải lên: 17/02/2014, 02:20
Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... released from the membrane (data not shown) Role of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches The first ... to the mitochondria In the present study, we observed no significant targeting of intact CYP1A1 to mitochondria, possibly due to the absence of cytosolic endoprotease specific for cleavage at the ... reduced to < 10% in the a ⁄ c mutant and < 3% in the a ⁄ b mutant, as compared to about 25% in the control strain We also tested the targeting to mitochondria of Su9-DHFR, in which the presequence of...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... independent of the thermodynamic and kinetic properties of the binding process and is solely based on the detectability of the peptides of interest We have used this method to show that binding of fosfomycin ... prior to digestion The mass peak of 1616 (m/z) is due to the peptide of amino acids 104– 120 and on binding of fosfomycin this mass shifts to 1754 (m/z) The peak at 1657 (m/z) is attributed to the ... replacement of R120 by lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine...
Ngày tải lên: 19/02/2014, 13:20
Tài liệu A Collection of State-Papers, Relative to the First Acknowledgment doc
... mentioned in the registers of their High Mightinesses of the date of the 4th of May 1781, and of the 9th of January 1782; moreover the resolutions of the Lords the States of the five other provinces, ... at the moment when the present war broke out, to prejudice in the least the fidelity of the Citizens of the Amstel, or to shake them in the observance of their duties; the inconveniencies and the ... resolved to authorise the deputies of this Province at the States General, as they authorise them by the present, to conform themselves in the name of this Province to the resolution of the Lords the...
Ngày tải lên: 20/02/2014, 08:20
Tài liệu Báo cáo khoa học: Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins pptx
... contrast to the CD11b I domain GST, the majority of the CD11a I domain GST was found in the insoluble fraction of the E coli lyzate Modification of the solubilization conditions and increasing the ... to find out possible differences in binding of ICAM-4 and the other two ICAMs for the I domains Many of these mAbs displayed similar inhibitory profiles in assays investigating the effects of the ... binding of cells to BSA was substracted The results are expressed as a relative percentage of bound cells, where 100% is given as the total number of cells bound to the CD18 integrins in the absence...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... affected the poultry sectors The countries also differ in various other factors, including the size and structure of the poultry sector, reliance of the poor on poultry, and the levels of diversification ... is found to be the most appropriate model to describe the determinants of the size of flock managed by the households In the logit component of the ZINB model (inflate panel), only the significant ... shocks (all other scenarios), as well as the impact of the supply shocks on poultry keepers of different scales The duration of the livelihoods impacts of these shocks are assumed to be one year...
Ngày tải lên: 21/02/2014, 01:20
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... 3B) The pK2 increased as the size of the residue at position 169 increased The effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of ... below pH 6.0 due to the protonation of His57 Ne2 These results not contradict the pH-activity profile of API shown in Fig Ion strength dependence of the pH-activity curve of API The pH-activity ... The parallel orientation of the imidazole–indole pair formed between Trp169 and His210 is the first case found in the active sites of serine proteases Although the role of a proton donor for the...
Ngày tải lên: 21/02/2014, 03:20
Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx
... solution of the crystal structure of Mls1p could also turn out to be helpful in elucidating whether the protein's selective import into peroxisomes might have something to with the exposure of the ... molecular mass of 62 000 in the lane with the wild-type extract that was absent from the lane corresponding to the mls1D mutant (arrow; Fig 1A), thereby con®rming the speci®city of the antibody ... Targeting of Mls1p to peroxisomes is advantageous for growth on oleic acid Two steps of the glyoxylate cycle take place in the cytosol: the splitting of isocitrate into succinate and glyoxylate, and the...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... The fatty acid is then transferred onto the acyl carrier protein DptF The C domain of DptA is predicted to catalyse the condensation reaction between the fatty acid and tryptophan S DptA daptomycin ... damage to eukaryotic cells For incorporation of the fatty acid moiety into nonribosomal peptides, condensation of the fatty acid with the N-terminal tryptophan of the nonribosomally synthesized ... 4¢-phosphopantethein group of DptF The observed substrate tolerance for loading a variety of fatty acids onto the ACP will facilitate future projects on the manipulation and combinatorial biosynthesis of...
Ngày tải lên: 07/03/2014, 04:20
THE ECONOMIC CONTRIBUTION OF WISCONSIN PUBLIC LIBRARIES TO THE ECONOMY OF WISCONSIN pptx
... contribute to the Wisconsin economy and are of growing importance to the citizens of the state The total economic contribution of Wisconsin public libraries to the Wisconsin economy is $753,699,545 The ... libraries contribute to the Wisconsin economy The other measure of value is the market value of public library services to consumers, businesses, governmental bodies and other sectors of the economy This ... chapter extends the analysis of the economic value of public libraries to the market value of services provided to the citizens of Wisconsin by Wisconsin’s public libraries The use of market value...
Ngày tải lên: 08/03/2014, 08:20