Ngày tải lên: 12/08/2014, 04:20
Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt
... binding of ACP to the docking site followed by a conformational change in ACP proposed to inject the acyl chain into the sub- strate-binding pocket [32]. If a similar mechanism is involved in ... chains. Both have been implicated in the binding of ACP [2], probably by donating hydrogen bonds to one of the carbonyl oxygens in malonyl-ACP, thereby stabilizing charge relocalization during ... all point to the orientation of H333 and its hydrogen bond donor properties as being the cornerstone of obtaining and ⁄ or retaining residual decarboxylase activity. The emerging picture of well-defined...
Ngày tải lên: 19/02/2014, 08:20
Human Capital and the Development of Financial Institutions: Evidence from Thailand docx
... effective monitoring of bank managers. The village banks that are the focus of this paper are examples of micro finance institutions. Micro finance institutions have been the focus of much interest and ... to financial sustainability. 6 Many, perhaps most, micro finance institutions operate with substantial professional help and support which adds of course to the expense of operating these institutions. On ... participation in savings banks and an analogous variable for saving in the case of the estimates of participation in banks which make loans. Membership in Savings Institutions in the Northeast Table...
Ngày tải lên: 06/03/2014, 10:20
Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
... 43.43% (E75G) lower than that of the wild-type protein, suggesting that Glu residues at positions 75 and 129 play key roles in maintaining the native structure of the protein. Furthermore, two mutants, ... destroyed. In addition to E75 forming a local stable area in SNase, in this study we searched for the existence of other local stable segments that may play similar key roles in sustaining protein native ... alkaline unfolding states of staphylococcal nuclease. J Mol Biol 220, 771– 778. 19 Chen HM, Markin VS & Tsong TY (1992) pH induced folding ⁄ unfolding of staphylococcal nuclease: Determin- ation...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
... calmodulin and PtdIns3K. In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50]. Involvement of Rac in ROS ... switch of a 5 b 1 integrin in CHO cells, suggesting also a role for Ca 2+ /calmodulin-dependent molecules in regulating the affinity state of integrins on neutrophils [48]. Although PtdIns3K has ... elevation of [Ca 2+ ] i are in themselves insufficient in the protection of neutrophils against apoptosis. DISCUSSION In this study, the role of Ca 2+ and its downstream effector calmodulin in G-protein-coupled...
Ngày tải lên: 08/03/2014, 10:20
Role of C-Reactive Protein and Procalcitonin in Differentiation of Tuberculosis from Bacterial Community Acquired Pneumonia potx
... examination, and radiographic findings. Therefore, CRP and PCT might have a role in the diagnostic algorithm as rapid, noninvasive tests. No difference was observed in the discriminating power of ... C-reactive protein: a critical update. J Clin Invest 2003;111:1805-1812. 30.Dandona P, Nix D, Wilson MF, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79:1605-1608. 31. ... variable time interval from the onset of symptoms before evaluating PCT and CRP might have affected the results because of the kinetics of each inflammatory marker [29,30]. Considering this point, a...
Ngày tải lên: 22/03/2014, 18:20
CENTRAL BANKING, FINANCIAL INSTITUTIONS AND CREDIT CREATION IN DEVELOPING COUNTRIES ppt
... constraints of domestic credit financing discussed above into account for explaining the two impressive cases of catch-up-growth in China and Germany, we see thus that China has been in fact in ... increase in domestic employment, further increasing aggregate income. However, as households save part of their income, also aggregate saving increases, providing the ex post finance of the initial ... protect the purchasing power of savings by offering indexed products or some interest payments on savings. Widening the view towards other countries not in the group of high investment-to-GDP...
Ngày tải lên: 22/03/2014, 20:20
Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
... fragmentation using mass spectrometry, by incubating Grx2 in standard buffer for 30 min or 2 h in the presence of n-PT. After incu- bation, standard Grx2 and fragments recovered by fil- tering the incubation ... glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cel Biol 19, 8180–8190. 19 Gan ZR (1992) Cloning and sequencing of a gene encoding ... degree of purity and absence of A B C Fig. 6. Stimulation of Grx2-dependent proteasome deglutathionyla- tion by cardiolipin. (A) Increased degradation of Grx2 in the pres- ence of cardiolipin...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Role of conformational flexibility for enzymatic activity in NADH oxidase from Thermus thermophilus pptx
... rate-limiting step in enzyme catalysis. This information may indicate a suitable amino-acid residue in the active site as a target for protein engineering that could result in activation of the enzyme ... the flavin cofactor is possible only in the dimeric structure of NADH oxidase. None of the tryptophan residues is close to the binding site of the flavin cofactor in the monomeric form of the enzyme ... quantum yield of tryptophan fluorescence in NADH oxidase shows efficient quenching of the trypto- phan residues in the protein. Such quenching can be the result of interactions with the flavin cofactor,...
Ngày tải lên: 23/03/2014, 15:21
Role of Non-Steroidal Anti-Inflammatory Drugs in Gynecology potx
... during, labor. Increased COX-2 expression precedes the onset of labor, suggesting that it may be involved in the initiation of labor, and in the increase of prostaglandin synthesis within the ... administration of antenatal indomethacin within 72 hours prior to delivery in premature infants. Necrotizing enteroclitis with administration of antenatal indomethacin in premature infants.This ... membranes at term [23]. The increase in prostaglandin during labor causes increased uterine contractility and inhibitors of prostaglandin synthesis delay the onset of labor [24-26]. NSAIDs...
Ngày tải lên: 28/03/2014, 14:20
Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... obtained by sequential exposure of cells to increasing concentrations of doxorubicin and was maintained in the presence of 0.5 lm doxorubicin. 2008 parental cells and their MRP1 over-expressing ... active uptake of TMRM into the mitochon- dria interferes with the second phase of TMA-DPH quenching (Fig. 2). Initially, there is significant inhibi- tion of the quenching in the respiring cells, ... up into cells accumulate in the cytoplasmic leaflet prior to being released into the cytoplasm. In the latter case, Pgp functioning as a flippase will have the added advantage of capturing incoming...
Ngày tải lên: 29/03/2014, 08:20
Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the fibrin polymerization process pdf
... the bC-domain in a ‘knob’–‘hole’ type of interaction [7,9]. The remain- ing part of site ‘C’ (Bb19–46) probably remains bound to the fibrin D-domain. To determine the localization of a complementary ... The curve of increasing turbidity during fibrin clotting shows the following parameters: s, the lag-time, which corre- sponds to the time of protofibril formation; V max , maxi- mum rate of fibrin polymerization, ... concentration of fibrinogen of 0.1 mgặmL )1 and a nal concentration of thrombin of 0.4 NIH unitsặmL )1 in the same polymerization medium. Electron microscopy The samples of polymerizing fibrin desAABB in...
Ngày tải lên: 30/03/2014, 03:20
Báo cáo khoa học: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage potx
... drug cisplatin, indicating that all three proteins may oper- ate as a functional unit in vivo, playing a role in the cisplatin response [9]. Cisplatin interferes with DNA function by causing intrastrand ... and interstrand cross- linking of nucleotide bases and, in replicating cells, DNA damage usually induces an intra-S-phase cell cycle arrest. Accordingly, we show in this article that treatment of ... presence of ionizing radiation [12], and in the present study, in the absence and the presence of cisplatin. In addition, we showed that Pph3p directly or indirectly binds to cH2AX, indicating that...
Ngày tải lên: 30/03/2014, 04:20
The Role Of The United States Postal Service In Public Safety And Security doc
... Security Training. USPS training is aimed at detecting and preventing mail crime, ensuring the security of the mail, and maintaining public safety. e safety and security of the mail at the point ... risk of increase for certain types of mail crime in particular, suspicious or hazardous incidents involving the mail. Summary Currently, the USPS and IS are doing much in the area of training ... percent of training is done by pay location, the data in USPS’s National Training Database (NTD) do not permit us to break down the number of employees by type of training course. In general,...
Ngày tải lên: 30/03/2014, 13:20
The Role of the Intensive Poultry Production Industry in the Spread of Avian Influenza pptx
... main risks in the spread of H5N1, how did a country of backyard farms, in the middle of the worst affected zone, see 93% of its outbreaks concentrated in intensive farms? Interestingly, in ... receptor binding properties of the 1918 influenza hemagglutinin. Science 303(5665): 1838-1842. GRAIN. 2006. Fowl play: The Poultry Industry’s central role in the bird flu crisis. GRAIN briefing. ... main vector Whilst wild birds may have played a role in the spread of H5N1, they are far from being the main culprits. Following the discovery of H5N1-infected migrating wild birds in Qinghai...
Ngày tải lên: 31/03/2014, 08:20
the role of ''too big to fai'' status in bank merger activity
... oversight role of the market in assessing the risk of banking institutions. The moral hazard created by the safety net enables banks to increase the risk of their investments without having to increase ... most profitable ventures first so the marginal benefit of funds decreases as assets increase. Banks maximize profits at the point where the marginal cost of raising funds equals the marginal ... Improvement Act (FDICIA) the method of pricing deposit insurance acted to offset some of the reduction in marginal borrowing costs resulting from the safety net. Deposit insurance prior to the reforms...
Ngày tải lên: 03/06/2014, 02:17
báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
Ngày tải lên: 20/06/2014, 04:20
báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
Ngày tải lên: 20/06/2014, 07:20