... more concentrated range of asset classes and the risk of a further credit crunch as a consequence of over -regulation A further area of uncertainty focuses on the impact ofthe new regime on smaller ... This raises the question of whether corporates, while attracted by the idea of greater security, fully understand the potential implications of an over-capitalised insuranceindustry for their future ... Williams of Legal & General makes the point that large insurers with a range of products have the resources to absorb additional overhead costs, and that at the other end ofthe spectrum the industry...
... price If patients want the brand, they must pay the difference between the MAC and the cost ofthe brand (plus any other co-payment) Thus the main customers of generic firms are the large pharmacy ... with the growth in number of drugs and with insurance coverage At the time ofthe 1962 Amendments, there were far fewer drugs on the market and virtually all consumers paid out of pocket Hence the ... III Effects of Safety and Efficacy Regulations: Evidence and Issues 18 Costs ofRegulation Much ofthe early economic analysis of pharmaceutical regulation focused on effects ofthe 1962 Kefauver-Harris...
... 2012)) The main references for theindustry are theInsurance Act No 553 (Act of Malaysia) of 1996 and 1996 Insurance Regulations amended in 2005, which includes the structure ofthe licensing, regulation ... efficiency oftheindustry itself to cater specific issues including the issues of fraud in theindustry Besides, the Central Bank of Malaysia (Bank Negara Malaysia abbreviation of BNM), is the main ... set the tone ofthe country‘s norms and traditions This will lead to the inclusion ofthe case study companies‘ introduction and their performance in theinsuranceindustry It will include the...
... used by at least the elites of almost every recorded human society, with the emergence ofthe modern commercial beauty industry in the nineteenth century Although the origins oftheindustry lay ... part of everyday life for many people There were multiple drivers behind the growth ofthe beauty industry during these decades The world wars introduced millions of soldiers to the importance of ... pharmaceutical company Hoffman La Roche, which had a large vitamin business, entered the personal care industry when the synthesis ofthe vitamin pathenol led to the development ofthe hair lotion Pantene.18...
... to the right ofthe decimal is less than (4, 3, 2, 1, or 0), then ignore all digits after the second one to the right ofthe decimal Example: In the number 98.74285, the third digit after the ... digits to the right ofthe decimal place, for example, 98.74 rather than 98.74285 To round off to two decimal places, you must examine the third digit to the right ofthe decimal ● If the third ... the use of or inability to use the work, even if any of them has been advised ofthe possibility of such damages This limitation of liability shall apply to any claim or cause whatsoever whether...
... activities of HSF1, HSF2 and HSF4 As the functions ofthe HSF family members differ, so also the molecular mechanisms by which they are regulated Albeit they all recognize and bind HSEs, theRegulation ... altered [88] These results shed light on the regulatory mechanisms steering the developmental expression pattern of HSF2, and they also provide the first example of involvement of miRNAs in the HSF ... development ofthe lens and maintenance ofthe olfactory epithelium [102] The first evidence for a developmental function of HSF4 was provided by population genetic studies where mutations ofthe Hsf4...
... and the use ofthe designation "European Venture Capital Fund" should be sanctioned by the prohibition ofthe use ofthe designation and the removal ofthe venture capital fund manager ofthe ... threshold of EUR 500 million or, in the Member States where the Euro is not the official currency, the corresponding value in the national currency on the date ofthe entry into force of this Regulation ... decision of revocation shall put an end to the delegation ofthe power specified in that decision It shall take effect the day following the publication ofthe decision in the Official Journal of the...
... remained in the pellet independently ofthe other components and the ionic strength ofthe mixture In the presence of ATP, the amount of bound HMM was very similar (average value of 52.5 ± 1.1%) ... solution On the other hand, the acceleration ofthe sliding velocity (and the lower number of stops) of thin filaments could be related to a diminution ofthe load in the actin–myosin interface The properties ... movement in the absence of Ca2+, independent ofthe addition of T800 This result, together with the fact that T800 increased the average and maximum velocity values of moving filaments, both in the absence...
... or indirectly ofthe use and application of any ofthe techniques or contents of this report If legal advice or other expert assistance is required, the services of a competent professional should ... In relationship to the consumer, the credit bureaus not concern themselves with the impact ofthe information This information often misrepresents the credit worthiness ofthe consumer By tagging ... our offices, we have noticed a high incidence of file mergers -the worst kind of file error In a file merger, the credit of another person with a similar name is spread onto the file ofthe innocent...
... the RNA content and cDNA synthesis in the different preparations Furthermore, the PCR primers for glyceraldehyde3-phosphate dehydrogenase and FAAH were selected on the basis ofthe sequence of ... view of these considerations, our findings should warrant further studies on the pharmacological effects of THC, endocannabinoids and PalEtn on dendritic cells, and on the possible regulationofthe ... marrow stem cells, are the most potent antigen-presenting cells ofthe immune system They play a central role in the initiation of primary immune response and in the enhancement of secondary immune...
... control of ligand binding [86] This is a result ofthe interaction ofthe distal segment ofthe JM, particularly the E663–S671 residues, with the C-terminal lobe ofthe kinase domain ofthe apposed ... Nck [72] The binding of these proteins could prevent the interaction ofthe Ca2+ ⁄ CaM complex to the receptor if the CaMBD were occluded at least in part Nevertheless, the docking of these adaptor ... activation ofthe EGFR, where the C-terminal lobe ofthe kinase domain of one ofthe monomers forming the dimeric receptor interacts with the N-terminal lobe ofthe apposed monomer [19,47,84] Of relevance...
... because the demand ofthe chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin ofthe signal, and thus regulation at the Tic complex could be one ofthe fastest ways to ... which anchor the protein in the membrane The position and function ofthe long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic ... is the recruitment of FNR from the stroma or even thylakoids to the Tic complex in order to become part ofthe hypothetical electron transfer chain mentioned above However, the involvement of the...
... Proposal for a REGULATIONOFTHE EUROPEAN PARLIAMENT AND OFTHE COUNCIL on the Cohesion Fund and repealing Council Regulation (EC) No 1084/2006 THE EUROPEAN PARLIAMENT AND THE COUNCIL OFTHE EUROPEAN ... transmission ofthe draft legislative act to the national Parliaments, Having regard to the opinion ofthe European Economic and Social Committee6, Having regard to the opinion ofthe Committee ofthe ... increasing the use of conditionalities and simplifying the delivery are among the major hallmarks ofthe proposal This Regulation sets out the provisions governing the Cohesion Fund, and repealing Regulation...
... hydrogenase of a photosynthetic eukaryotic cell, represents a novel type of Fe-hydrogenases Parts ofthe deduced amino-acid sequence ofthe cDNA correspond to the polypeptide sequence ofthe tryptic ... addition to the detection ofthe protein using antibodies raised against the Fe-hydrogenase, the localization ofthe mature protein in the chloroplast stroma is indicated by a high content of hydroxylated ... [50,51] Anaerobic treatment of maize seedlings alters the profile of total protein synthesis [52,53] It is known that the induction ofthe anaerobic proteins is the result of an increased mRNA level...
... authority ofthe Member State in whose territory the investigation is to be carried out ofthe investigation and ofthe identity ofthe authorised persons Officials ofthe competent authority ofthe ... provisions oftheRegulation have been breached The fine shall be dissuasive and proportionate to the nature and seriousness ofthe breach, the duration ofthe breach and the economic capacity ofthe ... committed a breach oftheRegulation Those measures include the temporary prohibition ofthe issuing of credit ratings and the suspension ofthe use ofthe credit ratings concerned until the infringement...
... in the sigG mutant The aforementioned result is expected in view ofthe downregulation of sigH and the upregulation of sigD upon the deletion of sigG in M tuberculosis [90] This finding further ... replication in the lung during the short-term infection of mice [109,110], the negative regulationof their synthesis by rM negates the possibility of its role in virulence during the early course of infection ... FEBS 607 The r-factors of M tuberculosis P Sachdeva et al the decreased levels ofthe sigA transcript might reflect a decrease in the mRNA pool relative to the total RNA ofthe cell [24] The sigA...
... 2.4.6 Positive Impacts ofthe Cruise Industry It is important to comment on some ofthe positive impacts ofthe cruise industryTheindustry contributes to the economy of destination areas For ... about ways to minimize their impact on the environment The fragmented nature ofthe tourism industry is not conducive to regulation that encompasses all aspects oftheindustry Therefore, educational ... INFLUENCE The previous section discussed the direct and indirect impacts of selected aspects ofthe tourism industry This section first presents the structure of selected components ofthe industry, ...
... majority ofthe studies have been done on the GnRH-I promoter, and there are only a few regarding regulationofthe GnRH-II gene Regulationof GnRH gene expression The GnRH-I promoter In view ofthe ... transfection studies on the hGnRH-II promoter construct coupled to luciferase Self -regulation of GnRH gene The role of GnRH in theregulationof synthesis and secretion of gonadotropins in the pituitary ... employed, they are unlikely to resemble the actual complexity of gene regulation in the brain or other organs Only recently has the development of various transgenic mice enabled the investigation of...
... [18–20] Other studies have suggested that the binding of p65 to the cofactors renders them unavailable for gene activation [20–22] In the context ofthe GnRH II promoter, there is a cluster of enhancing ... for the repression of GnRH II gene in TE671 cells On the other hand, over-expression of RARs together with the application of RAs in JEG-3 cells led to significant (P < 0.001) alleviation ofthe ... target gene repression [35,41] The present study discusses the transcriptional regulationofthe hGnRH II It is also the first report of differential regulationofthe gene in two GnRH IIexpressing...
... interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 ofthe iron box), explaining theregulationof desA expression by binding of DmdR1 to the iron box The same ... cluster expression ofthe des cluster is mediated by the DmdR1 regulator Results Deletion ofthe desA gene of S coelicolor blocks desferrioxamine biosynthesis The organization ofthe putative desferrioxamine ... extension analysis ofthe transcription start (TS) point ofthe S coelicolor desA promoter Comparison ofthe reaction sequences ofthe promoter region (T, G, C, A) with that ofthe primer extension...