qol study in breast cancer patients 54

... BC patients (Continued) n Age (years) mean 55.6 Patients? ?? clinical characteristics n Breast Cancer sub-types** 50 11 Luminal B 10 Triple negative Her2/neu overexpressing TNM (stage) 1 10 Clinical ... immunosurveillance of the T and APC compartments in cancer patients with clinical tumor response to Doxorubicin, in the present work we studied a group of 17 patients with BC in neoadjuvant therapy (three cycles ... (GE) and cryopreserved in liquid nitrogen in freezing media (RPMI-1640 50%, FBS 40% and 10% of DMSO) until used Clinical data of the included patients is shown in Table 1; clinical response was...

Ngày tải lên: 24/07/2020, 00:17

... parental relations (including attachment patterns) can influence interactions with healthcare professionals in breast cancer patients [24–29], thus suggesting that they may modulate more in general adjustment ... Denial may result in delay for undergoing breast biopsy in the suspect of breast cancer, while its use is associated with reduced distress in women with a diagnosis of breast cancer [12] Denial ... coping and defense mechanisms in breast cancer patients: an observational study Chiara Renzi1*, Giada Perinel1, Paola Arnaboldi1, Sara Gandini2, Valeria Vadilonga1, Nicole Rotmensz2, Angela Tagini3,...

Ngày tải lên: 10/01/2020, 13:42

... BMC Cancer (2020) 20:255 https://doi.org/10.1186/s12885-020-6639-4 RESEARCH ARTICLE Open Access Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients ... Keywords: Lapatinib, Trastuzumab, Resistance, Breast cancer Background Breast cancer is one of the most common invasive cancers and is expected to account for 14% of all cancer deaths in women worldwide ... rate during treatment was 5.9% in the LX group and 12.5% in the TBP group (P = 0.018) Conclusion: The combination of lapatinib and capecitabine showed a prolonged PFS relative to TBP in patients...

Ngày tải lên: 17/06/2020, 03:16

... (BCSS) in patients with breast cancer who received NAC Methods: We retrospectively studied patients who received NAC and subsequent surgical therapy for stage II–III invasive breast carcinoma ... with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study Yi Chen1,3, Kai Chen1,3, Xiaoyun Xiao2,3, Yan Nie1,3, Shaohua Qu1,3, ... of invasive breast cancer to NAC was analyzed Survival analysis was used to evaluate the predictive value of NLR Results: A total of 215 patients were eligible for analysis The pCR rate in patients...

Ngày tải lên: 21/09/2020, 01:24

... (decreased interest in sex, weight gain, feeling of tension in breast, mood swings, abdominal bloating, vaginal dryness, bone fracture, pain during sexual intercourse, cataract) resulting in a total ... Diagnosis and treatment are initiated independently of the study according to the German breast cancer guidelines by the interdisciplinary tumor board of the breast cancer center Patients are required ... chemotherapy, if indicated Patients are screened for eligibility during their hospital stay in the breast cancer center Women meeting the inclusion criteria are informed about the study concept and invited...

Ngày tải lên: 05/11/2020, 06:11

... < 0.025) in comparison to the non-irradiated skin thickness investigating chronic skin reactions. Patients with grade 2 acute skin toxicity presented with thinner skin as compared to patients ... skin in vivo for postmastectomy breast cancer patients with radiation i nduced fibrosis. Therefore, this study aimed to (1) measure chronic skin changes quan- titatively using u ltrasound, in patients ... determine if there is any correlation between late skin findings and acute visible changes using the RTOG scoring criteria in postmastectomy patients. Materials and methods Patients This study...

Ngày tải lên: 09/08/2014, 09:20

... cells proliferation In particular, they were found to cleave insulin-like growth factor binding proteins (IGFBPs), thus releasing, in this way, the mitogenic role of insulin-like growth factors ... (PSA)/KLK3, in male population screening, early diagnosis and monitoring of prostate cancer patients Nowadays, breast cancer represents the most frequently diagnosed carcinoma and the second leading ... cancer patients, aiming to examine its clinical value for the discrimination of the cancerous from non-cancerous breast lesions Materials and methods Breast tissue specimens and study population...

Ngày tải lên: 13/08/2014, 13:20

... decreased in the serum of breast cancer patients after surgery [27, 28] indicating that PSA derived from breast cancer tissues can be detected in serum In our study, the above findings indicate ... value in breast cancer patients and healthy controls sPSA value in post-menopausal breast cancer patients In present study, 132 healthy controls (53.8% were postmenopausal) and 144 breast cancer patients ... (AR) signaling plays a significant role in subsets of breast cancer Clinical trials testing AR-targeting therapies in breast cancer have been conducted Assessment of AR-signal in breast cancer tissue...

Ngày tải lên: 17/06/2020, 18:57

... in all breast cancer patients with different subtypes Additional file 2: Figure S2 Survival curves for the ER+ and ER- breast cancer subset A ER+ breast cancer patients; B ER- breast cancer patients ... important determinant of survival in HER2 negative rather than HER2 positive breast cancer patients Also in our study, RFS, OS and DMFS were better in TP53 wild-type breast carcinomas patients with ... M, Sepporta MV, Badalamenti G Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast CancerProgression: a Preliminary Report Cancer Investig 2016:1–9 PMID: 27636861...

Ngày tải lên: 17/06/2020, 18:59

... allele in normal tissue of cancer patients 56 p53 mutation in breast cancer population 57 Percentage of p53 mutation in breast cancer population 58 Expression of Gadd45 promoter in H1299 cell line ... polymorphism in preventing skin cancer 124 4.3 Effect of p53 polymorphism in melanin synthesis 124 4.3.1 p53Pro may protect individual from UV-induce stress 126 4.3.2 p53Arg allele predispose to skin cancer ... breast cancer patients 114 4.1.3 Association of p53Arg allele in breast cancer susceptibility 115 4.1.4 Mutation of p53 in breast cancer 116 4.1.5 Wild-type p53Arg form may predispose to breast cancer...

Ngày tải lên: 15/09/2015, 17:10

... primary infecting serotype can undergo altered signaling resulting in faulty cytotoxicity for DENV infected cells but instead shift to produce more inflammatory cytokines including gamma interferon ... (VH domain) and three constant domains (CH1, CH2 and CH3 domains) L chains contain a variable domain (VL domain) and a single constant domain (CL domain) The complementarity-determining regions ... from those in adults, with cough, vomiting and abdominal pain more common in children (Hanafusa et al., 2008) In a study conducted in a Vietnamese cohort, mortality rates observed in young children...

Ngày tải lên: 09/09/2015, 08:16

... contain long amino acids (aa) in the range about 750-850 They are composed by six conserved distinct functional domains, including an N-terminal domain, a coiledcoil domain, a DNA binding domain ... POU domain are N-terminal and C- terminal domains that reveal little conservation The N-terminal domain (N-domian) is rich in proline and acidic residues while the C-terminal domain (C-domain) is ... consisting of gp130 and the LIF receptor (LIFR) Normally, the tyrosine kinase JAK is inactive by binding to the intercellular domain of this gp130/LIFR complex Upon LIF binding, JAK kinase phosphorylates...

Ngày tải lên: 14/09/2015, 13:38

... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... domains, including an N-terminal STAT protein interaction domain, which strengthens interactions between STAT dimers on adjacent DNA-binding sites, a coiled-coil STAT protein all-alpha domain, ... STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3 In addition, for stat6 and...

Ngày tải lên: 16/02/2014, 09:20

... from swine, which showed clinical symptoms of FMD, in Fujian province of China (OIE, May 1999) The grinding suspension (1/10, w/v) was prepared in phosphate buffered saline (PBS) containing the ... heparin binding sites and antigenic site on the viral capsid may influence plaque size and the pathogenicity to suckling mice Discussion The PanAsia strain of FMDV serotype O originated in India ... cell-adapted PanAsia strain (O/Fujian/CHA/5/99) of FMDV isolated from swine in Fujian province of China in 1999, perform plaque assay and estimate the pathogenicity in suckling mice, determine the complete...

Ngày tải lên: 12/08/2014, 01:21

... P8A cell lines and absent from ICR-A cell lines Expression in R1A cell lines was significantly less than in P8A lines These data correlate with the findings in SAMR1 and SAMP8 brains in which ... are explained by generation of neurotoxins, mainly inducible nitric oxide (iNOS) from glial cells [30,31] Astroglial cells in healthy brain not express iNOS however iNOS is induced in both mice ... was merged with GFAP staining In accordance with Western blot analysis, the amount of CAgag staining was less in R1A cell lines than in P8A cell lines The difference in color of the merge pictures...

Ngày tải lên: 13/08/2014, 05:21

... and TGF-alpha in the cHCC cell line, which is in accordance with findings in human HCC [16] Binding of HGF to c-MET triggers tyrosine autophosphorylation of the intracellular domain in the c-MET ... cMET C-terminal part of canine cMET C-terminal part of canine cMET C-terminal part of canine cMET Serum albumin Serum albumin Ceruloplasmin Ceruloplasmin alpha-fetoprotein alpha-fetoprotein CCT TGG ... primary liver carcinomas [12] In our study, we detected an unknown point mutation near the tyrosine kinase domain, which results in a conserved change from a threonine to a serine Whether this...

Ngày tải lên: 13/08/2014, 13:20

... in pins mutant, no spindle uncoupling was observed, indicating that cortical Pins is required for spindle uncoupling phenotype When Pins-C-Pon is overexpressed in Gαi mutant, spindle uncoupling ... PAR6D PKCι/λ, PKCξ Gαo GPR-1/-2 Pins LGN, AGS3 Serine-threonine protein kinase Ring finger, PDZ Ser/Thr kinase Phosphoserine binding PDZ, semi-CRIB, PB1 Ser/Thr kinase, PB1 Heterotrimeric Gα subunit ... N-terminal region and three GoLoco motifs at the C-terminal TPR repeats are involved in protein-protein interaction, while GoLoco motifs are implicated in binding and regulating Gαi and Gαo proteins...

Ngày tải lên: 12/09/2015, 09:55

... replicon-carrying cell lines as described below 2.3.1 Maintenance of BHK-21 Cell Line BHK-21 cell line was maintained in ml of DMEM medium (Gibco) supplemented with 10% foetal calf serum (Gibco) (D10) in ... Kubo et al., 1993) S protein of SARS-CoV is 1255 amino acids long It is predicted to have a 13 amino acid signal peptide at the amino-terminus, a single ectodomain (1182 amino acids) and a transmembrane ... coronavius structural proteins, spanning the membrane bilayer three times, with a long carboxyl-terminal cytoplasmic domain inside the virion and a short amino-terminal domain outside (Holmes et al.,...

Ngày tải lên: 04/10/2015, 15:46

... of the following four distinct domains in Atrophin and related proteins, Fig 2.3(Shen, 2007) a) The extreme N terminus (a.a 1-200) amino acids is not present in Atrophin1 but only in Atro of Drosophilla, ... protein b) N terminus spanning the next 500 amino acids is essentially conserved in Atrophin1 and Atrophin2 c) Middle region, spanning the next 400 amino acids, is proline rich d) C-terminus, ... factors in these signaling cascades function together with Atro (Zhang, 2002) Figure 2.3 Domain architecture of Atrophin1 like protein red: Atrophin1 like domain; pink: Zinc finger domain; yellow,...

Ngày tải lên: 05/10/2015, 22:31

... Hexosamine was determined by the method of Blix (1948) with a glucosamine standard Phosphorus was determined using the molybdenum-H2SO4 method (Schinttger et al., 1959) Protein was determined according ... flocculating agents involving organic and inorganic compounds are widely used in wastewater treatment, dredging, and fermentation industries However, some of these substances such as inorganic compounds ... al., 1959) Protein was determined according to the method of Lowry et al (1951) using a standard of bovine serum albumin Nucleic acid and protein content in the gel filtration - 292 - Journal of...

Ngày tải lên: 05/09/2013, 09:08