pulmonary drug delivery systems for biomacromolecules

... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro ... used in drug delivery systems These functionalization methods provided candidate techniques, and there are great possibilities for them to be used in the construction of drug delivery systems ... suitable candidates for a nanoparticle-based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum warhead...

Ngày tải lên: 20/06/2014, 22:20

... Integrin targeted drug and gene delivery Expert opinion on drug delivery 2010; 7(2), 159-171 Wang Z., Chui WK Ho PC Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer ... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular targeting 15 1.3.2...

Ngày tải lên: 11/09/2015, 09:58

... Need for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... using drug delivery systems For drug delivery systems containing biodegradable polymers, the major motivations for clinical use have been to deliver drugs that are required for long periods, are ... Polymer Drug Conjugates A polymer drug conjugate is formed when a covalent bond is formed between a polymer and drug The physical properties of the molecule become dominated by 373 15 Drug Delivery Systems...

Ngày tải lên: 25/10/2013, 08:20

... nutraceuticals for cancer prevention, similar research is routinely accomplished in the search for new cancer drugs and drugs for other diseases Cell kinetics is the repetitive cycle (time) for cell ... Table 3.4 This information is similar to the information presented for a food ingredient/nutraceutical petition for FDA self-afÞrmed Generally Recognized as Safe (GRAS) status or for a health claim ... consume caffeine for performance Although sport beverages were originally designed for very competitive amateur and professional athletes, they are widely accepted as energy boosters for the average...

Ngày tải lên: 25/10/2013, 21:20

... Laser II Viral and non-viral delivery systems (Non-physical delivery methods) including: Biological gene delivery systems (viral vectors) Non-biological gene delivery systems (non-viral vectors) ... Page of 20 Figure Live/non-live delivery systems Live or biological gene delivery systems include viral and/or bacterial vectors Non-live or nonbiological delivery systems mainly include cationic ... nucleus for reporter gene expression advanced class of drug delivery systems, with several formulations in clinical trials Over the past 20 years, a variety of techniques have been developed for...

Ngày tải lên: 06/03/2014, 02:21

... Chemical Aspects of Drug Delivery Systems Table 5B Formulation systems for controlled drug release and drug targeting PARENTERAL AND PULMONARY ROUTES ADMINISTRATION ROUTE FORMULATION SYSTEMS INTRAVENOUS ... particulate formulations in terms of surface properties, such New Materials and Systems for Drug Delivery and Targeting Table 5A Formulation systems for controlled drug release and drug targeting ... Solutions for Controlled Release Coatings Manfred Penning 146 Information Requirements for Drug Delivery Systems Kassy Hicks 155 Subject Index 157 New Materials and Systems for Drug Delivery and...

Ngày tải lên: 28/03/2014, 10:20

... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ...  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered...

Ngày tải lên: 18/04/2014, 15:37

... carriers for drugs and biomacromolecules In: Gurny R, ed Nanoparticulate Drug- Delivery Systems 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 27 Challenges in Drug Delivery for ... properties and advantages when formulated as drug- delivery systems A brief description of each of the polymeric systems follows Hydrogel-Based Nanoparticulate Drug- Delivery Systems A progressively increasing ... platform is finding a place in drug discovery as well as NPDDS (27–31) DRUG- DELIVERY SYSTEMS An ideal drug- delivery system possesses two elements: the ability to target and to control the drug...

Ngày tải lên: 04/06/2014, 14:47

... research needed for the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure ... investigated for their use in cancer therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification...

Ngày tải lên: 20/06/2014, 00:20

... Marcel Dekker, Inc Foreword For new medications to be used effectively, and for those now available to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no ... ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal ... Mitra 251 III Drug Delivery Systems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular Drug Delivery Shiro...

Ngày tải lên: 10/08/2014, 00:20

... of drugs (61) Concentrations in retina were lower than those in aqueous for drugs that easily penetrate into the Copyright © 2003 Marcel Dekker, Inc General Considerations in Ocular Drug Delivery ... (1990) Ocular drug delivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and Drug Delivery ... consideration in topical ocular drug delivery Clin Exp Pharmacol Physiol., 27:558 Schoenwald, R D (1993) Ocular pharmacokinetics/pharmacodynamics, Ophthalmic Drug Delivery Systems (A K Mitra, ed.),...

Ngày tải lên: 10/08/2014, 00:20

... aqueous formation can also complicate the characterization of drug disposition As drug is absorbed and exerts the pharmacological effect resulting in decreased aqueous humor formation, for example, ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to ... weights ranging from 300 to 500 Da; therefore, Figure 14 (for a vitreous diffusivity of 5:6 Â 10À6 cm2 /s, 354 Da) will be representative of most drugs However, for smaller or larger compounds, the...

Ngày tải lên: 10/08/2014, 00:20

... times for atenolol Rabbit Enhanced Papp 1.7 times for atenolol, 2.9 times for carteolol, 2.3 times for timolol, and 1.6 times for befunolol Enhanced Papp 15.5 times for FDA and 39.0 times for FD-10 ... Concentration Drugs Animal Effect Enhanced Papp 29.1 times for acetazolamide, 16.3 times for guanethidine, >87.3 times for guanethidine, 31.3 times for cimetidine, 2.2 times for bunolol, and 2.2 times for ... for rational design of drug delivery systems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drug delivery across the conjunctiva...

Ngày tải lên: 10/08/2014, 00:20

... (1995) Review: Delivery systems for intraocular routes, Adv Drug Delivery Rev., 16:107–123 132 Velez, G., and Whitcup, S M (1999) New developments in sustained release drug delivery for the treatment ... basis of drug penetration via the noncorneal pathway The challenge for the future is to creatively apply the available knowledge to the practical design of drugs and drug delivery systems for ocular ... protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery...

Ngày tải lên: 10/08/2014, 00:20

... OCULAR DELIVERY OF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug ... future We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route REFERENCES Lee, V H L (1987) Ophthalmic delivery of peptides and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13...

Ngày tải lên: 10/08/2014, 00:20

... is straightforward and relatively simple to perform and bypasses the need for complex viral or non viral delivery systems Subretinal or intravitreal injections are common routes of delivery to ... Bispecific Mab aided liposomal drug delivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery vector for molecular medicine J Mol ... Limited capacity for foreign genes Requires helper adeno- or herpesvirus for replication Lack of specific integration for recombinant adenoassociated vectors (vira) lined rod cell function for a minimum...

Ngày tải lên: 10/08/2014, 00:20

... relevant—bibliography b For combination of drugs—Part 9a information for each drug c Foreign marketing i List of countries where marketed ii List of countries where drug has been withdrawn from marketing for reasons ... requirements for ophthalmic delivery systems in which a drug is incorporated in a carrier for its pharmacological effect on the human eye and is reviewed as a new drug product by the FDA’s Drug Center ... one-time fees for review of new human drug applications, user fees are also required on an annual basis for prescription drug manufacturing facilities and for approved prescription drug products...

Ngày tải lên: 10/08/2014, 00:20

... aqueous formation can also complicate the characterization of drug disposition As drug is absorbed and exerts the pharmacological effect resulting in decreased aqueous humor formation, for example, ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to ... weights ranging from 300 to 500 Da; therefore, Figure 14 (for a vitreous diffusivity of 5:6 Â 10À6 cm2 /s, 354 Da) will be representative of most drugs However, for smaller or larger compounds, the...

Ngày tải lên: 10/08/2014, 03:20