possible roles in angiogenesis endothelial dysfunction and diabetes mellitus
siRNA, miRNA and their possible roles in molecular therapy of chronic human hepatitis b virus infection and hepatocellular carcinoma
Ngày tải lên :
14/09/2015, 12:11
... of development and/ or progression of HCC still remain unclear and current approaches for screening and treatment of HCC remain disappointing In the next section, I will review the incidences of ... 60-70% of the incidences of HCC in Europe, 50-60% in North America and 70% in Japan In contrast, in the less developed countries, such as in Asia (except Japan) and Africa, HBV infection is the ... protein = HBV polymerase; L = large surface proteins; M= middle surface proteins; S = small surface proteins; TP: terminal protein During HBV infection in human, virus particles are present in...
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Effectiveness of PRECEDE model for health education on changes and level of control of HbA1c, blood pressure, lipids, and body mass index in patients with type 2 diabetes mellitus docx
Ngày tải lên :
05/03/2014, 22:21
... Patients meeting criteria for inclusion and not meeting any exclusion criteria were invited to participate, and were included after accepting and signing an informed consent form Methods Visits in both ... Researchers in the experimental group received training in the PRECEDE model before patients were included in the study This specific training involved two steps: first they were instructed about ... subsequently trained in the procedure to be used in the study in three sessions These covered the criteria for including/excluding patients, collecting variables, collecting biochemical/ Salinero-Fort...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... heat inactivated fetal bovine serum (FBS); 1% nonessential aminoacid, 1% sodium pyruvate and 1% antibiotic penicillin and streptomycin (all from Gibco, Scotland, UK) and were maintained under standard ... role of AEA in regulating 1) VCAM-1 expression in brain endothelial cells infected Page of 13 with TMEV and the possible receptors involved by using antagonists of the classical cannabinoid receptors, ... in the EAE model by administering the synthetic cannabinoid WIN 5,212-2 [23] In the TMEVIDD model we showed that WIN 5,212-2 at the time of virus infection inhibited brain VCAM-1 expression and...
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Báo cáo y học: "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis" pdf
Ngày tải lên :
09/08/2014, 06:23
... ADAMTS domain interacts with integrins The catalytic domains of ADAMTS proteinases share a high degree of similarity and contain the zinc-binding sequence HEXXHXXGXXH, in which the catalytic zinc is ... gene-6 and the complement proteins C1r, C1s and mannan-binding lectin-associated serine proteinases, among others [21], and there is evidence to suggest that these domains mediate protein–protein interactions ... metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs; for example ADAMTS-4) proteinases Note that most MMPs possess additional C-terminal extensions containing domains...
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báo cáo khoa học: " A review of co-morbidity between infectious and chronic disease in Sub Saharan Africa: TB and Diabetes Mellitus, HIV and Metabolic Syndrome, and the impact of globalization" pot
Ngày tải lên :
11/08/2014, 14:21
... diseases with examples including infective contributions to cervical, liver and stomach cancers, and possible infective triggers for some types of diabetes[ 2,3] In addition it is becoming clear that ... since 1950 Searches were undertaken in MEDLINE and EMBASE, plus screening of reference lists in identified articles Potentially relevant reports, bulletins and guidelines were also screened, including ... Sauerwein H: Zidovudine/lamivudine contributes to insulin resistance within months of starting combination antiretroviral therapy AIDS 2008, 22(2):227-236 Magula NP, Mayosi BM: Cardiac involvement in...
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Báo cáo y học: " Dimensionality and scale properties of the Edinburgh Depression Scale (EDS) in patients with type 2 diabetes mellitus: the DiaDDzoB study" pot
Ngày tải lên :
11/08/2014, 15:22
... by a decrease in hedonistic thoughts and an increase in sleeping problems, and to a lesser extent by an increase in feelings of panic and the feeling that things have been getting on top of oneself ... participated in statistical analysis and writing the manuscript; GN participated in data collection and preparation, and helped in writing the manuscript; VP participated in the design of the study, and ... helped in writing the manuscript; FP participated in the design of the study, and helped in writing the manuscript All the authors have read and approved the final manuscript Competing interests...
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60733 roles in the family idioms and conversation
Ngày tải lên :
27/08/2016, 15:24
... familyTo become independent from your mother.a match made in heavenChildren often suffer because of their parents’ mistakes When you think you’ll tie the knot? Who wears the trousers in your house? ... they targeted at? • What message are they trying to convey? • Is it wrong for women to embrace their masculine side or for men to embrace their feminine side? b g f c h a 7.e d 1.b 2.a 3.d 4.f ... a match made in heaven? Who’s the black sheep in your family? Who’s the apple of your father’s eye? Are you a chip off the old block? Do any of your family members fight like cat and dog? Is blood...
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Báo cáo khoa học: "Oxcarbazepine as monotherapy of acute mania in insufficiently controlled type-1 diabetes mellitus: a case-report" pdf
Ngày tải lên :
08/08/2014, 23:20
... comprising insulin (NPH) twice daily and rapid-acting regular insulin three times daily pre-prandially, followed by a regimen of NPH and very-rapid acting insulin analogue (lispro) pre-prandially ... DM since the age of 11 For her diabetes, she was initially treated with insulin (Novolente) once and then twice daily for 35 years Subsequently, she was administered an intensified insulin regimen ... control in a way that has been virtually impossible to achieve with exogenous insulin [4] A thorough clinical and laboratory pre-transplantation work-up was then performed, including CT and MRI brain...
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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt
Ngày tải lên :
09/08/2014, 07:20
... in the angiogenesis in RA synovium [13,14] All these VEGF isoforms bind to high-affinity receptors, namely VEGFR-1 (fms-like tyrosine kinase; Flt-1) and VEGFR-2 (kinase insert domain-containing ... synovial lining cells, endothelial cells of blood vessels and macrophage-like cells in the sublining layer of the RA synovium (Fig 5a,b), confirming the findings from in situ hybridization No staining ... in 2× standard saline citrate and twice in 0.2× standard saline citrate and blocking nonspecific binding with blocking solution (DakoCytomation Norden A/S, Glostrup, Denmark), they were incubated...
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Báo cáo y học: "Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis" pptx
Ngày tải lên :
09/08/2014, 06:22
... were invited to participate Only two patients refused, and the remaining 74 were included Patients receiving lipid-lowering and antidiabetic medications were excluded The baseline clinical and ... by endothelial cells in RA [4,31] Circulating cytokines could impair endothelial function directly [4] or through their effects on insulin sensitivity and on CRP and fibrinogen (a major determinant ... Biomarkers of endothelial dysfunction in RA patients and healthy control individuals We found that biomarkers of endothelial dysfunction were markedly higher in RA patients than in healthy control individuals...
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Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx
Ngày tải lên :
12/08/2014, 14:22
... receptor as prostaglandin I2 Iloprost is a potent IP receptor agonist that activates adenylate cyclase, resulting in an acute increase in intracellular cyclic AMP Such an increase in cAMP has profound ... collected in EDTA using a Vacutainer system (Becton Dickinson, NJ, USA) were drawn from patients before, and 72 hours after a single day or five days of being infused with iloprost for eight hours In ... FACS using anti-CD45 FITC, anti-CD146/CD31/CD34/CD133 PE and 7-AAD to confirm the endothelial origin and quantify the possible lymphocyte contamination RNA extraction We obtained CECs and EPCs...
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Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
Ngày tải lên :
25/10/2012, 10:02
... pre-existing increased insulin resistance and dysfunction of beta cells Insulin resistance is present in the acutely ill [13,15,18,28] in different intensity, but the factors determining the extent ... of cytokine-induced insulin resistance in obesity and other inflammatory settings Curr Opin Clin Nutr Metab Care 2002, 5:377-383 15 Marik PE, Raghavan M: Stress-hyperglycemia, insulin and immunomodulation ... mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: longterm results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
Ngày tải lên :
26/10/2012, 09:39
... Int J Med Sci 2010, 30 Introduction Diabetes mellitus and cardiovascular diseases are challenging medical and social problems Patients with diabetes mellitus are at a higher risk of developing ... NF-κB signaling might be associated with the pathogenesis of insulin resistance and type diabetes (48-51) In obesity and type diabetes it has been reported that antioxidants and IKK-B inhibitors ... and diseases such as type diabetes mellitus, obesity and the metabolic syndrome (30) In these conditions there is an elevation of both glucose and free fatty acid levels in the blood and an increase...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
Ngày tải lên :
16/02/2014, 14:20
... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain The DNA-binding domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLC terminal fragments High-mobility group (HMG) domains are involved in ... selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors [23] Similarly, in an independent study using a conditional...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
Ngày tải lên :
16/02/2014, 14:20
... ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the FYRC domain and the ... protein-binding platform for several other proteins to initiate a fundamental cellular process P-TEFb binds to the N-terminal portion of AF4, whereas the C-terminal portion of AF4 confers binding ... different signaling pathways, Role of MLL in human malignancies for example, protein kinase C, protein kinase A, RAS ⁄ RAF, WNT-, phosphatidylinositol 3-kinase and Hedgehog, and thus affects...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... (NOS) and NO synthesis, adhesion molecules, MCP-1 and M-CSF Adapted from Chudek and Wiecek [37] in adhesion molecules, and an increase in MCP-1 and M-CSF, causing endothelial injury and dysfunction ... hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52, 355–361 Wannamethee SG, Shaper AG, Morris RW & Whincup PH (2005) Measures of adiposity in the identification ... leptin, IL-6 and angiotensinogen, as well as reduced adiponectin levels This imbalance in such cytokines and adipokines results in increased nuclear factor kB It also results in a decrease in NO synthase...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
Ngày tải lên :
20/02/2014, 02:21
... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig 1B) in the active site for ligand and substrate binding For those ... arose resin a second chromatography step using the same resin was required (gradient of 15–150 mm NaCl contained in L buffer A) to obtain pure protein Redox potentiometry, ligand binding and stopped-flow ... be involved in ligand binding and counterpart residues in related enzymes and also the location of the tyrosine residue implicated as proton donor in OYE B constant for enzyme-ligand complexes,...
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Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives pptx
Ngày tải lên :
05/03/2014, 12:20
... 559-65 18 Cronin CC, Shanahan F Insulin-dependent diabetes mellitus and coeliac disease Lancet 1997; 349: 1096-7 19 Pocecco M, Ventura A Coeliac disease and insulin-dependent diabetes mellitus: a ... CD in Finnish healthy population *** The ratio was similar to prevalence of CD in diabetic Czech population (4.3%) and higher than in healthy population (0.69%) Prevalence of CD in T1DM and ... for IgAtTG Serum total IgA levels were within normal limits in these subjects Intestinal histopathology showed sub-total villous atrophy in the sibling (Marsh type 3c) Both parents refused endoscopic...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
Ngày tải lên :
07/03/2014, 03:20
... [4] We therefore introduced similar mutations in a and b, and analyzed the resulting activities and molecular forms produced by expressing the four cholinesterase combinations in COS cells This ... W8 and E9 together and separately; G13, N18, M22 and D23 together and separately; and N29 and D30 together, replacing these residues by the corresponding ones in a We also mutated KES to QDR, and ... protein–protein interactions [45], because their catalytic domain is homologous to adhesion proteins such as neuroligin [46,47] For example, AChE may be involved in neurite extension during brain...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
Ngày tải lên :
07/03/2014, 05:20
... overexpressing SMO cells further confirmed the increased SMO activity, with decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and ... oxidation of spermine to spermidine diminishes nuclear spermine pools Because spermine has essential roles in the the protection of DNA, including free radical scavenging and DNA shielding, this reduction ... media (Mediatech, Inc., Herndon, VA, USA) containing 9% iron-supplemented fetal bovine serum (Hyclone, Logan, UT, USA) and 1% penicillin and streptomycin Beas2B cells were maintained in LHC-9 serum-free...
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