planning operational scheduling and environment routing

... (TAM) and (B) paxlitaxel (PTX) 96 Figure 5.2 The free drugs (TAM and PTX), which have small molecular weight and is normally cleared rapidly from the blood, accumulate in both normal cells and ... of TAM and PTX from (A) TAM-TAT/FOL micelles and PTX-TAT/FOL micelles, and (B) TAM/PTX(0/6/1)-TAT/FOL micelles in PBS (pH 7.4) at 37ºC The experiments were conducted in triplicate The standard ... acid groups of co-polymers (PEG-PLA and FOL-PEG-PLA) and two anticancer drugs DOX and CDDP 120 Figure 6.2 Active targeting co-delivery of DOX and CDDP to cancer cells by the modification...

Ngày tải lên: 10/09/2015, 09:06

... outstanding advantages and challenges of the spray-drying method for the production of pure drug particles and drug-loaded polymeric particles and discusses the potential of this technique and ... MANUSCRIPT Advantages and challenges of the spray-drying technology for the PT production of pure drug particles and drug-loaded polymeric carriers SC RI Alejandro Sosnik1* and Katia P Seremeta2,3,4 ... or PVA, modified starch and maltodextrin) dissolved in D ultrapure water (0.1, and 10% w/w) [14] The micrographs of SEM showed TE homogeneous and spherical particles and the peak maxima of size...

Ngày tải lên: 02/09/2015, 13:31

... methods and instruments; followed by formulations, materials, and analysis of paint, plastics, adhesives, and inks; and finally reformulation methods to test the results of analysis Materials and ... tools, and materials such as polymers and pigments require corresponding instrumentation for identification and characterization such as infrared spectroscopy and X-ray diffraction The methods and ... 14.9.2 Waxes and Compounds 14.9.3 Lubricants and Greases 14.9.4 Reducing Oils and Solvents 14.9.5 Body Gum and Binding Varnish...

Ngày tải lên: 02/04/2014, 16:27

... publication in Macromolecules and was coauthored by H.R Allcock and D.A Stone Chapter has been adapted for publication in Chemistry of Materials and was coauthored by H.R Allcock and D.A Stone Chapter ... State Ionics and was coauthored by H.R Allcock and Y Chang Chapter has been adapted for publication in Solid State Ionics and was coauthored by H.R Allcock, R.M Morford, C.E Kellam III, and M.A Hoffmann ... opportunity to join his research program and for his constant support and guidance throughout my graduate studies The chemical knowledge, verbal and written presentation, and experimental skills which I...

Ngày tải lên: 13/11/2014, 11:13

... research fellow and mentor, for his invaluable guidance and insightful knowledge in continuum mechanics His passion and enthusiasm for research work was contagious and had been, and most surely ... understand how variations in temperature and moisture degrade mechanical properties of polymeric materials and adhesives and activate damage mechanisms which in turn lead to adhesive cracking and ... to predict the relation between crack advance and applied stress This method was also employed by Tvergaard and Hutchinson (1996) and Strohband and Dauskardt (2003) to study interface separation...

Ngày tải lên: 11/09/2015, 21:51

... their friendship and support, I have a wonderful time while I am far away from China Finally, I am most grateful to my parents and my brother whose love, support and understanding made this work ... anticancer activity against CFPAC, PANC-1, and Mia-Pa-Ca-2 pancreatic and HL-60 leukemia cell lines, and their antitumor activities have been evaluated in preclinical and clinical studies 70 Moreover, ... water soluble, biocompatible, and non-immunogenic; the spacer (and possibly also the polymer) has to be biodegradable; and the synthesis should be reproducible and inexpensive Polymers suitable...

Ngày tải lên: 12/09/2015, 08:20

... properties of the liposomes and the microspheres The LIM system could combine the advantages and avoid the disadvantages of the polymer-based and lipid-based systems, and open a room for new applications ... 50% glycolide and 50% dl-lactide degrades faster than either homopolymer [Stallforthe and Revell, 2000] Figure 1.1 Synthesis of PLGA 1.2.1.2 PLA and PEG copolymers Although the PLA and PLGA are ... more hydrophilic molecular structure and more amorphous state of the polymer, and smaller particle size and higher porosity of the polymeric microspheres [Edlund and Albertsson, 2002] By assuming...

Ngày tải lên: 17/09/2015, 17:20

... kinetic stability and stability in serum-containing medium The random distribution of acid and urea groups in polycarbonate block was favoured, and an optimal number of acid and urea functional ... with the scholarship and IBN for the financial support of my PhD research work Finally, this thesis would not be possible without the love and understanding from my family and friends during my ... polycarbonate (PUC) and PEG diblock copolymer to form unique and coherent mixed micelles via acid-urea hydrogen bonding interaction; and characterize the drug-loading capability and in vitro anticancer...

Ngày tải lên: 30/09/2015, 06:07

... fragility and oxidative damage of erythrocytes of zinc-deficient rats J Nutr 1997; 127: 1290–1296 Lajos N, Miki N, Sandor S Protein and non-protein sulfhydryls and disulfides in gastric mucosa and ... TCA and resuspended in 1.0 ml of M HCl for blank and M HCl containing 2% 2,4dinitrophenyl hydrazine After incubation for h at 37°C, protein samples were washed with alcohol and ethyl acetate, and ... gluteraldehyde Aldehyde was drained and rinsed times each of in phosphate buffer and post-fixed in osmium tetroxide for h After this, the samples were rinsed in distilled water and then dehydrated using...

Ngày tải lên: 25/10/2012, 11:40

... between bLG and AOT RM was carried out using CD, and steady-state and timeresolved fluorescence techniques In spite of the widespread use of the intrinsic fluorescence of Trp as a probe of microenvironmental ... appropriate fluorescence standards together with the standard provided with the instrument The quantum yields of NATA and bLG were determined relative to that of Trp alone, at pH 7.0 and in aerated aqueous ... for absorption at the excitation wavelength) and Fo and Fw are, respectively, the fluorescence intensities in the absence and Ó FEBS 2004 736 S M Andrade et al (Eur J Biochem 271) presence of...

Ngày tải lên: 07/03/2014, 15:20

... donor (TLL tryptophans) and an acceptor (fatty acid) is that there must exist a spectral overlap between the donor emission and the acceptor absorption spectra, and the donor and acceptor groups ... concentration Data from Fig Fig FRET between TLL (and its mutants) and cis-PnA in the presence and absence of NaTDC The protein concentration was 0.8 lM and the cis-PnA concentration was varied stepwise ... stereoview of OA binding modes in molecule A and B (OA_A and OA_B, respectively, thick lines); C9 and C10 correspond to the position of these atoms in the OA_A ligand, where the electron density was visible...

Ngày tải lên: 08/03/2014, 23:20

... properties and of the glass transition temperatures of the (A)n and (B)n homopolymers and of the (AB)n random and alternated copolymers and (BAB)n alternated copolymers has been achieved and showed ... led to an increased viscosity and difficulty in handling and degassing materials, producing remnant voids Nonetheless, Jang and other groups such as that of Sohn and Hu [28] showed that the use ... and 29 Si NMR spectroscopy The GPC analysis showed that high molecular weights were obtained (20 000–40 000) and the DSC and TGA analyses showed very low Tg s, in the range – 77 to – 80 ◦ C and...

Ngày tải lên: 02/04/2014, 16:28

... XXI Structure, Morphology, Physical Formats and Characterization of Polymer Supports Yolanda de Miguel, Thomas Rohr and David C Sherrington Synthesis and Molecular Structure of Polymer Supports ... Storer and Steven V Ley Introduction 53 Solid-supported Synthesis and Solution – Solution Manipulation Solid-supported Reagents and Catalysts 54 Supporting Materials 55 Facilitation of Work-up and ... Oxidation and Reduction Reactions 164 C-C Bond Formation Reactions 165 Palladium-Catalyzed Reactions 166 Grignard and Similar Reactions 168 Michael Reactions and 1,2-Addition Reactions 168 Wittig and...

Ngày tải lên: 03/04/2014, 12:15

... housed with free access standard food and tap water, and exposed to alternating 12 h periods of light and darkness Temperature and relative humidity were maintained at 25°C and 50%, respectively ... Page of alternating 12-h periods of light and darkness Temperature and relative humidity were maintained at 25°C and 50%, respectively All care and handling of animals were performed with the ... animals were provided with standard food and water ad libitum and were exposed to A certain volume of micelle solution was diluted with water to a definite volume in a flask and shaken gently to mix...

Ngày tải lên: 21/06/2014, 04:20

... (CoQ10 and GTCC), and the amount of lipid (CoQ10 and GTCC) was kept at a fixed concentration of 12.5% (w/w) with regard to the total mass of 100 g Briefly, CoQ10 and GTCC were mixed at 60°C, and then ... 10,000–50,000 and at a defocus of 3–5.46 lm 1563 by Image-pro plus software (Media Cybernetics, USA) The excitation and emission wavelengths were 549 and 628 nm for NR We selected green light and red ... lipid phase Several factors, e.g., type and concentration of lipids and surfactants [34], the viscosity of the lipid phase [24] and homogenisation pressure and cycle time [35], affected the mean...

Ngày tải lên: 21/06/2014, 17:20

... Chemicals Co Ltd., China) was dried over CaH2 and distilled under reduced pressure Triethylamine (TEA) and tetrahydrofuran (THF) were dried by CaH2 overnight, and then distilled under reduced pressure ... tetrahydrofuran (THF), ethanol, hydrofluoric acid, and other solvents used were all of analytical reagent grade and obtained from Tianjin Chemical Co., Tianjin, China, and were used without further purification ... collected by centrifugation, washed thoroughly with THF, and dried under vacuum Analysis and Characterization Elemental analysis (EA) of C, N, and H was performed on Elementar vario EL instrument...

Ngày tải lên: 22/06/2014, 00:20

... mother liquor and (b) PHPP-SMNPs Fig UV spectra of (a) PHPP, (b) PHPP mixed with SMNPs, (c) PHPP dissolved in HCl and ethanol, (d) SMNPs dissolved in HCl and ethanol, and (e) SMNPs and PHPP dissolved ... (d) indicated absorptions of SMNPs and HCl at 240, 314, and 364 nm, demonstrating that the 240, 314, and 364 nm peak of the spectrum (e) attributed to SMNPs and HCl Therefore, the 409 nm was the ... absorption of PHPP and SMNPs mixture was caused by the Fig 10 UV spectra of the PHPP-SMNPs treated with HCl and ethanol 123 406 Fig 11 The standard curve of PHPP dissolved in HCl and ethanol, measured...

Ngày tải lên: 22/06/2014, 01:20

... chloroform, methanol, and dichloromethanes were purchased from Acros Organics and used as supplied Fabrication of Ordered Nanodots and Nanowire Arrays PS-PVP and HABA (1 mol of HABA and mol of 4vinylpyridine ... action and hydrogen bonding, this ordered nanoporous template can be perfectly transferred, and thus achieved a methodology for the preparation of highly ordered sub-30 nm polymeric nanodot and ... h and keep h), to remove the PS-PVP and resulted ordered nanodots arrays (Fig 1) Nanoscale Res Lett (2009) 4:459–464 461 Fig Scheme of the fabrication of highly ordered polymeric nanodot and...

Ngày tải lên: 22/06/2014, 01:20

... developed and industrially applied, such as the Torrefaction and Rectification process in France [10, 50], the Thermowood process in Finland [49] and the Plato process in the Netherlands [7] This ... strength (parallel and perpendicular to the grain; respectively DIN 52185 and DIN 52192), and tensile strength (parallel to the grain; DIN 52188), and Brinell hardness (parallel and perpendicular ... model by Rowell and Winandy [55] They suggest that mechanical properties, which relates to internal stress and strain, are simply functions of chemical bond strength: covalent and hydrogen intrapolymer...

Ngày tải lên: 07/08/2014, 16:21

... using FT-IR and 1H NMR In the FT-IR spectra of the copolymer, the characteristic bands at 2875 cm-1 and 1100 cm-1 represent the C-H stretching and C-O-C band of PEG, respectively The band at 1726 ... treated cells on annexin staining suggested that 45.7 and 19.5% MCF7 and U87MG cells underwent apoptosis, whereas only 34.9 and 9.1%, MCF7 and U87MG cells were apoptotic after treatment with equivalent ... seeded (5.0 × 103/well) and incubated for 24 h in 96well plates Cells were incubated with various concentrations of VEV, free DOX and VEVDMs as indicated and incubated for 24, 48 and 72 h, respectively...

Ngày tải lên: 11/08/2014, 08:20