Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers

Ờ Å ỊÙ× Ư Ờ Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers Alejandro Sosnik, Katia P Seremeta PII: DOI: Reference: S0001-8686(15)00076-7 doi: 10.1016/j.cis.2015.05.003 CIS 1537 To appear in: Advances in Colloid and Interface Science Please cite this article as: Sosnik Alejandro, Seremeta Katia P., Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers, Advances in Colloid and Interface Science (2015), doi: 10.1016/j.cis.2015.05.003 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain ACCEPTED MANUSCRIPT Advantages and challenges of the spray-drying technology for the PT production of pure drug particles and drug-loaded polymeric carriers SC RI Alejandro Sosnik1* and Katia P Seremeta2,3,4 Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials NU Science and Engineering, Technion-Israel Institute of Technology, Technion City, Haifa, Israel Institute of Nanobiotechnology, National Science Research Council (CONICET), MA Buenos Aires, Argentina D Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, TE University of Buenos Aires, Buenos Aires, Argentina Department of Basic and Applied Sciences, Universidad Nacional del Chaco Austral, AC CE P Pcia Sáenz Peña, Chaco, Argentina *Corresponding author Prof Alejandro Sosnik, Ph.D Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology Technion City, 3200003 Haifa, Israel Email: alesosnik@gmail.com, sosnik@tx.technion.ac.il ACCEPTED MANUSCRIPT ABSTRACT Spray-drying is a rapid, continuous, cost-effective, reproducible and scalable process for PT the production of dry powders from a fluid material by atomization through an atomizer RI into a hot drying gas medium, usually air Often spray-drying is considered only a dehydration process, though it also can be used for the encapsulation of hydrophilic and SC hydrophobic active compounds within different carriers without substantial thermal NU degradation, even of heat-sensitive substances due to fast drying (seconds or milliseconds) and relatively short exposure time to heat The solid particles obtained MA present relatively narrow size distribution at the submicron-to-micron scale Generally, the yield% of spray-drying at laboratory scale with conventional spray-dryers is not D optimal (20-70%) due to the loss of product in the walls of the drying chamber and the TE low capacity of the cyclone to separate fine particles (