... specific birth prevalence series The studies differed in the number of series included, the method of pooling series, the type of regression equation andthe extent to which the maternal age range was ... events in the sequence are controversial Firstly, the proponents use the J-shape ofthe maternal age risk curve as evidence for the effect of hormonal imbalance around the time of menarche and approaching ... oocyte hypotheses The cause of DS has been sought in disturbances during stages of oogenesis, including the period of meiotic arrest ofthe oocyte [51] This has generated several hypotheses One...
... cut the tags out of every shirt they had because the tags rubbed their neck and constantly bothered them, being unable to wear blue jeans because ofthe way they feel at the waist or the back of ... events, the covert modes, that show before and at the end ofthe evident act The sensory symptoms are there, and they tell more than the visible and audible actions.’’ This fascinating and detailed ... Examples of dystonic tics are sustained tilt ofthe head, sustained elevation ofthe shoulder, sustained abduction ofthe shoulder, sustained flexion ofthe trunk, and sustained opening ofthe mouth...
... especially on the abdomen, face (moon face), neck and upper back (buffalo hump); thinning and weakness ofthe muscles ofthe upper arms and upper legs; thinning ofthe skin, with easy bruising and pink ... tumor in the lung, thymus gland, pancreas, or other organ This is called "ectopic" ACTH production When the source of excess cortisol production is a tumor ofthe adrenal gland itself, then it ... SYNDROME? Cortisol excess produces significant and serious change in the appearance and health of affected individuals Depending on the cause and duration ofthe Cushing's Syndrome, some people may...
... PATIENT'S LIFE? The symptoms, disabilities and life-style of a person with Cushing's Syndrome depend on the degree of cortisol excess, the duration ofthe disease, the basic health ofthe person, ... Unfortunately, they are usually discovered after they have already spread beyond the adrenal gland and are then not curable Chemotherapy including o, p'DDD and other medicines are often used to ... has the knowledge and experience in choosing the correct diagnostic studies and evaluating the results Finding the correct diagnosis often requires prolonged testing and even repetition of tests...
... thống lông phát triển, tóc rậm, nữ giới có nhiều ria mép giống đàn ông Nguyên nhân tăng tiết nhiều androgen - Da khô mảng, dễ xuất huyết va chạm, vết rạn da màu tím hồng (stria) nằm sâu da, thường...
... a variety of diseases and to determine the importance of cytokines such as IL-10 [54] Transgenic expression of IL-10 induced apoptosis of glandular tissue and promoted infiltration of lymphocytes ... gland inflammation, of which the MRL/lpr andthe NOD strains present with serum anti-Ro/SSA antibodies An insertion of an ET-transposon in the Fas gene has been found to be responsible for the ... Others have indicated a putative role for the cysteine-rich secretory protein (CRISP-3) gene as an early response gene that may participate in thepathophysiologyofthe autoimmune lesions of...
... antibodies [12] The objective of this study was to measure the presence of anti-α-fodrin antibodies in the sera of a cohort of patients with well-defined SjS at the Department of Rheumatology ofthe University ... 1) In our hands, the use of apoptotic extracts (to increase the amount of antigenic fodrin cleavage product) did not improve the suitability of these techniques for the detection of anti-α-fodrin ... (Table 1) From these results we conclude that antiα-fodrin antibodies are present in SjS sera and that the majority of these antibodies are ofthe IgG and IgA class, but that their frequency...
... contributions to the conception and design ofthe study and drafted the manuscript BK and KCA both read and approved the final manuscript Competing interests The authors declare that they have no ... in the right sacroiliac joint and sacral body, consistent with fractures, and most likely representing the cause ofthe patient’s pain Figure Anterior and posterior whole body bone scan views of ... consent was obtained from the patient for publication of this case report and any accompanying images A copy ofthe written consent is available for review by the Editor-in-Chief of this journal Abbreviations...
... analysis and writing ofthe manuscript RKN participated in the design ofthe study, collection ofthe patient material and drafting ofthe manuscript MM-G participated in the handling ofthe collection ... clinical protocol ofthe study nor the patients were aware ofthe treatment assignments At the onset ofthe study, the patients underwent a thorough oral and dental examination as a part of normal dental ... the statistical analysis Since the number ofthe marked scores decreased towards the end of each medication and washout period (because of apparent reduction of co-operation towards the end of...
... in the event of unsuccessful ERCP During the operation, there was no evidence of intestinal perforation A 3.5 cm gallstone was found proximal to a stricture in the second part ofthe duodenum There ... impacted in the duodenum in the absence of a fistula The most likely explanation in our patient is that multiple small stones passed from the gallbladder into the duodenum via the papilla and became ... from the patient for publication of this case report and any accompanying images A copy ofthe written consent is available for review by the Editor-in-Chief of this journal Competing interests The...
... conceived ofthe study, made substantial contributions to the acquisition of data, drafted the initial manuscript and revised the draft over the course of submission DS coordinated the design and drafting ... drafting ofthe initial version and revised the draft over the course of submission GO carried out endocrinological evaluation ofthe patient, made contributions to the acquisition of data and revised ... [3] The Weiss score ofthe tumor was (diffuse architecture and capsular invasion), compatible with a benign neoplasm Figure obesity ofthe patient Truncal Truncal obesity ofthe patient The tumor...
... raising the question ofthe importance of IL-17 in SS Thus, the goals ofthe present study were to determine whether IL-17A can directly influence the pathology leading to the onset of SS-like ... section of ± 0.83 (Table 1) Besides the number of LF detected in the salivary glands ofthe experimental animals, immunofluorescent staining to detect B and T cells revealed further differences in the ... produced and determined the titers ofthe Ad5-LacZ and Ad5-IL17A viral vectors HY and BL performed retrograde ductal cannulations/ instillations ofthe vectors into the salivary glands CQN designed the...
... index of suspicion is important for the early and correct diagnosis Cushing’s disease in children References 10 11 12 13 14 15 16 17 18 Cushing H The basophil adenomas ofthe pituitary body and their ... P.Y Hsu et al of these children may prevent future adult height deficits and osteopenia.9,15,16 Transsphenoidal pituitary adenomectomy is the treatment of choice in these children, and a high cure ... radiotherapy with a total dose of 5000 cGy The signs and symptoms improved, though panhypopituitarism was noted years after the second operation and radiotherapy The patient received continuing treatment...
... the cut-off limits for each ofthe QLIPS tests, the mean value ofthe 25 control samples plus SD in the first cohort was used and is indicated in the figures Additional analysis using a cut-off ... samples showed a mean and standard deviation by QLIPS and LIPS of 7,576 ± 6,046 and 29,770 ± 78,495 LU, respectively Of note, the markedly higher average and standard deviation ofthe control group ... steps, 10 minutes of washing and reading ofthe plate with a luminometer Due to the high signal to noise and large dynamic range ofthe LIPS assay, the coefficient of variation (CV) of approximately...
... 37% of patients compared to 12% of controls In order to assess the impact of gender and disability, and due to the small samples of men and work disabled in the PhysR patient group, the PhysR and ... validity of this sample is supported by the expected prevalence of dry eye and dry mouth, cardinal features ofthe disorder which are highly predictive ofthe diagnosis The generalizability ofthe ... paper and in the supplementary section, and drafted sections of this manuscript PCF participated in the design ofthe study FV participated in the design ofthe study NM participated in the design...
... follows: (a) The presence of any four ofthe six items is indicative of primary SS, as long as either item (Histopathology) or (Serology) is positive (b) The presence of any three ofthe four objective ... antibody test (at a dilution of 1:320) Anti-La/SS-B titre, other SLE and RA markers, and tests ofthe complement system (C3 and C ) were negative Electroencephalogram (EEG) and magnetic resonance imaging ... showed a poor fixation ofthe radionuclide Additionally, a stimulation test revealed no further functional activity ofthe salivary glands Those findings were characteristic ofthe sialoadenitis typically...
... CD5, further supporting the hypothesis of homing and activation of specific B cells in the glands B cell malignancies and Sjögren’s syndrome In contrast to the focal sialadenitis ofthe minor ... regardless of whether these autoantibodies are pathogenic [25] Despite intensive work on the characterization of autoantigens, the cellular basis of their production andthe strong association of certain ... salivary glands, the lymphocytic lesions ofthe major salivary glands often contain secondary lymph follicles B cells have been shown to infiltrate the glandular duct epithelium and thereby to...
... influences the activity of type regulatory T cells [7,8], thereby possibly contributing to autoimmunity The other pathway discussed is based on genes within the Aec2 locus, important in the homeostasis ... lupus erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential candidate ... genes located within the re-defined Aec2 interval, the authors elegantly discuss possible disease pathways One pathway starts out from the Tnfsf4 gene encoding the OX40 ligand (OX40L) This molecule...
... counted The histological evaluation ofthe number of foci, the presence of IL-18 in inflammatory foci and ducts, the degree of organization ofthe mononuclear aggregates, andthe presence of germinal ... at RT The sections were rinsed in TBS and stained for anti-IL-18 as described above To verify the specificity ofthe staining, sections with omission ofthe first, the second, or both ofthe primary ... salivary gland of SS, ductal IL-18 expression was observed both in the presence and in the absence of IL-18-producing cells in the periductal inflammatory foci and was also found in the absence of a...
... parotid gland andthe peripheral blood ofthe patient, there was no significant difference in the R/S ratios Comparison ofthe R/S ratio in the peripheral blood ofthe patient andof normal donors ... parotid gland ofthe SS patient, further analysis addressed the nature of these mutations The R/S ratio ofthe nonproductive Vκ and Vλ repertoire could not be assessed individually because ofthe small ... characterize the pattern of somatic hypermutation ofthe VL gene rearrangements of B cells from the patient’s peripheral blood andthe parotid gland in more detail, the contribution of mutations within the...