phase ii metabolism of endogenous compounds
báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
Ngày tải lên :
18/06/2014, 15:20
... preparation 5T4-MVA vaccine was produced by homologous recombination of human 5T4 cDNA into deletion region III of MVA under the control of the modified H5 promoter, as previously described [12] Individual ... booster immunizations were supported by the addition of high-dose bolus IL-2 Methods Patients This phase II trial was an open label study of MVA-5T4 vaccine in patients with metastatic clear ... analysis, or interpretation of the data, or in the writing of the report They also had no access to the raw Page of 11 (page number not for citation purposes) Journal of Translational Medicine...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
Ngày tải lên :
18/06/2014, 16:20
... disease of New York Heart Association Class III-IV Patients must have had no history of myocardial infarction within months of study entry and no history of deep venous thrombosis The requirement of ... A patients on day of cycles 2, 4, and as well as completion of treatment; for Arm B patients, on day 22 of cycle and day of cycles and and completion of treatment In the case of missing responses ... activity of this combination in limited studies We found a PSA response rate of 50%, progression free survival of 5.9 months, and overall survival of 19.4 months, consistent with clinical activity of...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
Ngày tải lên :
18/06/2014, 16:20
... results of immune monitoring and clinical benefit in terms of tumor responses This lack of correlation of immune parameters and response may relate to the likely low sensitivity of the detection of ... peptide-pulsed dendritic cells (DC) in firstline treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG Ann Oncol 2006, 17:563-570 12 Wolchok ... culture at a final concentration of ug/mL The peptide pools represented the following groups of melanoma tumor antigens: i) gp100 family, ii) tyrosinase and TRP-2 family, iii) MAGE family, and iv) additional...
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Báo cáo khoa học: "Long-term results from a randomized phase II trial of neoadjuvant combined-modality therapy for locally advanced rectal cancer" ppt
Ngày tải lên :
09/08/2014, 09:20
... approved by the ethic committees of the Institute of Oncology, Ljubljana, Slovenia and of the Republic of Slovenia and was in agreement with the Declaration of Helsinki week for weeks The small ... presented with stage III disease The WHO performance status was in 12.3% of patients The median distance of the tumour from the anal verge was 5.5 cm (range 1-12 cm), and in 49.1% of patients the ... multicentric phase II study Ann Oncol 2006, 17:246-251 27 Desai SP, El-Rayes BF, Ben-Josef E, Greenson JK, Knol JA, Huang EH, Griffith KA, Philip PA, McGinn CJ, Zalupski MM: A phase II study of preoperative...
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Báo cáo khoa học: " Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results" ppt
Ngày tải lên :
09/08/2014, 10:20
... UICC stage no (%) II III IV 59 (50) 49 (41.5) 10 (8.5) Tumor location no (%) Upper third of rectum Middle third of rectum Lower third of rectum 10 (8.5) 59 (50) 49 (41.5) Page of (page number not ... diarrhea Anal incontinence Number of patients (%) Grade III Grade IV (0.8) (2.5) (3.4) (2.5) (0.8) was 78%, 71% and 52% for UICC stage I, II and III, respectively A total of six local recurrences were ... and 70% after exclusion of UICC stage IV (Fig 1) OS was not statistically significant for UICC stages I to III: five-year OS was 81%, 74% and 59% for UICC stage I, II and III, respectively Five-year...
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Phase II: Estimating Health and Economic Damages (ILLNESS COSTS OF AIR POLLUTION) pdf
Ngày tải lên :
15/03/2014, 16:20
... mortality ii) the cost of reduced health care resource utilization (e.g., hospital care) iii) the value of avoided lost productive time (e.g., lost wages) iv) the value of increased quality of life ... further explanation of this aspect of ICAP) Potential sources of uncertainty in the results contained in this report include: i) scientific ignorance, ii) stochasticity, iii) imprecision, iv) ... are: i) complete elimination of anthropogenic ozone and particulate matter, ii) maintenance of current Ontario air pollution concentrations, iii) full implementation of Ontario’s Anti-Smog Action...
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Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
Ngày tải lên :
17/03/2014, 23:20
... sequence of the first FXRE Ó FEBS 2002 3500 T Gerloff et al (Eur J Biochem 269) Fig Decrease of basal activity and loss of CDCA-mediated stimulation of the minimal Bsep promoter after mutation of the ... or a combination of both (lanes and 8) resulted in a reduction of signal intensities of The ability of drugs to regulate Bsep gene transcription was assessed by transfection of the full length ... yeast tRNA as template (data not shown) Analysis of the 5¢ flanking region sequence of the Bsep gene A total of 2488 bp upstream from the 5¢-end of the Bsep cDNA was sequenced in both directions;...
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The National Study Report- Phase II of The National Study of Business Strategy and Workforce Development docx
Ngày tải lên :
23/03/2014, 02:20
... (73.8%) of the employees were full-time employees � Almost half (45.7%) of the employees were women � One-third (30.2%) of the employees were members of a racial/ethnic minority group � 18.1% of ... recruitment package As Table indicates, many employers are offering a range of benefits to all of their employees Table 4: Profiles of Available Benefits % respondent organizations reporting ... Ph.D., is Co-Director of the Center on Aging & Work/Workplace Flexibility He is also the Dean of the Graduate School of Arts and Sciences and a Professor in the Department of Psychology at Boston...
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Báo cáo khoa học: "Study of endogenous plant growth Douglas fir II. Gibberellin analysis" pptx
Ngày tải lên :
09/08/2014, 02:21
... immunoassay of gibberellins II Quantitation of GA3, GA4 and GA7 by ultrasensitive solid -phase enzyme immunoassays Planta 159, 7-11 Pharis R.P & F3oss S.D (198F} Hormonal promotion of flowering ... An example of a standard curve obtained is shown in Fig The detection limit is 40 fmol of GA3 methyl-ester and the working range of the assay is between about 50 fmol and 50 pmol of GA3 methyl-ester ... to separate several GAs in a timed program of 50 ELISA of individual fractions from plant extract HPLC eluates confirmed the presence of several peaks of cross-reactive material (Fig 3) In the...
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Báo cáo khoa học: " Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study" docx
Ngày tải lên :
09/08/2014, 09:21
... results of a randomised phase III study J Clin Oncol 2001, 19:2282-2292 Page of 11 Twelves C, Wong A, Nowacki MP, Abt M, Burris H, et al: Capecitabine as adjuvant treatment for stage III colon ... results of the German CAO/ARO/AIO-04 randomized phase III trial J Clin Oncol 2011, 29(suppl):Abst LBA3505 23 Mohiuddin M, Winter K, Mitchell E, Hanna N, Yuen A, et al: Randomized phase II study of ... determined by magnetic resonance imaging (MRI) of the pelvis of each patient Eligible patients had to have a histologically verified stage II or III adenocarcinoma of the rectum, the disease had be considered...
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Báo cáo khoa học: "Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study" docx
Ngày tải lên :
13/08/2014, 03:21
... in order to assess the opportunity of a larger phase III trial Making the hypothesis that the percentage of patients free of catecholamine at 10 days (end of study treatment) would be 60%, the ... would have allowed the detection of an absolute increase of 25% of this percentage of patients in a two-sided test performed with a type I error of 5% and a power of 80% Statistical analysis was ... one or more of a positive culture or Gram stain of a normally sterile body fluid, of a clinical patent focus of infection (for example, faecal peritonitis, community pneumonia) and of a nosocomial...
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Dictionary of food compounds additives, flavors, and ingredients yannai s 2004
Ngày tải lên :
16/09/2013, 21:58
... PRESENTATION are of six types The selection of compounds for DFC is broad Included Structural headings (WA) classify naturally occurring are all compounds or group of compounds of interest or food ... indication of crystal form and of recrystallisation solvent is often given but these are imprecise items of data; most compounds can be crystallised from several solvent systems and the crystal form often ... Occupational Safety and Health Service of the U.S Department of Health and Human Services of The United States of America All rights reserved (1996) xiii For each Accession Number, the RTECS®...
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Tài liệu WWEI phase II pdf
Ngày tải lên :
18/01/2014, 13:20
... lp thuc nhúm II: 1.062 group II of construction of work Cụng tỏc xõy lp thuc nhúm III: 1.171 group III of construction of work Legal holiday, public holiday or day off consists of days solar/western ... c ht Gii hn lng Gii hn T trng t Nộn n hụng Thớ nghim c kt Phase II - In the interception report As described in the Term Of Reference, the consultancy services shall cover all aspects of planning, ... ENVIRONMENT Js.Co Road engineer duty Detailed engineering design consists of (1) review of definitive plan: Phase II : IR, F/S Phase I : detailed design (detail drawing, main report and final report),...
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Tài liệu ADSORPTION OF ORGANIC COMPOUNDS doc
Ngày tải lên :
14/02/2014, 03:20
... presence of nonadsorbable compounds, the biodegradation of compounds in a biologically active column, slow adsorption of a fraction of the molecules present, and the critical depth of the column ... ADSORPTION OF ORGANIC COMPOUNDS 13.17 FIGURE 13.12 Effect of biodegradation and the presence of nonadsorbable compounds on the shapes of breakthrough curves steam and CO2 at temperatures of 800 to ... oxidation of Fe (II) to Fe(III) Adsorption Efficiency of Full-Scale Systems Taste and Odor Removal Many types of taste and odor problems are encountered in drinking water Troublesome compounds...
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Tài liệu NOMENCLATURE OF ORGANIC COMPOUNDS docx
Ngày tải lên :
14/02/2014, 08:20
... naming III Naming Aromatic Compounds Aromatic Compounds are cyclic hydrocarbons containing a benzene structure Benzene can be represented by the resonance structures: The actual structure of benzene, ... chemical and physical properties of another class of compounds A Halogen Derivatives of Hydrocarbons Functional Group: - X (F, Cl, Br, I) General Formula: R-X Naming of Halides Halogens attached ... alkanes are straight chained compounds, as shown in the previous table, they can have side chains or branches These variations of compounds which have the same number of carbon and hydrogen atoms,...
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Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
Ngày tải lên :
18/02/2014, 17:20
... of the bond between C20 and C22 [1,14] Another difference between the metabolism of vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs for the metabolism of ... further metabolism [4] In conclusion, the identification of new metabolites of vitamin D3 made by the action of P450scc will enable us to proceed with further biological testing of 2594 these compounds ... 2008 FEBS R C Tuckey et al Metabolism of vitamin D3 by cytochrome P450scc A B C Fig Identification of 17a,20,23-trihydroxyvitamin D3 (A) Expansion of proton– carbon HSQC of 20,23-dihydroxyvitamin...
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Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
Ngày tải lên :
20/02/2014, 11:20
... Cabantchik, Z.I (2000) The importance of non-transferrin bound iron in disorders of iron metabolism Transfus Sci 23, 185–192 Sarkar, B (1970) State of Fe (III) in normal human serum: low molecular ... percentage of the total, over 0–2 h uptake Effect of chelators and Fe status on subcellular distribution of NTBI in hepatocytes The effect of the chelators on the intracellular distribution of Fe in ... Fe mobilization is limited by the size of an intracellular chelatable Fe pool or permeability of the Fe–chelator complex In view of the similar efficacy of the multidentate pyridinones to DFO,...
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Báo cáo khoa học: Functional dissection of Escherichia coli phosphotransacetylase structural domains and analysis of key compounds involved in activity regulation potx
Ngày tải lên :
06/03/2014, 11:20
... with the C-terminal domain of PtaIIs A B Pi Acetyl-CoA Thus, the active site of PtaIIs is probably located at the C-terminal end of the protein, and the role of the PtaII N-terminal domain has ... Activation of the acetyl phosphate synthesis activity of E coli Pta by different concentrations of pyruvate and PEP Results are presented as percentage of activity in the presence of PEP or pyruvate ... (Fig 5A) In this way, these compounds acted as activators of the acetyl phosphateforming reaction while inhibiting the formation of acetyl-CoA (Fig 5A) The activation of the E coli 120 120 100...
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