phase i and phase ii

... 0 Time (s) Fig BIAcore analysis of IGF -II and IGF -II analogue binding to highanity recombinant IGF1R Binding of IGF -II (A), des-(1±6)-IGF -II (B) and Arg6-IGF -II (C) to rhIGF1R measured by BIAcore ... deprivation-induced cell death (Fig 4E) and Arg6IGF -II and des(1±6)-IGF -II were essentially equipotent to IGF -II Leu27-IGF -II and des-(1±6,10)-Leu27-IGF -II did not exhibit any survival-promoting ... relationship (Fig 5) Thus, those IGF -I mutants designed to investigate IGFBP binding [Long IGF -I, des-(1±3)-IGF -I, Arg3-IGF -I, Gly3IGF -I, Arg6-IGF -II and des(1±6)IGF -II] have basically equal abilities to...

Ngày tải lên: 08/03/2014, 22:20

... mammalian HDL and its principal apolipoproteins A -I and A -II in antimicrobial or antiviral activities in vitro [13,14,30], these proteins have not been yet recognized as important effectors in innate ... apoA -II, both major apolipoproteins contribute significantly to the antimicrobial activity displayed by carp plasma HDL Results Purification of HDL and apolipoproteins A -I and A -II As shown in Fig ... apolipoproteins A -I and A -II in the in vitro antimicrobial activity of carp HDL Both proteins inhibit the Ó FEBS 2004 growth of Gram-positive and -negative bacteria, including fish pathogens, at micromolar...

Ngày tải lên: 16/03/2014, 18:20

... peroxiredoxin [8] TryPs were originally identied and characterized in Crithidia fasciculata [812] and these have been subsequently identied and studied in a variety of trypanosomatids [1318] Additional ... TryX indicating that formation of an intramolecular disulde is important for interaction with TryX In contrast, this mutant displayed signicant activity with dithiothreitol (65% of wild-type) ... genomic DNA of L major Friedlin strain using forward primer containing an NdeI site and reverse primer containing a BamHI site (Table 3) The 525 bp PCR-product was digested with NdeI and BamHI and...

Ngày tải lên: 23/03/2014, 07:20

... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...

Ngày tải lên: 09/08/2014, 01:22

... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...

Ngày tải lên: 09/08/2014, 13:22

... Type II cadherins result in their distinct behaviour in vivo Type I cadherins, including E-cadherin, N-cadherin and C-cadherin etc., show stronger and more rapid adhesion than Type II cadherins and ... cadherins form cadherin-catenin complex with catenins and p120, no vinculin is recruited B) In the released state, the vinculin binding site in α-catenin is inhibited by a putative inhibitory domain ... observed in the Type II cadherins artificial junction under the similar condition (40) The different clustering mechanism of Type I and Type II cadherins may partly account for their distinct adhesion...

Ngày tải lên: 09/09/2015, 11:16

... Hospital with specific facilities………… xxiii Percentage of ISM & H Dispensary with specific facilities…………… xxiii CHAPTER I INTRODUCTION Table 1.1 Table 1.2 Regional agencies by states assigned ... deals with the health care facilities available in the District Hospitals Chapter III, IV, V, VI and VII are similar presentations respectively for FRU, CHC, PHC, SC, and ISM & H Hospital and Dispensary ... considering infrastructure, manpower and supplies adequate for rendering quality RCH services The main objectives of the facility survey are to assess i ii iii iv v 1.3 Percent of facilities having...

Ngày tải lên: 14/03/2014, 09:20

... uncertainty in the results contained in this report include: i) scientific ignorance, ii) stochasticity, iii) imprecision, iv) limited resolution, and v) methodological bias/limitations 25 4.2 Scientific ... quality conditions, ii) current and future size, distribution and composition of the exposed population, iii) E/RFs for key air pollutants, and iv) economic coefficients for air pollution-induced ... public policy decision-makers and the general public in considering these significant public health questions Understanding the complex interactions involving human activities, air pollutant emissions,...

Ngày tải lên: 15/03/2014, 16:20

... marketing initiatives (57.0%) training initiatives (44.1%) customer service initiatives (52.6%) diversity initiatives (33.8%) introduction of new technology (50.8%) wellness initiatives (43.4%) initiatives ... specific business priorities; and respond A simplified version of this “Awareness to Action” model is depicted in Figure Figure 2: Awareness to Action Action Response Examine Response Options Link ... felt it was “very true” that their organizations expect that employees will participate in decision-making which affects their work Figure 11: Orientation to Employee Participation in Decision-Making...

Ngày tải lên: 23/03/2014, 02:20

... provide directly and indirectly to the economy, including cleansing of polluted air and water; provision of productive soil; provision of biodiversity; provision of a predictable and relatively ... thousands) CPCB category ISIC Three digit description Aluminium smelter Basic drugs and Pharmaceuticals Cement Distilleries Fertiliser Iron and Steel Oil Refineries Pesticides Pulp and Paper Sugar 3720 ... 10 industries is taken from the Annual Survey of Industries (ASI) 2000-01 ASI is the principal source of industrial statistics in India IPPS pollution intensities for air pollutants (NO2, SO2 and...

Ngày tải lên: 29/03/2014, 14:20

... irinotecan, vinorelbine and gemcitabine Phase II trials of these new agents in combination with platinum have shown impressive response and survival results, leading to their widespread clinical ... Cruciani G, Masotti A, Ferrara G, Gozzelino F, Tonato M: Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: a randomized phase III study ... PK, Moinpour CM, Ramsey SD, Wozniak AJ, Weiss GR, Moore DF, Israel VK, Livingston RB, Gandara DR: A randomized phase III trial of paclitaxel plus cisplatin versus vinorelbine plus cisplatin in the...

Ngày tải lên: 18/06/2014, 15:20

... vaccine and high-dose IL-2 elicited 5T4-specific humoral and cell-mediated immunity All patients developed an increase in 5T4 antibody titers after vaccination, consistent with previous clinical ... RCC Additional material Additional file MVA- and 5T4- specific antibody responses (A) MVA-specific antibody titers, (B) 5T4-specific antibody titers The data provided antibody titers specific for ... Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/ II trial...

Ngày tải lên: 18/06/2014, 15:20

... toxicities Table shows toxicities experienced by patients during therapy Hemoglobin was the most frequently occurring toxicity Nineteen and five patients experienced life-threatening toxicities ... activity with estramustine-based combinations and the activity of combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine ... Aravantinos G, Kiamouris C, Adimchi O, Fountzilas G, Dimopoulos AM: The combination of estramustine, vinorelbine, and mitoxantrone in hormone-refractory prostate cancer: a Phase II feasibility study...

Ngày tải lên: 18/06/2014, 16:20

... locoregional disease was determined by magnetic resonance imaging (MRI) of the pelvis of each patient Eligible patients had to have a histologically verified stage II or III adenocarcinoma of ... data; involvement in drafting and reviewing the manuscript JO: contribution to acquisition of data, analysis and interpretation of data MM: contribution to acquisition of data, analysis and interpretation ... interpretation of data MB: contribution to acquisition of data FA: contribution to acquisition of data, analysis and interpretation of data IO: contribution to acquisition of data IE: contribution to...

Ngày tải lên: 09/08/2014, 09:21

... prospective controlled clinical studies for breast cancer patients including phase II and III trials comparing different agents in the treatment of radiation dermatitis In one Phase III trial, 194 ... treatment to prevent radiation dermatitis is directed at reducing the drying effect of radiation on the skin and involves instructing patients to avoid irritating the irradiated region Dryness due to ... APP cream Statistical considerations The study was designed as a prospective and randomized Phase III clinical trial with a planned accrual of 45 eligible patients The APP cream and aloe vera...

Ngày tải lên: 09/08/2014, 10:21

... ClinicalTrials.gov Identifier: NCT01222338 Randomization, clinical endpoints and exclusion/inclusion criteria Any patient who presented with pulmonary TB was enrolled into this study and randomly ... H: izoniazid; Hb: hemoglobin; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; MDR: multi-drugresistant; O: ofloxacin; P: para-aminosalicylic acid; Pt: prothionamide; ... Design Discovery 2007, 4:540-544 Batdelger D, Dandii D, Jirathitikal V, Bourinbaiar AS: Open label trial of therapeutic immunization with oral V-5 Immunitor (V5) vaccine in patients with chronic hepatitis...

Ngày tải lên: 11/08/2014, 08:21

... Soylak, M., 2004 Solid phase extraction of Cu (II) , Pb (II) , Fe(III), Co (II) and Cr(III) on Chelex 100 Column prior to their flame atomic absorption spectrometric determinations Anal Lett 37, 1203–1217 ... cadmium (II) and lead (II) ions that is based on solid phase extraction of cadmium (II) and lead (II) as their 1-phenyl-1Htetrazole-5-thiol on Diaion SP-207 resin 721 HNO3 and water, sequentially ... Salahinejad, M., Aflaki, F., 2011 Optimization and determination of Cd (II) in different environmental water samples with dispersive liquid–liquid microextraction preconcentration combined with inductively...

Ngày tải lên: 02/09/2015, 13:45

... Epidemiology, 2nd edition Philadelphia: Lippincot Williams & Wilkins 1998:385-386 36 Altman DG, Andersen PK Bootstrap investigation of the stability of a Cox regression model Statistics in Medicine ... investigation to try to validate a multivariate explanatory model of the diagnosis of SCRC in Dukes’ stages I and IIa using non-conditional logistic regression and “bootstrap” analyses The original ... and clinical pharmacology, and also family doctors in training o recycling periods The objectives of the investigation were explained to all participating physicians and they were provided with...

Ngày tải lên: 03/11/2012, 11:34

... SANITATION AND ENVIRONMENT Js.Co Road engineer duty Detailed engineering design consists of (1) review of definitive plan: Phase II : IR, F/S Phase I : detailed design (detail drawing, main ... xõy lp thuc nhúm II: 1.062 group II of construction of work Cụng tỏc xõy lp thuc nhúm III: 1.171 group III of construction of work Legal holiday, public holiday or day off consists of days solar/western ... and their features/applications Automating the estimating function is an evolutionary process There are many levels of computerized estimating, which vary in functionality, sophistication, time...

Ngày tải lên: 18/01/2014, 13:20

... near to the binding site(s) and their positive charge is a stringent requisite for the binding This is not surprising, if indeed collagen binds inside the concave surface of decorin, owing to the ... collagens and positive peptides, whereas fibronectin and a 30-kDa fibronectin fragment having heparin-binding ability showed interaction with tendon decorin (Fig 4) Fibronectin is known to interact with ... decorin and collagens or their CNBr peptides is quite sensitive to the ionic strength of the buffer, suggesting an ionic character of the binding The main decorin region implicated in the binding...

Ngày tải lên: 21/02/2014, 15:20