pharmacokinetic drug bioavailability and intraocular drug delivery systems

... Conjugation of drug with ligand for vascular targeting 15 1.3.2 Vascular targeted nanoparticle drug delivery 19 1.4 Conclusion 22 Chapter Targeted nanoparticulate drug delivery ... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Dots: Preparation and Two-Photon Fluorescence J Am Chem Soc 2009; 131(32), 1130011301 Wang Z., Chui WK., Ho PC Integrin targeted drug and gene delivery Expert opinion on drug delivery 2010; 7(2),...

Ngày tải lên: 11/09/2015, 09:58

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... J Frazier, and H Brem (2002) Local drug delivery to the brain Adv Drug Deliv Rev., 54 (7), 987–1013 Anderson, J.M and Shive, M.S (1997) Biodegradation and biocompatibility of PLA and PLGA microspheres ... the ability to use nanotechnology and biological mimicry to create drug delivery systems that penetrate into 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development articular...

Ngày tải lên: 25/10/2013, 08:20

... demand fbrther research and New Materials and Systems for Drug Delivery and Targeting Table Externally activated drug delivery systems EXTERNAL ACTIVATION FORMULATION SYSTEM MECHANISM FOR DRUG DELIVERY ... to advanced drug delivery systems Chemical Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE ... solubility and stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS...

Ngày tải lên: 28/03/2014, 10:20

... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ...  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered...

Ngày tải lên: 18/04/2014, 15:37

... Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner New Drugs: Discovery and Development, edited by Alan A Rubin Sustained and Controlled Release Drug Delivery Systems, ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems: Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... actives and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems...

Ngày tải lên: 04/06/2014, 14:47

... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure ... effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and biological ... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease...

Ngày tải lên: 20/06/2014, 00:20

... Such nanocarrier-based drug delivery systems for doxorubicin could be more selective and effective than the free drug and have the promise to result in reduced toxicity and side effects in patients, ... the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the lymphatic ... in anticancer drug delivery systems because there are many other anticancer drug delivery systems based on other nanomaterials, such as cationic polymers [98], fibrinogens [99], and PVP/PVAL nanoparticles...

Ngày tải lên: 20/06/2014, 22:20

... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and ... Practical and Clinical Applications, Second Edition, Revised and Expanded, Sanford Bolton Biodegradable Polymers as Drug Delivery Systems, edited by Mark Chasm and Robert Langer Preclmical Drug Disposition...

Ngày tải lên: 10/08/2014, 00:20

... L., and Anderson, J A (1985) Review: Corneal penetration and ocular bioavailability of drugs J Ocular Pharmacol., 1:309 Lee, V H L., and Robinson, J R (1986) Review: Topical ocular drug delivery: ... (1990) Ocular drug delivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and Drug Delivery ... Mazuel, C., Quint, M., and Rozier, A (1977) Pharmacokinetics and biopharmaceutical aspects of some anti-glaucoma drugs In: Ophthalmic Drug Delivery Biopharmaceutical Technological and Clinical Aspects...

Ngày tải lên: 10/08/2014, 00:20

... L., and Cringle, I J (1989) Pharmacokinetics of intravitreal injection Invest Ophthalmol Vis Sci 30:1055–1061 23 Urtii, A (1993) Animal pharmacokinetics studies In Ophthalmic Drug Delivery Systems, ... Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... area, thickness, concentration gradient, compartment volume, and ligand diffusion coefficient (43) Tissue and plasma proteins often bind drugs and other low molecular weight compounds Hypothesis regarding...

Ngày tải lên: 10/08/2014, 00:20

... to promote site-specific delivery of drugs to intraocular tissues in the back of the eye (23) The increasing interest in intraocular delivery of peptide and protein drugs, drug therapy targeting ... the design and evaluation of ocular drug delivery systems II OCULAR ANATOMY AND PHYSIOLOGY RELEVANT TO THE NONCORNEAL ROUTE The ocular anatomy and physiology relevant to ocular drug delivery was ... 64:1312–1316, 1975 Robinson, J R., and Mlynek, G M Bioadhesive and phase-change polymers for ocular drug delivery Adv Drug Delivery Rev 16:45–50, 1995 Salminen, L., and Urtti, H Prolonged pulse-entry...

Ngày tải lên: 10/08/2014, 00:20

... 128 Peyman, G A., and Ganiban, G J (1995) Delivery systems for intraocular routes, Adv Drug Delivery Rev., 16:107–123 129 Geroski, D H., and Edelhauser, H F (2000) Review: Drug delivery for posterior ... U., and Mondino, B J (1991) Device drug delivery to the eye Collagen shields, iontophoresis, and pumps, Ophthalmology., 98:725–732 147 Hill, J M (1991) Symposium on drug delivery V Ocular drug delivery; ... peptide and protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery...

Ngày tải lên: 10/08/2014, 00:20

... M., and Leesman, G D (1989) Absorption of difficult drug molecules: Carrier mediated transport of peptides and peptide analogues In: Novel Drug Delivery and Therapeutic Application L F Presscot and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 ... from ophthalmic timolol and their prevention, J Ocul Pharmacol., 3:177 22 Robinson, J R (1989) Ocular drug delivery Mechanism(s) of corneal drug transport and mucoadhesive systems, S.T.P Pharma.,...

Ngày tải lên: 10/08/2014, 00:20

... Coa, Y., and Suresh, M R (2000) Bispecific Mab aided liposomal drug delivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery ... nonpathogenic and cannot replicate; (d) immunogenicity, toxicity, and inflammation are minimized with their use; and (e) they can become completely synthetic While these are safe gene delivery systems, ... straightforward and relatively simple to perform and bypasses the need for complex viral or non viral delivery systems Subretinal or intravitreal injections are common routes of delivery to the...

Ngày tải lên: 10/08/2014, 00:20

... clinical investigations and NDAs for marketing approval The terms drug and new drug are inclusive of the drug substance and the drug product It is important to understand that a new drug is not just ... toxicity and pharmacokinetics of antisense oligonucleotides Anticancer Drug Des., 6:609–646 166 Y Rojanasakul (1996) Antisense oligonucleotide therapeutics: drug delivery and targeting Adv Drug Delivery ... NDA drugs approved since 1962 and thereby increase competition and lower drug prices An abbreviated NDA (ANDA) is required to be submitted for approval and must demonstrate that the generic drug...

Ngày tải lên: 10/08/2014, 00:20

... L., and Cringle, I J (1989) Pharmacokinetics of intravitreal injection Invest Ophthalmol Vis Sci 30:1055–1061 23 Urtii, A (1993) Animal pharmacokinetics studies In Ophthalmic Drug Delivery Systems, ... Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... area, thickness, concentration gradient, compartment volume, and ligand diffusion coefficient (43) Tissue and plasma proteins often bind drugs and other low molecular weight compounds Hypothesis regarding...

Ngày tải lên: 10/08/2014, 03:20