peroxisome proliferator activated receptors ppars

... the airways [8] Peroxisome proliferator- activated receptors (PPARs) have been suggested to play such an anti-inflammatory role [9-11] Peroxisome proliferator activated receptors (PPARs) are DNA-binding ... D: Peroxisome proliferator- activated receptor gamma: implications for cardiovascular disease Hypertension 2004, 43:297-305 Michalik L, Desvergne B, Wahli W: Peroxisome- proliferator- activated receptors ... murine peroxisome proliferatoractivated receptors Proc Natl Acad Sci U S A 1994, 91:7355-7359 Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator- activated...

Ngày tải lên: 12/08/2014, 18:20

... marked species differences in expression of the target receptors For example, the family of peroxisome proliferator activated receptors (PPARs) display differences in expression and activation ... gene by hypolipidemic peroxisome proliferators J Biol Chem 1996, 271:218-224 Tugwood JD, Aldridge TC, Lambe KG, Macdonald N and Woodyatt NJ Peroxisome proliferator- activated receptors: structures ... ligand for peroxisome proliferator- activated receptor gamma (PPAR gamma) J Biol Chem 1995, 270:12953-12956 Lehmann JM, Lenhard JM, Oliver BB, Ringold GM and Kliewer SA Peroxisome proliferator- activated...

Ngày tải lên: 13/08/2014, 13:20

... fit or be sick: peroxisome proliferator- activated receptors are down the road Mol Endocrinol 2004, 18:1321-1332 Willson TM, Brown PJ, Sternbach DD, Henke BR: The PPARs: from orphan receptors to ... target of peroxisome proliferator- activated receptors J Biol Chem 2006, 281:39607-39619 Varanasi U, Chu R, Huang Q, Castellon R, Yeldandi AV, Reddy JK: Identification of a peroxisome proliferator- responsive ... of the peroxisome proliferator- activated receptor J Clin Invest 1995, 96:741-750 Prieur X, Coste H, Rodriguez JC: The human apolipoprotein AV gene is regulated by peroxisome proliferator- activated...

Ngày tải lên: 14/08/2014, 08:20

... disruption of the a isoform of the peroxisome proliferator- activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol Cell Biol 15, 3012–3022 ... Desvergne B & Wahli W (2000) Roles of PPARs in health and disease Nature 405, 421–424 Palmer CN, Hsu MH, Griffin KJ, Raucy JL & Johnson EF (1998) Peroxisome proliferator activated receptor-a expression ... Corton JC (2004) Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator- activated receptor a, retinoid X receptor and liver X receptor in mouse liver Mol...

Ngày tải lên: 16/03/2014, 14:20

... (2002) The mechanisms of action of PPARs Annu Rev Med 53, 409–435 Bishop-Bailey D & Hla T (1999) Endothelial cell apoptosis induced by the peroxisome proliferator- activated receptor (PPAR) ligand ... Kubota N, Terauchi Y, Tobe K et al (2001) The mechanisms by which both heterozygous peroxisome proliferator- activated receptor gamma (PPARgamma) deficiency and PPARgamma Apoptosis induced by TZDs ... used clinically for type II diabetes TZDs activate the adipogenic transcription factor peroxisome proliferator- activated receptor-c (PPARc) and induce metabolic changes in adipose tissue [16] The...

Ngày tải lên: 16/02/2014, 09:20

... Invest 116, 581–589 19 Chinetti G, Fruchart JC & Staels B (2000) Peroxisome proliferator- activated receptors (PPARs) : nuclear receptors at the crossroads between lipid metabolism and inflammation ... by transcription factors, such as the nuclear receptors (NRs), which translate physiological signals into gene regulation Peroxisome proliferator- activated receptor gamma (PPARc) is a NR that ... Delerive P, Majd Z, Fruchart JC, Chapman J, Najib J & Staels B (1998) Activation of peroxisome proliferator- activated receptors a and g induces apoptosis of human monocyte-derived macrophages J Biol...

Ngày tải lên: 06/03/2014, 22:21

... Bishop-Bailey D (2000) Peroxisome proliferator- activated receptors in the cardiovascular system Br J Pharmacol 129, 823–834 17 Thiemermann C (2004) Ligands of the peroxisome proliferator- activated receptor-gamma ... the peroxisome proliferator- activated receptor J Clin Invest 96, 741–750 Marcus SL, Miyata KS, Zhang B, Subramani S, Rachubinski RA & Capone JP (1993) Diverse peroxisome proliferator- activated receptors ... via the peroxisome proliferator activated receptor nuclear receptors Prostaglandins Other Lipid Mediat 62, 1–13 Benson S, Wu J, Padmanabhan S, Kurtz TW & Pershadsingh HA (2000) Peroxisome proliferator- activated...

Ngày tải lên: 07/03/2014, 21:20

... (2007) The role of peroxisome proliferator- activated receptors in pulmonary vascular disease PPAR Res 2007, 18797 Duan SZ, Usher MG & Mortensen RM (2008) Peroxisome proliferator- activated receptor-gamma-mediated ... effects in the vasculature Circ Res 102, 283–294 Touyz RM & Schiffrin EL (2006) Peroxisome proliferator- activated receptors in vascular biology – molecular mechanisms and clinical implications ... (2007) Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator- activated receptors Arterioscler Thromb Vasc Biol 27, 1276–1282 Li M, Sun X, Li Z & Liu Y...

Ngày tải lên: 15/03/2014, 10:20

... (1999) Peroxisome proliferator- activated receptors: mediators of a fast food impact on gene regulation Curr Opin Clin Nutr Metab Care 2, 307–312 Hihi, A.K., Michalik, L & Wahli, W (2002) PPARs: ... Fruchart, J.C & Auwerx, J (1999) An update on the mechanisms of action of the peroxisome proliferator- activated receptors (PPARs) and their roles in inflammation and cancer Cell Mol Life Sci 55, 932–943 ... hormone receptor superfamily by peroxisome proliferators Nature 347, 645–650 Palmer, C.N., Hsu, M.H., Griffin, K.J., Raucy, J.L & Johnson, E.F (1998) Peroxisome proliferator activated receptor-alpha expression...

Ngày tải lên: 16/03/2014, 18:20

... experiments, we assessed the effects of agonists for peroxisome proliferator- activated receptor a (PPARa) and retinoid X receptor (RXR) PPARa–RXR dimers can be activated by both PPARa and RXR agonists PPARa–RXR ... into mitochondria Biochim Biophys Acta 1486, 1–17 11 Desvergne B & Wahli W (1999) Peroxisome proliferator- activated receptors: nuclear control of metabolism Endocr Rev 20, 649–688 12 Schuit F, Flamez ... mean ± SD, n ¼ 4–6, *P < 0.05, **P < 0.01, ***P < 0.001 Protein Gene transcription Peroxisome proliferator- activated receptor a Mitochondrial b-oxidation Carnitine palmitoyl transferase Acyl-CoA...

Ngày tải lên: 23/03/2014, 07:20

... of peroxisome proliferatoractivated receptor-beta ⁄ delta in epithelial cell growth and differentiation Cell Signal 18, 9–20 Michalik L, Desvergne B & Wahli W (2004) Peroxisome- proliferator- activated ... lipid metabolism, metabolic diseases, and peroxisome proliferator- activated receptors Endocrinology 144, 2201–2207 Evans RM, Barish GD & Wang YX (2004) PPARs and the complex journey to obesity ... B & Wahli W (2006) From molecular action to physiological outputs: peroxisome proliferator- activated receptors are nuclear receptors at the crossroads of key cellular functions Prog Lipid Res...

Ngày tải lên: 30/03/2014, 03:20

... Foufelle, F., Scotto, C., Dauca, M and Wahli, W Differential expression of peroxisome proliferator- activated receptors (PPARs) : tissue distribution of PPAR-alpha, -beta, and -gamma in the adult ... disruption of the alpha isoform of the peroxisome proliferator- activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol Cell Biol 1995, 15, ... gene EMBO J 1996, 15, 5336-48 Schoonjans, K., Staels, B., and Auwerx, J The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation...

Ngày tải lên: 07/08/2014, 17:22

... RC, Conway JG, Prop JA Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(di-ethylhexyl)phthalate and ... triplicate) *p < 0.001 compared with control Fig Mouse PPARα activation is stimulated by a potent peroxisome proliferator, Wy-14,643 and a hypolipidemic drug, clofibrate This transfection assay system ... been newly produced in the result of the fermentation process and act on PPARα like other peroxisome proliferators Discussion Fig Mouse PPARα activation is stimulated by BTE Although OTE and...

Ngày tải lên: 07/08/2014, 18:20

... fibroblasts by PPAR gamma 2, a lipid -activated transcription factor Cell 1994, 79:1147-1156 Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA: Peroxisome proliferator- activated receptor (PPAR) gamma: ... Paola R, Ialenti A, Genovese T, Chatterjee PK, et al.: Rosiglitazone, a ligand of the peroxisome proliferator- activated receptor-gamma, reduces acute inflammation Eur J Pharmacol 2004, 483:79-93 ... type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator- activated receptor gamma Arthritis Rheum 2003, 48:3544-3556 19 Kawahito Y, Kondo M,...

Ngày tải lên: 09/08/2014, 07:20

... the development of new efficacious therapeutic strategies Peroxisome proliferator- activated receptors (PPARs) are a family of ligand -activated transcription factors belonging to the nuclear receptor ... Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator- activated receptors (PPARs) : tissue distribution of PPAR-α, -β, and -γ in the adult rat Endocrinology ... 2005, 95:468-473 25 Cardell LO, Hagge M, Uddman R, Adner M: Downregulation of peroxisome proliferator- activated receptors (PPARs) in nasal polyposis Respir Res 2005, 6:132 26 Kitamura Y, Shimohama...

Ngày tải lên: 09/08/2014, 10:20

... J, Evans RM: The peroxisome proliferatoractivated receptors: ligands and activators Ann N Y Acad Sci 1996, 804:266-275 Mangelsdorf DJ, Evans RM: The RXR heterodimers and orphan receptors Cell 1995, ... Wang J, Rippe RA, Krishna V, Chatterjee K, Tsukamoto H: Peroxisome proliferator- activated receptor {gamma} induces a phenotypic switch from activated to quiescent hepatic stellate cells J Biol Chem ... IL-1-treated group versus the non-IL1-treated group 268, LG100268; NoTx, no treatment; PPRE, peroxisome proliferator- activated receptor-gamma response element; Rosi, rosiglitazone ing native chromatin...

Ngày tải lên: 09/08/2014, 13:22

... http://genomemedicine.com/content/1/12/115 Genome Medicine 2009, Background The peroxisome proliferator- activated receptors (PPARs) are ligand -activated transcription factors that control the expression of genes ... Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator- activated receptors (PPARs) : tissue distribution of PPAR-alpha, -beta, and -gamma in the adult ... JM: Peroxisome proliferator- activated receptor-delta attenuates colon carcinogenesis Nat Med 2004, 10:481-483 16 Peters, JM, Hollingshead, HE, Gonzalez FJ: Role of peroxisome- prolif erator-activated...

Ngày tải lên: 11/08/2014, 12:20

... however, be inhibited by the Peroxisome Proliferator- Activated Receptors α and γ (PPARs) , which thereby exert anti-inflammatory properties [6-8] PPARs are ligand -activated transcription factors ... binding to peroxisome proliferator- activated receptors Adv Exp Med Biol 1999, 447:199-209 Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S: The mouse peroxisome proliferator activated ... expression of peroxisome proliferator activated receptor gamma in cftr-/mice J Cell Physiol 2004, 200:235-244 Pall H, Zaman MM, Andersson C, Freedman SD: Decreased peroxisome proliferator activated...

Ngày tải lên: 12/08/2014, 16:20

... leading to a possible prevention or treatment therapeutic application Abbreviations Peroxisome proliferator- activated receptors (PPAR); 15deoxy-∆12,14-prostaglandin J2 (15D-PGJ2); thiazolidinediones ... overview on biological mechanisms of PPARs Pharmacol Res 2004 in press Mueller C, Weaver V, Vanden Heuvel JP, August A, Cantorna MT: Peroxisome proliferator- activated receptor gamma ligands attenuate ... in Cardiovascular Disease Med Res Rev 2000, 20:350-366 Ferre P: The biology of peroxisome proliferator- activated receptors: relationship with lipid metabolism and insulin sensitivity Diabetes...

Ngày tải lên: 12/08/2014, 18:22

... analysis Peroxisome proliferator- activated receptor Peroxisome proliferator- activated receptor alpha xv PPARβ PPARγ PS1 QC ROSI RT S/N SDH SI SNP SOD TCMS TIC TRO TZD UPLC-MS/MS VIP Peroxisome proliferator- activated ... CHO-APP695, which was attributed to its dual agonism of both peroxisome proliferatoractivated receptor gamma (PPARγ) and PPAR alpha (PPARα) receptors PIO treatment was also observed to have successfully ... SDH SI SNP SOD TCMS TIC TRO TZD UPLC-MS/MS VIP Peroxisome proliferator- activated receptor beta Peroxisome proliferator- activated receptor gamma Presenilin-1 Quality control Rosiglitazone Retention...

Ngày tải lên: 09/09/2015, 11:20