pax3+7+and+mrf+transcription+factors

... analysis ORF Protein MM1028 TBP2 MM2184 TBP3 MM 177 2 TFB MM1028rt MM1028rt MM2184rt MM2184rt MM 177 2rt MM 177 2rt Sequence 5¢ fi 3¢ Primer set FEBS Journal 277 (2010) 4398–4411 ª 2010 The Authors Journal ... plasmids were designated pRS 475 (MM10 27) , pRS231 (MM1028) and pRS 476 (MM 177 2) MM2184 (TBP3) was amplified using primers (Mm 2184 His.for 5¢-CCAAATACAGGATCCATGGAATCTAC and Mm 2184 His.rev 5¢-GAGAATTCATTTAATAAAGAAGTCCTAAG) ... activator-dependent archaeal transcription J Biol Chem 279 , 5 171 9–5 172 1 Thomm M (2000) Die Transkriptionsmachinerie der Archaea BIOspektrum 3, 179 –185 Cohen-Kupiec R, Blank C & Leigh JA (19 97) Transcriptional...

Ngày tải lên: 29/03/2014, 21:20

... WRKY18 and WRKY60 are weak transcriptional activators and WRKY40 is a weak transcriptional repressor (Figure 8) The relatively weak transcription regulatory activities would make the three transcription ... AT5G05410.1, AT1G 277 30, AT2G36 270 and AT3G24650 respectively and generated single sharp peeks in melt curves Acknowledgements We thank Guangdong Natural Science Foundation (grant no 06023150) and National ... WRKY group IId transcription factors interact with calmodulin FEBS Lett 2005, 579 (6):1545-1550 Kim KC, Fan B, Chen Z: Pathogen-Induced Arabidopsis WRKY7 Is a Transcriptional Repressor and Enhances...

Ngày tải lên: 11/08/2014, 11:21

... of bZIP Transcription Factors Human Ryu et al (20 07) [70 ]/ [71 ] The Drosophila Transcription Factor Database Fly Adryan et al (2006) [13]/ [72 ] wTF2.0: a collection of predicted C elegans transcription ... Cell Mol Life Sci 20 07, 64:14 57- 1 470 Swamynathan SK, Nambiar A, Guntaka RV: Role of single-stranded DNA regions and Y-box proteins in transcriptional regulation of viral and cellular genes FASEB ... finger-like subdomain and a flexible subdomain J Mol Biol 1999, 2 87: 593-6 07 Stefancsik R, Sarkar S: Relationship between the DNA binding domains of SMAD and NFI/CTF transcription factors defines a...

Ngày tải lên: 14/08/2014, 21:20

... are driving factors and which ones are passenger events One of the key themes of the meeting was the ability to target transcription factors using drugs Traditionally, transcription factors were ... to target, and kinase pathways or cell surface proteins have instead been popular therapeutic targets However, transcription factors are the downstream effectors of many pathways and this, coupled ... mice with various types of cancer and was bioavailable when administered orally These data confirm that proteinprotein interactions between transcription factors and regulatory proteins can be blocked...

Ngày tải lên: 14/08/2014, 21:20

... of cytokine gene FEBS Journal 277 (2010) 128–1 47 ª 2009 The Authors Journal compilation ª 2009 FEBS S Mitra et al 74 75 76 77 78 79 80 expression in human CD4(+) and CD8(+) T-lymphocyte subsets ... foxp3 86.90 43.40 42.50 17. 50 16.20 15.60 16.40 19.50 18.10 17. 60 43.90 43.80 17. 20 17. 50 16.60 15.60 19.20 18.80 16.80 91.00 17. 30 15.80 16 .70 17. 00 16.90 17. 20 16.30 17. 50 16.40 16.20 26.30 16.80 ... identification of transcription factors is that FEBS Journal 277 (2010) 128–1 47 ª 2009 The Authors Journal compilation ª 2009 FEBS S Mitra et al Zebrafish T-cell transcription factors t-bet, stat6 and foxp3...

Ngày tải lên: 16/02/2014, 09:20

... family transcription factors J Biol Chem 275 , 2 970 1–2 970 8 10 Williams T & Tjian R (1991) Analysis of the DNAbinding and activation properties of the human transcription factor AP-2 Genes Dev 5, 670 –682 ... 37 Yokota H, Goldring MB & Sun HB (2003) CITED2mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear J Biol Chem 278 , 472 75– 472 80 38 Agrawal A, Gajghate S, Smith H, Anderson ... binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2 Mol Cell Biol 22, 78 77 78 88 44 McPherson LA, Loktev AV & Weigel...

Ngày tải lên: 16/02/2014, 09:20

... unequivocally transcriptional for Cyr61/CCN1 and possibly transcriptional and post-transcriptional, albeit to different extents, for CTGF/CCN2 The difference between Cyr61/ CCN1 and CTGF/CCN2 ... 273 , 173 18– 173 25 26 Conway, A.M., Pyne, N.J & Pyne, S (19 97) Sphingosine 1-phosphate activation of MAP kinase – involvement of PI 3-kinase and protein kinase C Biochem Soc Trans 25, S585 27 ... the Cyr61/CCN1 promoter activity and that the region between ) 476 and ) 276 contains additional element(s) that further augment the promoter activity Potential transcription factor binding elements...

Ngày tải lên: 08/03/2014, 08:20

... gray and the conserved TATA box is shown in bold and boxed similar (compare the activities of ) 478 ⁄ )1 with ) 478 ⁄ + 47 and of )71 7 ⁄ + 47 with )74 7 ⁄ )1) TTF-1 is a strong repressor of Muc5b expression ... sites at )358 ⁄ )355 and )353 ⁄ )350; lanes and 6, mutated T211; lanes 7 10, T212, TTF-1 sites at )70 9 ⁄ )70 6 and )70 0 ⁄ )6 97; lanes 11 and 12, mutated T212 Lanes 1, 5, and 11, radiolabeled probe ... two sites at )70 9 ⁄ )70 6 and )70 0 ⁄ )6 97 The probes T213, T238 and T242 contain one predicted site at )112 ⁄ )109, )325 ⁄ )322 and )4 17 ⁄ )414, respectively Incubation of T211 and T212 radiolabeled...

Ngày tải lên: 15/03/2014, 00:20

... Arg56, Glu60 and His64 of the p50 subunit and mediated by Arg34, Arg35 and Arg1 87 of the p65 subunit are present, and are comparable to the NF-kB DNA –DNA hybrid molecule [41] CD analysis and melting ... target and p52 or p50 NF-kB factors The double stranded PDP –PDP chimera mimicking the HIV-1 NF-kB binding sites does not inhibit the interactions between NFIL2, GATA-1 and STAT-1 transcription factors ... process, were 53 ^ 8C for PDP – PDP and 55 ^ 8C for DNA duplex (DNA) The double stranded PDP –PDP chimera inhibits the interactions between NF-kB transcription factors and target DNA–DNA molecules When...

Ngày tải lên: 24/03/2014, 04:21

... (pBluescriptKS+ control and ⁄ or transcription factorexpressing vectors, Sp1 [73 ], Sp3 [74 ], VDR [75 ], CDP and CDP 878 –1505 [76 ], C ⁄ EBPa, C ⁄ EBPb and C ⁄ EBPe [77 ], and PU.1, IRF4 and IRF8 [78 ] The GenePORTER ... s, and 72 °C for 120 s; 22 cycles of 95 °C for 45 s, 54 °C for 60 s, and 72 °C for 120 s; 72 °C for 10 min) using Pfu polymerase (Stratagene) PCR products (145 and 651 bp, E2M2; 299 and 4 97 bp, ... antimicrobial response Science 311, 177 0– 177 3 11 Friedman AD (20 07) Transcriptional control of granulocyte and monocyte development Oncogene 26, 6816– 6828 12 Friedman AD (2002) Transcriptional regulation...

Ngày tải lên: 30/03/2014, 02:20

... T & Yoneda, Y (19 97) Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI1, but not Rch1 EMBO J 16, 70 67 70 77 16 Fahrenkrog, ... 277 , 30 072 –30 078 25 McBride, K.M., Banninger, G., McDonald, C & Reich, N.C (2002) Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha EMBO J 21, 175 4– 176 3 ... ubiquitin-proteasome pathway Science 273 , 171 7– 171 9 46 Lillemeier, B.F., Koster, M & Kerr, I.M (2001) STAT1 from the ¨ cell membrane to the DNA EMBO J 20, 2508–25 17 47 Lerner, L., Henriksen, M.A., Zhang,...

Ngày tải lên: 30/03/2014, 15:20

... - HD ZLZ START 70 8 221-454 - At1g73360 - HD ZLZ START 72 2 228-458 - NP_565223 At1g79840 GL2 HD ZLZ START 74 7 253-4 87 - NP_18 079 6 At2g32 370 - HD ZLZ START 72 1 245- 472 - NP_186 976 At3g03260 - HD ... (a) At1g34650 70 At5g 173 20 80 At3g03260 77 At4g 177 10 142 At5g46880 165 At1g 179 20 75 At1g73360 86 ATML1 72 PDF2 116 At1g05230 118 ANL2/AHDP 188 At3g61150 164 At5g52 170 111 At2g32 370 122 GL2 155 ... NP_191 674 At3g61150 - HD ZLZ START 808 312-539 - NP_5 671 83 At4g0 073 0 ANL2, AHDP HD ZLZ START 802 3 17- 544 - NP_5 672 74 At4g04890 PDF2 HD ZLZ START 74 3 245- 474 - NP_193506 At4g 177 10 - HD ZLZ START 70 9...

Ngày tải lên: 09/08/2014, 20:20

... manuscript DHL wrote the PHP and perl scripts to annotate and populate the database and worked on database and table design and interaction SMG contributed to manuscript preparation and future database ... family of transcription factors The NFI family of transcription factors is essential for the development of multiple organ systems including brain, lung, muscle, hematopoietic cells, and teeth ... by NFI transcription factors in the primary literature These control regions are annotated with transcription start sites, translation start sites, NFI binding sites, and the location and identity...

Ngày tải lên: 10/08/2014, 09:22

... 173 3 6.46 0.0033 A: 67. 96 C: 69. 87 1825 7. 38 G: 67. 96 0.0033 C: 67. 96 T: 69. 87 1890 7. 10 0.00 17 G: 67. 50 A: 69.54 2038 7. 52 0.0011 2520 7. 10 0.00 17 G: 67. 50 2562 6.46 0.0033 C: 67. 96 T: 69. 87 ... 0.60 EA 25 7. 6 11 0 .73 EU 23 7. 7 14 0.62 WANA 21 8.9 0 .77 2-rowed 6-rowed 23 25 7. 4 8 .7 14 14 0.56 0 .77 Total 45 2.4 18 0 .74 AM 34 2.8 0.80 EA 30 1.8 0.64 EU 31 2.1 0.68 WANA 37 2 .7 11 0.84 2-rowed ... T: 56 .77 C: 56 .73 -209 4.84 0.0003 G: 55. 57 A: 56 .74 -166 5.12 0.0001 G: 55.55 A: 56 .78 -101 4 .79 0.0001 C: 55.53 T: 56 .78 - 27 4.22 0.0001 T: 55.55 C: 56 .79 -3 3. 27 0.0008 C: 55.61 T: 56 .72 62...

Ngày tải lên: 12/08/2014, 03:21

... 13/13-5/5 13/13-4/5 13/13-5/5 13/13-4/5 7/ 7-14/14 0 /7- 13/14 7/ 7-14/14 0 /7- 13/14 7/ 7-14/14 0 /7- 13/14 7/ 7-14/14 0 /7- 13/14 0 /7- 11/14 7/ 7-14/14 0 /7- 13/14 7/ 7-14/14 5/5-2/2 4/5-2/2 5/5-2/2 6.00e-14 ... 3, 7, and 14) Each of the full length cDNA sequences were obtained Page of 17 (page number not for citation purposes) BMC Plant Biology 20 07, 7: 17 http://www.biomedcentral.com/1 471 -2229 /7/ 17 Table ... of 17 (page number not for citation purposes) BMC Plant Biology 20 07, 7: 17 http://www.biomedcentral.com/1 471 -2229 /7/ 17 Figure abundance for 13 spruce MYB genes and 4CL in various organs and tissues...

Ngày tải lên: 12/08/2014, 05:20

... interacts with the transcription initiation complex (consisting of RNA polymerase II and associated factors) via coactivators including CBP, P300, SRC-1, and TIF-2 (see [12] for details and literature ... Invest 19 97, 100:23 47 2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ... J, Kisiel W, Stern DM, Pinsky DJ: Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation J Clin Invest 19 97, 99: 172 9– 173 8 Yan SF, Lu J, Xu L, Zou YS, Tongers J,...

Ngày tải lên: 12/08/2014, 18:20

... 356:1 27- 132 36 Nesin M, Cunningham-Rundles S: Cytokines and neonates Am J Perinatol 2000, 17: 393-404 37 Saugstad OD: Oxygen radicals and pulmonary damage Pediatric Pulmonol 1985, 1:1 67- 175 38 ... erythropoietin Life Sci 1990, 47: 1 27- 134 67 Wenger RH, Gassmann M: Oxygen(es) and the hypoxia-inducible factor-1 Biol Chem 19 97, 378 :609-616 68 Budinger GR, Duranteau J, Chandel NS, Schumacker PT: ... such as TNF-α and lipopolysaccharide [36–46,169] and they serve as intracellular signals for the activation of redoxsensitive transcription factors [2,3,16–18,26, 27, 36– 46,164– 170 ] Among the...

Ngày tải lên: 12/08/2014, 18:20

... understanding and future clinical trials will assist in the realization of improved treatment and reduced mortality from oxidantmediated lung injury Competing interests None declared References 472 ... science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated α lung injury: role for hypoxia-inducible factor-1α Crit Care 2003, 7: in press Fein AM, Calalang-Colucci ... IL-13 J Immunol 1999, 162:1 071 -1 076 Haddad JJ, Land SC: A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha FEBS Lett 2001, 505:269- 274 Haddad JJ: Recombinant...

Ngày tải lên: 12/08/2014, 19:21

... activation of NF-κB and the signal transducer and activator of transcription, and that increases in IL-6 and granulocyte colony-stimulating factor mRNA levels in the lungs and livers measured ... 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 κ Baldwin AS: The transcription factor NF-κB and human disease J Clin Invest 2001, 1 07: 3-6 Housset B: Free radicals and respiratory pathology ... Biol 19 97, 17: 608-616 Wong HR, Wispe JR: The stress response and the lung Am J Physiol 19 97, 273 :L1-L9 Wong HR, Ryan M, Wispe JR: Stress response decreases NFκB nuclear translocation and increases...

Ngày tải lên: 12/08/2014, 19:21

... Biological 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 markers of acute lung injury: prognostic and pathogenetic significance Am J Respir Crit Care Med 19 97, 155:11 87- 1205 Kaminski N, Allard JD, ... regulation via specific and targeted genetic control of transcription factors, and can thus provide us with a novel way of controlling disease processes [71 75 ] Dynamic variation in pO2 and redox equilibrium ... that of NF-κB Indirect, but unprecedented and unequivocal, evidence was independently provided by Hellwig-Bürgel and colleagues [ 47 49] and by Haddad and Land [50,51], however, to indicate HIF-1...

Ngày tải lên: 12/08/2014, 19:21