pathways of ras function connections to the actin cytoskeleton

... the rate of synthesis of the protein [25,29,39]; (b) variations in the rate of degradation [40] and (c) transcriptional control [41] To evaluate the contribution of HR12 to the stability of the ... HR12 induces arrest of Rat1 /ras cells at the G1 phase of the cell cycle We next examined the effect of HR12 on the distribution of Rat1 /ras cells in the cell cycle To resolve the G1, S and G2/M ... Unprocessed Ras, (p) processed Ras The upper graph shows the levels of processed Ras, as a percentage of total Ras, over the course of HR12 treatment The lower graph shows levels of pRb phosphorylation,...

Ngày tải lên: 31/03/2014, 01:20

... (t) and call the polynomial part of pA (t) It is easy to see that PA (t) is a polynomial of degree n − (More generally, the degree of PA,λ(t) is one less than the number of values of i for which ... 1) To compute this residue, note that Res(f (z), z = 1) = Res(ez f (ez ), z = 0), so that PA (t) = − Res e−tz ,z = (1 − ea1 z ) · · · (1 − ean z ) (4) Proof of the theorem The coefficient of tn−1−m ... (3) follows from (5) and (6) Remark It is possible to avoid the use of complex analysis and give a purely formal power series proof of the theorem We indicate here how this can be done We work...

Ngày tải lên: 07/08/2014, 06:22

... contrast to the protein level, the At3g07430 transcript level of the FN028 line was higher than that of the 35S-At3g07430 line This is likely due to the difference between inserted transgenes The ... numbers of the sequences are indicated with the name of the species (B) Phylogenetic tree of the YLMG family The tree shown is the maximumlikelihood tree constructed by the PHYML program [48] The ... group I, was lost in parallel with the loss of photosynthetic activity in the ancestor of apicomplexans Given this scenario and the existence of ylmG in non-photosynthetic bacteria, it is suggested...

Ngày tải lên: 12/08/2014, 03:21

... contributed to the embryo, the resultant offspring will be chimeric (up to ca 50% of animals) The ESC contribution to a mouse can high (up to ca 80% of the cells), and will often include the germline ... attributed to the fortuitous removal or inhibition of IF(s) [43] Seminal fluid reportedly contains an inhibitory factor (IF-1) that appears to actively block the binding of exogenous DNA to sperm and to ... demanding, due in large part to the need to remove embryos from the female, to manipulate the embryos and finally to return the embryos to the reproductive tract By contrast, SMGT coupled with AI...

Ngày tải lên: 03/11/2012, 10:01

... in the specific section Figure 1: Geographical location of the province of Parma (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of ... this case the patient had a panuveitis, which recovered only after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme ... P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of severe Toxocara uveitis J Infect 2006; 52:159-161 http://www.medsci.org ...

Ngày tải lên: 03/11/2012, 11:11

... group of NMA represents a likely proton source The carbonyl O atom is a prime proton acceptor, as is the N atom One usually thinks of the lone pairs of O as the source of charge transfer, but the ... transfer from the S lone pairs to the CO p* antibonding orbital Altogether, these interactions add up to a total stabilization energy of more than kcal mol1, the largest of any of the complexes ... in CH3SCH3 The enhancement of the S atoms proton-accepting ability strengthens the NHãããS H-bond to the point where it is the sole contributor to the global minimum in the CH3SCH3/NMA heterodimer,...

Ngày tải lên: 16/12/2012, 15:21

... Most of these studies have focused on the evaluation of TBT concentration on acute and/or chronic toxicity to various marine organisms In general, acute toxicity studies have measured the LC50 (the ... under the “Law Concerning the Examination and Regulation of Manufacture, etc of Chemical Substances” in Japan The toxicity level of TBTCl may be as high as that of tributyltin oxide (TBTO) (e.g ... control Acetone solution of 0.05 mL/L, which was made by adding 0.1 mL of acetone to L of filtered seawater, was used as acetone-control The TBTCl solution was made by adding 2000 mg of tributyltin...

Ngày tải lên: 05/09/2013, 10:15

... collected data, due to the general nature of these tools and availability of sources, which can provide help in these respects 2.4 Outline of the report An overview of the sections of the report is ... organisation of repair and maintenance of tools and their final disposal at the end of their life For the example of the tool library, the following attributes could be suggested in the above context ... perceived behavioural control These theories provide some input to the discussion held above about social relevant actors and the importance of belonging to a group The Theory of Reasoned Action (TRA)...

Ngày tải lên: 04/11/2013, 10:15

... farmer of the Post Office, furnished to the Secretary of State "a perfect list" of all officers in the Post Office According to this list there were eight Clerks of the Roads, viz.:—Two of the Northern ... cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the toast of "the Visitors," and said that they had amongst them two representatives of the ... the street; on the east side being another building answerable thereto." These premises served as the Post Office for the long period of 118 years The first half of the present Bristol Post Office...

Ngày tải lên: 17/02/2014, 02:20

... mentioned in the registers of their High Mightinesses of the date of the 4th of May 1781, and of the 9th of January 1782; moreover the resolutions of the Lords the States of the five other provinces, ... at the moment when the present war broke out, to prejudice in the least the fidelity of the Citizens of the Amstel, or to shake them in the observance of their duties; the inconveniencies and the ... resolved to authorise the deputies of this Province at the States General, as they authorise them by the present, to conform themselves in the name of this Province to the resolution of the Lords the...

Ngày tải lên: 20/02/2014, 08:20

... contrast to the CD11b I domain GST, the majority of the CD11a I domain GST was found in the insoluble fraction of the E coli lyzate Modification of the solubilization conditions and increasing the ... degrees of inhibition were detected The most efficient inhibition of the binding of ICAM-1 L cell transfectants to the I domains was obtained with the ICAM-1 mAb LB-2 reacting with the first domain of ... receptor However, it is probable that other erythrocyte receptors for the CD11a and CD11b I domains exist because of the residual binding of the ICAM-4 negative cells The mAb 60.1 reacting with the...

Ngày tải lên: 20/02/2014, 11:20

... solution of the crystal structure of Mls1p could also turn out to be helpful in elucidating whether the protein's selective import into peroxisomes might have something to with the exposure of the ... molecular mass of 62 000 in the lane with the wild-type extract that was absent from the lane corresponding to the mls1D mutant (arrow; Fig 1A), thereby con®rming the speci®city of the antibody ... Targeting of Mls1p to peroxisomes is advantageous for growth on oleic acid Two steps of the glyoxylate cycle take place in the cytosol: the splitting of isocitrate into succinate and glyoxylate, and the...

Ngày tải lên: 22/02/2014, 04:20

... contribute to the Wisconsin economy and are of growing importance to the citizens of the state The total economic contribution of Wisconsin public libraries to the Wisconsin economy is $753,699,545 The ... libraries contribute to the Wisconsin economy The other measure of value is the market value of public library services to consumers, businesses, governmental bodies and other sectors of the economy This ... chapter extends the analysis of the economic value of public libraries to the market value of services provided to the citizens of Wisconsin by Wisconsin’s public libraries The use of market value...

Ngày tải lên: 08/03/2014, 08:20

... position 718, belonging to the putative a-DG-binding epitope (691–719) within the ectodomain of b-DG, was found to be one of the most influenced residues during the titration of [15N]b-DG(654–750) ... portion of the protein, and Glu667 fi Ala; only one mutation, Val736 fi Ala, was generated within the C-terminal region of the b-DG ectodomain, downstream of the a-DG-binding epitope A map of all the ... thioredoxin-a-DG(485–620) [15] Therefore, we decided to mutate it to an alanine, together with two other phenylalanines, Phe692 and Phe700, the only other aromatic residues located within the a-DG-binding epitope that...

Ngày tải lên: 16/03/2014, 12:20

... bound together by gluons, which are the carriers of the strong force, which binds protons and neutrons together into the nuclei of atoms The very strength of the strong force makes it hard to study: ... understanding of the material world complete the encyclopedia’s coverage of the history of particle physics The selection of physicists for the biographies was based on the desire to provide a historical ... such as the W and Z as well as the top quark The objective of elementary particle physics is twofold: to establish the identity of all the elementary particles of nature and to determine the means...

Ngày tải lên: 17/03/2014, 14:37

... and attempt to limit the damage caused by these chemicals In some places there are stockpiles, storage facilities, and – to put it bluntly – dumps of these toxic substances These stockpiles and ... evaluated using the best available scientific data to determine whether their chemical properties warrant their inclusion in the treaty The Committee makes recommendations to the Parties to the Convention ... governments to become familiar with the threats posed by hazardous chemicals, to realize they have to work together, and to become committed to joint action Now that the Convention has taken effect, the...

Ngày tải lên: 22/03/2014, 14:20

... series of campaigns against the belligerent peoples of the northeast from 238 to 245, which became one of the most impressive displays of Chinese power in the history of Korea A main target of the ... Summary of the Instructions of Commanding General Chistiakov at the Meeting of the Five Provinces Kim Il Sung, from “Report on the Work of the Central Committee to the Fourth Congress of the Workers ... Thus, the history of the Chinese presence in Korea was mainly the story of Lelang and Xuantu, with the former being the more populous and prosperous of the two outposts of Chinese civilization The...

Ngày tải lên: 04/04/2014, 12:22

... with a historic probability of winning ≥ r [3] We focus on the regime where the number of strategies in play is comparable to the total number available, and where r ∼ 0.5 In addition to producing ... proportional to S0 −S1 = S0−1 In addition, the number of agents taking part in the game at each timestep will be related to the total number of active strategies S0 + S1 = S0+1 , hence the error ... rate % Fig Moving average of the multi-agent game’s success rate for the real price-series of Fig (top left) and a random walk price-series (top right) Bottom: histogram of individual agents’ time-averaged...

Ngày tải lên: 23/04/2014, 16:11

... philosophy of linguistics is to the philosophy of language, or as the philosophy of physics is to the metaphysical question as to the nature of the physical world These fields are not of course totally ... as to the logical character of the concept of mind, we should say something about the status of our enquiry into the nature of mental phenomena and about the method of its prosecution A further ... conception of these mental states Thus it is natural to look to their ascription to others for the ground of their irreducibility to the physical; and here we find principles governing their ascription,...

Ngày tải lên: 10/06/2014, 21:27