parkinsons and vitamin d3
Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
... 20-hydroxyvitamin D3, other major metabolites of vitamin D3 were a dihydroxyvitamin D3 and a trihydroxyvitamin D3 product. Thedihydroxyvitamin D3 was clearly identified as 20,23-dihydroxyvitamin D3 by ... di-hydroxyvitamin D3 and trihydroxyvitamin D3 by com-paring their 1D proton NMR to that of the parent vitamin D3 (Fig. 5A–C). For both dihydroxyvitamin D3 and trihydroxyvitamin D3, the chemical ... D3, dihydroxyvitamin D3 and trihydroxyvitamin D3. (A) Vitamin D3; (B) dihydroxy metaboliteidentified as 20,23-dihydroxyvitamin D3; (C)trihydroxy metabolite identified as17a,20,23-trihydroxyvitamin...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... levels of the vitamins (retinol, tocopherol and cholecalcifer-ol), and trace elements and heavy metals (Zn, Cu, Fe, Cd, Pb and Mn) in patients with CAD and the control group are shown in Table ... RESULTS AND DISCUSSION Clinical characteristics and serum cholesterol levels were not significantly different in patients with and without CAD (Table 1). Comparisons of the levels of the vitamins ... peroxidation of LDL and this action could be paramount in the prevention of atherosclerosis. As lypophilic molecules, vitamin E and beta-carotene are incorporated into the LDL par-ticle. Vitamin E plays...
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Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"
... 1,25-Dihydroxyvitamin D3 receptors identified in the rat heart. J Mol Cell Cardiol 1986;18:67-72. 18. Ohsawa M, Koyama T, Yamamoto K, Hirosawa S, Kamei R. 1alpha,25-dihydroxyvitaminD3 and its potent ... themselves produce and excrete this active form of vitamin D and, therefore, by both autocrine and paracrin stimulation influence their own macrophage activity in addition to the T- and B-lymphocyte ... models and was unaffected by the1,25-vit D treatment. This is a well described pattern both in clinical and experimental sepsis and may be caused both by insuf-ficient secretion and effect...
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Báo cáo khoa học: The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism docx
... analysis of P1 and P3.NMR analysis of compound P1 showed that itrepresents 20-hydroxyvitamin D3 (Fig. 2, Fig. S1).Compared with vitamin D3 and as an effect ofFig. 1. Metabolism of vitamin D3 by purified ... z 361(433 ) 4H2O) and m ⁄ z 297 and 279 that are presenton MS3of vitamin D3. There was insufficient product P2 from the action ofP450scc on vitamin D3 to perform NMR and there-fore a full ... vitamin D3 is successively hydroxylated in liver and kidney to 1,25-dihydroxyvitamin D3 (calcitriol), theactive regulator of calcium metabolism [1]. Calcitriol and its precursors...
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lecture 11 dietary fiber and vitamin analysis
... analysis Vitamin • Vitamins are defined as relatively low-molecularweight compounds which humans require small quantities for normal metabolism. • Humans cannot synthesize most vitamins and therefore ... α-amylase, protease and γ-glutamyl hydrolase(conjugase).– Vitamins A, E, or D: Organic solvent extraction, saponification, and re-extraction with organic solvents. For unstable vitamins such as ... hydrolysis.• Nonsolubilized and/ or nondigested materials are collected by filtration, and the fiber residue is recovered, dried, and weighed.Dietary fiber analysis• Starches and proteins are removed...
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Báo cáo khoa học: Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1 doc
... 1,25,26-trihydroxyvitamin D3: isolation, identifi-cation, and biological activity. Arch Biochem Biophys210, 104–109.19 Peng X, Hawthorne M, Vaishnav A, St-Arnaud R &Mehta RG (2009) 25-Hydroxyvitamin D3 ... Partridge JJ, Uskokovic MR & Horst RL(1981) 1 Alpha-25,26-trihydroxyvitamin D3: an in vivo and in vitro metabolite of vitamin D3. Biochemistry 20,6230–6235.25 Omura T & Sato R (1964) The ... cells as a standard (Fig. 2).Metabolism of vitamin D3in the recombinantS. lividans cell cultureFigure 3 shows HPLC profiles of vitamin D3 and itsmetabolites. Their retention times and mass...
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Báo cáo y học: "1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss"
... Smad3 and T G F -β pathways and inducing HGF mRNA expression and HGF se-cretion in renal interstitial fibroblasts (40). So it was possible that 1,25-(OH) 2D3 could exert anti-apoptotic effect and ... number of podocytes and FPW in 1,25-(OH)2D3 group was higher and smaller than those in A DR group, respectively (Table 2 and Figure 1). Table 2 The number of podocytes and FPW in different ... collagenase and culture. Early cellular outgrowths at 5-7 days were selectively removed by a cylinder cloning technique. Cells were replated, and plates growing pure colonies were then expanded and...
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Vitamin and Colorant
... tone, balance, and strengthen liver function and for hepatitis and liver inflammation/pain 2. for high cholesterol 3. for skin care and skin anti-aging (for its antioxidant and ultraviolet ... oil, 3% fixed oil, 4.5% to 5.5% pigments, and 13% to 16% protein, as well as alpha- and beta-carotenoids and other constituents. 73. Properties•Oil- and Water-Soluble Annatto Extracts :- Oil-soluble ... 2Confectionery and frostings 0.3 2 4 0.00 0.0000 0Egg products 1.9 5 7 0.01 0.0002 0Fats and oils 17.5 2 4 0.04 0.0006 1Frozen dairy 25.6 2 10 0.05 0.0009 1Fruit ices 0.7 5 10 0.00 0.0001 0Gelatines and...
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Tài liệu Báo cáo khoa học: Gas6 and protein S Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily pptx
... expands theboundaries of signalling mediators, and it is thereforenot unlikely that Sky and Mer could be involved inTable 1. Affinities of Gas6 and protein S for Axl, Sky and Mer RTKs within and ... a ligand–receptor system that is emerging as amajor regulator of cell survival and turnover duringapoptosis under certain physiological and pathologicalscenarios.Gas6 and protein S, vitamin ... (N-terminal segment and LG1) and green (LG2), and Axl Igdomains are in yellow (IG1) and brown(IG2); a calcium ion in the LG1–LG2 inter-face is shown as a pink sphere, and theGas6–Axl contact...
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Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... theantibodyselection.PanelB:detectionofRARbyWesternblotting.C,control;D,vitaminA-deficientrats;H,hypervitaminosis.Ó FEBS 2003 Vitamin A status and proliferative control genes (Eur. J. Biochem. 270) 1499with a 12-h light : 12-h dark cycle. Rats were cared and handled ... ofc-jun,p53 and p21WAF1/CIF1in liver and lung of control, chronic vitamin A-deficiency and hypervitaminosis ratsBased on the results found in the differential display study and taking into ... (ATBC) trial [35] and theb-Carotene and Retinol Efficacy Trial (CARET) [36]revealed that individuals that were given b-carotene and vitamin A received no protection from cancer and theremay even...
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Quantification of vitamin e and ç oryzanol components in RiceGermandBran
... analyzed free vitamin E and γ-oryzanolcomponents in RG and FFRB. The profiles of free vitamin E and γ-oryzanol in RG and FFRB differ significantly. The levelsof free vitamin E and γ-oryzanol ... bran and germ, and profiles of vitamin E and γ-oryzanol components in these twodifferent materials are less well-studied. In the current study, vitamin E and γ-oryzanol componentsin rice bran and ... enables rapid and direct on-line identification and quantification of the vitamin E and γ-oryzanol components in ricebran and germ.KEYWORDS: Rice bran; rice germ; γ-oryzanol; vitamin E; LC-MS/MSINTRODUCTIONFree...
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Báo cáo khoa học: Vitamin C Biosynthesis, recycling and degradation in mammals doc
... of the synthesis and the recycling of vitamin C, and a novel pathway has been describedfor the degradation of vitamin C in bacteria. Thisforms the subject of this review. Vitamin C transport,which ... clearly different from glutaredox-in and PDI. SDS ⁄ PAGE analysis gave a single band at31 kDa and Kmvalues of 0.25 and 2.8 mm were repor-ted for DHA and GSH, respectively. The enzymehad ... Braun L, Mile V, Schaff Z, Csala M, Kardon T,Mandl J & Ba´nhegyi G (1999) Induction and C. L. Linster and E. Van Schaftingen Vitamin C metabolism and recycling in mammalsFEBS Journal 274 (2007)...
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Báo cáo Y học: Expression and characterization of recombinant vitamin K-dependent c-glutamyl carboxylase from an invertebrate, Conus textile doc
... form of vitamin K, molecular oxygen, carbondioxide, a vitamin K-dependent carboxylase that alsoco-ordinately oxidizes vitamin K to the vitamin K epox-ide, and a salvage enzyme, the vitamin ... Conus and vertebratepropeptides and is required for substrate binding, and theother that binds only the vertebrate propeptide and isrequired for enzyme stimulation. The marked functional and ... vertebrate vitamin K-dependent carboxy-lases, and to compare the structural and functionalhomologies of this enzyme between invertebrates and vertebrates. Whereas the sequences of the N-terminus and C-terminus...
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Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt
... 1.11.9α-PTENα-actinControl5-AzaVD35-Aza + VD3ABCDFig. 6. Vitamin D promoted the apoptosisinduced by 5-Aza. HGC-27 cells were trea-ted with VD3 and 5-Aza (5 lM), and westernblotting was used ... anticancer effect of vitamin D, but themechanisms underlying this action have not been fully explored. Here weshow that 1,25-dihydroxyvitamin D3 (VD3, the active form of vitamin D)significantly ... cells with5-Aza and VD3, either alone or in combination, and we found that the expression of PTEN was upregulat-ed by over 100-fold after combined treatment with5-Aza and VD3 (Fig. 6A). Meanwhile,...
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INTERNATIONAL AGENCY FOR RESEARCH ON CANCER WORLD HEALTH ORGANIZATION: Vitamin D and Cancer pptx
... of vitamin D content of food items. Absorption of vitamin D and metabolic action may be antagonised by other vitamins and nutrients, mainly vitamin A and the retinol compounds (Johansson and ... 25, 429-435. Vitamin D and Cancer 83Chapter 11 – Observational studies on dietary intakes of vitamin D and cancer 11.1 Background and methods Most studies on vitamin D intakes and cancer have ... Conclusions 105 14 – Randomised trials on vitamin D, cancer and mortality 113 14.1 Rationale for randomised trials 113 14.2 Randomised trials on vitamin D supplements and cancer incidence 113...
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