parkinson s disease and related conditions

... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders), Saskia Biskup, Germany and Andrew B Singleton, ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This...

Ngày tải lên: 14/02/2014, 17:20

... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... in Spain by T.G Hostench, S. A Contents Foreword Preface Acknowledgements Section A Review of Parkinson s Disease and Related Disorders Section Parkinson s Disease and Related Disorders Illustrated...

Ngày tải lên: 14/03/2014, 22:20

... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson' s disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...

Ngày tải lên: 14/03/2014, 22:20

... Figure 14 Positive glabellar tap Persistent blinking is a feature of Parkinson s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject ... cells (astrocytes and macrophages) Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts ... Histological sections from Parkinson' s disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology...

Ngày tải lên: 09/08/2014, 16:21

... normal subject (left) compared with that in Parkinson' s disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist of D2 receptors) Figure ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press ... (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in...

Ngày tải lên: 09/08/2014, 16:21

... 45 Histological section of cerebral cortex in corticobasal degeneration shows severe gliosis and an achromatic neuron (H & E) Figure 46 Histological sections of cerebral cortex showing swollen ... proved responsive to botulinum toxin ©2004 CRC Press LLC Figure 55 Abnormal neck posture in a patient with spasmodic torticollis Figure 56 Mechanisms of actions of various botulinum toxins (BTX) ... copy three hand postures (A–C, lower), in each instance, the patient 's version was defective (A–C, upper) ©2004 CRC Press LLC Figure 50 In this patient with corticobasal degeneration, sagittal T1-weighted...

Ngày tải lên: 09/08/2014, 16:21

... Histology in Wilson 's disease shows atrophy and rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus ... Huntington 's disease is accompanied by DNA gels (lower) which indicate trinucleotide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 68 Coronal section of brain in Huntington 's disease shows symmetrical ... fast blue) Figure 63 Histology of brain in Wilson 's disease shows a Bergmann type astrocyte within an atrophic putamen (H & E) ©2004 CRC Press LLC Figure 64 Histology of brain in Wilson 's disease...

Ngày tải lên: 09/08/2014, 16:21

... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, Ltd ISBN: ... McNaught, K .S and Jenner, P (2001) Proteasomal function is impaired in substantia nigra in Parkinson s disease Neuroscience Letters, 297 (3), 191 194 20 PARKINSON S DISEASE AND PARKINSONISM McNaught,...

Ngày tải lên: 14/02/2014, 17:20

... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the association ... paresis, however, has sinister implications; it is typical of certain multisystem cerebral disorders, such as progressive supranuclear palsy, variants of Niemann-Pick disease, and, sometimes,...

Ngày tải lên: 05/03/2014, 23:20

... dementia caused by medical conditions such as head injuries, diseases caused by the human immunodeficiency virus (HIV), Parkinson s disease, and Huntington s disease; and substance-induced persisting ... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS A gradual loss of memory, affecting a person s skills and behavior, characterizes Alzheimer s disease In Helen s case, she slowly lost her ... is essential in transmission of nerve impulses through the synapses of the brain and central nervous system (A synapse is the point at 33 LIFE OUT OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS...

Ngày tải lên: 05/03/2014, 23:20

... Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive impairment associated ... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... tests.33 Medical/Psychiatric/Surgical Histories and Review of Systems Gathering information about previous episodes of memory loss, mood or other psychiatric disorders, and medical conditions and...

Ngày tải lên: 05/03/2014, 23:20

... disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism or drug-induced dyskinesias ... disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are basal ganglia diseases ... pathophysiology of common human movement disorders such as Parkinson s and Huntington s diseases (PD/HD) These structures classically include: 1) the striatum, which comprises the caudate nucleus (CD),...

Ngày tải lên: 05/03/2014, 23:20

... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer s Disease and Related Disorders Association ... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer s Disease and Related Disorders Association ... individuals; IA = neuropathologic diagnosis is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer s Disease and Related...

Ngày tải lên: 28/03/2014, 22:21

... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...

Ngày tải lên: 19/06/2014, 10:20

... Although Parkinson s disease is most prominently identified with physical symptoms such as tremors and akinesia, this disease has a substantial impact beyond motor impairment and physical disability ... approach, and to assess the relationship between health utility scores and PD severity as measured using standard disease- specific tools In cross-sectional analyses, we identified ADL -related components ... diabetes mellitus [20], coronary artery disease [21], stroke [22] and arthritis [23] PD severity was assessed using UPDRS ADL and motor sub-scores (UPDRS II and III) [11], the Hoehn and Yahr Score...

Ngày tải lên: 20/06/2014, 16:20

... previously.64, 80, 81 Statistical analysis Responsiveness of PDQ-8SI scores was assessed using responsiveness indices including Cohen s effect size (ES)84, the standardized response mean (SRM)85 and ... national institute of neurological disorders and stroke PD - Parkinson s disease PDQ-8 - the 8-item Parkinson s disease questionnaire PDQ-8SI - the 8-item Parkinson s disease questionnaire summary ... living SD - standard deviation SF-36 - the short form 36 health survey SGD - Singapore dollars SLR - simple linear regression SRM - standardized response mean UPDRS - unified Parkinson s disease...

Ngày tải lên: 11/09/2015, 10:05