os and disease free survival dfs

... overall survival (OS) and disease- free survival (DFS) rates (72% and 61%) [29] Ragaz et al reported 5-year -OS and DFS rates of 60% and 47% [30] Page of Many reports suggested that premenopausal and ... Cooperative Group; OS: overall survival; DFS: disease- free survival; HRT: hormone replacement therapy Competing interests There is no conflict of interest and any financial and personal relationships ... size and grade and node positivity [33] and in the study of Komoike et al [34], risk factors of ipsilateral breast tumor recurrence were younger age, positive margin status and omission of postoperative...

Ngày tải lên: 09/08/2014, 03:21

... correlation between SF and SB is maintained for years, after which function and bother appear to have divergent trajectories Background Methods Prostate cancer and its treatments are costly and significantly ... AS, Gilliland FD, Stephenson RA, Eley JW, Albertsen PC, Harlan LC, Potosky AL: Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer ... Investigators: Prostate cancer and prostatic disease 2008, 11:67-73 Jonler M, Moon T, Brannan W, Stone NN, Heisey D, Bruskewitz RC: The effect of age, etnicity and geografical location on impotence and quality...

Ngày tải lên: 18/06/2014, 19:20

... at the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 2003, 144:3765-3773 Moreno-Aliaga MJ, Campion J, Milagro FI, Berjon A, Martinez JA: Adiposity and proinflammatory ... impaired fasting glucose (IFG) and/ or impaired glucose tolerance (IGT): American Diabetes Association diagnostic criteria [11]) A glycosylated hemoglobin (HbA1C) between 5.7 and 6.4% (recently ... correlates with dysglycemia and deregulated blood pressure We investigated this hypothesis by comparing disease free obese normoglycemic women and men with disease free obese adults with prediabetes...

Ngày tải lên: 11/08/2014, 03:20

... at the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 2003, 144:3765-3773 Moreno-Aliaga MJ, Campion J, Milagro FI, Berjon A, Martinez JA: Adiposity and proinflammatory ... impaired fasting glucose (IFG) and/ or impaired glucose tolerance (IGT): American Diabetes Association diagnostic criteria [11]) A glycosylated hemoglobin (HbA1C) between 5.7 and 6.4% (recently ... correlates with dysglycemia and deregulated blood pressure We investigated this hypothesis by comparing disease free obese normoglycemic women and men with disease free obese adults with prediabetes...

Ngày tải lên: 11/08/2014, 06:22

... eradication of Mycoplasma hyopneumoniae from pig herds and documentation of freedom of the disease Acta vet scand, 2001, 42, 355-364 Ross, R.F: Mycoplasmal diseases In: Leman, A.D., Straw, B., Glock, R., ... important As long as SPF and non-SPF regions exist in Switzerland, it is likely that spread of EP and APP is facilitated by direct and indirect contact between farms, pig herds and slaughter sites ... regarding re-infections in respiratorydisease -free areas in Switzerland The hatched areas in the total view of Switzerland represent the Cantons of Berne, Lucerne and Solothurn The number in each...

Ngày tải lên: 12/08/2014, 15:20

... children’s exposures to a range of pollutants and compounds and their potential effects on development and learning Environmental factors in diseases such as asthma, immune disorders, autism, and obesity ... goal of developing new clinical and public health applications to improve disease prevention, diagnosis and therapy NIEHS/EPA Children’s Environmental Health and Disease Prevention Research Centers ... understand the persistent effects of chemicals and other exposures on the fetus and child as they relate to brain and organ system development, growth and development of the child through young adulthood...

Ngày tải lên: 12/02/2014, 19:20

... auto- and ⁄ or transphosphorylation, and that mediate interaction with Vav, c-Cbl and the p85a subunit of phosphatidylinositol 3-kinase, whereas the kinase domain harbors two unique tyrosines ... binds to phosphatidylinositol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signaling proteins In SYK, the linker B region contains key tyrosines that ... autoinhibited and is believed to exist in a closed conformation [65–67] Following cellular stimulation, SYK becomes phosphorylated by an SRC family kinase and binds to the immunoreceptor tyrosinebased...

Ngày tải lên: 14/02/2014, 18:20

... chromosome gains and losses due to chromosome segregation errors, a so called “whole chromosomal” aneuploidy, or due to rearrangements of chromosomal parts, often accompanied by their deletion and ... Aneuploidy in Health and Disease 3.1 Whole chromosome aneuploidy Whole chromosome aneuploidy results mostly from chromosome segregation errors, thus generating daughter cells that have lost or gained ... get exposed due to telomere attrition and become free for the double strand break repair, mostly via non-homologous end joining with another chromosome, thus generating a bi-centric chromosome...

Ngày tải lên: 21/02/2014, 23:20

... identify the most important routes of exposure to lead Today almost everyone is exposed to environmental lead Exposure to lead and lead chemicals can occur through inhalation, ingestion and dermal ... features of the exposure history Name the symptoms of low dose lead toxicity Describe how exposure dose and symptoms can vary Describe key features of the physical examination Name the most useful test ... showed hypochromia and microcytosis There was no evidence of blood loss, and stool examination was negative for occult blood The diagnosis was “mild iron deficiency anemia,” and elemental iron...

Ngày tải lên: 05/03/2014, 10:20

... Sergei B Kuksin, Randomly forced nonlinear PDEs and statistical hydrodynamics in space dimensions Pavel Etingof, Calogero-Moser systems and representation theory Guus Balkema and Paul Embrechts, ... Gaussian free elds, Poisson gases of Markovian loops, and random interlacements The stimulating atmosphere during the live lectures was an encouragement to write a eshed-out version of the handwritten ... Fukaya Categories and PicardLefschetz Theory Alexander H.W Schmitt, Geometric Invariant Theory and Decorated Principal Bundles Michael Farber, Invitation to Topological Robotics Alexander Barvinok,...

Ngày tải lên: 05/03/2014, 11:20

... maltose (glucose-glucose), sucrose (glucose-fructose), and lactose (glucose-galactose) Other carbohydrates include trioses (glycerose, C 3H 6O3), tetroses (erythrose, C 4H8O4), and pentoses (ribose, ... starch (and the animal polymer glycogen), but the group includes pectins, cellulose, and gums Simple carbohydrates include the hexose monosaccharides (glucose, galactose, and fructose) and the ... today and in the days ahead Abbreviations: ADP—adenosine diphosphate; AMP—adenosine monophosphate; ATP—adenosine triphosphate; A-V—arteriovenous; BCAA—branched-chain amino acid; GMP—guanosine...

Ngày tải lên: 06/03/2014, 05:21

... subsequent radiation exposure and apoptosis [28] Furthermore, induction of spermine oxidase in gastric and lung epithelial cells by Helicobacter pylori and tumor necrosis factor-a, respectively, ... human prostate cancer and prostatic intraepithelial neoplasia tissues Prostate, 68, doi: 10.1002/pros.20735 2806 32 Murray-Stewart T, Wang Y, Devereux W & Casero RA Jr (2002) Cloning and characterization ... have recently demonstrated elevated SMO expression in prostatic epithelial tissue from prostate cancer patients compared to prostate disease- free control patients [31] Subsequent to the initial...

Ngày tải lên: 07/03/2014, 05:20

... generic addition and multiplication operation, ⊕ and ⊗, and their identities and Multiplication and addition must be associative Multiplication must distribute over addition, and v ⊗ The design ... Dean and S Ghemawat 2004 MapReduce: Simplified data processing on large clusters In Proc of the 6th Symposium on Operating System Design and Implementation (OSDI 2004), pages 137–150 F Sha and ... production in the source and target language, and alternative translation possibilities are expressed as alternative edges Edges are further annotated with feature values, and are annotated with...

Ngày tải lên: 07/03/2014, 22:20

... on-scene (prehospital) and hospital medical management of patients exposed during a hazardous materials incident Volumes I and II are planning guides to assist first responders and hospital emergency ... Occupational Safety and Health Administration (OSHA) and the Mine Safety and Health Administration (MSHA), and trains professionals in occupational safety and health Contact: NIOSH, 200 Independence ... testosterone in perinatally exposed rats This effect can be also considered an antiandrogenic effect since hydroxylated testosterone is more polar than testosterone and can be conjugated and...

Ngày tải lên: 14/03/2014, 09:20

... Sergei B Kuksin, Randomly forced nonlinear PDEs and statistical hydrodynamics in space dimensions Pavel Etingof, Calogero-Moser systems and representation theory Guus Balkema and Paul Embrechts, ... Gaussian free elds, Poisson gases of Markovian loops, and random interlacements The stimulating atmosphere during the live lectures was an encouragement to write a eshed-out version of the handwritten ... Fukaya Categories and PicardLefschetz Theory Alexander H.W Schmitt, Geometric Invariant Theory and Decorated Principal Bundles Michael Farber, Invitation to Topological Robotics Alexander Barvinok,...

Ngày tải lên: 14/03/2014, 22:20

... regulatory element, TnI, and the cytoskeletal protein a-actinin [11,135,136] Other possible MMP-2 substrates in cardiac myocytes are desmin and myosin light chain-1 [136,137] The most probable mode ... inhibitors may also lead to new treatment of acute and chronic inflammatory and vascular diseases [99] Most known MMPIs are targeting the catalytic region and the catalytic zinc, which are very similar ... repair enzyme poly-ADP-ribose polymerase and X-ray cross-complementary factor 1, which protect cells from apoptosis) These two factors were shown to be processed by MMP-2 and MMP-9 [124,128] Thus,...

Ngày tải lên: 15/03/2014, 00:20

... confused about pro- and anti-inflammatory prostaglandins and leukotrienes, here’s an easy way to keep them straight: most of those with an even number are pro-inflammatory, whereas those with an odd ... diseases are fueled by inflammation as well Most of us understand inflammation as something that causes redness, tenderness, stiffness, and pain It is the core of inflammatory “-itis” disease, and ... midforties and felt worn down and much older because of a growing list of health problems She was overweight and prediabetic and had high blood pressure, allergies, inflammatory bowel disease, rosacea,...

Ngày tải lên: 15/03/2014, 04:20

... occur in diabetes through insulin overdose, liver disease, and in many enzyme deficiencies, such as glucose-6-phosphatase, fructose-1,6-biphosphatase, phosphoenol-pyruvate carboxykinase, pyruvate ... energy demands, glycogen synthesis also declines The uridine diphosphoglucose, formed from glucose-1-P, is the unit transferred and linked, via a -1,4-glycosidic bond, to the terminal glucose on ... nitric oxide, adenosine, potassium, and pH (30–35) Finally, vascular (endothelial cells and vascular smooth muscle) and parenchymal (neurons and glia) cells cooperate closely, and directly influence...

Ngày tải lên: 15/03/2014, 19:20

... interferes with cross-talk between the EGFR and the androgen receptor in prostate carcinoma cells [50] The interplay between decorin and the EGFR is further underscored by osteosarcoma cells which ... binds to and sequesters the IGF-I (KD  18 nm), the natural ligand of this RTK [55] By binding to the IGF-IR, decorin triggers phosphorylation and downstream activation of phosphoinositide-3 ... FEBS R V Iozzo and L Schaefer factor jB and results in the synthesis and secretion of tumor necrosis factor a and macrophage inflammatory protein Consequently, additional neutrophils and macrophages...

Ngày tải lên: 15/03/2014, 23:20

... Syndecans-1 and -3 core proteins are larger than those of syndecan-2 and -4, and can bear both heparan and chondroitin sulfate chains The GAG chains are substituted on core protein serine residues and ... region syndecan-3 can mostly be found in neuronal tissues and some musculoskeletal tissue Here, our understanding of syndecan shedding and its function in wound healing and tumour progression ... with phosphatidylinositol 4,5-bisphosphate and protein kinase Ca has been described [9], whereas others partners are the actin-associated protein a-actinin as well as syndesmos, about whose function...

Ngày tải lên: 15/03/2014, 23:20