nonsmall cell lung cancer with multiple brain metastases

... on histopathological features, non-small -cell lung cancer (NSCLC) and small cell lung cancer (SCLC) accounts for 85% and 15% of all patients with lung cancer, respectively (Travis et al., 2013) ... ABSTRACT Lung cancer is the most common cause of cancer death worldwide, with most deaths having distant metastases It has become increasingly complex to get effective treatment for lung cancer ... associated with BRAF mutations in nonsmall cell lung cancer Clin Cancer Res., 19(16): 4532−4540 Chong C R and Jänne P A., 2013 The quest to overcome resistance to EGFR-targeted therapies in cancer

Ngày tải lên: 27/09/2020, 13:34

... BMC Cancer (2020) 20:837 Background Lung cancer is the cancer with the world’s highest morbidity and mortality [1] Non-small cell lung cancer (NSCLC) accounts for 80–85% of the cases of lung cancer ... et al Gefitinib alone or with concomitant whole brain radiotherapy for patients with brain metastasis from non-small -cell lung cancer: a retrospective study Asian Pac J Cancer Prev 2012;13:909–14 ... Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib Clin Cancer Res 2010;16:5873–82 17

Ngày tải lên: 28/09/2020, 09:27

... patients with NSCLC Keywords: SET domain containing (SETD5), Non-small cell lung cancer, Invasion, ERK signaling, Prognosis Background Non-small cell lung cancer (NSCLC) is a malignant tumor of the lung ... immunohistochemical analysis in 147 patients with non-small cell lung cancer SETD5 was overexpressed in A549 cells or suppressed with siRNA in H1299 cells Wound healing and transwell assays were ... prostate and mammary cancers [22–24], but the mechanism of its role in nonsmall cell lung cancer remains unclear This study showed that SETD5 was significantly correlated with lymph node metastasis,

Ngày tải lên: 17/06/2020, 16:59

... catastrophe in non-small cell lung cancer cells Int J Cancer 2006, 119:1028-1038 Adjei AA, Hidalgo M: Intracellular signal transduction pathway proteins as targets for cancer therapy J Clin Oncol ... levels of protein kinase Calpha in non-small -cell lung cancer Clin Lung Cancer 2004, 6:184-189 Brognard J, Dennis PA: Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway ... biochemical environment and implementing both cell- cell and cell- matrix interactions [70] are planned steps at the cellular level that should help representing the cancer system of interest in more detail

Ngày tải lên: 13/08/2014, 16:21

... influencing overall survival, recurrence and postrecurrence survival in resected stage I nonsmall- cell lung cancer Chengdi Wang , Yuxuan Wu , Jun Shao , Dan Liu* and Weimin Li* Abstract Background: ... experienced curative-intent surgical resection of stage I non-small -cell lung cancer (NSCLC) Methods: We investigated a series of 1387 patients with stage I NSCLC who underwent surgical resection from 2008 ... Wang et al BMC Cancer (2020) 20:150 https://doi.org/10.1186/s12885-020-6621-1 RESEARCH ARTICLE Open Access Clinicopathological

Ngày tải lên: 17/06/2020, 03:11

... BMC Cancer (2020) 20:275 Background Non-small -cell lung carcinoma (NSCLC) is one of the most common cancers worldwide, contributing for 13% of all cancer types [1] NSCLC represent the 85% of lung ... results within 2.5 h This test encompasses 51 EGFR clinically relevant mutations from exons 18 to 21 in human lung cancer FFPE material (according to the latest IASLC atlas of EGFR testing in lung cancer) ... American Cancer Society Global Cancer Facts & Figures 2nd edition Atlanta: American Cancer Society; 2011 Miller KD, Siegel RL, Lin CC, et al Cancer treatment and survivorship statistics, 2016 CA Cancer

Ngày tải lên: 17/06/2020, 11:13

... practice in lung cancer care This can be explained by the fact that there is lack of familiarity with SDM [13, 14], and also because the care of lung cancer patient can be complex due to multiple ... Mokhles et al BMC Cancer (2018) 18:79 DOI 10.1186/s12885-018-3986-5 RESEARCH ARTICLE Open Access Treatment selection of early stage nonsmall cell lung cancer: the role of the patient ... considered the preferred treatment for patients with early-stage non-small cell lung cancer (NSCLC) A less invasive option for patients with comorbidities is stereotactic body radiotherapy (SBRT) [1, 2]

Ngày tải lên: 24/07/2020, 00:19

... stated Rouanne et al BMC Cancer (2016) 16:483 Background Lung cancer, with non-small cell lung cancer (NSCLC) constituting 85 % of cases, remains the most prevalent and lethal cancer worldwide [1] ... overlooked [7] It is suggested that tumor cells not act alone but in close interaction with the extracellular matrix (ECM) and with non-genetically altered stromal cells [8] Nevertheless, the dynamic ... protein composed of multiple functional domains that mediate cell- to -cell and cell- to-matrix interactions The diverse biological activities of TSP-1 are mediated by its interaction with corresponding

Ngày tải lên: 20/09/2020, 14:15

... Guo et al BMC Cancer 2014, 14:834 http://www.biomedcentral.com/1471-2407/14/834 RESEARCH ARTICLE Open Access Non-small cell lung cancer with EML4-ALK translocation in Chinese ... stated Guo et al BMC Cancer 2014, 14:834 http://www.biomedcentral.com/1471-2407/14/834 Background Lung cancer is one of the most common cancers and is by far the leading cause of cancer- related deaths ... leading cause of cancer- related deaths worldwide [1] Nearly 80% of lung cancer patients are diagnosed as non-small cell lung cancer (NSCLC) at advanced stages of the disease [2] The average survival

Ngày tải lên: 30/09/2020, 14:59

... Non-small cell lung cancer Background Lung cancer is the leading cause of cancer- related deaths globally, with an estimated 1,589,900 deaths in 2012 [1] In the USA, over 220,000 patients with lung cancers ... usually poor [5–7] In recent years, the molecular targets of lung cancer, especially for the main histological type non-small cell lung cancer (NSCLC), have been investigated, including epidermal ... cancer? ??, ? ?lung carcinoma”, “CT”, and “imaging” in the Boolean expression: ((epidermal growth factor receptor) OR EGFR) AND ( (lung Page of 10 cancer) OR (lung carcinoma)) AND ((CT) OR (imaging)) without

Ngày tải lên: 24/11/2022, 17:45

... EGFRmutated NSCLC patients with brain metastases Keywords: NSCLC, EGFR-TKI, Brain metastasis, Brain radiotherapy, Uncommon mutations Background Of patients with non-small cell lung cancer (NSCLC), approximately ... treatment in newly diagnosed nonsmall cell lung cancer with brain metastases: survey by outcome research network for evaluation of treatment results in oncology Cancer 2007;109(2):274–81 Bearz ... Estimating survival in patients with lung Cancer and brain metastases: an update of the graded prognostic assessment for lung Cancer using molecular markers (lung- molGPA) JAMA Oncol 2017;3(6):827–31

Ngày tải lên: 17/06/2020, 18:13

... in patients with brain- only NSCLC oligometastases Non-small lung cancer (NSCLC) patients with brain metastases is not rare However, sync-oligometastases (Brain- only metastases NSCLC with active ... patients with brain- only oligometastases of non-small cell lung cancer (NSCLC) treated with stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) Methods: Patients treated with SRS ... Abbreviations: Brain- LC, Local control of brain metastases; Cranial-LC, Cranial local control; DFI, Interval to initial brain recurrence; KPS, Karnofsky performance status; NSCLC, Non-small cell lung cancer;

Ngày tải lên: 20/09/2020, 15:26

... RNAnon small cell lung cancer Abstract Lung cancer has emerged as a leading cause of cancer death in the world. Non-small cell lung cancer (NSCLC) accounts for 75–80% of all lung cancers. Current ... purposes) Background Lung cancer is a leading cause of cancer death in Australia and the world [1,2]. There are two types of lung cancers, non small cell (NSCLC) and small cell (SCLC). NSCLC accounts ... shown. (a) Cells were stained with FITC-conjugated secondary antibody. (b) Cells were stained with an EGFR-specific antibody and secondary antibody. (c) FITC staining of cells transfected with unrelated

Ngày tải lên: 14/08/2014, 19:22

... Locally advanced, Non-small -cell lung cancer, ECOG 2, Chemoradiotherapy, Efficacy, Toxicity Background Non-small -cell lung cancer (NSCLC) accounts for 85% of all lung cancers [1], and approximately ... conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB nonsmall- cell lung cancer (RTOG 0617): a randomised, ... locally advanced nonsmall- cell lung cancer J Clin Oncol 2010;28(13):2181–90 Lilenbaum RC, Cashy J, Hensing TA, Young S, Cella D Prevalence of poor performance status in lung cancer patients:

Ngày tải lên: 17/06/2020, 11:38

... Keywords: Non-small cell lung cancer, Inflammatory response biomarker, Nomogram Background Lung cancer remains the leading cause of cancer- related death worldwide and 85% of lung cancers diagnosis ... with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive biomarkers to predict the survivals of patients with non-small cell lung cancer ... Cancer (2018) 18:692 https://doi.org/10.1186/s12885-018-4513-4 RESEARCH ARTICLE Open Access An inflammation-related nomogram for predicting the survival of patients with non-small cell lung cancer

Ngày tải lên: 24/07/2020, 01:15

... cancer treatments [1] In Japan, 65% of lung cancer morbidity cases and 73% of lung cancer- related deaths were attributed to elderly individuals aged ≥70 years in 2012 [2] Patients with lung cancer, ... Non-small -cell lung cancer, Elderly, Cancer cachexia, Activity of daily living, Length of hospital stay, Medical cost Background The number of elderly people living with advanced lung cancer is ... inpatient medical costs among elderly patients with advanced non-small -cell lung cancer (NSCLC) receiving chemotherapy Methods: Thirty patients aged ≥70 years with advanced NSCLC (stage III-IV) scheduled

Ngày tải lên: 06/08/2020, 03:21

... associations with lung cancer related death rate (P < 0.001) Patients who received chemotherapy and radiotherapy had significant higher lung cancer related death rate but were associated with significant ... BMC Cancer (2020) 20:666 https://doi.org/10.1186/s12885-020-07147-y RESEARCH ARTICLE Open Access A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with ... for non-small cell lung cancer (NSCLC) patients who received surgery Methods: We collected data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute

Ngày tải lên: 06/08/2020, 05:41

... patients with non-small cell lung cancer: a systematic review and meta-analysis Oncotarget 2016;7(48):78985–93 Midha A, Dearden S, McCormack R EGFR mutation incidence in non-smallcell lung cancer ... second-line treatment in patients with nonsmall cell lung cancer previously treated with platinum-based chemotherapy (KCSG-LU0801): an open-label, phase trial Cancer 2012;118(24):6234–42 Gridelli ... mutation in non-small cell lung Cancer Transl Oncol 2018;11(1):94–101 Li S, Ding C, Zhang H, Song J, Wu L Radiomics for the prediction of EGFR mutation subtypes in non-small -cell lung Cancer Med Phys

Ngày tải lên: 06/08/2020, 05:46

... Treatment of Cancer -Lung Cancer Group Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small -cell lung cancer J Natl Cancer Inst 2007;99:442–450 ... III non-small cell lung cancer? ??the ETOP NICOLAS trial Lung Cancer 2019;133:83–7 Lin SH, Lin Y, Yao L, Kalhor N, Carter BW, Altan M, et al Phase II trial of concurrent atezolizumab with chemoradiation ... non-small -cell lung cancer N Engl J Med 2016;375:1823–33 Hellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, AudigierValette C, et al Nivolumab plus ipilimumab in lung cancer with a high

Ngày tải lên: 19/09/2020, 22:12

... staining of tumor cells; 1+, tumor cells with faint cytoplasmic reactivity without any background staining; 2+, tumor cells with moderate cytoplasmic reactivity; and 3+, tumor cells with strong granular ... tyrosine kinase insulin receptor, has been recognized as a driver of non-small cell lung cancer (NSCLC) [2] since it can fuse with other genes (e.g CD74, SLC34A2, FIG, TPM3, SDC4, EZR, LRIG3, CCDC6, ... NSCLC patients with ROS1 rearrangement Keywords: ROS1, Immunohistochemistry, Fluorescent in situ hybridization, Quantitative real-time polymerase chain reaction, Non-small cell lung cancer, Tyrosine

Ngày tải lên: 20/09/2020, 15:04