noninvasive imaging of cerebral activation with diffuse optical tomography

... neuronal differentiation of P19 cells Conversely, the cytoplasmic fluorescent activity of P19 cells with NeuroD gradually increased with treatment with miR124a or RA by days, with stronger signals ... increase of miR124a expression during the neuronal differentiation of P19 cells treated with RA, the endogenous gene expression of five of the candidates was gradually decreased over the period of neuronal ... of miR124a and the 3¢-UTR of the c14orf24 gene showed a strong evidence of miR124amediated repression of c14orf24 during neurogenesis The coding region of c14orf24 (NM_173607), the function of...

Ngày tải lên: 07/03/2014, 02:20

... equipped with a motorized stage (Olympus, Melville, NY) and the MCID 6.0 Elite Imaging Software (Imaging Research, Inc.) Sections were tiled under 4× magnification Five equal sections of entorhinal ... 3xTg-AD mice is coincident with the increase of TNF-α and MCP-1 We believe this could be due to microglial proliferation, activation of the resting resident population of brain microglia and macrophages ... design of and generated the 3xTg-AD mouse model HJF and WJB conceived the design of the study, aided in the preparation of the manuscript, and provided critical analysis of the manuscript Page 11 of...

Ngày tải lên: 19/06/2014, 22:20

... CPS for ISAR imaging of ship target with high maneuverability In this paper, a new algorithm called IHMPT is proposed to estimate the parameters of the multicomponent CPS Combined with the RID ... idth In this section, the results of simulated and measured data are provided to demonstrate the effectiveness of the IHMPT algorithm for ISAR imaging of ship target with high maneuverability Figure ... signal Figure 2: Results of the numerical example Principle of IHMPT 3.1 The High-Order Matched Phase Transform (HMPT) Consider the discrete form of monocomponent CPS with the following structure:...

Ngày tải lên: 21/06/2014, 05:20

... I Noninvasive cardiac imaging is an integral part of the practice of current clinical cardiology During the past three decades a number of distinctly different noninvasive imaging techniques of ... assessments of patients with CAD by noninvasive imaging techniques, and imaging in the Emergency Department in patients with chest pain Risk stratification in patients with coronary heart disease, imaging ... 38 Noninvasive Imaging of Myocardial Ischemia Figure 3.1 Effect of ECG triggering on image quality Left, without ECG gating; right, with ECG gating images of the heart at a specific time point of...

Ngày tải lên: 28/06/2014, 20:20

... (NIR) diffuse optical tomography (DOT) has been proven in last decade as a promising non-invasive optical imaging modality for soft tissue imaging, especially suitable for human breast imaging ... novel non-invasive optical imaging modalities, especially the diffuse optical tomography (DOT) and the time-resolved diffuse optical spectroscopy (DOS) techniques 3.1 Biomedical imaging modalities ... radionuclide imaging like single photon emission computed tomography (SPECT) positron emission tomography (PET) [46] [46] , near-infrared optical imaging and [47] , diffuse optical imaging (DOT)...

Ngày tải lên: 12/09/2015, 11:35

... data of images of DU 145 cells nuclei treated with RNase after illumination are not shown) Figure gives insight into the proportionality between the duration of activation and the increase of fluorescence ... (red – of the fusion protein KRED-Lamin B1 and green – derived from dNTP functionalized with ATTO 633) are hardly detectable inside of the nuclei transfected with pKillerRed-Lamin B1 without activation ... inside of the nuclei of DU145 cells Figure visualizes the degree of the DNA damage in nuclei as a result of DNA strand breaks caused by ROS produced by the fluorescent protein KillerRed after activation...

Ngày tải lên: 25/10/2012, 11:15

... position of Fig 11), approaching asymptotically the value of the band-gap of the undoped Si-nw This is another indication of how doping can modify the electronic and optical properties of the Si ... structural, electronic and optical properties of Si nanostructures doped with different numbers of B and P impurities have been studied from first-principles We have considered Si-nc with the impurities ... level The dependence of the emission spectra both on the nanocrystals size and on the impurities positions reveals once more the possibility of tuning the optical response of Si-nc Many-body results...

Ngày tải lên: 16/03/2014, 15:15

... route of intramolecular activation of the zymogen into the active enzyme, E, and one or more peptides represented by W [route (a), Scheme 3] [12,22,25–27] and a route of autocatalytic activation of ... for each of these mechanisms with the experimental results, these authors suggested a reaction mechanism including both intra- and intermolecular activation of the zymogen by the action of the ... short time after the onset of the reaction, so that the kinetic behaviour of all of the species becomes uni-exponential from this time The higher the value of |k2| compared with k1, the shorter the...

Ngày tải lên: 16/03/2014, 18:20

... immunoprecipitated with antibody to STAT5B, suggesting that STAT5B interacts with AP-1 Treatment of VSMCs with Ang II for and h resulted in an increase in the interaction of STAT5B with c-Jun The interaction of ... expression of the AGT gene in VSMCs stimulated with Ang II, the effect of Ang II on the phosphorylation of STAT5 and c-Jun was measured Ang II stimulated the phosphorylation of STAT5B and c-Jun, with ... treatment of VSMCs with Ang II for different periods of time, AGT mRNA was detected using RT-PCR As shown in Fig 1A, the level of AGT mRNA peaked h after stimulation with Ang II, showing an increase of...

Ngày tải lên: 30/03/2014, 02:20

... intravenous injection of DiD-labeled monocytes (a) In vivo optical imaging of a control FVB/n mouse after (a) In vivo optical imaging of a control FVB/n mouse after intravenous injection of DiD-labeled ... Nearinfrared optical imaging of the breast with model-based reconstruction Acad Radiol 2002, 9:186-194 Ntziachristos V, Yodh AG, Schnall M, Chance B: Concurrent MRI and diffuse optical tomography of breast ... integration of DiD Triplicate samples of million cells Page of (page number not for citation purposes) Journal of Translational Medicine 2009, 7:94 labeled with microliters of DiD were optically...

Ngày tải lên: 18/06/2014, 15:20

... in the liver tumors The growth of liver metastasis was analyzed with magnetic resonance imaging (MRI) Tumors are marked with arrows Picture of liver metastasis of mock treated (PBS) animal (A) ... mice were treated with two intravenous injections of × 10e10 VP of WT, WTRGD, or WT-RGDK in 100 μl volume of PBS (n = 4, 11, and 9, respectively) Mock animals (n = 9) were treated with PBS only Tumor ... survival of animals was followed Viral replication in tumor tissue 29 days after intrasplenic injection of tumor cells, mice were treated with × 10e10 VP of WT, WT-RGD, or WT-RGDK in 100 μl of PBS,...

Ngày tải lên: 18/06/2014, 16:20

... quality of life, affects more than half of the population over 60 years of age [1] Spatial learning and memory is one of the domains of cognitive function most frequently and severely impacted with ... proliferation of astrocytes, the number of GFAP+ cells per subregion of interest was quantified using ImageJ software with the cell counter plug-in (NIH, Bethesda, MD) Quantitation of total microglia ... Journal of Neuroinflammation 2011, 8:138 http://www.jneuroinflammation.com/content/8/1/138 Page 15 of 21 Figure Activation of hippocampal microglia with aging Immunohistochemical co-localization of...

Ngày tải lên: 19/06/2014, 22:20

... ANOVA with Bonferroni post hoc test, with a p-value of < 0.05 considered significant the concentration of TNF in the brain of TAI+Hx rats was significantly increased at h when compared with sham ... decreased again to 50% of sham values, and remained at between 30-60% of shams for the remainder of the experimental period Discussion Cerebral hypoxia, along with hypotension, is one of the most critical ... the increased acute production of IL-1b and TNF may be associated with disruption of BBB integrity and consequently formation of cerebral edema, while late elevation of IL-6 may trigger repair mechanisms...

Ngày tải lên: 19/06/2014, 22:20

... dissected For the biodistribution study with bevacizumab, a total of 30 FaDu-bearing mice with a tumor size of 600 ± 200 mm3 were injected with 0.37 MBq of 89 Zr-bevacizumabIRDye800CW (1.0 or ... significantly different for conjugates with 2.0 eq compared with those with eq; levels of blood and of several normal organs were too low at this time point to be of any statistical value Cohen et ... did not show significant changes Imaging To confirm selective tumor targeting of the 89Zr-mAbIRDye800CW product with an optical imaging device, mice injected with the 89Zr-mAb-IRDye800CW conjugates...

Ngày tải lên: 20/06/2014, 21:20

... colored side of each butterfly wing sample was mounted vertically in a panel containing a black hole of 3- or 1-cm diameter The hole ensured a proper black background within the field of view of the ... reference image was obtained from a white diffuser (Edmund Optics opal diffuser 50 mm) The white diffuser minimized the effect of non-homogeneous spatial distribution of intensity in the white reference ... estimation of the dark current noise of the CCD camera and was obtained in the dark room with the sample holder empty, with the same exposure times as in the white reference image and with the...

Ngày tải lên: 21/06/2014, 03:20

... a carrier gas of high-purity Ar mixed with 5% H2 was kept flowing at a rate of 60 sccm (standard cubic centimeter per minute) The furnace was heated to 800 °C with a heating rate of 100 °C min-1 ... thickness of 20– 40 nm, the base width of 2–5 lm, and the length of 10– 30 lm and possess triangle morphology They have smooth surfaces, and their width reduces sharply with the increase of length ... to obtain the excellent optical property of taped CdS nanobelts in this work In Fig 4b, the spectrum of CdSe nanowires shows a single peak centered at 717 nm with fwhm of 31 nm, which is attributed...

Ngày tải lên: 22/06/2014, 00:20

... ISAR imaging of maneuvering targets, and the quality of ISAR images improves greatly REFERENCES [1] Z Bao, G Wang, and L Luo, “Inverse synthetic aperture radar imaging of maneuvering targets,” Optical ... estimation of t0 based on (17) will produce error with low signal to-noise-ratio (SNR), and the derivation of (17) is based on the high SNR for the signals, which is appropriate for the ISAR imaging of ... window must be small The precise implementation of the window width may be computationally expensive, but in the condition of ISAR imaging, the accuracy of the window width is not the main factor...

Ngày tải lên: 22/06/2014, 01:20

... vol 3194 of Proceedings of SPIE, pp 409–416, San Remo, Italy, September 1997 [7] V V Lyubimov, “On the spatial resolution of optical tomography of strongly scattering media with the use of the ... laser tomography, ” in Laser Optics ’95: Biomedical Applications of Lasers, vol 2769 of Proceedings of SPIE, pp 107–110, St Petersburg, Russia, June 1996 [5] V V Lyubimov, Optical tomography of ... [10] O V Kravtsenyuk and V V Lyubimov, “Application of the method of smooth perturbations to the solution of problems of optical tomography of strongly scattering objects containing absorbing...

Ngày tải lên: 22/06/2014, 23:20

... (a) TPM image of MCF-7 cells incubated with mM A (left) and overlap (right) (b) TPM image of the same cells containing mM B (left) and overlap (right) (c) The fluorescent imaging of the MCF-7 cells ... biological imaging or optical fields Acknowledgments This work was supported by a grant for the National Natural Science Foundation of China (21071001), Department of Education Committee of Anhui ... Synthesis, optical properties and biological imaging of the rare earth complexes with curcumin and pyridine J Mater Chem 2012;22:22774e80 [25] Demas JN, Crosby GA The measurement of photoluminescence...

Ngày tải lên: 01/07/2014, 13:22