nmda receptor antagonists amantadine and ketamine
Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
Ngày tải lên :
12/08/2014, 18:20
... insulin signaling, the insulin receptor substrate (IRS)-1, IRS2 and signal transducer and activator of transcription (Stat)-6 [23] IRS1 and IRS2 regulate proliferation and protection from apoptosis ... and IL-5, Asthma has been linked to chromosome 5q31–33 through genome searches and screening of candidate genes [21,22] This locus includes the genes for the TH2 cytokines IL-4, IL-5, IL-9, and ... lymphocytes is a unique biological activity of IL-4 because IL-4 receptors and not IL-13 receptors are expressed on T cells [10] IgE production and the induction of VCAM-1 are activities shared with the...
- 5
- 365
- 0
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
Ngày tải lên :
16/02/2014, 09:20
... 30821065 and 30870559 from the China National Nature Sciences Foundation, 2006CB910703 from the Ministry of Sciences and Technology of China, and 07dz05907 from the Committee of Sciences and Technology ... by using 3T3-L1 adipocytes and rat primary adipocytes Adipocyte apoptosis could be induced by troglitazone, pioglitazone or 15-deoxy-D12,14-prostaglandin J2 (PGJ2), and reversed by GW9662, a PPARc ... of GW9662 In addition, pioglitazone, another TZD, and PGJ2, which directly binds to and activates PPARc [29], also induce adipocyte apoptosis, and GW9662 treatment blocked this induction (Fig...
- 10
- 594
- 0
Báo cáo khoa học: A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbb and removes Rev-erbb-induced inhibition of apoCIII transcription potx
Ngày tải lên :
07/03/2014, 05:20
... J Wang et al ligand-dependent activation of transcription by other members of the NR superfamily [5] Therefore, Reverb receptors constitutively behave as unliganded receptors and repress transcription ... Geneticin (Gibco ⁄ BRL, Grand Island, NY, USA) Cells were grown in selective media for weeks, and G418-resistant colonies were established in six-well plates, expanded and cloned independently ... between ZNHIT-1 and Rev-erb The interaction between Rev-erbb and ZNHIT-1 was further verified by a GST pull-down assay and a Fig Validation of the interaction between ZNHIT-1 and Reverbb or Rev-erba...
- 12
- 423
- 0
Báo cáo khoa học: Improvement of ecdysone receptor gene switch for applications in plants: Locusta migratoria retinoid X receptor (LmRXR) mutagenesis and optimization of translation start site pptx
Ngày tải lên :
15/03/2014, 23:20
... addition of the ligand, and reached maximum levels 24 h after the addition of the ligand (Fig 4B) The luciferase activity began to decrease 24 h after withdrawal of the ligand, and showed a continuous ... collected at 0, 6, 12, 24 and 96 h after the addition of ligand, and the luciferase activity was measured and expressed in terms of RLU per microgram of protein In ligand withdrawal experiments, ... ± standard deviation (B) Comparison of performance of LmRXR, LmRXR double mutant A62S:T81H (SHLmRXR) and LmRXR triple mutant A62S:T81H:V123I (SHILmRXR) as a partner of CfEcR The receptor and...
- 11
- 461
- 0
Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf
Ngày tải lên :
16/03/2014, 06:20
... ecdysone receptor (CfEcR), and the VP16 activation domain (AD) was fused to the LBD of Locusta migratoria retinoid X receptor (LmRXR) or Homo sapiens retinoid X receptor (HsRXR) The ligand sensitivity ... VCH9, and GCfEVY + VCH9) and VGCfEQ454E, and monopartite (VGCfEH436E, VGCfEVY) switch formats and compared to the data obtained from the gene switches containing wild-type CfEcR (GCfEWt + VCH9 and ... steroid hormones (dexamethasone and estradiol), and both steroidal and nonsteroidal agonists of the insect hormone 20-hydroxyecdysone [3,4,6,17,28–31] The nuclear receptors used in monopartite...
- 16
- 454
- 0
Báo cáo khoa học: Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR–/– pdf
Ngày tải lên :
16/03/2014, 18:20
... (A) and whole embryos (B) mRNAs E7, E11, E15, E17: embryo stages (days post-coitum) The LSR probe reveals a 2.1 kb band, and the GAPDH probe a 1.35 kb band and (in some tissues) a 1.2 kb band ... this new receptor as a lipoprotein receptor It was found that LSR was not only expressed in liver (adult and fetal), but also in steroidogenic organs (ovaries, testes, and adrenal glands), lung, ... intestine and brain (respectively 41.9% and 15.9% of liver) The expression in muscle was very low (0.5% of liver) Figure 3B and Table show that LSR mRNA is rather abundant in lung and kidney (55.8% and...
- 12
- 423
- 0
Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
Ngày tải lên :
16/03/2014, 22:20
... ª 2005 FEBS to decrease cancer invasion and metastasis These methods include the use of antibodies, small molecule antagonists, and antisense strategies and have been reviewed elsewhere [3] Although ... uPA and uPAR to further inhibit cancer cell invasion and metastasis complex, the medium was replaced with DMEM containing 10% fetal bovine serum Cells were collected and assayed by northern and ... were washed and exposed to Kodak Biomax MR film Multiple film exposures were used to ensure linearity of band intensities The intensities of mRNA bands in the autoradiographs were scanned and quantified...
- 11
- 315
- 0
Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
Ngày tải lên :
28/03/2014, 23:20
... ligand specificity and signal transduction activity Two of these receptors contain intrinsic GC activity, and have been designated GC-A ⁄ NPRA and GC-B ⁄ NPRB; they are also referred to as GC-A and ... understanding of the normal and abnormal control of cellular and physiological processes Although there has been much appreciation of the functional roles of natriuretic peptides and their cognate receptors ... studies on the natriuretic peptides and their receptors should yield new therapeutic targets and novel loci for the control and treatment of hypertension and cardiovascular disorders Natriuretic...
- 16
- 635
- 0
nmda receptor protocols
Ngày tải lên :
11/04/2014, 07:11
... 2C (hNMDAR2C), and 2D (hNMDAR2D) subunits (710), and confirmed transient expression of hNMDAR1A/2A, hNMDAR1A/2B, hNMDAR1A/2C, and hNMDAR1A/2D receptor complexes in both Xenopus oocytes and HEK293 ... cultured in the absence and presence of the NMDA receptor antagonists, MK801 (1 àM), ketamine (1 mM), DL-AP5 (1 mM), 5,7 DKA (1 mM), magnesium chloride (20 mM), and the non -NMDA receptor antagonist ... response and expand the cell line on 10-cm2 dishes (see Notes and 8) The hNMDAR1A/2A-expressing HEK72-4 cell line (hNMDAR1A/2A/HEK72-4) and the hNMDAR1A/2B-expressing HEK4-3 cell line (hNMDAR1A/2B/HEK4-3)...
- 184
- 166
- 0
báo cáo hóa học:" Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients" potx
Ngày tải lên :
18/06/2014, 15:20
... contributions FS, and AS have made substantial contribution in the acquisition and alignment of sequences, in the analysis and interpretation of data, and helped to draft the manuscript LC, BP, PGN, and PN, ... N-D-N region of Mel/M-A and Ctrl/ M-A sequences there was an increased Leucine usage (Figure 2A), and Glycine and Leucine were overrepresented at CDR3 positions 110, 112 and 113 (Figure 2B) Moreover, ... only few nucleotides deletion from V, D and J germline and no or minimal random nucleotide additions [61,62] but the extent of exonucleolytic nibbling and the substantial number of nucleotide...
- 14
- 532
- 1
Báo cáo y học: "Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men" doc
Ngày tải lên :
08/08/2014, 16:23
... Bsm I, and Fok I VDR polymorphisms VDR, vitamin D receptor; SD, standard deviation Table Genotype and allele frequencies of Apa I, Bsm I, and Fok I VDR polymorphisms in subjects with and without ... collected and classified using the LightTyper genotyping software, and genotypes were determined The absence or presence of the ApaI, BsmI, and FokI sites were designated as A, B, and F alleles and ... status and the three genotypes The study subjects included 42 current smokers (43.3%) and diabetics (2.1%) The distribution of the CPI scores between and were 13.4, 15.5, 14.4, 39.2, and 17.5%,...
- 7
- 353
- 0
Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
Ngày tải lên :
08/08/2014, 20:23
... EIB18 but to a lesser degree and for a shorter duration when compared with the use of receptor antagonists. 19 Leukotriene Receptor Antagonists Leukotriene receptor antagonists (LTRAs) have been ... leukotriene receptor subtype 1, CysLT1) on airway smooth muscle and bronchial vasculature, and they contribute to the bronchospasm, increased bronchial hyperresponsiveness, mucus production and mucosal ... probably relates to drying and/ or cooling of the airway mucosa and to mediator release.3 Many studies, however, have demonstrated the protective effect of CysLT1 receptor antagonists against EIB,...
- 5
- 663
- 0
Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf
Ngày tải lên :
09/08/2014, 07:20
... elderly Dutch men and women It can be expected that the same polymorphisms could be important for both knee OA and hand OA, although no association between the VDR genotypes and hand OA was found ... bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes J Bone Miner Res 2001, 16:758-764 46 Ghosh P, Smith M: Osteoarthritis, genetic and molecular ... the risk of hand OA in Finnish middleaged women In addition, we evaluated whether the calcium intake modifies the relationship between the VDR gene polymorphisms and hand OA Materials and methods...
- 9
- 613
- 0
báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
Ngày tải lên :
10/08/2014, 10:21
... polymorphisms of leptin and leptin receptor genes and their products in ALL survivors Therefore, the aim of our study was to determine the polymorphisms of leptin and leptin receptor genes and plasma levels ... plasma levels of leptin and leptin soluble receptors in survivors of childhood ALL The study assessed the influence of chemo- and radiotherapy on leptin secretion and regulation and their effect on ... with and without CRT was 10%/23% and 20%/35%, respectively (table 3) Leptin and soluble leptin receptor Significant differences were found between leptin levels in patients treated with and without...
- 9
- 356
- 0
Báo cáo y học: "Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report" potx
Ngày tải lên :
11/08/2014, 00:23
... alert and oriented in all hemispheres Cranial nerves II-XII were grossly intact His peripheral neurological exam revealed decreased sensation to light touch and pinprick in both hands and feet ... (TIVA) using propofol, ketamine, and fentanyl A total of 100 mg ketamine was used throughout the entire procedure Neuromuscular monitoring was performed during the case and remained without any ... monitoring and care MRI and angiography revealed a normal Circle of Willis and no evidence of post-surgical complications in the cervical spine after the C3-C7 decompression (Figures and 5) Elyassi...
- 5
- 254
- 0
Báo cáo khoa hoc:" Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats" doc
Ngày tải lên :
11/08/2014, 07:21
... classified into groups I, II, and III Group II (mGluR2 and mGluR3) and group III (mGluR4, mGluR6, and mGluR7) receptors are negatively coupled to adenylate cyclase by Go and possibly Gi protein [11,12] ... ionotropic or metabotropic (mGluRs) receptors [7] Activation of the ionotropic N-methyl-D-aspartate receptors (NMDARs) plays a central role in brain development and learning and memory, which have been ... that antagonists and agonists of mGluRs can modulate the induction, formation, and maintenance of LTP [11-15], a form of neuronal plasticity that is involved in memory and learning The mGluR3 receptors...
- 8
- 280
- 0
Báo cáo y học: "Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha" doc
Ngày tải lên :
12/08/2014, 01:21
... LY, Tatsuo Kanda, FI and OY conceived and designed the study LY, Tomoko Kiyohara and Tatsuo Kanda performed the experiments LY, Tomoko Kiyohara, Tatsuo Kanda and FI analyzed data and wrote the ... translation by amantadine and IFN-alpha Suppression effects at 48 h after transfection by the combination of amantadine and IFN-alpha against HAV replication were stronger than those by amantadine ... to appropriate wells The final concentrations of amantadine, IFN-alpha, and their combination were 50 μg/ml, 100 IU/ml and 50 μg/ml of amantadine and 100 IU/ml of IFN-alpha, respectively After...
- 5
- 301
- 0
báo cáo khoa học: " STIL, a peculiar molecule from styles, specifically dephosphorylates the pollen receptor kinase LePRK2 and stimulates pollen tube growth in vitro" ppt
Ngày tải lên :
12/08/2014, 03:21
... [36,37] among others [15] Receptors for CLV3, TPD1 and SCR/SP11 have been identified [38-40] Binding of SCR/SP11 to the S-locus Receptor Kinase (SRK) and TPD1 binding to the receptor kinase EXCESS ... Violaceae, Rubiaceae and Cucurbitaceae [43] Cyclotides are heat stable and are resistant to proteases and to acid hydrolysis Their N- and C- termini are covalently linked and three intramolecular ... [20-22] and rapid-alkalinization factor (RALF) [23] Specific physiological or biochemical effects were associated with these polypeptides [14,15] and their receptors were identified and biochemically...
- 11
- 379
- 0
Báo cáo y học: "Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis" pdf
Ngày tải lên :
12/08/2014, 15:23
... binds two receptors, bradykinin receptor B1 (BKB1) and bradykinin receptor B2 (BKB2) The effects of BK in OA occur largely via BKB1, a receptor implicated in articular nociception [18,19] and pro-inflammatory ... (a) No surgery and saline treatment; (b) sham surgery and saline treatment; (c) ACLT and saline treatment; (d) ACLT and BQ-123 treatment; (e) ACLT and R-954 treatment; (f) ACLT and BQ-123+R-954 ... (a) No surgery and saline treatment; (b) sham surgery and saline treatment; (c) ACLT and saline treatment; (d) ACLT and BQ-123 treatment; (e) ACLT and R-954 treatment; (f) ACLT and BQ-123+R-954...
- 11
- 378
- 0
Báo cáo y học: " Interleukin-4 receptor α gene variants and allergic disease" potx
Ngày tải lên :
12/08/2014, 18:20
... development of asthma and atopy both in the Hutterite population and in other outbred populations However, despite a number of clinical studies and functional studies on signalling of the receptor in vitro, ... IL-4 to the receptor and/ or signalling of the receptor Additional polymorphisms in the downstream signalling pathways could also contribute to the overall response to produce ‘high’ and ‘low’ IL-4 ... reported an association between the Pro478 and Arg551 alleles and low IgE levels Hershey et al [5] reported an association between the Arg551 allele and IgE levels and atopic dermatitis Functional evidence...
- 3
- 224
- 0