nanoparticulate drug delivery systems an overview

... area of nanoparticulate drug- delivery systems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate ... Poorly Soluble Drugs 71 Jan Möschwitzer and Rainer H Müller Lipid-Based Nanoparticulate Drug Delivery Systems 89 Jun Wu, Xiaobin Zhao, and Robert J Lee Nanoengineering of Drug Delivery Systems Ashwath ... Epstein-Barash, and Gershon Golomb 16 Ocular Applications of Nanoparticulate Drug- Delivery Systems 271 Annick Ludwig 17 Nanoparticulate Systems for Central Nervous System Drug Delivery 281 Jean-Christophe...

Ngày tải lên: 04/06/2014, 14:47

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... References Langer, R (1990) New methods of drug delivery Science, 249 (4976), 1527–1533 Weinberg, B.D., Blanc, E., and Ga, J.M (2008) Polymer implants for intratumoral drug delivery and cancer therapy ... materials 375 376 15 Drug Delivery Systems [41] Living systems use peptides and proteins to achieve many chemical and mechanical properties within cells These properties can be generated in synthetic...

Ngày tải lên: 25/10/2013, 08:20

... some of the advances in the Chemical Aspects of Drug Delivery Systems New materials for drug delivery and targeting are reviewed and a representative range of excipients and delivery systems is considered ... intravenous, subcutaneous and intramuscular drug delivery The types of carrier materials used, the drug substance and the biological environment for drug delivery all influence the mechanisms of drug release ... controlled drug delivery and targeting Success in these areas is important both to improve the bioperfiormance and efficiency of drug delivery systems and to deal with recent trends in drug discovery...

Ngày tải lên: 28/03/2014, 10:20

... American Chemical Society, Wiley InterScience journals… CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug ... the way of delivery:  Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells…  Controlled-release drug delivery systems: preprogramed drug release ... route of delivery:  Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs...

Ngày tải lên: 18/04/2014, 15:37

... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease ... soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure Several anti-cancer ... the drug and modification of drug pharmacokinetics and biological distribution Too often, chemotherapy fails to cure cancer because some tumor cells develop resistance to multiple anticancer drugs...

Ngày tải lên: 20/06/2014, 00:20

... in anticancer drug delivery systems because there are many other anticancer drug delivery systems based on other nanomaterials, such as cationic polymers [98], fibrinogens [99], and PVP/PVAL nanoparticles ... CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to ... of carbon nanotubes and bundles of carbon nanotubes Carbon 2001, 4:507-514 Yang Z, Zhang Y, Yang Y, Sun L, Han D, Hong Li, Wang C: Pharmacological and toxicological target organelles and safe use...

Ngày tải lên: 20/06/2014, 22:20

... Revised and Expanded, edited by Gilbert S Banker and Christopher T Rhodes 122 Surfactants and Polymers in Drug Delivery, Martin Malmsten 123 Transdermal Drug Delivery: Second Edition, Revised and ... Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and ... Example Channel Na+, K+, and ClÀ channels Cotransporter (symporter) Na+-glucose and Na+amino acid transporters Exchanger (antiporter) Na+/H+ and ClÀ /HCOÀ exchangers Uniporter Glucose transporter...

Ngày tải lên: 10/08/2014, 00:20

... more than one route The primary advantages of direct topical drug administration include targeted drug delivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of ... of an ophthalmic solution results in decreased drainage (33) Over the range of 1–15 centipoise, there was a threefold change in drainage rate constant and another threefold change over the range ... sustained drug delivery than with subconjunctival administration Retrobulbar (or peribulbar) injection is another option for delivering drug to the posterior segment and the vitreous Hyndiuk and Reagan...

Ngày tải lên: 10/08/2014, 00:20

... from the lens and posterior chamber by the anterior vitreous membrane (anterior hyaloid membrane), which is anchored by ligaments to the retina Vitreous chamber has three important anatomical adhesions: ... clean up procedures and ex vivo enzymatic degradation; (e) the samples can be analyzed by any analytical technique, which contributes to the selectivity and sensitivity of the method Its disadvantages ... barrier in myopia An analysis employing vitreous fluorophotometry and computer simulation Acta Ophth Suppl 185:95–99, 1988 15 Larsen, J., Lund-Andersen, H., and Krogsaa, B Transient transport across...

Ngày tải lên: 10/08/2014, 00:20

... and evaluation of ocular drug delivery systems II OCULAR ANATOMY AND PHYSIOLOGY RELEVANT TO THE NONCORNEAL ROUTE The ocular anatomy and physiology relevant to ocular drug delivery was reviewed by ... Rabbit Enhanced ocular and systemic absorption significantly 0.025–1.0% Cimetidine Rabbit Enhanced Papp 14.1–87.0 times Lee and Robinson Enhancers Enhancers Concentration Drugs Animal Effect Enhanced ... following mechanisms (13): Altering membrane structure and enhancing transcellular transport by extracting membrane components and/or increasing fluidity Enhancing paracellular transport: Chelating...

Ngày tải lên: 10/08/2014, 00:20

... T., and Leverge, R (1998) Ophthalmic drug delivery systems recent advances, Prog Retinal Eye Res., 17:33–58 95 Robinson, J C (1993) Ocular anatomy and physiology relevant to ocular drug delivery ... 128 Peyman, G A., and Ganiban, G J (1995) Delivery systems for intraocular routes, Adv Drug Delivery Rev., 16:107–123 129 Geroski, D H., and Edelhauser, H F (2000) Review: Drug delivery for posterior ... including Candida albicans, histoplasmosis, and Cryptococcus neoformans Grossman et al (87) performed both transcorneal and transscleral iontophoresis of ketoconazole and measured the resulting drug...

Ngày tải lên: 10/08/2014, 00:20

... both retinal and stem cells transplants The results obtained from animal models and clinical trials of blind individuals are promising and show potential for retinal transplants as an intervention ... intervention strategy that can improve and stabilize vision Animal Studies a RPE Transplant An animal model of hereditary retinal degeneration, often used to study the effects of transplants in the eyes, ... viability and influence of such transplants on the host retina of the cats Also, clinical and pathological features, light and electron microscopy, and the electrophysiology of an autosomal dominant,...

Ngày tải lên: 10/08/2014, 00:20

... innovative nonviral delivery system is still in its infancy, but many advantages are associated with their use in gene transfer applications: (a) they can package and deliver a transgene of any size; (b) ... Fang, S R., Kaplan, H J., Del Piore, L V., Liu, Y., Wang, X., Hornbect, R., Landgraf, M., Mason, G., and Silverman, M S (1993) Development of a surgical procedure and instrument for transplantation ... 82 Danos, O., and Mulligan, R C (1988) Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges PNAS, 85:6460–6464 83 Markowitz, D., Goff, S., and Bank,...

Ngày tải lên: 10/08/2014, 00:20

... toxicity and pharmacokinetics of antisense oligonucleotides Anticancer Drug Des., 6:609–646 166 Y Rojanasakul (1996) Antisense oligonucleotide therapeutics: drug delivery and targeting Adv Drug Delivery ... guidance/index.htm Chemistry, Manufacturing and Control drug substance and drug product Microbiology—applicable only if for an anti-infective drug Human Pharmacokinetics—ADME data from human studies ... clinical investigations and NDAs for marketing approval The terms drug and new drug are inclusive of the drug substance and the drug product It is important to understand that a new drug is not just...

Ngày tải lên: 10/08/2014, 00:20

... from the lens and posterior chamber by the anterior vitreous membrane (anterior hyaloid membrane), which is anchored by ligaments to the retina Vitreous chamber has three important anatomical adhesions: ... clean up procedures and ex vivo enzymatic degradation; (e) the samples can be analyzed by any analytical technique, which contributes to the selectivity and sensitivity of the method Its disadvantages ... barrier in myopia An analysis employing vitreous fluorophotometry and computer simulation Acta Ophth Suppl 185:95–99, 1988 15 Larsen, J., Lund-Andersen, H., and Krogsaa, B Transient transport across...

Ngày tải lên: 10/08/2014, 03:20

... Ocular drug delivery Mechanism(s) of corneal drug transport and mucoadhesive delivery systems, S.T.P Pharma, 5:839 11 Mikos, A G., and Peppas, N A (1986) Systems for controlled release of drug ... subnanoscopic or nanoscaled reactants (19) Subnanoscopic reactants can be a variety of small molecules, while nanoscaled reactants are composed of larger molecules such as DNA, antibodies, and ... Microparticles and Nanoparticles in Ocular Drug Delivery II PARTICULATE SYSTEMS IN OCULAR DRUG DELIVERY A 441 Topical Systems The isolation of the vitreous caused by the blood-retinal and blood-aqueous...

Ngày tải lên: 10/08/2014, 03:20