... with GM-CSF in the SF may be involved in RA pathogenesis in vivo To address the effects of GM-CSF in SF on the growth of RA FLSs, we cultured the RA FLSs in culture media containing SF Page of ... in line with their gene expression patterns by microarray-based molecular studies [27] The histology of RA affected joints indicates chronic inflammation with hyperplasia in the synovial lining ... incubation overnight at 65°C, the slide was washed twice with × SSC containing 0.1% SDS for minutes at 42°C, once with 0.1 × SSC containing 0.1% SDS for 10 minutes at room temperature, and finally...
Ngày tải lên: 09/08/2014, 08:23
... and other complications in survivors were reported, including mechanical ventilation for 72 hours or more in 42% (tracheotomy in 13%), and transient cerebral ischemia in 13% On the other hand, ... final manuscript YO carried out the study design, Data analysis and writing, NK, NS, SK and HS performed data collection Competing interests The authors declare that they have no competing interests ... After total aortic arch replacement with an elephant trunk procedure In cases with multiple adjacent aneurysms, a single-step procedure is theoretically possible, but because of excessive invasiveness,...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Efficacy of TachoSil® patches in controlling Dacron suture-hole bleeding after abdominal aortic aneurysm open repair" potx
... hole bleeding are ethylcyanoacyrlate glue, different forms of collagen, oxidized cellulose, topical thrombin and gelatine sponge or fibrin [11] However, combining fibrin glue components in a collagen ... may be effective in delivering drugs locally In this study TachoSil® was used to provide fibrinogen and thrombin locally at the site of bleeding Upon contact with fluid the clotting factors of ... second look adding to a total of 30% haemostasis after Haemostasis was achieved within in 90% of the patients in Group I compared to only 70% within in Group II The mean blood loss during the operation...
Ngày tải lên: 10/08/2014, 10:20
How to maximize part-time students ’ involvement in English speaking lessons at Hai Phong Foreign Languages Centre
... participation in speaking lessons 1.3 Learners difficulties in getting involved in speaking lessons The finding states that learners themselves have difficulties in getting involved in speaking lessons ... their involvement in speaking lessons including: subjective factors from the learners themselves such as finding ideas, finding words, poor pronunciation ect and objective ones such as uninteresting ... mother-tongued inference have bad influence on their involvement in English speaking lessons 1.4 Teachers difficulties in teaching speaking in speaking lessons The result from the survey indicates...
Ngày tải lên: 07/11/2012, 14:50
Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... also involves tyrosine dephosphorylation of cortactin, vinculin and ezrin, which are three wellknown actin-binding proteins [6] The phosphatases involved in this scenario, however, remain unknown ... revealed the involvement of ADAM17, a metalloprotease involved in catalyzing ectodomain shedding of RTK ligands In nonstimulated cells, ADAM17 is normally in complex with the integrin member a5b1 ... bacteria gain access to integrins and inject CagA The basal injection model of CagA can also explain why H pylori does not cause more gastric damage in infected individuals and may only inject virulence...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
... (2000) RGS domain in the amino-terminus of G protein-coupled receptor kinase inhibits Gq-mediated signaling Int J Mol Med 5, 335–340 20 Chen CA & Manning DR (2001) Regulation of G proteins by covalent ... with 10 lCiÆmL)1 [3H]inositol for 24 h in inositol-free medium containing 10% (v ⁄ v) dialyzed fetal bovine serum Cells were then washed and incubated in NaCl ⁄ Pi containing 20 mm Li+ with the ... degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha ⁄ G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells Biochem...
Ngày tải lên: 20/02/2014, 03:20
Báo cáo khoa học: Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase doc
... ⁄ Km (Eqn 9) fitting were obtained leaving all unknown parameters (i.e KB1 and KB2) floating CAD: kc (Eqn 5) fitting was obtained leaving all unknown parameters floating; in the fitting of Km (Eqn ... were obtained by fitting kinetic parameters to equations for kc and Km of CAD and HEX, as reported in the Discussion The dashed line in panel C is a curve obtained fitting (kc ⁄ Km)CAD according to ... spermidine) and four aromatic amines have been interpreted in terms of hydrophobic interactions prevailing over polar interactions in PSAO Our results partially match those of these authors, in that...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... resolving cysteine (Cys-SR) In typical 2-Cys, Sp at the N terminus and SR at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in atypical ... found in A pernix because in the genome data base of P horikoshii neither a homologue of A pernix thioredoxin-like nor other types of thioredoxins were found In this study we examined the involvement ... Peroxiredoxin mechanisms (A) 1-Cys Prx (B) 2-Cys Prx Sp peroxidatic cysteine; X unidentified electron donor; SR resolving cysteine; RSH protein or domain with CXXC motif (e.g thioredoxin) In typical...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking potx
... chitin-binding proteins in T tridentatus Amino acid compositions of high molecular mass (HMM) chitin-binding proteins HMM chitin-binding proteins resolved by 2D SDS ⁄ PAGE were categorized into ... crab chitin-binding protein [15], as well as with the chitin-binding domain of hevein (Cys12 to Cys33), a plant chitin-binding protein [41,42], as shown in Fig This segment of tachycitin forms ... similarity to other known cysteine-containing chitin-binding domains [14], such as plant chitin-binding proteins and horseshoe crab antimicrobial peptides with chitin-binding affinity [15–17] Rebers...
Ngày tải lên: 07/03/2014, 21:20
Challenges and Opportunities for Male Involvement in Reproductive Health in Cambodia pdf
... providers, reassessing clinic opening times, and perhaps scheduling male-only clinics and improving the privacy of male clients Existing service providers need further training in counseling male clients ... and donors incorporate male involvement into their workplans Respondents wanted the guidelines to be practical • • B • • • • • • • • male involvement guidelines for incorporation into the new ... A set of guiding principles needs to be developed to assist those involved in the health sector with mainstreaming male involvement into reproductive health strategies The guidelines should be...
Ngày tải lên: 14/03/2014, 16:20
Prevalence and Its Predictors of Extrapulmonary Involvement in Patients with Pulmonary Tuberculosis pdf
... fitness of the final model was good in terms Table Sites and methods of diagnois of extrapulmonary involvement in 40 patients Involved organ* Miliary involvement Lymph node Intestine Larynx Soft ... common in patients with bilateral lung involvement but without cavity formation or low levels of serum albumin Clinicians should keep in mind the possibility of extrapulmonary involvement in these ... analysis for predicting combined extra-pulmonary involvement in patients with pulmonary TB EPTB, pulmonary TB with extra-pulmonary involvement; sAlbumin, serum level of albumin regarded as a marker...
Ngày tải lên: 15/03/2014, 03:20
Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... domain of p47phox binds intramolecularly to the SH3 domain in the same protein, and that this intramolecular interaction suppresses the lipid-binding activity of the PX domain in the resting ... putative protein of 910 amino acids that contains a PX domain (solid underlining) and four SH3 domains (dotted underlining) (Fig 2A) Moreover, the encoded protein also contained ten polyprolines (boxed), ... found in the FAD49 PX domain, as in many PX domains, suggesting that the PX domain could bind to an SH3 domain of FAD49 To test whether the PX domain could interact with an SH3 domain in FAD49,...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: The first cytochrome P450 in ferns Evidence for its involvement in phytoecdysteroid biosynthesis in Polypodium vulgare doc
... balance in plant tissues, as depicted in Fig In vivo E bioconversion measured in callus culture was a linear function of the P450 microsomal protein content, and was inhibited by P450 inhibitors ... protein was determined using the Bradford procedure with bovine serum albumin as a standard [42] The protein concentration of partially or total purified P450 protein was estimated from silver-stained ... of microgram quantities of protein utilizing the principle of protein–dye binding Anal Biochem 72, 248–254 43 Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of...
Ngày tải lên: 16/03/2014, 23:20
AORTIC ANEURYSM RECENT ADVANCES potx
... recent findings in understanding the complex pathogenic mechanisms of a wide spectrum of diseases, including aortic aneurysm, provides an interesting and challenging research domain The deep insight ... renin angiotensin inhibitors (Daugherty et al., 2011) Using mouse model with Angiotensin II-induced abdominal aortic aneurysm formation, the involvement of oxidative stress-induced changes in ... is down regulated in abdominal aortic aneurysms and in intracranial aneurysms (Shi et al., 2009; Hinterseher et al., 2013) NTRK3 represents a tyrosine kinase receptor involved in cellular development...
Ngày tải lên: 17/03/2014, 02:20
Determinants of male involvement in maternal and child health services in sub-Saharan Africa: a review potx
... different definitions of male involvement in PMTCT are used in different studies resulting in difficulties when comparing data between these studies Determining a consensus definition of male involvement ... universally accepted definition of male involvement in PMTCT is lacking The definition of the term “male involvement varies according to authors Some authors define male involvement as male partners‟ ... participation in HIV testing solely during ANC [9,10,14] Others consider participating in couple counseling as male involvement [9,11-13] In this paper we will use the composite term “Male Involvement...
Ngày tải lên: 22/03/2014, 12:20
Báo cáo khoa học: Calpain involvement in the remodeling of cytoskeletal anchorage complexes potx
... Z-line and N1-line on each side of the Z-disk and in the N2-line vicinity (Fig 2B) At least three proteins in this region, titin, a-actinin and c-filamin, are able to bind calpain with increasing ... ABP against proteolysis L-Plastin The cleavage separates the N-terminal domain from the core of the molecule Vinculin Talin Paxillin MARCKS Cortactin Spectrin P130Cas Tensin Gelsolin In platelets, ... domains In favor of this hypothesis are the results that we have obtained with an actin crosslinking protein, l-plastin, found in FAs and podosomes [25] We have found that this actin-binding...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx
... formation, indicating that Sec14p and the two homologues act as inhibitors of Plb1p in vivo This observation explains at least in part the low Plb1p activity in wild-type cells Interestingly, the inhibitory ... fetal bovine heart endothelial cells, PITP-a was predominantly present in the nucleus and in the cytoplasm [48] Ó FEBS 2003 Fig Phosphatidylcholine turnover in strains overexpressing Sfhproteins ... turnover observed in SFH2 and SFH4 overexpressing cells is linked to Pld1p activity Determination of choline release in a strain overexpressing Sfh-proteins in a sec14ts CKI1 background (data not shown)...
Ngày tải lên: 23/03/2014, 18:20
Thrift Involvement in Commercial and Industrial Lending ppt
... to be involved in C&I lending, for those that are involved in such lending, the proportion of assets invested in C&I loans tends to decline with increasing institution size Thrifts operating primarily ... thrifts that engage in C&I lending Also examined are the ways in which the change between 1991 and 1997 in an institution’s involvement in C&I lending is related to certain institutional characteristics ... also in uence thrift involvement in C&I lending Thrifts owned by bank holding companies might be expected to behave more like banks, and thus to be more heavily involved in C&I lending, than independent...
Ngày tải lên: 29/03/2014, 08:20
báo cáo hóa học:" “It is her responsibility": partner involvement in prevention of mother to child transmission of HIV programmes, northern Tanzania" ppt
... to HIV-infected wives; attitudes to condom use within marriage; attitudes to couple counselling and testing; involvement in infant feeding; and views on how to increase male involvement in the ... collate information relating to socio-demographic characteristics; clinic attendance; place of birth; infant feeding practices; PMTCT practices at the clinic including counselling and testing for ... offered During the post-test counselling, the mothers were asked to bring their partners to the clinic for testing If the mother succeeded in bringing her partner to the clinic, couple counselling and...
Ngày tải lên: 20/06/2014, 08:20