metal complexes of heterocyclic sulfonamides as carbonic anhydrase inhibitors

... concerned with the use of metal ions to control the assembly of appropriate molecular components containing metal- binding domains."20 The principle of the formation of metallosupramolecules depends ... Doublet of doublets ddd Doublet of doublets of doublets dt Doublet of triplets td Triplet of doublets m Multiplet br Broad Mass Spectrometry (MS) EI Electron impact ES Electrospray ionisation FAB Fast-atom ... orientation of the coordination sites of ligands [molecular components containing metal- binding domains] and (2) the coordination number and geometry of the metal ions A variety of metallosupramolecular...

Ngày tải lên: 02/07/2014, 13:33

... strain of 0.1%, frequency of rad s-1 and 25°C Steady shear measurements of viscosity as function of shear rate of hydrogel IIIC-1 at 25°C Creep retardation and recovery (relaxation) curves of hydrogel ... understanding various aspects of bioinorganic and coordination chemistry.8 Particular research interest has been devoted to transition metal complexes of salicyaldehyde-amino acid Schiff bases as they have ... transition metal complexes with reduced Schiff base ligands derived from salicylaldehyde and amino acids In most of the cases, the stability of Schiff base compounds depend on many factors such as polarity...

Ngày tải lên: 14/09/2015, 08:47

... CA9 ASO could enhance PYM-induced caspase activation and subsequent PARP cleavage (F) Effect of CA9 ASO on PYM-induced caspase activation on Tca8113 ⁄ PYM cells The relative activation of caspase ... 0.01 E D 24 h of treatment, caspase activity was determined As shown in Fig 4F, Atz and CA9 ASO significantly increased PYM-induced caspase activity in Tca8113 ⁄ PYM cells (P < 0.01) as compared ... expression of tumor-associated carbonic anhydrases Cancer Res 60, 7075–7083 16 Robertson N, Potter C & Harris AL (2004) Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion...

Ngày tải lên: 06/03/2014, 22:21

... hereafter referred to as R pachyptila carbonic anhydrase trophosome (RpCAtr) From the body wall-subtracted branchial plume cDNA library, we obtained a carbonic anhydrase transcript of 171 nucleotides, ... zooxanthellate cnidarians: role of carbonic anhydrase Mar Biol 100, 195–202 Kochevar RE, Govind NS & Childress JJ (1993) Identification and characterization of two carbonic anhydrases from the hydrothermal ... mechanism of human carbonic anhydrase II studied with a site-specific mutant Biochemistry 28, 7913–7918 29 Liang J-Y & Lipscomb WN (1987) Hydratation of carbon dioxide by carbonic anhydrase: internal...

Ngày tải lên: 18/02/2014, 16:20

... viability of 5.61 cells was significantly less than Rat1 cells at each concentration of H2O2 (Fig 3A) The viability of the entire panel of cell populations was examined by Relative caspase activity ... degenerative diseases of aging Proc Natl Acad Sci USA 90, 7915–7922 15 Wu WS (2006) The signalling of ROS in tumor progression Cancer Metastasis Rev 25, 695–705 16 Wistrand PJ (2002) Carbonic anhydrase III ... vector control transfected cells, as determined by measuring caspase catalytic activity (Fig 8B) Finally, we measured intracellular levels of ROS to determine if the basal oxidized state varied between...

Ngày tải lên: 29/03/2014, 08:20

... SY, Hwang YJ, et al: Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer J Cancer Res Clin Oncol 2006, 132(5):302-308 Wykoff CC, Beasley N, Watson PH, Campo ... SK, English R, Pastorek J, Sly WS, Ratcliffe P, Harris AL: Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast Am J Pathol 2001, ... gene expression was amplified and marked (thick arrow) (B) Examination of CA12 mRNA quantity by real-time PCR The quantity of CA12 gene was expressed as a ratio of mean quantity of CA12 to b-actin...

Ngày tải lên: 09/08/2014, 09:20

... Cleavage of structural proteins during assembly of the head of bacteriophage T4 Nature 1970, 227:680-685 Nishita T, Kondo H, Ishida S, Ochiai H, Asari M: Isolation and measurement of carbonic anhydrase ... 1.78 mg/g of Hb It was about 11% of those of 49-week-old female WL-chickens, about 25% of those of 52-week-old male WL-chickens and 14 times of the levels of CA-II in erythrocytes of Beagles ... weeks old) was 96.1 ± 12.2 mg/g of Hb, and it was 59 times of the levels of CA-II in erythrocytes of Beagles The mean level of CA-II in hemolysate of 53-week-old female Araucana-chickens was 23.4...

Ngày tải lên: 12/08/2014, 18:22

... example of a metal- templated carbene synthesis, though unrecognized at the time, was Tschugajeff’s synthesis of mono- and bis(carbene) complexes of platinum(II) The attack of hydrazine on metal- bound ... Werner-type ligand has been devised by Lever, and is based on the E0 value of a Ru(II)/Ru(III) redox couple of complexes incorporating the ligands of interest.46 The electron density of the metal center, ... such as acetate can still give good yields of NHC complex Coinage metal oxides are particularly useful basic metal sources 63 As a byproduct of the deprotonation, only water is formed In the case...

Ngày tải lên: 09/09/2015, 09:58

... of metal complexes using solid state [2+2] photo cycloaddition These metal complexes have been obtained by the coordination of Zn2+ with 4spy and its 2-fluoro derivative ligands These metal complexes ... information of VII-1a - VII-1e, VII- 7-19 & VII-3 XV List of Figures Figure Description Page Figure 1- A schematic representation of a MOF structure 1-5 Figure 1- Classification of CPs 1-7 Figure 1- Basic ... transformation of 2D interdigitated MOF, V-1.2 5.1-12 to doubly interpenetrated 3D MOF, V-1.3 Figure 5.1- Comparison of PXRD data of V-1.2 & V-1.3 5.1-13 Figure 5.1- 10 A perspective view of a portion of...

Ngày tải lên: 09/09/2015, 11:15

... Containing soft and hard donor groups, the phosphorus-oxygen and phosphorus – nitrogen based ligands represent some of the extensively studied class of ligands.10 One of the virtues of these mixed-donor ... 70.42 1.4 Complexes with mixed donor hybrid ligands of interest Most of the transition metal catalytic applications reported consist of the combination use of mixed donor hybrid ligands and metal ... examples of reported Rh complexes. 45 Scheme 1.7 Reactions of rhodium complexes with phosphine-ether ligands.14 22 Chapter Scheme 1.8 Catalytic studies of carbonylation of MeI using rhodium/18b-d complexes. 8a...

Ngày tải lên: 11/09/2015, 10:18

... applications of chiral alcohols as building block or precursors for syntheses of chiral compounds 6.1.2 Asymmetric rhodium-catalyzed hydrosilylation of ketones to alcohols Asymmetric metal- catalyzed ... rhodium complexes have been widely used as catalysts in asymmetric hydrosilylation of ketones owing to their high catalytic activity.166 Equation 6.1 Metal- catalyzed asymmetric hydrosilylation of ... bombardment with fast xenon atoms (FAB), using of 3-nitrobenzyl alcohol (3-NBA) as matrix and sometimes potassium chloride as additive in the latter case The data are given in mass units per charge...

Ngày tải lên: 11/09/2015, 10:18

... 118 measured of a CH2Cl2 solution of complex 38 Figure 4.11 Molecular structure of the complex-cation of 39·2CH2Cl2 121 XIII List of Schemes List of Schemes Scheme 1.1 Arduengo’s synthesis of the ... reagent to other metals such as palladium, gold and rhodium, and thus afford a wide range of metal complexes This method has become a standard procedure in the synthesis of NHC complexes nowadays ... Synthesis of Pt (II) complexes cis-15 and trans-16 63 Scheme 2.11 Synthesis of Pt(II) complexes trans-17, cis-17 and trans-18 69 Scheme 3.1 Synthesis of complex 19 74 Scheme 3.2 Synthesis of complexes...

Ngày tải lên: 14/09/2015, 14:12

... materials of molecular scale in various fields such as optical, electronic and medical materials This thesis consists of two parts of work on the synthesis and characterization of metal complexes of ... two groups The objective of the first part of work was to develop d10 complexes of interesting structural properties by utilizing metal- metal and/or - interactions for assembling molecules In ... states of the molecule Such a similarity is also observed for the two crystal forms of complex The profiles of the 39 solid state emission spectra of complexes and are similar to those of complexes...

Ngày tải lên: 15/09/2015, 17:10

... release of drug was studied also in plasma and in PBS after addition of glutaraldehyde Pravastatin assay by UPLC A reversed phase UPLC method was developed and used throughout the study for pravastatin ... fragility was studied for each drug concentration In vitro releasing study The release of pravastatin as well as hemoglobin from carrier erythrocytes were determined as following, ml of packed ... using glutaraldehyde as a membrane stabilizer Also the figure shows the hemoglobin release The releasing curves of pravastatin show release phases, the first is rapid release phase and the second...

Ngày tải lên: 25/10/2012, 11:10

... storage stability of PANs was studied in the aqueous medium, and the acute toxicity of PANs was evaluated in mice Morever, EPI was loaded into PANs and its pharmacokinetics was also assessed in rats ... the C-18 column was used and the mobile phase (0.02 M KH2PO4/CH3CN/CH3OH = 49:17:34 v/v/v) was delivered at a rate of 1 ml/min Sample (20 μl) was injected and the column effluent was detected with ... concentration of total EPI in plasma was 14.65 mg/L at 1 min after injection and then decreased to nearly undetectable levels after 24 h The maximum concentration (Cmax) of PA/EPI at 5 min was 9.80 mg/L,...

Ngày tải lên: 23/04/2013, 21:38

... poly-aluminum chloride (PAC) as well as waste steel slag (WSS) (E5) A natural tidal flat (C3) at the same tidal level was chosen as a reference for monitoring benthic communities as well as physicochemical ... range of values observed in the five artificial tidal flats (E1―E5) of the seashore experiment Mountain sand (MS) was used because of its importance as the alternative to sea sand which is of limited ... survived in the mixtures of MS and DS as well as MS itself, however, its growth was dependent on the mixing ratio of DS At 5% silt and clay, the liability and shell length increase of R philippinarum...

Ngày tải lên: 05/09/2013, 09:38

... hydrolysis of cellulose microfibrils to release glucose involves synergistic action of three enzymes: endo-glucanase, exo-glucanase and β-glucosidase Endo-and exo-glucanases are commonly referred to as ... to the profits of a biorefinery The use of oxidative pretreatments that rely on degradation of this component would not be feasible as great amounts of this valuable commodity would be wasted Besides ... general, the ash content of crop materials is significantly higher than that of wood [34] Silica accounts for around 80% of wheat straw ash, the rest being metals such as sodium and potassium [47]...

Ngày tải lên: 05/09/2013, 15:28

... of discipline as a synthesis presence of a number of complementary factors She also emphasizes the equal importance among the factors as well as pictures the general look of a disciplined classroom ... agreement, which has it that ‘Learners’ motivation makes teaching and learning immeasurably easier and more pleasant, as well as more productive’ In the book entitled ‘Expectations about classrooms’, ... classroom, the outlined qualities seem relevant and justified as far as a given classroom is concerned commonly For a more detailed understanding of the roles of the teacher in language classroom,...

Ngày tải lên: 07/09/2013, 13:06

... from this horrible job of washing socks! Voice B: Buy a bottle of Onwash, Mrs Bloggs! Voice C: Onwash is so soft and strong Voice D: You dont want lots of hot water with onwash - Practice /:/ Announcer: ... third phase is called the release phase when the articulators used to form stricture are moved to allow air to escape In this phase, /p/, //, /k/ are heard by a burst of noise The fourth phase is ... happened was misunderstood by listener that action has not taken place 5.1.2 Types of Grammatical Endings There are three basic types of grammatical endings in English: The first is ending of the...

Ngày tải lên: 18/12/2013, 21:45

... < 0) // Negative number of rows returns all rows numRows = dt.Rows.Count; else // Set number of rows to the lesser of the user entered // number of rows and the number of rows in the table numRows ... over the collection of rows for(int i = 0; i < numRows; i++) { // Iterate over the collection of columns foreach (object col in dt.Rows[i].ItemArray) { // Replace null values as they occur String ... method of the ADO Recordset or a method that converts the Recordset to a string This solution presents an ADO.NET method, which is also called GetString( ), that duplicates the functionality of the...

Ngày tải lên: 24/12/2013, 05:15