lost on the moon group activity

... oxygen of the alcohol attacks the carbonyl carbon. In the second step, the proton bonded to the oxygen from the alcohol transfers to the oxygen that was the carbonyl oxygen. This proton transfer ... case, is the carbonyl carbon. In the carboxylic acid family, the leaving group (the electronegative group bonded to the carbonyl carbon) is a base, but is generally a weaker base than the nucleophile. ... a leaving group. In reactions with a leaving group, the behavior of the leaving group significantly affects the course of the reaction. The reactivity of the various members of the carboxylic...

Ngày tải lên: 05/03/2014, 22:28

... inhibition potency on the polymerase function; and (c) the K-61 analogue showed a fourfold reduction in its RDDP activity inhi- bition potency. By contrast, when the AQ derivatives were tested on the ... similar conformation (RMS 0.57), on the other hand, in the crystal reported by Pata et al. [30] the NNRTI binding pocket most closely resembles the RT unliganded conformation. Therefore, the AQ ... steric modifications occur. The binding mode of K-49 in the Y181C RT is different, and the contribu- tion of the p–p stacking interaction is lost. Furthermore, the low number of good contacts with...

Ngày tải lên: 22/03/2014, 16:20

Ngày tải lên: 22/06/2014, 00:20

... rise. • This leads to disruption of the weather patterns eg drought, floods • Some weeds may thrive on the extra carbon dioxide while other plants are killed Biological Control of Pests • This means ... from the water • This means the fish suffocate and die • This process is called Eutrophication • Raw sewage pumped into rivers has the same effect The Influence of Human Activity on the Environment Benefits ... cars and power stations produces carbon dioxide, sulphur dioxide and other greenhouse gases • carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise. •...

Ngày tải lên: 26/01/2014, 10:20

... proposed for the binding of the SRL to the active site of RTA in which the principal difference lies in the conformation of the second ÔGÕ in the target GAGA motif in the 28S rRNA substrate. In one model, ... of RTA resulted in different effects on the activity of RTA. Whereas, one had no effect on the activity of the enzyme (R258A), others reduced activity by one (R213A, R258D, R48A) or by two (R213D) ... hydrogen bonds to be formed between the base G 4 and the sidechain of Asn122. In the second model (Fig. 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions...

Ngày tải lên: 19/02/2014, 12:20

... to the iron(III) of Fe(ToCPP) and Fe(ToCPP))13G10 The second part of our results concerns the binding of imidazole d erivatives on the iron of Fe(ToCPP) either alone in solution or inside the ... this inhibition was due to the binding of the imidazole ligand on the iron atom. In addition, measurement of the kinetic parameters for the oxidation of ABTS by H 2 O 2 catalyzed by Fe(ToCPP))13G10 in the ... (Table 1). The bind- ing of the ®rst CN ± ligand to the iron was thus more easy in the hydrophobic binding pocket of the antibody than the binding of the second one, most probably because of the steric...

Ngày tải lên: 21/02/2014, 03:20

... in a convex set X consisting of certain positive definite functions on the group. In our concrete situation, the elements of the set X are positive definite functions on U(∞), constant on conjugacy ... By Proposition 5.3 the kernel K describes the correlation functions of the L-ensemble in question. On the other hand, the same correla- tion functions are also expressed in terms of the kernel ... through the correlation kernel of the original process. Thus, one way to obtain the correlation functions for the two-component log-gas is to apply the complementation principle to the (one-component)...

Ngày tải lên: 06/03/2014, 08:21

... that the TH value reflects the fraction of ice-bound AFPs on the flat ice plane. Indeed, TH increases in proportion with the total concentration of nfeAFP8, as can be seen in Fig. 3A. The fraction ... AFP based on the ‘adsorption–inhibition’ model [3,4]. (A) A convex ice front is created after primary binding of type III AFP onto the flat ice plane. (B) Overgrowth of the convex ice front, giving ... value. (C) Possible secondary ice binding of type III AFP onto the convex ice front during the annealing period (2–3 h). (D) AFPs bound onto the convex ice front narrow the growth area (dashed...

Ngày tải lên: 07/03/2014, 05:20

... 74 th Amendments to the Constitutionand the recommendationsof the XI FinanceCommission.Further,CentralGovernmenthasbeenentrusting the implementation ofvarioussocio‐economicdevelopmentalschemestoautonomousagencies/societies.More oftenthannot,CentralGovernmentschemeshavealsoenvisageddirecttransferoffunds ... of the audits by the CAG of India. On our part, one of the biggest limitations of not being able to reach the beneficiaries for their perception and verificationofdeliveryof the programmes,including the existenceof the communityassets and ... SynergyandPartnershipbetweenSocialAuditandCAG’sAudit The Task Group isof the opinionthatrecognisingthatsocialauditsaffordanopportunityto strengthen the micro level scrutiny of the programme planning, implementation and monitoring,...

Ngày tải lên: 15/03/2014, 20:20

... iden- tified as the major and the minor forms of the holo- ACP structure, on the basis of their percentage contri- butions (65% and 35%, respectively) to the overall structure of the protein. The structures ... mC m , the two-state assumption for the unfolding reaction, and linear pretransition and post- transition baselines, which are dependent on the concentra- tion of guanidine hydrochloride by the ... interactions, and the blue lines denote CH–O hydro- gen bonds. The 4¢-PP group is linked to the protein by the Ser37 O-c atom. Only residues 31–38 of the protein make extensive contacts with the cofactor....

Ngày tải lên: 16/03/2014, 10:20

... cloned through the flanking NcoI and XhoI restriction sites into the expression vector pET28a. The sequences of the constructions were verified by DNA sequencing. The primer pairs for the cloning ... column, the highest inhibi- tory activity was found in the unbound fraction (data not shown). The unbound fraction was then further purified on a Superdex-75 column (Fig. 2A) and then on a Hamilton ... fractions were finally obtained and assayed for their inhibitory activity. Among them, the major fractions P2, P3 and P4 have a strong inhibitory activity against furin. The homogeneity of the three...

Ngày tải lên: 16/03/2014, 13:20

... record, as contained in papers published on the WGIG web site and in e-mails exchanged among the members of the group. A concluding section provides some personal views on the principal themes that ... in the consultations. By April 2005 the Group had started talking about recommendations, but the real discussion was to be at the final June meeting. Usually the group met in the United Nations’ ... that they had to listen and respond to the doubts and questions raised. Instead of talking at one another, the members started talking with one another. The members of the group were there...

Ngày tải lên: 22/03/2014, 21:20

... both the ini- tiation and elongation of DNA replication [13], and these proteins migrate on the genome together with the replication forks [14,15]. One of the intricacies related to the function ... solution (0.4 lL) containing or lacking heliquinomycin was added to the reaction mixture. The final con- centrations of heliquinomycin added to the reaction mixture are indicated at the top. The ... DNA was considered to be 100% in the control reaction mixture lacking heliquinomycin, and the proportions in the mixtures containing heliquinomycin were cal- culated in relation to the control...

Ngày tải lên: 23/03/2014, 04:21

... Fig. 1 on the oxidation of exo- genous NADH as the expression of the activity of the complete system. Discussion The data presented provide new insights into the role of magnesium ions in the permeability ... provides direct evidence that, in these latter conditions, the addition of magnesium mimics the results obtained with the addition of cyto-c, the only difference being that the potential is lower and ... mitochondria, activates the oxida- tion of extramitochondrial NADH and the generation of a membrane potential, both linked to the activity of the cytosolic NADH/cyto-c electron transport pathway. The...

Ngày tải lên: 23/03/2014, 06:20

... agreement with the reduced DMA of the AMY1 Y380A ‘sugar tongs’ mutant, these effects may stem from allosteric regula- tion. The mutational analysis of the ‘sugar tongs’ in barley AMY1 explored the role ... This is the first demonstration of a function for a C domain from the large GH clan-H. The work contributes to the unraveling of the molecular basis of multivalent enzyme–polysaccharide interactions. ... connects b5 and a5 of the catalytic (b ⁄ a) 8 -barrel at the end of the aglycon-binding area of the active site cleft. Earlier, significant deviation was found in this region between the backbone...

Ngày tải lên: 23/03/2014, 07:20

Ngày tải lên: 23/03/2014, 09:21

Ngày tải lên: 28/03/2014, 23:20

Ngày tải lên: 31/03/2014, 07:20

Ngày tải lên: 31/03/2014, 09:20

Ngày tải lên: 31/03/2014, 21:21