jak stat3 pathway activation as therapeutic targets in ibc
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... -(CH2)3- with a terminal cationic nitrogen-containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], ... T, Shin-ya K, Sashida G, Sumi M, Okabe S, Ohyashiki JH & Ohyashiki K (2006) Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute ... haematological cancers Notable findings include that of single-agent activity for RHSP4 in a metastatic melanoma model, as well as in a melanoma line resistant to the platinum drug DDP [56] RHPS4 FEBS...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
Ngày tải lên :
11/09/2015, 16:04
... IkappaB kinase kinases IL Interleukin JNK c-Jun N-terminal kinases LPS Lipopolysaccharide MAPK Mitogen-activated protein kinases XIV MCP-1 Monocyte chemotactic protein-1 MIP-1a Macrophage inflammatory ... feeding also induces a decrease in caspase expression and an increase in cathepsin B expression, indicating that ethanol abuse may prevent apoptosis of pancreatic cells and activate trypsinogen ... pancreas The pro-inflammatory cytokines including Tumor necrosis factor- (TNF), Interleukin (IL)-1, IL-6, anti-inflammatory mediators including IL-10, IL-1 receptor antagonist, chemokines including...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
Ngày tải lên :
09/08/2014, 03:24
... enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J 2003, 17(2):330-2 96 Rosati B, et al: Glucose- and arginine-induced insulin secretion ... terminus on activation results in perinuclear localisation of the channel leading to activation of Mitogen activated protein kinase (MARP) pathway resulting in increased cell proliferation The Eag ... channels Increased expression of K+ channels on cell membrane results in increased influx of Ca2+ ions resulting in increased transition of cells through G1/S phase of cell cycle The channels in presence...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... activated protein kinase (MEK) inhibitor such as CI-1040 was used to test the potential therapeutic agent in in vitro ovarian cancer cell line (51) This cell lines containing KRAS or BRAF mutations, ... variant was found to be associated with increased breast cancer risk in all Chinese in Tianjin, Nanjing, Taiwan and Hong Kong This was also in agreement with three studies conducted in Japanese ... high-grade serous subtype was related to overexpression of Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
Ngày tải lên :
09/09/2015, 11:21
... APAP APR AST ATP TTP BSA BTI CAT Apoptosis-inducing factor Alkaline phosphatase Alanine aminotransferase Activating protein-1 Acetaminophen (paracetamol) Acute phase response Aspartate aminotransferase ... Sphingomyelinase/ Ceramide pathway MAP-kinase pathway JAK/ STAT pathway Signal transduction NF-B AP-1 C/EBP STAT3 Transcription factors Acute Phase Proteins Removal the source of injury Healing ... mechanisms in DILI has been studied extensively Therefore, the role of signaling pathways involved in DILI can be examined based on the signaling pathways that are important in mediating APAP-induced...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
Ngày tải lên :
09/08/2014, 01:21
... proapoptotic pathways, further increasing the antibody’s depleting activity [7] Rituximab has been used in the treatment of B-cell non-Hodgkin’s lymphoma as a single agent as well as in combination ... immunoglobulin levels are usually maintained, possibly as a consequence of plasma cells being spared B-cell depletion in antibody-mediated diseases It is understandable that rituximab has been most ... confirm that, at least in some patients, plasma cells are not sufficient to maintain autoantibody levels and that continuous B-cell recruitment and activation are necessary to maintain autoantibody...
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Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
Ngày tải lên :
09/08/2014, 01:22
... protein kinases Mitogen-activated protein (MAP) kinases are stress-activated serine/threonine kinases that include the p38, ERK (extracellular regulating kinase), and JNK (c-Jun-N-terminal kinase) ... c-Jun N-terminal kinase; MAPKAPK, mitogen-activated protein kinase-activated protein kinase; MEK1/2, mitogen-activated protein kinase kinases types p38 inhibitors are effective in preclinical models ... respectively The cascade generally has three levels (shown on the left), including the MAP kinase kinase kinases (MAP3Ks), which activate the MAP kinase kinases (MAPKKs or MKKs), which, in turn, activate...
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Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx
Ngày tải lên :
09/08/2014, 10:23
... patients, remained unchanged in one, and increased in three, rendering the authors’ results statistically insignificant HMGB1 mRNA expression remained unchanged after infliximab therapy as indicated ... arthritis upon rHMGB1 administration, and the improvement of disease after HMGB1 inhibition implicate HMGB1 as a key mediator and potential therapeutic target in RA HMGB1 as a novel therapeutic The recent ... arthritis in animals and shares key histological features observed in RA, including pannus formation, synovial membrane hypertrophy, and mononuclear cell predominance within synovial tissue [7] The injection...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... association with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and ... longitudinal analysis of individual patients indicated that ICOS was significantly elevated during the active phase when compared with clinical remission Sialic acid binding immunoglobulin-like lectin ... validated as a predictor of clinical response At least one pharmaceutical company is applying the IFN signature as a rapid indicator of clinical response in early phase I/II trials targeting IFNα...
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Báo cáo y học: " mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway" docx
Ngày tải lên :
10/08/2014, 05:21
... CHPG, directly binding to glutamate binding site, and DFB as well as CDPPB, binding to the heptahelical transmembrane domain of mGluR5, increase the intrinsic efficacy of the endogenous glutamate ... recordings of field potentials in hippocampal slices of mouse brains The basal spontaneous potential in an individual hippocampal slice was initially recorded for min, and then NMDA (100 μM) was ... whether the influence of NMDA receptor activation and suppression by positive mGluR5 modulators was involved in the protein kinase C (PKC) dependent pathway Pretreatment with chelerythrine (CTC,...
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Báo cáo khoa học: "Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway" pdf
Ngày tải lên :
12/08/2014, 04:21
... expression of HCV in the infected cells is associated with the increase in viral RNA, the titer of HCV positive strand RNA was measured using a real-time RT-PCR The level of HCV RNA in the infected cell ... deleted mutant clone was determined by measuring intracellular GFP expression There was an increase in the number of GFP positive cells after 24, 48 and 72 hours suggesting the replication of ... RT-PCR was used to quantify the HCV RNA level in the infected cells using a primer targeted to the HCV 5’UTR region HCV RNA titer in the infected cultures was increased with time suggesting that...
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Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
Ngày tải lên :
12/08/2014, 04:21
... STAT1 gene in mice revealed a role for STAT1 in the JAK- STAT signaling pathway [40] The JAK- STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... fold increase in HSV-1 replication in STAT1 deficient mice may be due, at least in part, to increased replication of virus in DCs and macrophages In this regard, it has been reported that HSV-infected ... 37°C Monolayers were washed 3× and total virus remaining associated with the cells was determined by plaque assay as described in Materials and Methods In both panels each point represents the mean...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
Ngày tải lên :
12/08/2014, 04:21
... STAT1 gene in mice revealed a role for STAT1 in the JAK- STAT signaling pathway [40] The JAK- STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... fold increase in HSV-1 replication in STAT1 deficient mice may be due, at least in part, to increased replication of virus in DCs and macrophages In this regard, it has been reported that HSV-infected ... 37°C Monolayers were washed 3× and total virus remaining associated with the cells was determined by plaque assay as described in Materials and Methods In both panels each point represents the mean...
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Báo cáo y học: " Therapeutic targets for HIV-1 infection in the host proteome" pot
Ngày tải lên :
13/08/2014, 09:21
... cycle in Tat expressing cells, including ribosome and actin/cytoskeleton genes dependence on efficient protein processing and intracellular transport These findings suggest an increase in Tatinduced ... protein thioredoxin domain containing (protein disulfide isomerase) calumenin protective protein for beta-galactosidase (galactosialidosis) pituitary tumor-transforming interacting protein FK506 ... lymphotoxin B receptor), signaling mediators (Grb2, AKAP1, IRAK1, CaM-kinase II, calcineurin), and proteins involved in transcriptional regulation (BAF60C, NFI/C, ATF6) Interestingly, 26 genes in this...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
Ngày tải lên :
15/09/2015, 22:19
... many proteins in different pathways [55] For instance, in addition to interacting with its main target protein cyclooxygenase, anti-inflammatory drug aspirin is known to affect NF-kappa B pathway ... first aspect was concerned development of pharmainformatics databases; the second aspect of this research involved in silico mining the therapeutic targets and ADME-AP data by using bioinformatics ... therapeutic target information As indicated in previous section, three important information communities should be included in TTD: therapeutic target information, information about targets binding ligands...
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Managing people working as individuals and in groups
Ngày tải lên :
14/09/2012, 11:41
... ble Instill basic discipline into workforce activities Compensation Training Per formance management Staffing Communication Work environment Initial ©Ian Sommerville 2004 Software Engineering, ... Part-time involvement may be inevitable Skills such as UI design and hardware interfacing are in short supply Recent graduates may not have specific skills but may be a way of introducing new skills ... This may provide an indicator of the basic fundamentals that the candidate should know and of their ability to learn This factor becomes increasingly irrelevant as engineers gain experience across...
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A STUDY ON GRAMMATICAL MEANS AND PROSODIC MEANS AS COHENSIVE DEVICES IN NARRATIVE DISCOURSE
Ngày tải lên :
07/09/2013, 13:02
... Summary…………………………………………………………………30 CHAPTER III: Intonation as a cohesive device in narrative discourse……………….31 I Introduction…………………………………………………………………………31 II Intonation as a mean of cohesive device in “The Perfect Man” ... Crystal, D 1992 Introduction to Linguistics London: Penguin Georgakopoulou, A and Goutsos, D 1997 Discourse Analysis: An introduction Edinburgh: Edinburgh University Press Halliday, M, and Hasan, R 1976 ... Some basic functions of intonation……….……………… 19 III.3.2.2.2 Some communicative function of tones……….………… 20 CHAPTER II: Grammatical means as cohesive devices in narrative discourse…………21 I Introduction………………………………………………………………………...
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A STUDY ON GRAMMATICAL MEANS AND PROSODIC MEANS AS COHENSIVE DEVICES IN NARRATIVE DISCOURSE
Ngày tải lên :
29/01/2014, 10:33
... regions in English When you say something you can not say without some kind of intonation, even a monotone can be classed as a kind of intonation Intonation is integral in speech III.2 Tone vs intonation ... exist for linking something with what has gone before Since this linking is achieved through relations in meaning (we are excluding from consideration the effect of formal devices such as syntactic ... with rising tone as the Dr Pitch was not sure and he wanted to ask Answering the question, Jean uses the falling tone to definitely affirm in contrast with what Dr Fitch said before The falling tone...
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SLIDE a STUDY ON GRAMMATICAL MEANS AND PROSODIC MEANS AS COHENSIVE DEVICES IN NARRATIVE DISCOURSE
Ngày tải lên :
29/01/2014, 10:33
... and conjunction function in particular become cohesive devices in narrative discourse How prosodic means in general and intonation in particular become a cohesive device in narrative discourse ... The linguists has discussed and given various concept about how intonation and grammatical means as cohesive devices in narrative discourse SCOPE OF THE STUDY AIMS OF THE STUDY CONTENTS • Introduction ... focus on the grammatical means and intonation as cohesive devices in the film “The Perfect Man” on HBO channel METHODS OF THE STUDY Major method: inductive method Minor method: analytic method Technique:...
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